Psychiatry Research: Neuroimaging
Volume 182, Issue 2 , Pages 123-133 , 30 May 2010

Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults

  • Cecilie Bhandari Hartberg

      Affiliations

    • Institute of Psychiatry, Section Vinderen, University of Oslo, Norway
    • Corresponding Author InformationCorresponding author. P.O. Box 85 Vinderen, University of Oslo, N-0319 Oslo, Norway. Tel.: +47 22029967; fax: +47 22495862.
    • ,
  • Glenn Lawyer

      Affiliations

    • Institute of Psychiatry, Section Vinderen, University of Oslo, Norway
    • ,
  • Håkan Nyman

      Affiliations

    • Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Erik G. Jönsson

      Affiliations

    • Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Unn K. Haukvik

      Affiliations

    • Institute of Psychiatry, Section Vinderen, University of Oslo, Norway
    • ,
  • Peter Saetre

      Affiliations

    • Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Petr S. Bjerkan

      Affiliations

    • Institute of Psychiatry, Section Vinderen, University of Oslo, Norway
    • ,
  • Ole A. Andreassen

      Affiliations

    • Department of Psychiatry, Ulleval University Hospital and Institute of Psychiatry, University of Oslo, Norway
    • ,
  • Håkan Hall

      Affiliations

    • Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Ingrid Agartz

      Affiliations

    • Institute of Psychiatry, Section Vinderen, University of Oslo, Norway
    • Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    • Diakonhjemmet Hospital, Department of Psychiatric Research, Oslo, Norway

Received 28 May 2009 ,Revised 20 October 2009 ,Accepted 7 January 2010.

References 

  1. American Psychiatric Association . In: Diagnostic and Statistical Manual of Mental Disorders — Revised (DSM-III-R). 1987;APA, Washington, DC
  2. American Psychiatric Association . In: Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). 1994;APA, Washington, DC
  3. Andreasen NC, Flaum M, Swayze V, O'Leary DS, Alliger R, Cohen G, et al. Intelligence and brain structure in normal individuals. American Journal of Psychiatry. 1993;150:130–134
  4. Antonova E, Kumari V, Morris R, Halari R, Anilkumar A, Mehrotra R, et al. The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biological Psychiatry. 2005;58:457–467
  5. Antonova E, Sharma T, Morris R, Kumari V. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophrenia Research. 2004;70:117–145
  6. Baare WF, Hulshoff Pol HE, Hijman R, Mali WP, Viergever MA, Kahn RS. Volumetric analysis of frontal lobe regions in schizophrenia: relation to cognitive function and symptomatology. Biological Psychiatry. 1999;45:1597–1605
  7. Bonilha L, Molnar C, Horner MD, Anderson B, Forster L, George MS, et al. Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia. Schizophrenia Research. 2008;101:142–151
  8. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: Erlbaum; 1988;
  9. Colom R, Jung RE, Haier RJ. Distributed brain sites for the g-factor of intelligence. Neuroimage. 2006;31:1359–1365
  10. Dale AM, Fischl B, Sereno MI. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage. 1999;9:179–194
  11. Dale AM, Sereno MI. Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction — a linear-approach. Journal of Cognitive Neuroscience. 1993;5:162–176
  12. Damasio H, Grabowski TJ, Tranel D, Hichwa RD, Damasio AR. A neural basis for lexical retrieval. Nature. 1996;380:499–505
  13. DeLisi LE, Hoff AL, Schwartz JE, Shields GW, Halthore SN, Gupta SM, et al. Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biological Psychiatry. 1991;29:159–175
  14. Dickerson BC, Fenstermacher E, Salat DH, Wolk DA, Maguire RP, Desikan R, et al. Detection of cortical thickness correlates of cognitive performance: reliability across MRI scan sessions, scanners, and field strengths. Neuroimage. 2008;39:10–18
  15. Ekholm B, Ekholm A, Adolfsson R, Vares M, Osby U, Sedvall GC, et al. Evaluation of diagnostic procedures in Swedish patients with schizophrenia and related psychoses. Nordic Journal of Psychiatry. 2005;59:457–464
  16. Fischl B, Liu A, Dale AM. Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Transactions on Medical Imaging. 2001;20:70–80
  17. Fischl B, Sereno MI, Dale AM. Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system. Neuroimage. 1999;9:195–207
  18. Flaum M, Andreasen NC, Swayze VW, O'Leary DS, Alliger RJ. IQ and brain size in schizophrenia. Psychiatry Research. 1994;53:243–257
  19. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage. 2002;15:870–878
  20. Goldberg TE, Torrey EF, Berman KF, Weinberger DR. Relations between neuropsychological performance and brain morphological and physiological measures in monozygotic twins discordant for schizophrenia. Psychiatry Research. 1994;55:51–61
  21. Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”?. Schizophrenia Bulletin. 2000;26:119–136
  22. Gur RE, Cowell PE, Latshaw A, Turetsky BI, Grossman RI, Arnold SE, et al. Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia. Archives of General Psychiatry. 2000;57:761–768
  23. Gur RE, Turetsky BI, Cowell PE, Finkelman C, Maany V, Grossman RI, et al. Temporolimbic volume reductions in schizophrenia. Archives of General Psychiatry. 2000;57:769–775
  24. Haier RJ, Jung RE, Yeo RA, Head K, Alkire MT. Structural brain variation and general intelligence. Neuroimage. 2004;23:425–433
  25. Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G. Wisconsin Card Sorting Test Manual, Revised and Expanded. Odessa, FL; 1993;
  26. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445
  27. Hokama H, Shenton ME, Nestor PG, Kikinis R, Levitt JJ, Metcalf D, et al. Caudate, putamen, and globus pallidus volume in schizophrenia: a quantitative MRI study. Psychiatry Research: Neuroimaging. 1995;61:209–229
  28. Honea R, Crow TJ, Passingham D, Mackay CE. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. American Journal of Psychiatry. 2005;162:2233–2245
  29. Hoptman MJ, Volavka J, Weiss EM, Czobor P, Szeszko PR, Gerig G, et al. Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder. Psychiatry Research: Neuroimaging. 2005;140:133–145
  30. Jonsson EG, Edman-Ahlbom B, Sillen A, Gunnar A, Kulle B, Frigessi A, et al. Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2006;30:924–933
  31. Jonsson EG, Sillen A, Vares M, Ekholm B, Terenius L, Sedvall GC. Dopamine D2 receptor gene Ser311Cys variant and schizophrenia: association study and meta-analysis. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics. 2003;119:28–34
  32. Jung RE, Haier RJ. The Parieto-Frontal Integration Theory (P-FIT) of intelligence: converging neuroimaging evidence. The Behavioral and Brain Sciences. 2007;30:135–154
  33. Kuperberg GR, Broome MR, McGuire PK, David AS, Eddy M, Ozawa F, et al. Regionally localized thinning of the cerebral cortex in schizophrenia. Archives of General Psychiatry. 2003;60:878–888
  34. Kurtz MM. Neurocognitive impairment across the lifespan in schizophrenia: an update. Schizophrenia Research. 2005;74:15–26
  35. Lawyer G, Nyman H, Agartz I, Arnborg S, Jonsson EG, Sedvall GC, et al. Morphological correlates to cognitive dysfunction in schizophrenia as studied with Bayesian regression. BMC Psychiatry. 2006;6:31
  36. Maher BA, Manschreck TC, Woods BT, Yurgelun-Todd DA, Tsuang MT. Frontal brain volume and context effects in short-term recall in schizophrenia. Biological Psychiatry. 1995;37:144–150
  37. Lezak MD. Neuropsychological Assessment. New York: Oxford Univ. Press; 1995;
  38. Mamah D, Wang L, Barch D, de Erausquin GA, Gado M, Csernansky JG. Structural analysis of the basal ganglia in schizophrenia. Schizophrenia Research. 2007;89:59–71
  39. McDaniel MA. Big-brained people are smarter: a meta-analysis of the relationship between in vivo brain volume and intelligence. Intelligence. 2005;33:337–346
  40. Nakamura M, Nestor PG, Levitt JJ, Cohen AS, Kawashima T, Shenton ME, et al. Orbitofrontal volume deficit in schizophrenia and thought disorder. Brain. 2008;131:180–195
  41. Narr KL, Woods RP, Thompson PM, Szeszko P, Robinson D, Dimtcheva T, et al. Relationships between IQ and regional cortical gray matter thickness in healthy adults. Cerebral Cortex. 2007;17:2163–2171
  42. Nestor PG, O'Donnell BF, McCarley RW, Niznikiewicz M, Barnard J, Jen SZ, et al. A new statistical method for testing hypotheses of neuropsychological/MRI relationships in schizophrenia: partial least squares analysis. Schizophrenia Research. 2002;53:57–66
  43. Nestor PG, Onitsuka T, Gurrera RJ, Niznikiewicz M, Frumin M, Shenton ME, et al. Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia. Schizophrenia Research. 2007;91:103–106
  44. Nestor PG, Shenton ME, McCarley RW, Haimson J, Smith RS, O'Donnell B, et al. Neuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia. American Journal of Psychiatry. 1993;150:1849–1855
  45. Nesvag R, Frigessi A, Jonsson EG, Agartz I. Effects of alcohol consumption and antipsychotic medication on brain morphology in schizophrenia. Schizophrenia Research. 2007;90:52–61
  46. Nesvag R, Lawyer G, Varnas K, Fjell AM, Walhovd KB, Frigessi A, et al. Regional thinning of the cerebral cortex in schizophrenia: effects of diagnosis, age and antipsychotic medication. Schizophrenia Research. 2008;98:16–28
  47. Newman SD, Just MA, Keller TA, Roth J, Carpenter PA. Differential effects of syntactic and semantic processing on the subregions of Broca's area. Brain Research. Cognitive Brain Research. 2003;16:297–307
  48. Nyberg L, McIntosh AR, Cabeza R, Habib R, Houle S, Tulving E. General and specific brain regions involved in encoding and retrieval of events: what, where, and when. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:11280–11285
  49. Pakkenberg B. Post-mortem study of chronic schizophrenic brains. British Journal of Psychiatry. 1987;151:744–752
  50. Prasad KM, Keshavan MS. Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct “extended endophenotypes”?. Schizophrenia Bulletin. 2008;34:774–790
  51. Premkumar P, Kumari V, Corr PJ, Fannon D, Sharma T. Neuropsychological function–brain structure relationships and stage of illness: an investigation into chronic and first-episode schizophrenia. Psychiatry Research: Neuroimaging. 2008;162:195–204
  52. Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, et al. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology. 2002;58:695–701
  53. Rusch N, Spoletini I, Wilke M, Bria P, Di PM, Di IF, et al. Prefrontal–thalamic–cerebellar gray matter networks and executive functioning in schizophrenia. Schizophrenia Research. 2007;93:79–89
  54. Sanfilipo M, Lafargue T, Rusinek H, Arena L, Loneragan C, Lautin A, et al. Cognitive performance in schizophrenia: relationship to regional brain volumes and psychiatric symptoms. Psychiatry Research: Neuroimaging. 2002;116:1–23
  55. Seidman LJ, Yurgelun-Todd D, Kremen WS, Woods BT, Goldstein JM, Faraone SV, et al. Relationship of prefrontal and temporal lobe MRI measures to neuropsychological performance in chronic schizophrenia. Biological Psychiatry. 1994;35:235–246
  56. Shaw P, Greenstein D, Lerch J, Clasen L, Lenroot R, Gogtay N, et al. Intellectual ability and cortical development in children and adolescents. Nature. 2006;440:676–679
  57. Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophrenia Research. 2001;49:1–52
  58. Spitzer RL. Structured Clinical Interview for DSM-IV (SCID). New York: New York State Psychiatric Institute, Biometrics Research; 1995;
  59. Stuss DT, Bisschop SM, Alexander MP, Levine B, Katz D, Izukawa D. The Trail Making Test: a study in focal lesion patients. Psychological Assessment. 2001;13:230–239
  60. Stuss DT, Levine B, Alexander MP, Hong J, Palumbo C, Hamer L, et al. Wisconsin Card Sorting Test performance in patients with focal frontal and posterior brain damage: effects of lesion location and test structure on separable cognitive processes. Neuropsychologia. 2000;38:388–402
  61. Sullivan EV, Shear PK, Lim KO, Zipursky RB, Pfefferbaum A. Cognitive and motor impairments are related to gray matter volume deficits in schizophrenia. Biological Psychiatry. 1996;39:234–240
  62. Szendi I, Kiss M, Racsmany M, Boda K, Cimmer C, Voros E, et al. Correlations between clinical symptoms, working memory functions and structural brain abnormalities in men with schizophrenia. Psychiatry Research: Neuroimaging. 2006;147:47–55
  63. Szeszko PR, Bilder RM, Lencz T, Ashtari M, Goldman RS, Reiter G, et al. Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia. Schizophrenia Research. 2000;43:97–108
  64. Toulopoulou T, Grech A, Morris RG, Schulze K, McDonald C, Chapple B, et al. The relationship between volumetric brain changes and cognitive function: a family study on schizophrenia. Biological Psychiatry. 2004;56:447–453
  65. Vares M, Ekholm A, Sedvall GC, Hall H, Jonsson EG. Characterization of patients with schizophrenia and related psychoses: evaluation of different diagnostic procedures. Psychopathology. 2006;39:286–295
  66. Vita A, Dieci M, Giobbio GM, Caputo A, Ghiringhelli L, Comazzi M, et al. Language and thought disorder in schizophrenia: brain morphological correlates. Schizophrenia Research. 1995;15:243–251
  67. Walhovd KB, Fjell AM, Dale AM, Fischl B, Quinn BT, Makris N, et al. Regional cortical thickness matters in recall after months more than minutes. Neuroimage. 2006;31:1343–1351
  68. Wechsler D. The Wechsler Adult Intelligence Scale-Revised. New York: Psychological Corporation; 1981;
  69. Wechsler D. The Wechsler Adult Intelligence Scale-III. New York: Psychological Corporation; 1997;
  70. Wexler BE, Zhu H, Bell MD, Nicholls SS, Fulbright RK, Gore JC, et al. Neuropsychological near normality and brain structure abnormality in schizophrenia. American Journal of Psychiatry. 2009;166:189–195
  71. Wolf RC, Hose A, Frasch K, Walter H, Vasic N. Volumetric abnormalities associated with cognitive deficits in patients with schizophrenia. European Psychiatry. 2008;23:541–548
  72. Zuffante P, Leonard CM, Kuldau JM, Bauer RM, Doty EG, Bilder RM. Working memory deficits in schizophrenia are not necessarily specific or associated with MRI-based estimates of area 46 volumes. Psychiatry Research: Neuroimaging. 2001;108:187–209

PII: S0925-4927(10)00026-0

doi: 10.1016/j.pscychresns.2010.01.001

Psychiatry Research: Neuroimaging
Volume 182, Issue 2 , Pages 123-133 , 30 May 2010

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