Psychiatry Research: Neuroimaging
Volume 182, Issue 2 , Pages 146-151 , 30 May 2010

Voxel-based morphometry in eating disorders: Correlation of psychopathology with grey matter volume

  • Andreas Joos

      Affiliations

    • University of Freiburg, Department of Psychosomatic Medicine and Psychotherapy, Freiburg, Germany
    • Corresponding Author InformationCorresponding author. University of Freiburg, Department of Psychosomatic Medicine and Psychotherapy, Hauptstraße 8, D-79104 Freiburg, Germany.
    • ,
  • Stefan Klöppel

      Affiliations

    • University of Freiburg, Department of Psychiatry and Psychotherapy, Section of Gerontopsychiatry and Neuropsychology, Freiburg, Germany
    • University of Freiburg, Department of Psychiatry and Psychotherapy, Section for Experimental Neuropsychiatry, Freiburg, Germany
    • ,
  • Armin Hartmann

      Affiliations

    • University of Freiburg, Department of Psychosomatic Medicine and Psychotherapy, Freiburg, Germany
    • ,
  • Volkmar Glauche

      Affiliations

    • University of Freiburg, Department of Neurology, Freiburg, Germany
    • ,
  • Oliver Tüscher

      Affiliations

    • University of Freiburg, Department of Neurology, Freiburg, Germany
    • ,
  • Evgeniy Perlov

      Affiliations

    • University of Freiburg, Department of Psychiatry and Psychotherapy, Section for Experimental Neuropsychiatry, Freiburg, Germany
    • ,
  • Barbara Saum

      Affiliations

    • University of Freiburg, Department of Psychosomatic Medicine and Psychotherapy, Freiburg, Germany
    • ,
  • Tobias Freyer

      Affiliations

    • University of Freiburg, Department of Psychiatry and Psychotherapy, Section for Experimental Neuropsychiatry, Freiburg, Germany
    • ,
  • Almut Zeeck

      Affiliations

    • University of Freiburg, Department of Psychosomatic Medicine and Psychotherapy, Freiburg, Germany
    • Professor Zeeck and Professor Tebartz van Elst equally contributed to this work as senior authors.
    • ,
  • Ludger Tebartz van Elst

      Affiliations

    • University of Freiburg, Department of Psychiatry and Psychotherapy, Section for Experimental Neuropsychiatry, Freiburg, Germany
    • Professor Zeeck and Professor Tebartz van Elst equally contributed to this work as senior authors.

Received 28 August 2009 ,Revised 3 February 2010 ,Accepted 5 February 2010.

References 

  1. Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage. 2007;38:95–113
  2. Ashburner J, Friston KJ. Voxel-based morphometry—the methods. Neuroimage. 2000;11:805–821
  3. Bailer UF, Price JC, Meltzer CC, Mathis CA, Frank GK, Weissfeld L, et al. Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness. Neuropsychopharmacology. 2004;29:1143–1155
  4. Beato-Fernandez L, Rodriguez-Cano T, Garcia-Vilches I, Garcia-Vicente A, Poblete-Garcia V, Castrejon AS, et al. Changes in regional cerebral blood flow after body image exposure in eating disorders. Psychiatry Research: Neuroimaging. 2009;171:129–137
  5. Beck AT, Hautzinger M, Bailer M, Worall H, Keller F. Beck-Depressions-Inventar (BDI). 2 edn.. Göttingen: Hogrefe; 1995;
  6. Bjoertomt O, Cowey A, Walsh V. Near space functioning of the human angular and supramarginal gyri. Journal of Neuropsychology. 2009;3:31–43
  7. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences. 2000;4:215–222
  8. Cabeza R, Nyberg L. Neural bases of learning and memory: functional neuroimaging evidence. Current Opinion in Neurology. 2000;13:415–421
  9. Castro-Fornieles J, Bargallo N, Lazaro L, Andres S, Falcon C, Plana MT, et al. A cross-sectional and follow-up voxel-based morphometric MRI study in adolescent anorexia nervosa. Journal of Psychiatric Research. 2009;43:331–340
  10. Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006;129:564–583
  11. Connan F, Murphy F, Connor SE, Rich P, Murphy T, Bara-Carill N, et al. Hippocampal volume and cognitive function in anorexia nervosa. Psychiatry Research: Neuroimaging. 2006;146:117–125
  12. Delvenne V, Goldman S, DeM.V. , Lotstra F. Brain glucose metabolism in eating disorders assessed by positron emission tomography. International Journal of Eating Disorders. 1999;25:29–37
  13. Fairburn CG, Harrison PJ. Eating disorders. Lancet. 2003;361:407–416
  14. Fairburn CG, Cooper Z, Shafran R. Cognitive behaviour therapy for eating disorders: a “transdiagnostic” theory and treatment. Behaviour Research and Therapy. 2003;41:509–528
  15. Frank GK, Bailer UF, Henry S, Wagner A, Kaye WH. Neuroimaging studies in eating disorders. CNS Spectrums. 2004;9:539–548
  16. Garner DM. Eating Disorder Inventory-2. Professional Manual. Psychological Assessment Resources. Florida, U.S.A.: Odessa; 1991;
  17. Giordano GD, Renzetti P, Parodi RC, Foppiani L, Zandrino F, Giordano G, et al. Volume measurement with magnetic resonance imaging of hippocampus–amygdala formation in patients with anorexia nervosa. Journal of Endocrinological Investigation. 2001;24:510–514
  18. Goethals I, Vervaet M, Audenaert K, Jacobs F, Ham H, Van HC. Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients?. Journal of Psychiatric Research. 2007;41:1005–1011
  19. Hayasaka S, Phan KL, Liberzon I, Worsley KJ, Nichols TE. Nonstationary cluster-size inference with random field and permutation methods. Neuroimage. 2004;22:676–687
  20. Hoffman GW, Ellinwood EH, Rockwell WJ, Herfkens RJ, Nishita JK, Guthrie LF. Cerebral atrophy in bulimia. Biological Psychiatry. 1989;25:894–902
  21. Hudson JI, Hiripi E, Pope HG, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biological Psychiatry. 2007;61:348–358
  22. Husain MM, Black KJ, Doraiswamy PM, Shah SA, Rockwell WJ, Ellinwood EH, et al. Subcortical brain anatomy in anorexia and bulimia. Biological Psychiatry. 1992;31:735–738
  23. Joos AA, Cabrillac E, Hartmann A, Wirsching M, Zeeck A. Emotional perception in eating disorders. International Journal of Eating Disorders. 2009;42:318–325
  24. Katzman DK, Lambe EK, Mikulis DJ, Ridgley JN, Goldbloom DS, Zipursky RB. Cerebral gray matter and white matter volume deficits in adolescent girls with anorexia nervosa. The Journal of Pediatrics. 1996;129:794–803
  25. Kerem NC, Katzman DK. Brain structure and function in adolescents with anorexia nervosa. Adolescent Medicine. 2003;14:109–118
  26. Kiriike N, Nishiwaki S, Nagata T, Inoue Y, Inoue K, Kawakita Y. Ventricular enlargement in normal weight bulimia. Acta Psychiatrica Scandinavica. 1990;82:264–266
  27. Kojima S, Nagai N, Nakabeppu Y, Muranaga T, Deguchi D, Nakajo M, et al. Comparison of regional cerebral blood flow in patients with anorexia nervosa before and after weight gain. Psychiatry Research: Neuroimaging. 2005;140:251–258
  28. Krieg JC, Lauer C, Pirke KM. Structural brain abnormalities in patients with bulimia nervosa. Psychiatry Research. 1989;27:39–48
  29. Kumar P, Waiter G, Ahearn T, Milders M, Reid I, Steele JD. Frontal operculum temporal difference signals and social motor response learning. Human Brain Mapping. 2009;30:1421–1430
  30. McCormick LM, Keel PK, Brumm MC, Bowers W, Swayze V, Andersen A, et al. Implications of starvation-induced change in right dorsal anterior cingulate volume in anorexia nervosa. International Journal of Eating Disorders. 2008;41:602–610
  31. Medina J, Kannan V, Pawlak MA, Kleinman JT, Newhart M, Davis C, et al. Neural substrates of visuospatial processing in distinct reference frames: evidence from unilateral spatial neglect. Journal of Cognitive Neuroscience. 2009;21:2073–2084
  32. Merz J, Lehrl S, Galster V, Erzigkeit H. [The multiple selection vocabulary test (MSVT-B)-an accelerated intelligence test.]. [In German] Psychiatrie, Neurologie, und medizinische Psychologie (Leipzig). 1975;27:423–428
  33. Muhlau M, Gaser C, Ilg R, Conrad B, Leibl C, Cebulla MH, et al. Gray matter decrease of the anterior cingulate cortex in anorexia nervosa. American Journal of Psychiatry. 2007;164:1850–1857
  34. Neumarker KJ, Bzufka WM, Dudeck U, Hein J, Neumarker U. Are there specific disabilities of number processing in adolescent patients with anorexia nervosa? Evidence from clinical and neuropsychological data when compared to morphometric measures from magnetic resonance imaging. European Child & Adolescent Psychiatry. 2000;9(Suppl 2):S111–S121
  35. Paul T, Thiel A. Eating Disorder Inventory — 2. Göttingen: Hogrefe; 2005;
  36. Peat C, Mitchell JE, Hoek HW, Wonderlich SA. Validity and utility of subtyping anorexia nervosa. International Journal of Eating Disorders. 2009;42:590–594
  37. Rizzolatti G, Craighero L. The mirror-neuron system. Annual Review of Neuroscience. 2004;27:169–192
  38. Ruuska J, Kaltiala-Heino R, Rantanen P, Koivisto AM. Are there differences in the attitudinal body image between adolescent anorexia nervosa and bulimia nervosa?. Eating and Weight Disorders. 2005;10:98–106
  39. Sachdev P, Mondraty N, Wen W, Gulliford K. Brains of anorexia nervosa patients process self-images differently from non-self-images: an fMRI study. Neuropsychologia. 2008;46:2161–2168
  40. Santel S, Baving L, Krauel K, Munte TF, Rotte M. Hunger and satiety in anorexia nervosa: fMRI during cognitive processing of food pictures. Brain Research. 2006;1114:138–148
  41. SAS Publishing . Correlations and multivariate techniques. In: JMP 8 Statistics and Graphics Guide. SAS, Cary, NC. 2008;p. 525–544
  42. Schonheit B, Meyer U, Kuchinke J, Schulz E, Neumarker KJ. Morphometrical investigations on lamina-V-pyramidal-neurons in the frontal cortex of a case with anorexia nervosa. Journal für Hirnforschung. 1996;37:269–280
  43. Swayze VW, Andersen AE, Andreasen NC, Arndt S, Sato Y, Ziebell S. Brain tissue volume segmentation in patients with anorexia nervosa before and after weight normalization. International Journal of Eating Disorders. 2003;33:33–44
  44. Takano A, Shiga T, Kitagawa N, Koyama T, Katoh C, Tsukamoto E, et al. Abnormal neuronal network in anorexia nervosa studied with I-123-IMP SPECT. Psychiatry Research: Neuroimaging. 2001;107:45–50
  45. Uher R, Murphy T, Brammer MJ, Dalgleish T, Phillips ML, Ng VW, et al. Medial prefrontal cortex activity associated with symptom provocation in eating disorders. American Journal of Psychiatry. 2004;161:1238–1246
  46. Uher R, Yoganathan D, Mogg A, Eranti SV, Treasure J, Campbell IC, et al. Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving. Biological Psychiatry. 2005;58:840–842
  47. Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nature Reviews Neuroscience. 2005;6:533–544
  48. Wagner A, Ruf M, Braus DF, Schmidt MH. Neuronal activity changes and body image distortion in anorexia nervosa. Neuroreport. 2003;14:2193–2197
  49. Wagner A, Greer P, Bailer UF, Frank GK, Henry SE, Putnam K, et al. Normal brain tissue volumes after long-term recovery in anorexia and bulimia nervosa. Biological Psychiatry. 2006;59:291–293
  50. Zastrow A, Kaiser S, Stippich C, Walther S, Herzog W, Tchanturia K, et al. Neural correlates of impaired cognitive-behavioral flexibility in anorexia nervosa. American Journal of Psychiatry. 2009;166:608–616

PII: S0925-4927(10)00070-3

doi: 10.1016/j.pscychresns.2010.02.004

Psychiatry Research: Neuroimaging
Volume 182, Issue 2 , Pages 146-151 , 30 May 2010

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