Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 174-176, 30 August 2010

Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia — Relationship to auditory event-related potentials

  • James M. Stone

      Affiliations

    • Division of Experimental Medicine, Imperial College London, Burlington Danes Building, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    • Department of Psychological Medicine and Psychiatry, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 20 7848 0915; fax: +44 20 7848 0976.
    • ,
  • Elvira Bramon

      Affiliations

    • Department of Psychological Medicine and Psychiatry, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    • ,
  • Astrid Pauls

      Affiliations

    • Department of Psychological Medicine and Psychiatry, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    • ,
  • Alex Sumich

      Affiliations

    • Department of Psychological Medicine and Psychiatry, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    • Division of Psychology, School of Social Sciences, Nottingham Trent University, Burton Street, Nottingham, NG1 4BU, UK
    • ,
  • Philip K. McGuire

      Affiliations

    • Department of Psychological Medicine and Psychiatry, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK

Received 11 January 2010; received in revised form 20 March 2010; accepted 13 May 2010.

Abstract 

Thalamic neurochemical abnormalities may underlie psychotic symptoms and auditory event-related potential (ERP) abnormalities in schizophrenia. We investigated this hypothesis in subjects at risk of psychosis using magnetic resonance spectroscopy and electroencephalography (EEG). Reduced thalamic glutamate plus glutamine and N-acetyl aspartate levels were associated with abnormal frontal ERPs, supporting a thalamic basis for filtering impairments.

Keywords: EEG, Mismatch negativity, P300, Glutamate/glutamine, NAA, Magnetic resonance spectroscopy [MRS]

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PII: S0925-4927(10)00183-6

doi:10.1016/j.pscychresns.2010.05.004

Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 174-176, 30 August 2010

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