Psychiatry Research: Neuroimaging
Volume 183, Issue 1 , Pages 30-37 , 30 July 2010

Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder

  • Mark Walterfang

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    • Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, Australia
    • Corresponding Author InformationCorresponding author. Level 2, John Cade Building, Royal Melbourne Hospital 3050, Australia.
  • ,
  • Andrew M. Chanen

      Affiliations

    • Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia
    • Orygen Youth Health Clinical Program, Northwestern Mental Health, Melbourne, Australia
  • ,
  • Sarah Barton

      Affiliations

    • Department of Medicine, Southern Clinical School, Monash University, Melbourne, Australia
  • ,
  • Amanda G. Wood

      Affiliations

    • Department of Medicine, Southern Clinical School, Monash University, Melbourne, Australia
    • Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia
  • ,
  • Sheena Jones

      Affiliations

    • Victorian Dual Disability Service, St Vincent's Hospital, Melbourne, Australia
  • ,
  • David C. Reutens

      Affiliations

    • Advanced Imaging Centre, Queensland Brain Institute, University of Queensland, Brisbane, Australia
  • ,
  • Jian Chen

      Affiliations

    • Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia
  • ,
  • Dennis Velakoulis

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    • Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, Australia
  • ,
  • Patrick D. McGorry

      Affiliations

    • Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia
    • Orygen Youth Health Clinical Program, Northwestern Mental Health, Melbourne, Australia
  • ,
  • Christos Pantelis

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia

Received 21 February 2010 ,Accepted 7 April 2010.

References 

  1. Achenbach TM. Manual for the Youth Self-Report and 1991 Profiles. Department of Psychiatry, University of Vermont, Burlington, VT; 1991;
  2. Achenbach TM. Manual for the Young Adult Self-Report and Young Adult Behavior Checklist. Department of Psychiatry, University of Vermont, Burlington, VT; 1997;
  3. Akiskal H. Demystifiying borderline personality: critique of the concept and unorthodox reflections on its natural kinship with bipolar spectrum. Acta Psychiatrica Scandinavica. 2004;110:401–407
  4. Barnow S, Völker KA, Möller B, Freyberger HJ, Spitzer C, Grabe HJ, et al. Neurophysiological correlates of borderline personality disorder: a transcranial magnetic stimulation study. Biological Psychiatry. 2009;65(4):313–318
  5. Bermudez P, Zatorre R. Sexual dimorphism in the corpus callosum: methodological considerations in MRI morphometry. Neuroimage. 2001;13:1121–1130
  6. Brambilla P, Nicoletti MA, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, et al. Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder. Biological Psychiatry. 2003;54:1294–1297
  7. Brambilla P, Nicoletti M, Sassi RB, Mallinger AG, Frank E, Keshavan MS, et al. Corpus callosum signal intensity in patients with bipolar and unipolar disorder. Journal of Neurology, Neurosurgery and Psychiatry. 2004;75:221–225
  8. Brunner R, Henze R, Parzer P, Kramer J, Feigl N, Lutz K, et al. Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: is it disorder specific?. Neuroimage. 2010;49(1):114–120
  9. Chanen A, Jovev M, Jackson H. Adaptive functioning and psychiatric symptoms in adolescents with borderline personality disorder. Journal of Clinical Psychiatry. 2007;68:297–306
  10. Chanen M, Velakoulis D, Carison K, Gaunson K, Wood SJ, Yuen HP, et al. Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder. Psychiatry Research: Neuroimaging. 2008;163:116–125
  11. Chanen AM, McCutcheon LK, Germano D, Nistico H, Jackson HJ, McGorry PD. The HYPE Clinic: an early intervention service for borderline personality disorder. Journal of Psychiatric Practice. 2009;15:163–172
  12. Clarke R, Zaidel E. Anatomical–behavioral relationships: corpus callosum morphometry and hemispheric specialization. Behavioural Brain Research. 1994;41:397–403
  13. De Bellis MD, Keshavan MS, Clark DB, Casey BJ, Giedd JN, Boring AM, et al. A.E. Bennett Research Award. Developmental traumatology. Part II: brain development. Biological Psychiatry. 1999;45:1271–1284
  14. de Lacoste M, Kirkpatrick J, Ross E. Topography of the human corpus callosum. Journal of Neuropathology and Experimental Neurology. 1985;44:578–591
  15. Eritaia J, Wood SJ, Stuart GW, Bridle N, Dudgeon P, Maruff P, et al. An optimized method for estimating intracranial volume from magnetic resonance images. Magn Reson Med. 2000;44(6):973–977
  16. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Version (SCID-I/P). Biometrics Research Department. New York State Psychiatric Institute; 1996;
  17. First MB, Spitzer RL, Gibbon M, Williams JBW. User's Guide for the Structured Clinical Interview for DSM-IV Axis II Personality Disorders. American Psychiatric Press; 1997;
  18. Giedd JN, Blumenthal J, Jeffries NO, Rajapakse JC, Vaituzis AC, Liu H, et al. Development of the human corpus callosum during childhood and adolescence: a longitudinal MRI study. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1999;23:571–588
  19. Goodman M, New A, Siever L. Trauma, genes, and the neurobiology of personality disorders. Annals of the New York Academy of Sciences. 2004;1032:104–116
  20. Grant JE, Correia S, Brennan-Krohn T, Malloy PF, Laidlaw DH, Schulz SC. Frontal white matter integrity in borderline personality disorder with self-injurious behavior. The Journal of Neuropsychiatry and Clinical Neuroscience. 2007;19:383–390
  21. Hallam BJ, Brown WS, Ross C, Buckwalter JG, Bigler ED, Tschanz JT, et al. Regional atrophy of the corpus callosum in dementia. Journal of the International Neuropsychological Society. 2008;14:414–423
  22. Hasan KM, Ewing-Cobbs L, Kramer LA, Fletcher JM, Narayana PA. Diffusion tensor quantification of the macrostructure and microstructure of human midsagittal corpus callosum across the lifespan. NMR in Biomedicine. 2008;21(10):1094–1101
  23. Hasan KM, Kamali A, Kramer LA, Papnicolaou AC, Fletcher JM, Ewing-Cobbs L. Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan. Brain Research. 2008;1227:52–67
  24. Hasan KM, Kamali A, Iftikhar A, Kramer LA, Papanicolaou AC, Fletcher JM, et al. Diffusion tensor tractography quantification of the human corpus callosum fiber pathways across the lifespan. Brain Research. 2009;1249:91–100
  25. Hazlett EA, New AS, Newmark R, Haznedar MM, Lo JN, Speiser LJ, et al. Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biological Psychiatry. 2005;58:614–623
  26. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics. 1979;6:65–70
  27. Holmes AP, Blair RC, Watson JD, Ford I. Nonparametric analysis of statistic images from functional mapping experiments. Journal of Cerebral Blood Flow and Metabolism. 1996;16:7–22
  28. Irle E, Lange C, Sachse U. Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder. Biological Psychiatry. 2005;57:173–182
  29. Kaufer DI, Miller BL, Itti L, Fairbanks LA, Li J, Fishman J, et al. Midline cerebral morphometry distinguishes frontotemporal dementia and Alzheimer's disease. Neurology. 1997;48:978–985
  30. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36(7):980–988
  31. Keshavan MS, Diwadkar VA, DeBellis M, Dick E, Kotwal R, Rosenberg DR, et al. Development of the corpus callosum in childhood, adolescence and early adulthood. Life Sciences. 2002;70:1909–1922
  32. Lis E, Greenfield B, Henry M, Guilé JM, Dougherty G. Neuroimaging and genetics of borderline personality disorder: a review. Journal of Psychiatry & Neuroscience. 2007;32:162–173
  33. Makris N, Biederman J, Valera EM, Bush G, Kaiser J, Kennedy DN, et al. Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder. Cerebral Cortex. 2007;17:1364–1375
  34. New AS, Hazlett EA, Buchsbaum MS, Goodman M, Mitelman SA, Newmark R, et al. Amygdala-prefrontal disconnection in borderline personality disorder. Neuropsychopharmacology. 2007;32:1629–1640
  35. Otsu N. A threshold selection method from gray level histograms. IEEE Transactions on Systems, Man, and Cybernetics. 1979;9:62–66
  36. Pandya D, Seltzer B. The topography of commisural fibers. In:  Lepore F,  Ptito M,  Jasper H editor. Two Hemispheres — One Brain: Functions of the Corpus Callosum. New York: Alan R. Liss, Inc.; 1986;
  37. Paris J, Gunderson J, Weinberg I. The interface between borderline personality disorder and bipolar spectrum disorders. Comprehensive Psychiatry. 2007;48:145–154
  38. Riffkin J, Yücel M, Maruff P, Wood SJ, Soulsby B, Olver J, et al. A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive–compulsive disorder: comparison with healthy controls and patients with schizophrenia. Psychiatry Research: Neuroimaging. 2005;138:99–113
  39. Rüsch N, van Elst LT, Ludaescher P, Wilke M, Huppertz HJ, Thiel T, et al. A voxel-based morphometric MRI study in female patients with borderline personality disorder. Neuroimage. 2003;10:385–392
  40. Rüsch N, Luders E, Lieb K, Zahn R, Ebert D, Thompson PM, et al. Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. Journal of Psychiatry & Neuroscience. 2007;32:417–422
  41. Rüsch N, Weber M, Il'yasov KA, Lieb K, Ebert D, Hennig J, et al. Inferior frontal white matter microstructure and patterns of psychopathology in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. Neuroimage. 2007;35:738–747
  42. Schiffer F, Teicher M, Papanicolaou A. Evoked potential evidence for right brain activity during the recall of traumatic memories. The Journal of Neuropsychiatry and Clinical Neurosciences. 1995;7:169–175
  43. Schmahl C, Bremner J. Neuroimaging in borderline personality disorder. Journal of Psychiatric Research. 2006;40:419–427
  44. Seidman L, Valera E, Makris N. Structural brain imaging of attention-deficit/hyperactivity disorder. Biological Psychiatry. 2005;57:1263–1272
  45. Smith S. Fast robust automated brain extraction. Human Brain Mapping. 2002;17:143–155
  46. Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K, Lemieux L, et al. Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biological Psychiatry. 2003;54:163–171
  47. Teicher MH, Ito Y, Glod CA, Andersen SL, Dumont N, Ackerman E. Preliminary evidence for abnormal cortical development in physically and sexually abused children using EEG coherence and MRI. Annals of the New York Academy of Sciences. 1997;821:160–175
  48. Teicher MH, Dumont NL, Ito Y, Vaituzis C, Giedd JN, Andersen SL. Childhood neglect is associated with reduced corpus callosum area. Biological Psychiatry. 2004;56:80–85
  49. Velut S, Destrieux C, Kakou M. Morphologic anatomy of the corpus callosum. Neuro-Chirurgie. 1998;44:S17–S30
  50. Venkatasubramanian G, Anthony G, Reddy US, Reddy VV, Jayakumar PN, Benegal V. Corpus callosum abnormalities associated with greater externalizing behaviors in subjects at high risk for alcohol dependence. Psychiatry Research: Neuroimaging. 2007;156:209–215
  51. Walterfang M, McGuire PK, Yung AR, Phillips LJ, Velakoulis D, Wood SJ, et al. White matter volume changes in people who develop psychosis. British Journal of Psychiatry. 2008;193:210–215
  52. Walterfang M, Wood AG, Reutens DC, Wood SJ, Chen J, Velakoulis D, et al. Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness. British Journal of Psychiatry. 2008;192:429–434
  53. Walterfang M, Yung A, Wood AG, Reutens DC, Phillips L, Wood SJ, et al. Corpus callosum shape alterations in individuals prior to the onset of psychosis. Schizophrenia Research. 2008;103:1–10
  54. Walterfang M, Malhi GS, Wood AG, Reutens DC, Chen J, Barton S, et al. Corpus callosum size and shape in established bipolar affective disorder. Australian and New Zealand Journal of Psychiatry. 2009;43:838–845
  55. Walterfang M, Wood AG, Barton S, Velakoulis D, Chen J, Reutens DC, et al. Corpus callosum size and shape alterations in individuals with bipolar disorder and their first-degree relatives. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009;33:1050–1057
  56. Walterfang M, Wood AG, Reutens DC, Wood SJ, Chen J, Velakoulis D, et al. Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis. Psychiatry Research: Neuroimaging. 2009;173:77–82
  57. Walterfang M, Yücel M, Barton S, Reutens DC, Wood AG, Chen J, et al. Corpus callosum size and shape in individuals with current and past depression. Journal of Affective Disorders. 2009;115:411–420
  58. Walterfang M, Wood AG, Reutens DC, Wood SJ, Chen J, Velakoulis D, et al. Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis. Psychiatry Research: Neuroimaging. 2009;173(1):77–82
  59. Weniger G, Lange C, Sachsse U, Irle E. Reduced amygdala and hippocampus size in trauma-exposed women with borderline personality disorder and without posttraumatic stress disorder. Journal of Psychiatry & Neuroscience. 2009;34(5):383–388
  60. Whittle S, Chanen AM, Fornito A, McGorry PD, Pantelis C, Yücel M. Anterior cingulate volume in adolescents with first-presentation borderline personality disorder. Psychiatry Research: Neuroimaging. 2009;172:155–160
  61. Williams LM, Sidis A, Gordon E, Meares RA. “Missing links” in borderline personality disorder: loss of neural synchrony relates to lack of emotion regulation and impulse control. Journal of Psychiatry & Neuroscience. 2006;31:181–188
  62. Witelson S. Hand and sex differences in the isthmus of the corpus callosum in schizophrenia: a post-mortem morphological study. Brain. 1989;112:799–835
  63. Woods RP, Grafton ST, Holmes CJ, Cherry SR, Mazziotta JC. Automated image registration I: general methods and intrasubject, intramodality validation. Journal of Computer Assisted Tomography. 1998;22:155–165
  64. Yamauchi H, Fukuyama H, Nagahama Y, Katsumi Y, Hayashi T, Oyanagi C, et al. Comparison of the pattern of atrophy of the corpus callosum in frontotemporal dementia, progressive supranuclear palsy, and Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry. 2000;69:623–629
  65. Zanetti MV, Soloff PH, Nicoletti MA, Hatch JP, Brambilla P, Keshavan MS, et al. MRI study of corpus callosum in patients with borderline personality disorder: a pilot study. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2007;31:1519–1525

PII: S0925-4927(10)00114-9

doi: 10.1016/j.pscychresns.2010.04.001

Psychiatry Research: Neuroimaging
Volume 183, Issue 1 , Pages 30-37 , 30 July 2010