Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 144-150 , 30 August 2010

Anterior thalamic radiation integrity in schizophrenia: A diffusion-tensor imaging study

  • Daniel Mamah

      Affiliations

    • Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States
    • Corresponding Author InformationCorresponding author. Department of Psychiatry (Box 8134), Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, United States. Tel.: +1 314 747 2160; fax: +1 314 747 2182.
    • ,
  • Thomas E. Conturo

      Affiliations

    • Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States
    • ,
  • Michael P. Harms

      Affiliations

    • Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States
    • ,
  • Erbil Akbudak

      Affiliations

    • Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States
    • ,
  • Lei Wang

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
    • ,
  • Amanda R. McMichael

      Affiliations

    • Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States
    • ,
  • Mokhtar H. Gado

      Affiliations

    • Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States
    • ,
  • Deanna M. Barch

      Affiliations

    • Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States
    • Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States
    • Department of Psychology, Washington University School of Medicine, St. Louis, MO, United States
    • ,
  • John G. Csernansky

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States

Received 20 May 2009 ,Revised 30 March 2010 ,Accepted 26 April 2010.

References 

  1. Andreasen NC. The role of the thalamus in schizophrenia. Canadian Journal of Psychiatry. 1997;42:27–33
  2. Andreasen NC, Olsen S. Negative v positive schizophrenia. Archives of General Psychiatry. 1982;39:789–794
  3. Axer H, Keyserlingk DG. Mapping of fiber orientation in human internal capsule by means of polarized light and confocal scanning laser microscopy. Journal of Neuroscience Methods. 2000;94:165–175
  4. Axer H, Lippitz BE, Keyserlingk DG. Morphological asymmetry in anterior limb of human internal capsule revealed by confocal laser and polarized light microscopy. Psychiatry Research: Neuroimaging. 1999;91:141–154
  5. Basser PJ, Mattiello J, LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophysics Journal. 1994;66:259–267
  6. Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR in Biomedicine. 1995;8:333–344
  7. Beasley CL, Dwork AJ, Rosoklija G, Mann JJ, Mancevski B, Jakovski Z, et al. Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia. Schizophrenia Research. 2009;109-159-66
  8. Brickman AM, Buchsbaum MS, Ivanov Z, Borod JC, Foldi NS, Hahn E, et al. Internal capsule size in good-outcome and poor-outcome schizophrenia. Journal of Neuropsychiatry and Clinical Neuroscience. 2006;18:364–376
  9. Buchsbaum MS, Schoenknecht P, Torosjan Y, Newmark R, Chu KW, Mitelman S, et al. Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia. Annals of General Psychiatry. 2006;5:19
  10. Buchsbaum MS, Someya T, Teng CY, Abel L, Chin S, Najafi A, et al. PET and MRI of the thalamus in never-medicated patients with schizophrenia. American Journal of Psychiatry. 1996;153:191–199
  11. Byne W, Buchsbaum MS, Mattiace LA, Hazlett EA, Kemether E, Elhakem SL, et al. Postmotem assessment of thalamic nuclear volumes in subject with schizophrenia. American Journal Psychaitry. 2002;159:59–65
  12. Byne W, Hazlett EA, Buchsbaum MS, Kemether E. The thalamus and schizophrenia: current status of research. Acta Neuropathologica. 2009;117:347–368
  13. Byne W, Kidkardnee S, Tatusov A, Yiannoulos G, Buchsbaum MS, Haroutaunian V. Schizophrenia-associated reduction of neuronal and oligodendrocyte numbers in the anterior principal thalamic nuclei. Schizophrenia Research. 2006;85:245–253
  14. Cheng, Y.W., Chung, H.W., Chen, C.Y., Chou, M.C, 2010. Diffusion tensor imaging with cerebrospinal fluid suppression and signal-to-noise preservation using acquisition combining fluid-attenuated inversion recovery and conventional imaging: comparison of fiber tracking. European Journal of Radiology (Electronic publication ahead of print, 3 February). doi:10.1016/j.ejrad.2009.12.032.
  15. Cheung V, Cheung C, McAlonan GM, Deng Y, Wong JG, Yip L, et al. A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychological Medicine. 2008;38:877–885
  16. Conturo TE, McKinstry RC, Akbudak E, Robinson BH. Encoding of anisotropic diffusion with tetrahedral gradients: a general mathematical diffusion formalism and experimental results. Magnetic Resonance in Medicine. 1996;35:399–412
  17. Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, et al. Schizophrenia as an anomaly of development of cerebral asymmetry: a postmortem study and a proposal concerning the genetic basis of the disease. Archives of General Psychiatry. 1989;46:1145–1150
  18. Csernansky JG, Schindler MK, Splinter NR, Wang L, Gado M, Selemon LD, et al. Abnormalities of thalamic volume and shape in schizophrenia. American Journal of Psychiatry. 2004;161:896–902
  19. Cunningham DJ. Text-book of Anatomy. Pentland; 1903;
  20. Deicken RF, Eliaz Y, Chosiad L, Feiwell R, Rogers L. Magnetic resonance imaging of the thalamus in male patients with schizophrenia. Schizophrenia Research. 2002;58:135–144
  21. Delawalla Z, Barch DM, Fisher Eastep JL, Thomason ES, Hanewinkel MJ, Thompson PA, et al. Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia. Schizophrenia Bulletin. 2006;32:525–537
  22. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-P), Version 2. New York: New York State Psychiatric Institute, Biometrics Research; 1995;
  23. Floresco SB, Grace AA. Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area. Journal of Neuroscience. 2003;23:2930–2943
  24. Harms MP, Wang L, Mamah D, Barch DM, Thompson PA, Csernansky JG. Thalamic shape abnormalities in individuals with schizophrenia and their non-psychotic siblings. Journal of Neuroscience. 2007;27:13835–13842
  25. Hasan KM, Narayana PA. Computation of the fractional anisotropy and mean diffusivity maps without tensor decoding and diagonalization: theoretical analysis and validation. Magnetic Resonance in Medicine. 2003;50:589–598
  26. Hasan KM, Parker DL, Alexander AL. Comparison of gradient encoding schemes for diffusion-tensor MRI. Journal of Magnetic Resonance Imaging. 2001;13:769–780
  27. Hazlett EA, Buchsbaum MS, Byne W, Wei TC, Spiegel-Cohen J, Geneve C, et al. Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrum. American Journal of Psychiatry. 1999;156:1190–1199
  28. Hendelman W. Atlas of Functional Neuroanatomy. CRC Press; 2006;
  29. Kahle W, Platzer W, Frotscher M, Leonhardt H. Color Atlas and Textbook of Human Anatomy. Medical Publishers, Inc., New York: Thieme; 2002;
  30. Kanaan RA, Kim JS, Kaufmann WE, Pearlson GD, Barker GJ, McGuire PK. Diffusion tensor imaging in schizophrenia. Biological Psychiatry. 2005;58:921–929
  31. Kay J. Crystallized intelligence versus fluid intelligence. Psychiatry. 2005;68:9–13
  32. Kito S, Jung J, Kobayashi T, Koga Y. Fiber tracking of white matter integrity connecting the mediodorsal nucleus of the thalamus and the prefrontal cortex in schizophrenia: a diffusion tensor imaging study. European Psychiatry. 2009;24:269–274
  33. Konick LC, Friedman L. Meta-analysis of thalamic size in schizophrenia. Biological Psychiatry. 2001;49:28–38
  34. Kubicki M, McCarley R, Westin CF, Park HJ, Maier S, Kikinis R, et al. A review of diffusion tensor imaging studies of schizophrenia. Journal of Psychiatry Research. 2007;41:15–30
  35. Kubicki M, Park H, Westin CF, Nestor PG, Mulkern RV, Maier SE, et al. DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity. Neuroimage. 2005;26:1109–1118
  36. Lang DJ, Khorram B, Goghari VM, Kopala LC, Vandorpe RA, Rui Q, et al. Reduced anterior internal capsule and thalamic volumes in first-episode psychosis. Schizophrenia Research. 2006;87:89–99
  37. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, et al. Diffusion tensor imaging: concepts and applications. Journal of Magnetic Resonance Imaging. 2001;13:534–546
  38. Madler B, Drabycz SA, Kolind SH, Whittall KP, MacKay AL. Is diffusion anisotropy an accurate monitor of myelination? Correlation of multicomponent T2 relaxation and diffusion tensor anisotropy in human brain. Magnetic Resonance Imaging. 2008;26:874–888
  39. Mamah D, Harms MP, Wang L, Barch D, Thompson P, Kim J, et al. Basal ganglia shape abnormalities in the unaffected siblings of schizophrenia patients. Biological Psychiatry. 2008;64:111–120
  40. Meyer A, Beck E, McLardy T. Prefrontal leukotomy: a neuroanatomical report. Brain. 1947;70:18–49
  41. Mitchell AS, Dairymple-Alford JC, Christie MA. Spatial working memory and the brainstem cholinergic innervation to the anterior thalamus. Journal of Neuroscience. 2002;22:1922–1928
  42. Mitelman SA, Torosjan Y, Newmark RE, Schneiderman JS, Chu KW, Brickman AM, et al. Internal capsule, corpus callosum and long association fibers in good and poor outcome schizophrenia: a diffusion tensor imaging survey. Schizophrenia Research. 2007;92:211–224
  43. Munoz Maniega S, Lymer GK, Bastin ME, Marjoram D, Job DE, Moorhead TW, et al. A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia. Schizophrenia Research. 2008;106:132–139
  44. Oh JS, Kubicki M, Rosenberger G, Bouix S, Levitt JJ, McCarley RW, et al. Thalamo-frontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography study. Human Brain Mapping. 2009;30:3812–3825
  45. Park HJ, Westin CF, Kubicki M, Maier SE, Niznikiewicz M, Baer A, et al. White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study. Neuroimage. 2004;23:213–223
  46. Peled S, Gudbjartsson H, Westin CF, Kikinis R, Jolesz FA. Magnetic resonance imaging shows orientation and asymmetry of white matter fiber tracts. Brain Research. 1998;780:27–33
  47. Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology. 1996;201:637–648
  48. Portas CM, Goldstein JM, Shenton ME, Hokama HH, Wible CG, Fischer I, et al. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biological Psychiatry. 1998;43:649–659
  49. Shimizu M, Fujiwara H, Hirao K, Namiki C, Fukuyama H, Hayashi T, et al. Structural abnormalities of the adhesio interthalamica and mediodorsal nuclei of the thalamus in schizophrenia. Schizophrenia Research. 2008;101:331–338
  50. Shimony JS, McKinstry RC, Akbudak E, Aronovitz JA, Snyder AZ, Lori NF, et al. Quantitative diffusion-tensor anisotropy brain MR imaging: normative human data and anatomic analysis. Radiology. 1999;212:770–784
  51. Skare S, Hedehus M, Moseley ME, Li TQ. Condition number as a measure of noise performance of diffusion tensor data acquisition schemes with MRI. Journal of Magnetic Resonance. 2000;147:340–352
  52. Spalteholz W. Hand Atlas of Human Anatomy. Lippincott, Philadelphia; 1923;
  53. Stieltjes B, Kaufman WE, van Zijl PC, Fredericksen K, Pearlson GD, Solaiyappan M, et al. Diffusion tensor imaging and axonal tracking in the human brainstem. Neuroimage. 2001;14:723–735
  54. Sussmann JE, Lymer GK, McKirdy J, Moorhead TW, Maniega SM, Job D, et al. White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging. Bipolar Disorders. 2009;11:11–18
  55. Szeszko PR, Ardekani BA, Ashtari M, Kumra S, Robinson DG, Sevy S, et al. White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study. American Journal of Psychiatry. 2005;162(3):602–605
  56. Vaessen MJ, Hofma PA, Tijssen HN, Aldenkamp AP, Jansen JF, Backes WH. The effect and reproducibility of different clinical DTI gradient sets on small world brain connectivity measures. Neuroimage. 2010;51(3):1106–1116
  57. Van der Werf YD, Jolles J, Witter MP, Uylings HB. Contributions of thalamic nuclei to declarative memory functioning. Cortex. 2003;39:1047–1062
  58. Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S. Fiber tract-based atlas of human white matter anatomy. Radiology. 2004;230:77–87
  59. Wobrock T, Gruber O, Schneider-Axmann T, Wolwer W, Gaebel W, Riesbeck M, et al. Internal capsule size associated with outcome in first-episode schizophrenia. European Archives of Psychiatry and Clinical Neuroscience. 2009;259:278–283
  60. Wright IC, Rabe-Hesketh S, Woodruff PWR, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry. 2000;157:16–25
  61. Wright SJ, Locke S. Fiber systems of medial and anterior thalamus of Macaque. Journal of Comparative Neurology. 1971;143:313–322
  62. Yoshihara Y, Sugihara G, Matsumoto H, Suckling J, Nishimura K, Toyoda T, et al. Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia. Annals of General Psychiatry. 2008;7:25
  63. Young KA, Manaye KF, Liang C, Hicks PB, German DC. Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia. Biological Psychiatry. 2000;47:944–953
  64. Zhou SY, Suzuki M, Hagino H, Takahashi T, Kawasaki Y, Nohara S, et al. Decreased volume and increased asymmetry of the anterior limb of the internal capsule in patients with schizophrenia. Biological Psychiatry. 2003;54:427–436
  65. Zoppelt D, Koch B, Schwarz M, Daum I. Involvement of the mediodorsal thalamic nucleus in mediating recollection and familiarity. Neuropsychologia. 2003;41(9):1160–1170
  66. Zou LQ, Xie JX, Yuan HS, Pei XL, Dong WT, Liu PC. Diffusion tensor imaging study of the anterior limb of the internal capsule in neuroleptic-naïve schizophrenia. Academic Radiology. 2008;15:285–289

PII: S0925-4927(10)00149-6

doi: 10.1016/j.pscychresns.2010.04.013

Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 144-150 , 30 August 2010

Article Tools

* Image Usage & Resolution