Psychiatry Research: Neuroimaging
Volume 183, Issue 1 , Pages 85-88 , 30 July 2010

Dopamine D1 receptor binding in the anterior cingulate cortex of patients with obsessive–compulsive disorder

  • James S. Olver

      Affiliations

    • Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia
    • Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, University of Melbourne, Austin Health, Studley Rd, Heidelberg, Victoria 3084, Australia. Tel.: +61 3 9496 5511; fax: 61 3 9459 0821.
  • ,
  • Graeme O'Keefe

      Affiliations

    • Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    • Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
  • ,
  • Gareth R. Jones

      Affiliations

    • Centre for PET, Austin Health, Heidelberg, Victoria, Australia
  • ,
  • Graham D. Burrows

      Affiliations

    • Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia
  • ,
  • Henri J. Tochon-Danguy

      Affiliations

    • Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    • Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
  • ,
  • Uwe Ackermann

      Affiliations

    • Centre for PET, Austin Health, Heidelberg, Victoria, Australia
  • ,
  • Andrew M. Scott

      Affiliations

    • Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    • Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
  • ,
  • Trevor R. Norman

      Affiliations

    • Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia

Received 3 July 2009 ,Revised 27 January 2010 ,Accepted 8 April 2010.

References 

  1. Adler CM, McDonough-Ryan P, Sax KW, Holland SK, Arndt S, Strakowski SM. fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder. Journal of Psychiatric Research. 2000;34:317–324
  2. Bergson C, Mrzljak L, Smiley JF, Pappy M, Levenson R, Goldman-Rakic PS. Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain. Journal of Neuroscience. 1995;15:7821–7836
  3. Breiter HC, Rauch SL, Kwong KK, Baker JR, Weisskoff RM, Kennedy DN, et al. Functional magnetic resonance imaging of symptom provocation in obsessive–compulsive disorder. Archives of General Psychiatry. 1996;53:595–606
  4. Cohen J. Statistical Power Analysis for the Behavioural Sciences. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988;
  5. Dougherty D, Baer L, Cosgrove GR, Cassem E, Price B, Nierenberg A, et al. Prospective long-term follow-up of 44 patients who received cingulotomy for treatment-refractory obsessive–compulsive disorder. American Journal of Psychiatry. 2002;159:269–275
  6. Ebert D, Speck O, Konig A, Berger M, Hennig J, Hohagen F. 1H-magnetic resonance spectroscopy in obsessive–compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum. Psychiatry Research: Neuroimaging. 1997;74:173–176
  7. Ekelund J, Slifstein M, Narendran R, Guillin O, Belani H, Guo N-N, et al. In vivo DA D1 receptor selectivity of NNC 112 and SCH 23390. Molecular Imaging and Biology. 2007;9:117–125
  8. Fitzgerald KD, Welsh RC, Gehring WJ, Abelson JL, Himle JA, Liberzon I, et al. Error-related hyperactivity of the anterior cingulate cortex in obsessive–compulsive disorder. Biological Psychiatry. 2005;57:287–294
  9. Gehring WJ, Himle J, Nisenson LG. Action-monitoring dysfunction in obsessive–compulsive disorder. Psychological Sciences. 2000;11:1–6
  10. Hall H, Sedvall G, Magnusson O, Kopp J, Halldin C, Farde L. Distribution of D1- and D2-dopamine receptors, and dopamine and its metabolites in the human brain. Neuropsychopharmacology. 1994;11:245–256
  11. Hurd YL, Suzuki M, Sedvall GC. D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain. Journal of Chemical Neuroanatomy. 2001;22:127–137
  12. Jang JH, Kwon JS, Jang DP, Moon WJ, Lee JM, Ha TH, et al. A proton MRSI study of brain N-acetylaspartate level after 12weeks of citalopram treatment in drug-naive patients with obsessive–compulsive disorder. American Journal of Psychiatry. 2006;163:1202–1207
  13. Johannes S, Wieringa BM, Nager W, Rada D, Dengler R, Emrich HM, et al. Discrepant target detection and action monitoring in obsessive–compulsive disorder. Psychiatry Research. 2001;108:101–110
  14. Kinahan PE, Rogers JB. Analytic 3D image reconstruction using all detected events. IEEE Transactions on Nuclear Science. 1989;36:964–968
  15. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4:153–158
  16. Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, et al Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(−)-cocaine PET studies in human subjects. Journal of Cerebral Blood Flow and Metabolism. 1990;10:740–747
  17. Maltby N, Tolin DF, Worhunsky P, O'Keefe TM, Kiehl KA. Dysfunctional action monitoring hyperactivates frontal–striatal circuits in obsessive–compulsive disorder: an event-related fMRI study. Neuroimage. 2005;24:495–503
  18. McGuire PK, Bench CJ, Frith CD, Marks IM, Frackowiak RS, Dolan RJ. Functional anatomy of obsessive–compulsive phenomena. British Journal of Psychiatry. 1994;164:459–468
  19. Olver J, O'Keefe G, Jones G, Burrows GD, Tochon-Danguy H, Ackermann U, et al. Dopamine D1 receptor binding in the striatum of patients with obsessive–compulsive disorder. Journal of Affective Disorders. 2009;114:321–326
  20. Onn SP, Wang XB. Differential modulation of anterior cingulate cortical activity by afferents from ventral tegmental area and mediodorsal thalamus. European Journal of Neuroscience. 2005;21:2975–2992
  21. Perani D, Colombo C, Bressi S, Bonfanti A, Grassi F, Scarone S, et al. [18F]FDG PET study in obsessive–compulsive disorder. A clinical/metabolic correlation study after treatment. British Journal of Psychiatry. 1995;166:244–250
  22. Pitman RK. A cybernetic model of obsessive–compulsive psychopathology. Comprehensive Psychiatry. 1987;28:334–343
  23. Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Savage CR, et al. Regional cerebral blood flow measured during symptom provocation in obsessive–compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Archives of General Psychiatry. 1994;51:62–70
  24. Scheffers MK, Coles MG, Bernstein P, Gehring WJ, Donchin E. Event-related brain potentials and error-related processing: an analysis of incorrect responses to go and no-go stimuli. Psychophysiology. 1996;33:42–53
  25. Schweimer J, Hauber W. Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making. Learning and Memory. 2006;13:777–782
  26. Shin YW, Kwon JS, Kim JJ, Kang DH, Youn T, Kang KW, et al. Altered neural circuit for working memory before and after symptom provocation in patients with obsessive–compulsive disorder. Acta Psychiatrica Scandinavica. 2006;113:420–429
  27. Sossi V, Holden JE, Chan G, Krzywinski M, Stoessl AJ, Ruth TJ. Analysis of four dopaminergic tracers kinetics using two different tissue input function methods. Journal of Cerebral Blood Flow and Metabolism. 2000;20:653–660
  28. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. New York: Georg Thieme Verlag; 1988;
  29. Ursu S, Stenger VA, Shear MK, Jones MR, Carter CS. Overactive action monitoring in obsessive–compulsive disorder: evidence from functional magnetic resonance imaging. Psychological Sciences. 2003;14:347–353
  30. Yucel M, Harrison BJ, Wood SJ, Fornito A, Wellard RM, Pujol J, et al. Functional and biochemical alterations of the medial frontal cortex in obsessive–compulsive disorder. Archives of General Psychiatry. 2007;64:946–955

PII: S0925-4927(10)00117-4

doi: 10.1016/j.pscychresns.2010.04.004

Psychiatry Research: Neuroimaging
Volume 183, Issue 1 , Pages 85-88 , 30 July 2010