Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 167-169, 30 August 2010

Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: An event-related functional MRI study

  • Heide Klumpp

      Affiliations

    • Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, University of Michigan, Rachel Upjohn Building, Room 2744, 4250 Plymouth Road, Ann Arbor, MI 48109-2700, United States. Tel.: +1 734 232 0194; fax: +1 734 936 7868.
    • ,
  • Mike Angstadt

      Affiliations

    • Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
    • ,
  • Pradeep J. Nathan

      Affiliations

    • Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    • ,
  • K. Luan Phan

      Affiliations

    • Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States

Received 18 February 2010; received in revised form 30 April 2010; accepted 5 May 2010.

Abstract 

Using functional magnetic resonance imaging, we measured amygdala reactivity to faces varying on threat intensity in patients with generalized social phobia (GSP) and healthy controls. GSP patients exhibited greater amygdala reactivity to threat faces at high and moderate intensities. More subtle displays of social threat are sufficient to evoke a fear-related neural response.

Keywords: Social anxiety, Brain imaging, Threat

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PII: S0925-4927(10)00157-5

doi:10.1016/j.pscychresns.2010.05.001

Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 167-169, 30 August 2010

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