Psychiatry Research: Neuroimaging
Volume 194, Issue 3 , Pages 205-211 , 30 December 2011

Improvement of cognitive flexibility and cingulate blood flow correlates after atypical antipsychotic treatment in drug-naive patients with first-episode schizophrenia

  • Bernardo M. Pardo

      Affiliations

    • Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    • Department of Mental Health, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain
    • Corresponding Author InformationCorresponding author at: Parc Sanitari Sant Joan de Deu. Hospital de Sant Boi - Area de Salut Mental, Antoni Pujadas 42, 08830 Sant Boi de Llobregat, Barcelona, Spain. Tel.: +34 93 6406350x2267; fax: +34 93 6002653.
  • ,
  • Maite Garolera

      Affiliations

    • Neuropsychological Unit, Hospital de Terrassa-Consorci Sanitari de Terrassa, Terrassa, Spain
    • Department of Mental Health, Hospital de Terrassa-Consorci Sanitari de Terrassa, Terrassa, Spain
  • ,
  • Mar Ariza

      Affiliations

    • Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    • Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain
  • ,
  • Deborah Pareto

      Affiliations

    • Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain
  • ,
  • Manel Salamero

      Affiliations

    • Department of Clinical Psychology, Hospital Clinic of Barcelona, Barcelona, Spain
  • ,
  • Vicenç Valles

      Affiliations

    • Department of Mental Health, Hospital de Terrassa-Consorci Sanitari de Terrassa, Terrassa, Spain
  • ,
  • Luis Delgado

      Affiliations

    • Department of Mental Health, Hospital de Terrassa-Consorci Sanitari de Terrassa, Terrassa, Spain
  • ,
  • Joan Alberni

      Affiliations

    • Department of Mental Health, Hospital de Terrassa-Consorci Sanitari de Terrassa, Terrassa, Spain

Received 12 December 2010 ,Revised 2 June 2011 ,Accepted 3 June 2011.

References 

  1. Aarts E, Roelofs A, van Turennout M. Attentional control of task and response in lateral and medial frontal cortex: brain activity and reaction time distributions. Neuropsychologia. 2009;47:2089–2099
  2. Akdede BB, Anil Yagcioglu AE, Alptekin K, Turgut TI, Tumuklu M, Yazici MK, et al. A double-blind study of combination of clozapine with risperidone in patients with schizophrenia: effects on cognition. The Journal of Clinical Psychiatry. 2006;67:1912–1919
  3. Aubin G, Stip E, Gelinas I, Rainville C, Chapparo C. Daily activities, cognition and community functioning in persons with schizophrenia. Schizophrenia Research. 2009;107:313–318
  4. Badzakova-Trajkov G, Barnett KJ, Waldie KE, Kirk IJ. An ERP investigation of the Stroop task: the role of the cingulate in attentional allocation and conflict resolution. Brain Research. 2009;1253:139–148
  5. Bernal B, Altman N. Neural networks of motor and cognitive inhibition are dissociated between brain hemispheres: an fMRI study. International Journal of Neuroscience. 2009;119:1848–1880
  6. Bobes J, Arango C, Garcia-Garcia M, Rejas J. Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: findings from the CLAMORS study. The Journal of Clinical Psychiatry. 2009;71:280–286
  7. Borges A, San Luis C, Sánchez-Bruno A. Dominance statistics: a simulation study of the d statistic. Quality and Quantity. 2003;37:303–316
  8. Brewer WJ, Yucel M, Harrison BJ, McGorry PD, Olver J, Egan GF, et al. Increased prefrontal cerebral blood flow in first-episode schizophrenia following treatment: longitudinal positron emission tomography study. The Australian and New Zealand Journal of Psychiatry. 2007;41:129–135
  9. Camchong J, MacDonald AW, Bell C, Mueller BA, Lim KO. Altered functional and anatomical connectivity in schizophrenia. Schizophrenia Bulletin. 2011;37(3):640–650
  10. Catale C, Marique P, Closset A, Meulemans T. Attentional and executive functioning following mild traumatic brain injury in children using the Test for Attentional Performance (TAP) battery. Journal of Clinical and Experimental Neuropsychology. 2009;31:331–338
  11. Cliff N. Dominance statistics: ordinal analyses to answer ordinal questions. Psychological Bulletin. 1993;114:494–509
  12. Cliff N. Answering ordinal questions with ordinal data using ordinal statistics. Multivariate Behavioral Research. 1996;31:331–350
  13. Cremasco L, Cappa SF. Attentional dysfunction of chronic schizophrenia: No association with long-term institutionalization. Psychiatry and Clinical Neurosciences. 2002;56:419–423
  14. Crespo-Facorro B, Rodriguez-Sanchez JM, Perez-Iglesias R, Mata I, Ayesa R, Ramirez-Bonilla M, et al. Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparison. The Journal of Clinical Psychiatry. 2009;70:717–729
  15. Cuesta MJ, Jalon EG, Campos MS, Peralta V. Cognitive effectiveness of olanzapine and risperidone in first-episode psychosis. The British Journal of Psychiatry. 2009;194:439–445
  16. Davidson M, Galderisi S, Weiser M, Werbeloff N, Fleischhacker WW, Keefe RS, et al. Cognitive effects of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: a randomized, open-label clinical trial (EUFEST). The American Journal of Psychiatry. 2009;166:675–682
  17. de la Torre JC, Barrios M, Junque C. Frontal lobe alterations in schizophrenia: neuroimaging and neuropsychological findings. European Archives of Psychiatry and Clinical Neuroscience. 2005;255:236–244
  18. Goldberg TE, Goldman RS, Burdick KE, Malhotra AK, Lencz T, Patel RC, et al. Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?. Archives of General Psychiatry. 2007;64:1115–1122
  19. Gonzalez-Blanch C, Crespo-Facorro B, Alvarez-Jimenez M, Rodriguez-Sanchez JM, Perez-Iglesias R, Pelayo-Teran JM, et al. Lack of association between clinical and cognitive change in first-episode psychosis: the first 6weeks of treatment. Canadian Journal of Psychiatry. 2008;53:839–847
  20. Gurpegui M, Alvarez E, Bousono M, Ciudad A, Carlos GJ, Olivares JM. Effect of olanzapine or risperidone treatment on some cognitive functions in a one-year follow-up of schizophrenia outpatients with prominent negative symptoms. European Neuropsychopharmacology. 2007;17:725–734
  21. Harvey PD, Patterson TL, Potter LS, Zhong K, Brecher M. Improvement in social competence with short-term atypical antipsychotic treatment: a randomized, double-blind comparison of quetiapine versus risperidone for social competence, social cognition, and neuropsychological functioning. The American Journal of Psychiatry. 2006;163:1918–1925
  22. Houthoofd SA, Morrens M, Sabbe BG. Cognitive and psychomotor effects of risperidone in schizophrenia and schizoaffective disorder. Clinical Therapeutics. 2008;30:1565–1589
  23. Hyafil A, Summerfield C, Koechlin E. Two mechanisms for task switching in the prefrontal cortex. Journal of Neuroscience. 2009;29:5135–5142
  24. Jones HM, Brammer MJ, O'Toole M, Taylor T, Ohlsen RI, Brown RG, et al. Cortical effects of quetiapine in first-episode schizophrenia: a preliminary functional magnetic resonance imaging study. Biological Psychiatry. 2004;56:938–942
  25. Keedy SK, Rosen C, Khine T, Rajarethinam R, Janicak PG, Sweeney JA. An fMRI study of visual attention and sensorimotor function before and after antipsychotic treatment in first-episode schizophrenia. Psychiatry Research. 2009;172:16–23
  26. Keefe RS, Young CA, Rock SL, Purdon SE, Gold JM, Breier A. One-year double-blind study of the neurocognitive efficacy of olanzapine, risperidone, and haloperidol in schizophrenia. Schizophrenia Research. 2006;81:1–15
  27. Kerns JG, Cohen JD, MacDonald AW, Johnson MK, Stenger VA, Aizenstein H, et al. Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia. The American Journal of Psychiatry. 2005;162:1833–1839
  28. Krabbendam L, O'Daly O, Morley LA, van Os J, Murray RM, Shergill SS. Using the Stroop task to investigate the neural correlates of symptom change in schizophrenia. British Journal of Psychiatry. 2009;194:373–374
  29. Lahr D, Beblo T, Hartje W. Cognitive performance and subjective complaints before and after remission of major depression. Cognitive Neuropsychiatry. 2007;12:25–45
  30. Lahti AC, Weiler MA, Holcomb HH, Tamminga CA, Cropsey KL. Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia. Neuropsychopharmacology. 2009;34:2675–2690
  31. Lipkovich IA, Deberdt W, Csernansky JG, Buckley P, Peuskens J, Kollack-Walker S, et al. Defining “good” and “poor” outcomes in patients with schizophrenia or schizoaffective disorder: a multidimensional data-driven approach. Psychiatry Research. 2009;170:161–167
  32. Lysaker PH, Tsai J, Henninger LL, Vohs JL, Viverito K. Decrements in sustained attention across trials in a continuous performance test: associations with social functioning in schizophrenia. The Journal of Nervous and Mental Disease. 2010;198:154–158
  33. Manes F, Villamil AR, Ameriso S, Roca M, Torralva T. “Real life” executive deficits in patients with focal vascular lesions affecting the cerebellum. Journal of the Neurological Sciences. 2009;283:95–98
  34. Matthias E, Schandry R, Duschek S, Pollatos O. On the relationship between interoceptive awareness and the attentional processing of visual stimuli. International Journal of Psychophysiology. 2009;72:154–159
  35. Milham MP, Banich MT, Barad V. Competition for priority in processing increases prefrontal cortex's involvement in top-down control: an event-related fMRI study of the stroop task. Brain Research. Cognitive Brain Research. 2003;17:212–222
  36. Minzenberg MJ, Laird AR, Thelen S, Carter CS, Glahn DC. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Archives of General Psychiatry. 2009;66:811–822
  37. Moll J, Oliveira-Souza R, Moll FT, Bramati IE, Andreiuolo PA. The cerebral correlates of set-shifting: an fMRI study of the trail making test. Arquivos de Neuro-Psiquiatria. 2002;60:900–905
  38. Montaldi D, Mayes AR. The neuroactivation of cognitive processes investigated with SPECT. Behavioural Neurology. 2000;12:53–67
  39. Mulert C, Gallinat J, Dorn H, Herrmann WM, Winterer G. The relationship between reaction time, error rate and anterior cingulate cortex activity. International Journal of Psychophysiology. 2003;47:175–183
  40. O'Grada C, Dinan T. Executive function in schizophrenia: what impact do antipsychotics have?. Human Psychopharmacology. 2007;22:397–406
  41. Ohira H, Ichikawa N, Nomura M, Isowa T, Kimura K, Kanayama N, et al. Brain and autonomic association accompanying stochastic decision-making. NeuroImage. 2010;49:1024–1037
  42. Pavia J, Ros D, Catafau AM, Lomena FJ, Huguet M, Setoain J. Three-dimensional realignment of activation brain single-photon emission tomographic studies. European Journal of Nuclear Medicine. 1994;21:1298–1302
  43. Penades R, Boget T, Salamero M, Catarineu S, Bernardo M. Neuropsychological changes in schizophrenia and its modification. Actas Españolas de Psiquiatría. 2000;28:59–69
  44. Pflueger MO, Gschwandtner U, Stieglitz RD, Riecher-Rossler A. Neuropsychological deficits in individuals with an at risk mental state for psychosis—working memory as a potential trait marker. Schizophrenia Research. 2007;97:14–24
  45. Polli FE, Barton JJ, Thakkar KN, Greve DN, Goff DC, Rauch SL, et al. Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia. Brain. 2008;131:971–986
  46. Prouteau A, Doron J. Cognitive predictors of the community functioning dimensions in schizophrenia: state of the art and future directions. L'Encéphale. 2008;34:360–368
  47. Reske M, Habel U, Kellermann T, Backes V, Jon SN, von Wilmsdorff M, et al. Differential brain activation during facial emotion discrimination in first-episode schizophrenia. Journal of Psychiatric Research. 2009;43:592–599
  48. Rocca P, Montemagni C, Castagna F, Giugiario M, Scalese M, Bogetto F. Relative contribution of antipsychotics, negative symptoms and executive functions to social functioning in stable schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2009;33:373–379
  49. Sabri O, Owega A, Schreckenberger M, Sturz L, Fimm B, Kunert P, et al. A truly simultaneous combination of functional transcranial Doppler sonography and H(2)(15)O PET adds fundamental new information on differences in cognitive activation between schizophrenics and healthy control subjects. Journal of Nuclear Medicine. 2003;44:671–681
  50. Salgado-Pineda P, Caclin A, Baeza I, Junque C, Bernardo M, Blin O, et al. Schizophrenia and frontal cortex: where does it fail?. Schizophrenia Research. 2007;91:73–81
  51. Salgado-Pineda P, Junque C, Vendrell P, Baeza I, Bargallo N, Falcon C, et al. Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients. NeuroImage. 2004;21:840–847
  52. Salgado-Pineda P, Vendrell P, Bargallo N, Falcon C, Junque C. Functional magnetic resonance in the evaluation of the activity of the anterior cingulate cortex using Stroop's paradigm. Revista de Neurologia. 2002;34:607–611
  53. Scherwath A, Poppelreuter M, Weis J, Schulz-Kindermann F, Koch U, Mehnert A. Psychometric evaluation of a neuropsychological test battery measuring cognitive dysfunction in cancer patients—recommendations for a screening tool. Fortschritte der Neurologie-Psychiatrie. 2008;76:583–593
  54. Schlagenhauf F, Dinges M, Beck A, Wustenberg T, Friedel E, Dembler T, et al. Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activation. Schizophrenia Research. 2010;118:189–200
  55. Snitz BE, MacDonald A, Cohen JD, Cho RY, Becker T, Carter CS. Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment. The American Journal of Psychiatry. 2005;162:2322–2329
  56. Tana MG, Montin E, Cerutti S, Bianchi AM. Exploring cortical attentional system by using fMRI during a Continuous Perfomance Test. Computational Intelligence and Neuroscience. 2010;
  57. Tislerova B, Brunovsky M, Horacek J, Novak T, Kopecek M, Mohr P, et al. LORETA functional imaging in antipsychotic-naive and olanzapine-, clozapine- and risperidone-treated patients with schizophrenia. Neuropsychobiology. 2008;58:1–10
  58. Vargha A, Delaney H. A critique and improvement of the CL common language effect size statistics of McGraw and Wong. Journal of Educational and Behavioral Statistics. 2000;25:101–132
  59. Williams LM, Whitford TJ, Flynn G, Wong W, Liddell BJ, Silverstein S, et al. General and social cognition in first episode schizophrenia: identification of separable factors and prediction of functional outcome using the IntegNeuro test battery. Schizophrenia Research. 2008;99:182–191
  60. Yucel M, Brewer WJ, Harrison BJ, Fornito A, O'Keefe GJ, Olver J, et al. Anterior cingulate activation in antipsychotic-naive first-episode schizophrenia. Acta Psychiatrica Scandinavica. 2007;115:155–158
  61. Zavitsanou K, Huang XF. Decreased [(3)H]spiperone binding in the anterior cingulate cortex of schizophrenia patients: an autoradiographic study. Neuroscience. 2002;109:709–716
  62. Zimmermann P, Fimm B. A test battery for attentional performance. In:  Zimmermann P,  Leclercq M editor. Applied Neuropsychology of Attention. Theory, Diagnosis and Rehabilitation. London: Psychology Press; 2002;p. 110–151

PII: S0925-4927(11)00205-8

doi: 10.1016/j.pscychresns.2011.06.001

Psychiatry Research: Neuroimaging
Volume 194, Issue 3 , Pages 205-211 , 30 December 2011