Psychiatry Research: Neuroimaging
Volume 182, Issue 3 , Pages 211-215 , 30 June 2010

Decreased regional homogeneity in insula and cerebellum: A resting-state fMRI study in patients with major depression and subjects at high risk for major depression

  • Zhifen Liu

      Affiliations

    • Department of Psychiatry, First Hospital of Shanxi Medical University, 030001, PR China
    • These authors contributed equally to this work.
    • ,
  • Cheng Xu

      Affiliations

    • Department of Radiology, Shanxi Provincial Hospital, Taiyuan, 030012, PR China
    • These authors contributed equally to this work.
    • ,
  • Yong Xu

      Affiliations

    • Department of Psychiatry, First Hospital of Shanxi Medical University, 030001, PR China
    • ,
  • Yanfang Wang

      Affiliations

    • Department of Psychiatry, First Hospital of Shanxi Medical University, 030001, PR China
    • ,
  • Bing Zhao

      Affiliations

    • Department of Psychiatry, First Hospital of Shanxi Medical University, 030001, PR China
    • ,
  • Yating Lv

      Affiliations

    • State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, PR China
    • ,
  • Xiaohua Cao

      Affiliations

    • Department of Psychiatry, First Hospital of Shanxi Medical University, 030001, PR China
    • ,
  • Kerang Zhang

      Affiliations

    • Department of Psychiatry, First Hospital of Shanxi Medical University, 030001, PR China
    • Corresponding Author InformationCorresponding authors. Zhang is to be contacted at Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, 030001, PR China. Tel.: +86 351 4639869; fax: +86 351 4639956. Du, Department of Radiology, Shanxi Provincial Hospital, Taiyuan, 030012, PR China. Tel.: +86 13934115391; fax: +86 351 8330265.
    • ,
  • Chongxi Du

      Affiliations

    • Department of Radiology, Shanxi Provincial Hospital, Taiyuan, 030012, PR China
    • Corresponding Author InformationCorresponding authors. Zhang is to be contacted at Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, 030001, PR China. Tel.: +86 351 4639869; fax: +86 351 4639956. Du, Department of Radiology, Shanxi Provincial Hospital, Taiyuan, 030012, PR China. Tel.: +86 13934115391; fax: +86 351 8330265.

Received 10 August 2008 ,Revised 17 February 2010 ,Accepted 11 March 2010.

References 

  1. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, et al. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biological Psychiatry. 2005;57:1079–1088
  2. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, et al. Antidepressant effect on connectivity of the mood-regulating circuit: an FMRI study. Neuropsychopharmacology. 2005;30:1334–1344
  3. Anand A, Li Y, Wang Y, Gardner K, Lowe MJ. Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an FMRI study. The Journal of Neuropsychiatry and Clinical Neurosciences. 2007;19:274–282
  4. Biswal B, Yetkin FZ, Haungton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magnetic Resonance in Medicine. 1995;34:537–541
  5. Biver F, Wikler D, Lotstra F, Damhaut P, Goldman S, Mendlewicz J. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British Journal of Psychiatry. 1997;171:444–448
  6. Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, et al. Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and (11C)DASB; comparison with bipolar disorder. Biological Psychiatry. 2007;62:870–877
  7. Cordes D, Haughton VM, Arfanakis K, Wendt GJ, Turski PA, Moritz CH, et al. Mapping functionally related regions of brain with functional connectivity MR imaging. American Journal of Neuroradiology. 2000;21:1636–1644
  8. Dannlowski U, Ohrmann P, Bauer J, Kugel H, Arolt V, Heindel W, et al. Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: a 3T fMRI study. Journal of Neuropsychiatry and Neuroscience. 2007;32:423–429
  9. Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ. The neural basis of mood-congruent emotional processing biases in depression. Archives of General Psychiatry. 2002;59:597–604
  10. Escalona PR, Early B, McDonald WM. Reduction of cerebellar volume in major depression: a controlled magnetic resonance imaging study. Depression. 1993;1:156–158
  11. First MB, Spitzer RL, Gibbon M. Structured Clinical Interview for DSM-IV Axis 1 Disorder. New York: Biometrics Research Department, New York State Psychiatric Institute; 1995;
  12. Fitzgerald PB, Srithiran A, Benitez J, Daskalakis ZZ, Oxley TJ, Kulkarni J, et al. An fMRI study of prefrontal brain activation during multiple tasks in patients with major depressive disorder. Human Brain Mapping. 2008;29:490–501
  13. Fu CH, Williams SC, Cleare AJ, Brammer MJ, Walsh ND, Kim J, et al. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Archives of General Psychiatry. 2004;61:877–889
  14. Greicius MD, Flores BH, Menon V, Glover GH, Solvason HB, Kenna H, et al. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biological Psychiatry. 2007;62:429–437
  15. Hamilton JP, Gotlib IH. Neural substrates of increased memory sensitivity for negative stimuli in major depression. Biological Psychiatry. 2008;63:1155–1162
  16. Lee BT, Cho SW, Khang HS, Lee BC, Choi IG, Lyoo IK, et al. The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder. Progress in neuro-psychopharmacology and biologicalpsychiatr. 2007;31:1487–1492
  17. Lee BT, Seok JH, Lee BC, Cho SW, Yoon BJ, Lee KU, et al. Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2008;32:778–785
  18. Liu H, Liu Z, Liang M, Hao Y, Tan L, Kuang F, et al. Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study. Neuroreport. 2006;17:19–22
  19. Malhi GS, Lagopoulos J, Ward PB, Kumari V, Mitchell PB, Parker GB, et al. Cognitive generation of affect in bipolar depression: an fMRI study. European Journal of Neuroscience. 2004;19:741–754
  20. Manes F, Paradiso S, Robinson RG. Neuropsychiatric effects of insular stroke. Journal of Nervous and Mental Disease. 1999;187:707–712
  21. Mannie ZN, Norbury R, Murphy SE, Inkster B, Harmer CJ, Cowen PJ. Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. The British Journal of Psychiatry. 2008;192:356–361
  22. Mitterschiffthaler MT, Kumari V, Malhi GS, Brown RG, Giampietro VP, Brammer MJ, et al. Neural response to pleasant stimuli in anhedonia: an fMRI study. Neuroreport. 2003;14:177–182
  23. Parvizi J, Anderson SW, Martin CO, Damasio H, Damasio AR. Pathological laughter and crying: a link to the cerebellum. Brain. 2001;124:1708–1719
  24. Pillay SS, Yurgelun-Todd DA, Bonello CM, Lafer B, Fava M, Renshaw PF. A quantitative magnetic resonance imaging study of cerebral and cerebellar grey matter volume in primary unipolar major depression: relationship to treatment response and clinical severity. Biological Psychiatry. 1997;42:79–84
  25. Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121:561–579
  26. Tian L, Jiang T, Wang Y, Zang Y, He Y, Liang M, et al. Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder. Neuroscience Letters. 2006;400:39–43
  27. Turner BM, Paradiso S, Marvel CL, Pierson R, Boles-Ponto LL, Hichwa RD, et al. The cerebellum and emotional experience. Neuropsychologia. 2007;45:1331–1341
  28. Walter H, Wolf RC, Spitzer M, Vasic N. Increased left prefrontal activation in patients with unipolar depression: an event-related, parametric performance-controlled fMRI study. Journal of Affective Disorders. 2007;101:175–185
  29. Wolfensberger SP, Veltman DJ, Hoogendijk WJ, Boomsma DI, de-Geus EJ. Amygdala responses to emotional faces in twins discordant or concordant for the risk for anxiety and depression. NeuroImage. 2008;41:544–552
  30. Yao Z, Wang L, Lu Q, Liu H, Teng G. Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study. Journal of Affective Disorders. 2009;115:430–438
  31. Zang Y, Jiang T, Lu Y, He Y, Tian L. Regional homogeneity approach to fMRI data analysis. Neuroimage. 2004;22:394–400
  32. Zhou Y, Liang M, Jiang T, Tian L, Liu Y, Liu Z, et al. Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI. Neuroscience Letters. 2007;417:297–302
  33. Zhu CZ, Zang YF, Liang M, Tian LX, He Y, Sui MQ, et al. Discriminative analysis of brain function at resting-state for attention deficit/hyperactivity disorder. Medical Image Computing and Computer-assisted Intervention—MICCAI. 2005;8:468–475

PII: S0925-4927(10)00105-8

doi: 10.1016/j.pscychresns.2010.03.004

Psychiatry Research: Neuroimaging
Volume 182, Issue 3 , Pages 211-215 , 30 June 2010

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