Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 170-173, 30 August 2010

5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder

Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

Received 8 January 2010; received in revised form 19 March 2010; accepted 28 April 2010.

Abstract 

We investigated whether the promoter region of the serotonin transporter gene (5-HTTLPR) polymorphism influenced neurochemical metabolism in 26 individuals with autism spectrum disorder. Individuals with the S/S genotype of the 5-HTTLPR polymorphism showed significantly lower levels of N-acetylaspartate/creatine in the right medial prefrontal cortex compared with those with the S/L genotype.

Keywords: Proton magnetic resonance spectroscopy (1H-MRS), Serotonin transporter gene, Allele

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PII: S0925-4927(10)00151-4

doi:10.1016/j.pscychresns.2010.04.015

Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 170-173, 30 August 2010

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