5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder
Received 8 January 2010; received in revised form 19 March 2010; accepted 28 April 2010.
Abstract
We investigated whether the promoter region of the serotonin transporter gene (5-HTTLPR) polymorphism influenced neurochemical metabolism in 26 individuals with autism spectrum disorder. Individuals with the S/S genotype of the 5-HTTLPR polymorphism showed significantly lower levels of N-acetylaspartate/creatine in the right medial prefrontal cortex compared with those with the S/L genotype.
Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Corresponding author. Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan. Tel.: +81 25 227 2213; fax: +81 25 227 0777.
ABSTRACT