Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 133-139 , 30 August 2010

Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms

  • Ulrich W. Preuss

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • Department of Psychiatry, Martin-Luther-University of Halle-Wittenberg, Julius-Kühn-Str. 7, 06097 Halle/Saale, Germany
    • Corresponding Author InformationCorresponding author. Leitender Oberarzt/Stellvertreter des Direktors, Klinik für Psychiatrie und Psychotherapie der Martin-Luther-Universität Halle, Julius-Kühn-Straße 7, 06097 Halle/Saale, Germany. Tel.: +49 0345 5 57 4595; fax: +49 0345 557 3500.
    • ,
  • Thomas Zetzsche

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • ,
  • Oliver Pogarell

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • ,
  • Christoph Mulert

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • ,
  • Thomas Frodl

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • ,
  • Dirk Müller

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • ,
  • Gisela Schmidt

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • ,
  • Christine Born

      Affiliations

    • Department of Radiology, Ludwig-Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany
    • ,
  • Maximilian Reiser

      Affiliations

    • Department of Radiology, Ludwig-Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany
    • ,
  • Hans-Jürgen Möller

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • ,
  • Ulrich Hegerl

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany
    • ,
  • Eva M. Meisenzahl

      Affiliations

    • Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany

Received 12 May 2009 ,Revised 19 April 2010 ,Accepted 16 May 2010.

References 

  1. Andreasen NC, Cizadlo T, Harris G, Swayze V, O'Leary DS, Cohen G, et al. Voxel processing techniques for the antemortem study of neuroanatomy and neuropathology using magnetic resonance imaging. Journal of Neuropsychiatry and Clinical Neuroscience. 1993;5:121–130
  2. Andreasen NC, Nopoulos P, O'Leary DS, Miller DD, Wassink T, Flaum M. Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biological Psychiatry. 1999;46:908–920
  3. Ashton L, Barnes A, Livingston M, Wyper D Scottish Schizophrenia Research Group. Cingulate abnormalities associated with PANSS negative scores in first episode schizophrenia. Behavioral Neurology. 2000;12:93–101
  4. Benes FM. Neurobiological investigations in cingulate cortex of schizophrenic brain. Schizophrenia Bulletin. 1993;19:537–549
  5. Blackwood DHR, St. Clair DM, Muir WJ, Duffy J. Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Archives of General Psychiatry. 1991;48:899–909
  6. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Science. 2000;4:215–222
  7. Carter CS, Mintun M, Nichols T, Cohen JD. Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: an [15O] H2O PET study during single trial Stroop task performance. American Journal of Psychiatry. 1997;154:1670–1675
  8. Donchin E, Coles MGH. Is the P300 component a manifestation of context updating?. Behavioral and Brain Sciences. 1988;11:357–374
  9. Eikmeier G, Lodemann E. Ereigniskorrelierte Hirnpotentiale und primäre Negativsymptomatik bei schizophrenen Patienten. EEG-EMG. 1993;24:234–241
  10. Farrow TF, Whitford TJ, Williams LM, Gomes L, Harris AW. Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorder. Biological Psychiatry. 2005;58:713–723
  11. Ford JM, Gray M, Whitfield SL, Turken AU, Glover G, Faustman WO, et al. Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging. Archives of General Psychiatry. 2004;61:119–129
  12. Frodl T, Meisenzahl EM, Müller D, Greiner J, Juckel G, Leinsinger G, et al. Corpus callosum and P300 in schizophrenia. Schizophrenia Research. 2001;49:107–119
  13. Frodl T, Meisenzahl EM, Muller D, Holder J, Juckel G, Moller HJ, et al. P300 subcomponents and clinical symptoms in schizophrenia. International Journal of Psychophysiology. 2002;43:237–246
  14. Fukuda M, Niwa S, Hiramatsu K, Hata A, Saitoh O, Hayashida S, et al. Behavioral and P3 amplitude enhancement in schizophrenia following feedback training. Schizophrenia Research. 1997;25:231–242
  15. Gallinat J, Riedel M, Juckel G, Sokullu S, Frodl T, Moukhtieva R, et al. P300 and symptom improvement in schizophrenia. Psychopharmacology (Berl). 2001;158:55–65
  16. Ha TH, Youn T, Ha KS, Rho KS, Lee JM, Kim IY, et al. Gray matter abnormalities in paranoid schizophrenia and their clinical correlations. Psychiatry Research: Neuroimaging I. 2004;132:251–260
  17. Harris G, Andreasen NC, Cizadlo T, Bailey JM, Bockholt HJ, Magnotta VA, et al. Improving tissue classification in MRI: a three-dimensional multispectral discriminant analysis method with automated training class selection. Journal of Computer Assisted Tomography. 1999;23:144–154
  18. Haznedar MM, Buchsbaum MS, Hazlett EA, Shihabuddin L, New A, Siever LJ. Cingulate gyrus volume and metabolism in the schizophrenia spectrum. Schizophrenia Research. 2004;71:249–262
  19. Honey GD, Pomarol-Clotet E, Corlett PR, Honey RA, McKenna PJ, Bullmore ET, et al. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain. 2005;128:2597–2611
  20. Jeon YW, Polich J. Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. Psychophysiology. 2003;40:684–701
  21. Job DE, Whalley HC, McConnell S, Glabus M, Johnstone EC, Lawrie SM. Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry. Neuroimage. 2002;17:880–889
  22. Johnson R. On the neural generators of the P300 component of the event-related potential. Psychophysiology. 1993;30:90–97
  23. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  24. Kidogami Y, Yoneda H, Asaba H, Sakai T. P300 in first degree relatives of schizophrenics. Schizophrenia Research. 1991;6:9–13
  25. Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry. 2005;57:1029–1040
  26. Koo MS, Levitt JJ, Salisbury DF, Nakamura M, Shenton ME, McCarley RW. A cross-sectional and longitudinal magnetic resonance imaging study of cingulate gyrus gray matter volume abnormalities in first-episode schizophrenia and first-episode affective psychosis. Archives of General Psychiatry. 2008;65:746–760
  27. Kubicki M, Shenton ME, Salisbury DF, Hirayasu Y, Kasai K, Kikinis R, et al. Voxel-based morphometric analysis of gray matter in first episode schizophrenia. Neuroimage. 2002;17:1711–1719
  28. Lahti AC, Weiler MA, Holcomb HH, Tamminga CA, Carpenter WT, McMahon R. Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia. Neuropsychopharmacology. 2006;31:221–230
  29. Lewis DA, Lieberman JA. Catching up on schizophrenia: natural history and neurobiology. Neuron. 2000;28:325–334
  30. Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RS. Patterns of cerebral blood flow in schizophrenia. British Journal of Psychiatry. 1992;160:179–186
  31. MacLean PD. Perspectives on cingulate cortex in the limbic system. In:  Vogt BA,  Gabriel M editor. Neurobiology of Cingulate Cortex and Limbic Thalamus. Boston: Birkhauser; 1993;
  32. Marneros A, Deister A, Rohde A. Long-term investigation in stability of negative/positive distinction. In:  Marneros A,  Andreasen NC,  Tsuang MT editor. Negative Versus Positive Schizophrenia. Berlin: Springer; 1991;p. 28–51
  33. McCarley RW, Shenton ME, O'Donnell BF, Faux SF, Kikinis R, Nestor PG, et al. Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Archives of General Psychiatry. 1993;50:190–197
  34. McIntosh AM, Job DE, Moorhead WJ, Harrison LK, Whalley HC, Johnstone EC, et al. Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure. American Journal of Medical Genetics. Part B. Neuropsychiatric Genetics. 2006;141:76–83
  35. Meisenzahl EM, Frodl T, Muller D, Schmitt G, Gallinat J, Zetzsche T, et al. Superior temporal gyrus and P300 in schizophrenia: a combined ERP/structural magnetic resonance imaging investigation. Journal of Psychiatric Research. 2004;38:153–162
  36. Mintz M, Hermesh H, Glicksohn J, Munitz H, Radwan M. First month of neuroleptic treatment in schizophrenia: only partial normalization of the late positive components of visual ERP. Biological Psychiatry. 1995;37:402–409
  37. Mitelman SA, Shihabuddin L, Brickman AM, Hazlett EA, Buchsbaum MS. Volume of the cingulate and outcome in schizophrenia. Schizophrenia Research. 2005;72:91–108
  38. Paillère-Martinot M, Caclin A, Artiges E, Poline JB, Joliot M, Mallet L, et al. Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. Schizophrenia Research. 2001;50:19–26
  39. Potkin SG, Alva G, Fleming K, Anand R, Keator D, Carreon D, et al. A PET study of the pathophysiology of negative symptoms in schizophrenia. Positron emission tomography. American Journal of Psychiatry. 2002;159:227–237
  40. Preuss UW, Zetzsche T, Jager M, Groll C, Frodl T, Bottlender R, et al. Thalamic volume in first episode and chronic schizophrenic subjects: a volumetric MRI study. Schizophrenia Research. 2005;73:91–101
  41. Riffkin J, Yucel M, Maruff P, Wood SJ, Soulsby B, Olver J, et al. A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive–compulsive disorder: comparison with healthy controls and patients with schizophrenia. Psychiatry Research: Neuroimaging. 2005;138:99–113
  42. Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K, et al. Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. American Journal of Psychiatry. 2001;158:234–243
  43. Stahl SM, Buckley PF. Negative symptoms of schizophrenia: a problem that will not go away. Acta Psychiatrica Scandinavica. 2007;115:4–11
  44. Stip E, Fahim C, Liddle P, Mancini-Marie A, Mensour B, Bentaleb LA, et al. Neural correlates of sad feelings in schizophrenia with and without blunted affect. Canadian Journal of Psychiatry. 2005;50:909–917
  45. Strik WK, Dierks T, Maurer K. Amplitudes of auditory P300 in remitted and residual schizophrenics: correlations with clinical features. Neuropsychobiology. 1993;27:54–60
  46. Suzuki M, Zhou SY, Hagino H, Niu L, Takahashi T, Kawasaki Y, et al. Morphological brain changes associated with Schneider's first-rank symptoms in schizophrenia: a MRI study. Psychological Medicine. 2005;35:549–560
  47. Szeszko PR, Bilder RM, Lencz T, Ashtari M, Goldman RS, Reiter G, et al. Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia. Schizophrenia Research. 2000;43:97–108
  48. Takahashi T, Suzuki M, Kawasaki Y, Kurokawa K, Hagino H, Yamashita I, et al. Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder. European Archives of Psychiatry and Clinical Neuroscience. 2002;252:268–277
  49. Takahashi T, Suzuki M, Kawasaki Y, Hagino H, Yamashita I, Nohara S, et al. Perigenual cingulate gyrus volume in patients with schizophrenia: a magnetic resonance imaging study. Biological Psychiatry. 2003;53:593–600
  50. Tamminga CA, Vogel M, Gao X, Lahti AC, Holcomb HH. The limbic cortex in schizophrenia: focus on the anterior cingulate. Brain Research. Brain Research Reviews. 2000;31:364–370
  51. Tien RD, Felsberg GJ, Krishnan R, Heinz ER. MR imaging of diseases of the limbic system. American Journal of Roentgenology. 1994;163:657–665
  52. Velakoulis D, Wood SJ, Smith DJ, Soulsby B, Brewer W, Leeton L, et al. Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulated grey matter in patients with chronic schizophrenia. Schizophrenia Research. 2002;57:43–49
  53. Verleger R. Event-related potentials and cognition: a critique of the context updating hypothesis and an alternative interpretation of P3. Behavioral and Brain Sciences. 1988;11:343–427
  54. Ward PB, Catts SV, Fox AM, Michie PT, McConaghy N. Auditory selective attention and event-related potentials in schizophrenia. British Journal of Psychiatry. 1991;158:534–539
  55. Woods SM. Chlorpromazine equivalent doses for the newer atypical antipsychotics. Journal of Clinical Psychiatry. 2003;64:6643–6667
  56. Yamasue H, Fukui T, Fukuda R, Yamada H, Yamasaki S, Kuroki N, et al. 1H-MR spectroscopy and gray matter volume of the anterior cingulate cortex in schizophrenia. NeuroReport. 2002;13:2133–2137
  57. Yücel M, Pantelis C, Stuart GW, Wood SJ, Maruff P, Velakoulis D, et al. Anterior cingulate activation during Stroop task performance: a PET to MRI coregistration study of individual patients with schizophrenia. American Journal of Psychiatry. 2002;159:251–254
  58. Zetzsche T, Preuss U, Frodl T, Watz D, Schmitt G, Koutsouleris N, et al. In-vivo topography of structural alterations of the anterior cingulate in patients with schizophrenia: new findings and comparison with the literature. Schizophrenia Research. 2007;96:34–45

PII: S0925-4927(10)00187-3

doi: 10.1016/j.pscychresns.2010.05.008

Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 133-139 , 30 August 2010

Article Tools

* Image Usage & Resolution