Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 105-113 , 30 August 2010

Habitual emotion regulation strategies and depressive symptoms in healthy subjects predict fMRI brain activation patterns related to major depression

  • Birgit Abler

      Affiliations

    • Department of Psychiatry, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 731 500 61560; fax: +49 731 500 61412.
  • ,
  • Christian Hofer

      Affiliations

    • Department of Psychiatry, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany
  • ,
  • Henrik Walter

      Affiliations

    • Department of Psychiatry, Division of Medical Psychology, University of Bonn, Bonn, Germany
  • ,
  • Susanne Erk

      Affiliations

    • Department of Psychiatry, Division of Medical Psychology, University of Bonn, Bonn, Germany
  • ,
  • Holger Hoffmann

      Affiliations

    • University Clinic for Psychosomatic Medicine and Psychotherapy, Medical Psychology, Ulm, Germany
  • ,
  • Harald C. Traue

      Affiliations

    • University Clinic for Psychosomatic Medicine and Psychotherapy, Medical Psychology, Ulm, Germany
  • ,
  • Henrik Kessler

      Affiliations

    • University Clinic for Psychosomatic Medicine and Psychotherapy, Medical Psychology, Ulm, Germany

Received 1 October 2008 ,Revised 7 May 2010 ,Accepted 20 May 2010.

References 

  1. Abercrombie HC, Schaefer SM, Larson CL, Oakes TR, Lindgren KA, Holden JE, et al. Metabolic rate in the right amygdala predicts negative affect in depressed patients. NeuroReport. 1998;9:3301–3307
  2. Abler B, Kessler H. Emotion Regulation Questionnaire—Eine deutschsprachige Fassung des ERQ von Gross and John. Diagnostica. 2009;55:144–152
  3. Abler B, Erk S, Herwig U, Walter H. Anticipation of aversive stimuli activates extended amygdala in unipolar depression. Journal of Psychiatric Research. 2007;41:511–522
  4. Abler B, Hofer C, Viviani R. Habitual emotion regulation strategies and baseline brain perfusion. NeuroReport. 2008;19:21–24
  5. Adolphs R. Is the human amygdala specialized for processing social information?. Annals of the New York Academy of Sciences. 2003;985:326–340
  6. Amodio DM, Frith CD. Meeting of minds: the medial frontal cortex and social cognition. Nature Reviews. Neuroscience. 2006;7:268–277
  7. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, et al. Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage. 2006;30:588–600
  8. Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, et al. Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Archives of General Psychiatry. 1997;54:364–374
  9. Brown TA, Barlow DH. Dimensional versus categorical classification of mental disorders in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders and beyond: comment on the special section. Journal of Abnormal Psychology. 2005;114:551–556
  10. Compas BE, Ey S, Grant KE. Taxonomy, assessment, and diagnosis of depression during adolescence. Psychological Bulletin. 1993;114:323–344
  11. Deighton RM, Traue HC. Emotional inhibition and somatization across cultures. International Review of Social Psychology. 2005;18:109–140
  12. Dougherty D, Rauch SL. Neuroimaging and neurobiological models of depression. Harvard Review of Psychiatry. 1997;5:138–159
  13. Drevets WC. Neuroimaging abnormalities in the amygdala in mood disorders. Annals of the New York Academy of Sciences. 2003;985:420–444
  14. Drevets WC, Raichle ME. Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: implications for interactions between emotion and cognition. Cognition and Emotion. 1998;12:353–385
  15. Drevets WC, Videen TO, Price JL. A functional anatomical study of unipolar depression. The Journal of Neuroscience. 1992;12:3628–3641
  16. Drevets WC, Bogers W, Raichle ME. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. European Neuropsychopharmacology. 2002;12:527–544
  17. Fitzgerald DA, Angstadt M, Jelsone LM, Nathan PJ, Phan KL. Beyond threat: amygdala reactivity across multiple expressions of facial affect. Neuroimage. 2006;30:1441–1448
  18. Goldin PR, McRae K, Ramel W, Gross JJ. The neural bases of emotion regulation: reappraisal and suppression of negative emotion. Biological Psychiatry. 2008;63:577–586
  19. Gross J. Emotion regulation: affective, cognitive, and social consequences. Psychophysiology. 2002;39:281–291
  20. Gross J, John OP. Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. Journal of Personality and Social Psychology. 2003;85:348–362
  21. Gross JJ, Levenson RW. Emotional suppression: physiology, self-report, and expressive behavior. Journal of Personality and Social Psychology. 1993;64:970–986
  22. Gross J, Munoz RF. Emotion regulation and mental health. Clinical Psychology: Science and Practice. 1995;2:151–164
  23. Gusnard DA, Akbudak E, Shulman GL, Raichle ME. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:4259–4264
  24. Hautzinger M, Bailer M, Worall H, Keller F. Beck-Depressions-Inventar (BDI). Bern: Huber; 1994;
  25. Herwig U, Abler B, Walter H, Erk S. Expecting unpleasant stimuli—an fMRI study. Psychiatry Research: Neuroimaging. 2007;154:1–12
  26. Kim H, Somerville LH, Johnstone T, Polis S, Alexander AL, Shin LM, et al. Contextual modulation of amygdala responsivity to surprised faces. Journal of Cognitive Neuroscience. 2004;16:1730–1745
  27. Laux L, Glanzmann P, Schaffner P, Spielberger CD. Das Stait-Trait-Angstinventar. Weinheim, Germany: Beltz; 1981;
  28. Lewinsohn PM, Solomon A, Seeley JR, Zeiss A. Clinical implications of “subthreshold” depressive symptoms. Journal of Abnormal Psychology. 2000;109:345–351
  29. Mai JK, Assheuer J, Paxinos G. Atlas of the Human Brain. New York: Thieme; 1997;
  30. Mayberg HS. Limbic-cortical dysregulation: a proposed model of depression. The Journal of Neuropsychiatry and Clinical Neurosciences. 1997;9:471–481
  31. Mayberg HS. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. British Medical Bulletin. 2003;65:193–207
  32. Murphy FC, Nimmo-Smith I, Lawrence AD. Functional neuroanatomy of emotions: a meta-analysis. Cognitive, Affective & Behavioral Neuroscience. 2003;3:207–233
  33. Nitschke JB, Sarinopoulos I, Mackiewicz KL, Schaefer HS, Davidson RJ. Functional neuroanatomy of aversion and its anticipation. Neuroimage. 2006;29:106–116
  34. Norris CJ, Chen EE, Zhu DC, Small SL, Cacioppo JT. The interaction of social and emotional processes in the brain. Journal of Cognitive Neuroscience. 2004;16:1818–1829
  35. Ochsner KN, Bunge SA, Gross JJ, Gabrieli JD. Rethinking feelings: an FMRI study of the cognitive regulation of emotion. Journal of Cognitive Neuroscience. 2002;1215–1229
  36. Ochsner KN, Ray RD, Cooper JC, Robertson ER, Chopra S, Gabrieli JD, et al. For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage. 2004;23:483–499
  37. Ohman A. The role of the amygdala in human fear: automatic detection of threat. Psychoneuroendocrinology. 2005;30:953–958
  38. Phan KL, Wager TD, Taylor SF, Liberzon I. Functional neuroimaging studies of human emotions. CNS Spectrums. 2004;9:258–266
  39. Phillips ML, Ladouceur CD, Drevets WC. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Molecular Psychiatry. 2008;13:833–857
  40. Posner IM, Rothbart MK. Attention, self-regulation and consciousness. Philosophical Transactions of the Royal Society of London. 1998;353:1915–1927
  41. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement. 1977;1:385–401
  42. Scherer KR. What are emotions? And how can they be measured?. Social Science Information. 2005;44:693–727
  43. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biological Psychiatry. 2001;50:651–658
  44. Siegle GJ, Steinhauer SR, Thase ME, Stenger VA, Carter CS. Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biological Psychiatry. 2002;51:693–707
  45. Siegle GJ, Thompson W, Carter CS, Steinhauer SR, Thase ME. Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biological Psychiatry. 2007;61:198–209
  46. Urry HL, van Reekum CM, Johnstone T, Kalin NH, Thurow ME, Schaefer HS, et al. Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. The Journal of Neuroscience. 2006;26:4415–4425
  47. Whalen PJ, Shin LM, Somerville LH, McLean AA, Kim H. Functional neuroimaging studies of the amygdala in depression. Seminars in Clinical Neuropsychiatry. 2002;7:234–242

PII: S0925-4927(10)00189-7

doi: 10.1016/j.pscychresns.2010.05.010

Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 105-113 , 30 August 2010