Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 119-125 , 30 August 2010

Corpus callosum abnormalities and potential age effect in men with schizophrenia: An MRI comparative study

  • Giuseppe Bersani

      Affiliations

    • Department of Psychiatric Sciences and Psychological Medicine, “Sapienza” University of Rome, Polo Pontino, “A. Fiorini” Hospital, Terracina (LT), Italy
    • Corresponding Author InformationCorresponding author. Tel./fax: +39 6 4454765.
    • ,
  • Adele Quartini

      Affiliations

    • Department of Psychiatric Sciences and Psychological Medicine, “Sapienza” University of Rome, Polo Pontino, “A. Fiorini” Hospital, Terracina (LT), Italy
    • ,
  • Angela Iannitelli

      Affiliations

    • Department of Psychiatric Sciences and Psychological Medicine, “Sapienza” University of Rome, Polo Pontino, “A. Fiorini” Hospital, Terracina (LT), Italy
    • ,
  • Marco Paolemili

      Affiliations

    • Department of Psychiatric Sciences and Psychological Medicine, “Sapienza” University of Rome, Polo Pontino, “A. Fiorini” Hospital, Terracina (LT), Italy
    • ,
  • Flavia Ratti

      Affiliations

    • Department of Psychiatric Sciences and Psychological Medicine, “Sapienza” University of Rome, Polo Pontino, “A. Fiorini” Hospital, Terracina (LT), Italy
    • ,
  • Claudio Di Biasi

      Affiliations

    • I Medical Clinic, Magnetic Resonance Imaging Unit, “Sapienza” University of Rome, Italy
    • ,
  • Gianfranco Gualdi

      Affiliations

    • I Medical Clinic, Magnetic Resonance Imaging Unit, “Sapienza” University of Rome, Italy

Received 29 July 2009 ,Revised 8 April 2010 ,Accepted 14 April 2010.

References 

  1. Agartz I, Andersson JL, Skare S. Abnormal white matter in schizophrenia. NeuroReport. 2001;12:2251–2254
  2. Andreasen NC. Scale for the Assessment of Negative Symptoms (SANS). Iowa City, IA: University of Iowa; 1983;
  3. Andreasen NC. Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, IA: University of Iowa; 1984;
  4. Ardekani BA, Nierenberg J, Hoptman NJ, Javitt DC, Lim KO. MRI study of white matter diffusion anisotropy in schizophrenia. NeuroReport. 2003;14:2025–2029
  5. Arnone D, McIntosh AM, Tan GMY, Ebmeier KP. Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia. Schizophrenia Research. 2008;101:124–132
  6. Bachmann S, Pantel J, Flender A, Bottmer C, Essig M, Schroder J. Corpus callosum in first-episode patients with schizophrenia—a magnetic resonance imaging study. Psychological Medicine. 2003;33:1019–1027
  7. Barch DM, Csernansky JG. Abnormal parietal cortex activation during working memory in schizophrenia: verbal phonological coding disturbances versus domain-general executive dysfunctions. American Journal of Psychiatry. 2007;164:1090–1098
  8. Bartzokis G, Lu PH, Nuechterlein KH, Gitlin M, Doi C, Edwards N, et al. Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia. Schizophrenia Research. 2007;93:13–22
  9. Bastin ME, Piatkowski JP, Storkey AJ, Brown LJ, MacLullich AMJ, Clayden JD. Tract shape modelling provides evidence of topological change in corpus callosum genu during normal aging. Neuroimage. 2008;43:20–28
  10. Bazire S. Psychotropic Drug Directory 2009. Tarxien, Malta: Gutenberg Press Limited; 2009;
  11. Bermudez P, Zatorre . Sexual dimorphism in the corpus callosum: methodological considerations in MRI morphometry. Neuroimage. 2001;13:1121–1130
  12. Bigelow LB, Nasrallah HA, Rauscher FP. Corpus callosum thickness in chronic schizophrenia. British Journal of Psychiatry. 1983;142:284–287
  13. Boroojerdi B, Töpper R, Foltys H, Meincke U. Transcallosal inhibition and motor conduction studies in patients with schizophrenia using transcranial magnetic stimulation. British Journal of Psychiatry. 1999;175:375–379
  14. Butler PD, Zemon V, Schechter I, Saperstein AM, Hoptman MJ, Lim KO, et al. Early-stage visual processing and cortical amplification deficits in schizophrenia. Archives of General Psychiatry. 2005;62:495–504
  15. Butler PD, Hoptman MJ, Nierenberg J, Foxe JJ, Javitt DC, Lim KO. Visual matter integrity in schizophrenia. American Journal of Psychiatry. 2006;163:2011–2013
  16. Coger RW, Serafetinides EA. Schizophrenia, corpus callosum, and interhemispheric communication: a review. Psychiatry Research. 1990;34:163–184
  17. Daskalakis ZJ, Christensen BK, Chen R, Fitzgerald PB, Zipursky RB, Kapur S. Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation. Archives of General Psychiatry. 2002;59:347–354
  18. De Lacoste MC, Kirkpatrick JB, Ross ED. Topography of the human corpus callosum. Journal of Neuropathology & Experimental Neurology. 1985;44:578–591
  19. De Lacoste-Utamsing C, Holloway R. Sexual dimorphism in the human corpus callosum. Science. 1982;216:1431–1432
  20. Desco M, Gispert JD, Reig S, Sanz J, Pascau J, Sarramea F, et al. Cerebral metabolic patterns in chronic and recent-onset schizophrenia. Psychiatry Research: Neuroimaging. 2003;122:125–135
  21. Doniger GM, Foxe JJ, Murray MM, Higgins BA, Javitt DC. Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia. Archives of General Psychiatry. 2002;59:1011–1020
  22. Dougherty RF, Ben-Shachar M, Bammer R, Brewe AA, Wandell BA. Functional organization of human occipital–callosal fiber tracts. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:7350–7355
  23. Downhill J, Buchsbaum MS, Wei T, Spiegel-Cohen J, Hazlett EA, Haznedar MM, et al. Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder. Schizophrenia Research. 2000;42:193–208
  24. Driesen NR, Raz N. The influence of sex, age, and handedness on corpus callosum morphology: a meta-analysis. Psychobiology. 1995;23:240–247
  25. Duara R, Kushch A, Gross-Glenn K, Barker WW, Jallad B, Pascal S, et al. Neuroanatomic differences between dyslexic and normal readers on magnetic resonance imaging scans. Archives of Neurology. 1991;48:410–416
  26. Ellison-Wright I, Bullmore E. Meta-analysis of diffusion tensor imaging studies in schizophrenia. Schizophrenia Research. 2009;108:3–10
  27. Foong J, Mayer M, Clark CA, Barker GJ, Miller DH, Ron MA. Neuropathological abnormalities of the corpus callosum in schizophrenia. A diffusion tensor imaging study. Journal of Neurology. Neurosurgery & Psychiatry. 2000;68:242–244
  28. Foong J, Symms MR, Barker GJ, Maier M, Woermann FG, Miller DH, et al. Neuropathological abnormalities in schizophrenia: evidence from magnetization transfer imaging. Brain. 2001;124:882–892
  29. Gegenfurtner KR, Kiper DC, Levitt JB. Functional properties of neurons in macaque area V3. Journal of Neurophysiology. 1997;77:1906–1923
  30. Goghari VM, Lang DJ, Flynn SW, Mackay AL, Honer WG. Smaller corpus callosum subregions containing motor fibers in schizophrenia. Schizophrenia Research. 2005;73:59–68
  31. Grill-Spector K, Malach R. The human visual cortex. Annual Review of Neuroscience. 2004;27:649–677
  32. Günther W, Petsch R, Steinberg R, Moser E, Streck P, Heller H, et al. Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging. Biological Psychiatry. 1991;29:535–555
  33. Hofer S, Frahm J. Topography of the human corpus callosum revisited—comprehensive fiber tractography using diffusion tensor magnetic resonance imaging. Neuroimage. 2006;32:989–994
  34. Höppner J, Kunesch E, Grossmann A, Tolzin CJ, Schulz M, Schlafke D, et al. Dysfunction of transcallosally mediated motor inhibition and callosal morphology in patients with schizophrenia. Acta Psychiatrica Scandinavica. 2001;104:227–235
  35. Hulshoff Pol HE, Schnack HG, Mandl RC, Cahn W, Collins DL, Evans AC, et al. Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity. Neuroimage. 2004;21:27–35
  36. Innocenti GM, Ansermet F, Parnas E. Schizophrenia, neurodevelopment and corpus callosum. Molecular Psychiatry. 2003;8:261–274
  37. Jacobsen LK, Giedd JN, Rajapakse JC, Hamburger SD, Vaituzis AC, Frazier JA, et al. Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia. Psychiatry Research: Neuroimaging. 1997;68:77–86
  38. John JP, Shakeel MK, Jain S. Corpus callosal area differences and gender dimorphism neuroleptic-naïve, recent onset schizophrenia and healthy control subjects. Schizophrenia Research. 2008;103:11–21
  39. Keller A, Jeffries NO, Blumenthal J, Clasen LS, Liu H, Giedd JN, et al. Corpus callosum development in childhood-onset schizophrenia. Schizophrenia Research. 2003;62:105–114
  40. Keshavan MS, Anderson S, Beckwith C, Nash K, Pettergrew J, Krishnan KRR. A comparison of stereology and segmentation techniques for volumetric measurements of brain ventricles. Psychiatry Research: Neuroimaging. 1995;61:53–60
  41. Keshavan MS, Diwadkar VA, Harenski K, Rosenberg DR, Sweeney JA, Pettegrew JW. Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia. Journal of Neurology, Neurosurgery & Psychiatry. 2002;72:757–760
  42. Kubicki M, Styner M, Bouix S, Gerig G, Markant D, Smith K, et al. Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum. Schizophrenia Research. 2008;106:125–131
  43. Lyoo IK, Kwon JS, Lee SJ, Han MH, Chang CG, Seo CS, et al. Decrease in genu of the corpus callosum in medication-naive, early-onset dysthymia and depressive personality disorder. Biological Psychiatry. 2002;52:1134–1143
  44. McLaughlin NC, Paul RH, Grieve SM, Williams LM, Laidlaw D, DiCarlo M, et al. Diffusion tensor imaging of the corpus callosum: a cross-sectional study across the lifespan. International Journal of Developmental Neuroscience. 2007;25:215–221
  45. Meisenzahl EM, Frodl T, Greiner J, Leisinger G, Maag KP, Heiss D, et al. Corpus callosum size in schizophrenia—a magnetic resonance imaging study. European Archives of Psychiatry and Clinical Neuroscience. 1999;249:305–312
  46. Mitelman SA, Nikiforova YK, Canfield EL, Hazlett EA, Brickman AM, Shihabuddin L, et al. A longitudinal study of the corpus callosum in chronic schizophrenia. Schizophrenia Research. 2009;114:144–153
  47. Ota M, Obata T, Akine Y, Ito H, Ikehira H, Asada T, et al. Age-related degeneration of corpus callosum measured with diffusion tensor imaging. Neuroimage. 2006;31:1445–1452
  48. Pandya DN, Rosene DL. Some observations on trajectories and topography of commissural fibers. In:  Reeves AG editors. Epilepsy and the Corpus Callosum. New York: Plenum; 1985;p. 21–39
  49. Pandya DN, Seltzer B. The topography of commissural fibers. In:  Lepore P,  Ptito M,  Jasper HH editor. Two Hemispheres–One Brain: Functions of the Corpus Callosum. New York: Alan R. Liss; 1986;p. 47–73
  50. Panizzon MS, Hoff AL, Nordhal TE, Kremen WS, Reisman B, Wieneke M, et al. Sex differences in the corpus callosum of patients with schizophrenia. Schizophrenia Research. 2003;62:115–122
  51. Park HJ, Kim JJ, Lee SK, Seok JH, Chun J, Kim DI, et al. Corpus callosal connection mapping using cortical gray matter parcellation and DT-MRI. Human Brain Mapping. 2008;29:503–516
  52. Pérez-Iglesias R, Tordesillas-Gutiérrez D, Barker GJ, McGuire PK, Roiz-Santiañez R, Mata I, et al. White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imaging. Neuroimage. 2010;49:199–204
  53. Piven J, Bailey J, Ranson BJ, Arndt S. An MRI study of the corpus callosum in autism. American Journal of Psychiatry. 1997;154:1051–1056
  54. Pujol J, Vendrell P, Junque C, Marti-Vilalta JL, Capdevila A. When does human brain development end? Evidence of corpus callosum growth up to adulthood. Annals of Neurology. 1993;34:71–75
  55. Reichenberg A, Harvey PD. Neuropsychological impairments in schizophrenia: integration of performance-based and brain imaging findings. Psychological Bulletin. 2007;133:833–858
  56. Rogowska J, Gruber SA, Yurgelun-Todd DA. Functional magnetic resonance imaging in schizophrenia: cortical response to motor stimulation. Psychiatry Research: Neuroimaging. 2004;130:227–243
  57. Rosenthal R, Bigelow LB. Quantitative brain measures in chronic schizophrenia. British Journal of Psychiatry. 1972;121:259–264
  58. Rotarska-Jagiela A, Schönmeyer R, Oertel V, Haenschel C, Vogeley K, Linden DEJ. The corpus callosum in schizophrenia-volume and connectivity changes affect specific regions. Neuroimage. 2008;39:1522–1532
  59. Rumsey JM, Casanova M, Mannheim GB, Patronas N, DeVaughn N, Hamburger SD, et al. Corpus callosum morphology, as measured with MRI in dyslexic men. Biological Psychiatry. 1996;36:769–775
  60. Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophrenia Research. 2001;49:1–52
  61. Sullivan EV, Rosenbloom MJ, Desmond JE, Pfefferbaum A. Sex differences in corpus callosum size: relationship to age and intracranial size. Neurobiology of Aging. 2001;22:603–611
  62. Sullivan EV, Adalsteinsson E, Pfefferbaum A. Selected age-related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking. Cerebral Cortex. 2006;16:1030–1039
  63. Takeda S, Hirashima Y, Ikeda H, Yamamoto H, Sugino M, Endo S. Determination of indices of the corpus callosum associated with normal aging in Japanese individuals. Neuroradiology. 2003;45:513–518
  64. Tamagaki C, Sedvall GC, Jönsson EG, Okugawa G, Hall H, Pauli S, et al. Altered white matter/gray matter proportions in the striatum of patients with schizophrenia: a volumetric MRI study. American Journal of Psychiatry. 2005;162:2315–2321
  65. Tek C, Gold J, Blaxton T, Wilk C, McMahnon RP, Buchanan RW. Visual perceptual and working memory impairments in schizophrenia. Archives of General Psychiatry. 2002;59:146–153
  66. Tomasch J. Size, distribution, and number of fibres in the human corpus callosum. Anatomical Record. 1954;119:119–135
  67. Venkatasubramaian G, Anthony G, Reddy US, Reddy VV, Jayakumar PN, Benegal V. Corpus callosum abnormalities associated with greater externalizing behaviours in subjects at high risk for alcohol dependence. Psychiatry Research: Neuroimaging. 2007;156:209–215
  68. Von Plessen K, Lundervold A, Duta N, Heiervang E, Klauschen F, Smievoll AI, et al. Less developed corpus callosum in dyslexic subjects—a structural MRI study. Neuropsychologia. 2002;40:1035–1044
  69. Walterfang M, Wood AG, Reutens DC, Wood SJ, Chen J, Velakoulis D, et al. Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness. British Journal of Psychiatry. 2008;192:429–434
  70. Walterfang M, Wood AG, Reutens DC, Wood SJ, Chen J, Velakoulis D, et al. Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis. Psychiatry Research: Neuroimaging. 2009;173:77–82
  71. Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. Brain. 1989;112:799–835
  72. Woodruff PWR, Pearlson GD, Geer MJ, Barta PE, Chilcoat HD. A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia. Psychological Medicine. 1993;23:45–56
  73. Woodruff PWR, Phillips ML, Rushe T, Wright IC, Murray RM, David AS. Corpus callosum size and interhemispheric function in schizophrenia. Schizophrenia Research. 1997;23:189–196
  74. Zhou SH, Suzuki M, Hagino H, Takahashi T, Kawasaki Y, Matsui M, et al. Volumetric analysis of sulci/giry-defined in vivo frontal lobe regions in schizophrenia: precentral gyrus, cingulated gyrus, and prefrontal region. Psychiatry Research: Neuroimaging. 2005;139:127–139

PII: S0925-4927(10)00124-1

doi: 10.1016/j.pscychresns.2010.04.011

Psychiatry Research: Neuroimaging
Volume 183, Issue 2 , Pages 119-125 , 30 August 2010

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