Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 22-29 , 30 April 2010

fMRI abnormalities in dorsolateral prefrontal cortex during a working memory task in manic, euthymic and depressed bipolar subjects

  • Jennifer Townsend

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, United States
  • ,
  • Susan Y. Bookheimer

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, United States
  • ,
  • Lara C. Foland–Ross

      Affiliations

    • Laboratory of NeuroImaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, United States
  • ,
  • Catherine A. Sugar

      Affiliations

    • Department of Biostatistics, School of Public Health, University of California, Los Angeles, CA, United States
    • Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, United States
  • ,
  • Lori L. Altshuler

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, United States
    • Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, United States
    • Corresponding Author InformationCorresponding author. 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095-7057, United States. Tel.: +1 310 794 9911; fax: +1 310 794 9915.

Received 29 October 2008 ,Revised 5 October 2009 ,Accepted 22 November 2009.

References 

  1. Adler CM, Holland SK, Schmithorst V, Tuchfarber MJ, Strakowski SM. Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task. Bipolar Disorders. 2004;6:540–549
  2. Altshuler LL. Bipolar disorder: are repeated episodes associated with neuroanatomic and cognitive changes?. Biological Psychiatry. 1993;33:563–565
  3. Altshuler LL, Ventura J, van Gorp WG, Green MF, Theberge DC, Mintz J. Neurocognitive function in clinically stable men with bipolar I disorder or schizophrenia and normal control subjects. Biological Psychiatry. 2004;56:560–569
  4. Altshuler L, Bookheimer S, Proenza MA, Townsend J, Sabb F, Firestine A, et al. Increased amygdala activation during mania: a functional magnetic resonance imaging study. American Journal of Psychiatry. 2005;162:1211–1213
  5. Altshuler L, Bookheimer S, Townsend J, Proenza MA, Sabb F, Mintz J, et al. Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study. Bipolar Disorders. 2008;10:708–717
  6. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, et al. Antidepressant effect on connectivity of the mood-regulating circuit: an FMRI study. Neuropsychopharmacology. 2005;30:1334–1344
  7. Anand A, Li Y, Wang Y, Gardner K, Lowe MJ. Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an FMRI study. The Journal of Neuropsychiatry and Clinical Neurosciences. 2007;19:274–282
  8. Beckmann CF, Jenkinson M, Smith SM. General multilevel linear modeling for group analysis in FMRI. Neuroimage. 2003;20:1052–1063
  9. Belger A, Puce A, Krystal JH, Gore JC, Goldman-Rakic P, McCarthy G. Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Human Brain Mapping. 1998;6:14–32
  10. Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, et al. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry. 2003;60:601–609
  11. Buckner RL, Logan J, Donaldson DI, Wheeler ME. Cognitive neuroscience of episodic memory encoding. ACTA Psychologica (Amsterdam). 2000;105:127–139
  12. Cabeza R, Nyberg L. Neural bases of learning and memory: functional neuroimaging evidence. Current Opinion in Neurology. 2000;13:415–421
  13. Carlson S, Martinkauppi S, Rama P, Salli E, Korvenoja A, Aronen HJ. Distribution of cortical activation during visuospatial n-back tasks as revealed by functional magnetic resonance imaging. Cerebral Cortex. 1998;8:743–752
  14. Carter CS, Heckers S, Nichols T, Pine DS, Strother S. Optimizing the design and analysis of clinical functional magnetic resonance imaging research studies. Biological Psychiatry. 2008;64:842–849
  15. Clark L, Iversen SD, Goodwin GM. A neuropsychological investigation of prefrontal cortex involvement in acute mania. American Journal of Psychiatry. 2001;158:1605–1611
  16. Coffman JA, Bornstein RA, Olson SC, Schwarzkopf SB, Nasrallah HA. Cognitive impairment and cerebral structure by MRI in bipolar disorder. Biological Psychiatry. 1990;27:1188–1196
  17. Cohen JD, Perlstein WM, Braver TS, Nystrom LE, Noll DC, Jonides J, et al. Temporal dynamics of brain activation during a working memory task. Nature. 1997;386:604–608
  18. Cole MW, Schneider W. The cognitive control network: integrated cortical regions with dissociable functions. Neuroimage. 2007;37:343–360
  19. Curtis CE. Prefrontal and parietal contributions to spatial working memory. Neuroscience. 2006;139:173–180
  20. Depp CA, Moore DJ, Sitzer D, Palmer BW, Eyler LT, Roesch S, et al. Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjects. Journal of Affective Disorders. 2007;101:201–209
  21. Drapier D, Surguladze S, Marshall N, Schulze K, Fern A, Hall MH, et al. Genetic liability for bipolar disorder is characterized by excess frontal activation in response to a working memory task. Biological Psychiatry. 2008;64:513–520
  22. Eldridge LL, Knowlton BJ, Furmanski CS, Bookheimer SY, Engel SA. Remembering episodes: a selective role for the hippocampus during retrieval. Nature Neuroscience. 2000;3:1149–1152
  23. Ferrier IN, Stanton BR, Kelly TP, Scott J. Neuropsychological function in euthymic patients with bipolar disorder. British Journal of Psychiatry. 1999;175:246–251
  24. Frangou S, Kington J, Raymont V, Shergill SS. Examining ventral and dorsal prefrontal function in bipolar disorder: a functional magnetic resonance imaging study. European Psychiatry. 2008;23:300–308
  25. Friston KJ. Testing for anatomically specified regional effects. Human Brain Mapping. 1997;5:133–136
  26. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage. 2002;15:870–878
  27. Glahn DC, Bearden CE, Niendam TA, Escamilla MA. The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disorders. 2004;6:171–182
  28. Goldberg TE, Gold JM, Greenberg R, Griffin S, Schulz SC, Pickar D, et al. Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery. American Journal of Psychiatry. 1993;150:1355–1362
  29. Gruber SA, Rosso IM, Yurgelun-Todd D. Neuropsychological performance predicts clinical recovery in bipolar patients. Journal of Affective Disorders. 2008;105:253–260
  30. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry. 1960;12:56–62
  31. Hassel S, Ladouceur C, Kerr N, Fissell K, Almeida J, Kupfer D, et al. Increased ventral striatal activity but not amygdala to mild happy faces in euthymic bipolar disorder: comorbid anxiety, illness duration and medication effects. Bipolar Disorders. 2008;10:916–927
  32. Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Statistics in Medicine. 1990;9:811–818
  33. Jenkinson M, Smith S. A global optimisation method for robust affine registration of brain images. Medical Image Analysis. 2001;5:143–156
  34. Jenkinson M, Bannister P, Brady M, Smith S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 2002;17:825–841
  35. Lagopoulos J, Ivanovski B, Malhi GS. An event-related functional MRI study of working memory in euthymic bipolar disorder. Journal of Psychiatry and Neuroscience. 2007;32:174–184
  36. Lawrence NS, Williams AM, Surguladze S, Giampietro V, Brammer MJ, Andrew C, et al. Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biological Psychiatry. 2004;55:578–587
  37. MacLeod AK, Buckner RL, Miezin FM, Petersen SE, Raichle ME. Right anterior prefrontal cortex activation during semantic monitoring and working memory. Neuroimage. 1998;7:41–48
  38. Malhi GS, Ivanovski B, Hadzi-Pavlovic D, Mitchell PB, Vieta E, Sachdev P. Neuropsychological deficits and functional impairment in bipolar depression, hypomania and euthymia. Bipolar Disorders. 2007;9:114–125
  39. Martinez-Aran A, Vieta E, Reinares M, Colom F, Torrent C, Sanchez-Moreno J, et al. Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. American Journal of Psychiatry. 2004;161:262–270
  40. Martinez-Aran A, Vieta E, Colom F, Torrent C, Reinares M, Goikolea JM, et al. Do cognitive complaints in euthymic bipolar patients reflect objective cognitive impairment?. Psychotherapy and Psychosomatics. 2005;74:295–302
  41. Monks PJ, Thompson JM, Bullmore ET, Suckling J, Brammer MJ, Williams SC, et al. A functional MRI study of working memory task in euthymic bipolar disorder: evidence for task-specific dysfunction. Bipolar Disorders. 2004;6:550–564
  42. Morice R. Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania. British Journal of Psychiatry. 1990;157:50–54
  43. Murphy FC, Sahakian BJ, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, et al. Emotional bias and inhibitory control processes in mania and depression. Psychological Medicine. 1999;29:1307–1321
  44. Nehra R, Chakrabarti S, Pradhan BK, Khehra N. Comparison of cognitive functions between first- and multi-episode bipolar affective disorders. Journal of Affective Disorders. 2006;93:185–192
  45. Nystrom LE, Braver TS, Sabb FW, Delgado MR, Noll DC, Cohen JD. Working memory for letters, shapes, and locations: fMRI evidence against stimulus-based regional organization in human prefrontal cortex. Neuroimage. 2000;11:424–446
  46. Phillips ML, Travis MJ, Fagiolini A, Kupfer DJ. Medication effects in neuroimaging studies of bipolar disorder. American Journal of Psychiatry. 2008;165:313–320
  47. Poldrack RA. Can cognitive processes be inferred from neuroimaging data?. Trends in Cognitive Sciences. 2006;10:59–63
  48. Rossi A, Arduini L, Daneluzzo E, Bustini M, Prosperini P, Stratta P. Cognitive function in euthymic bipolar patients, stabilized schizophrenic patients, and healthy controls. Journal of Psychiatric Research. 2000;34:333–339
  49. Roth RM, Koven NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, et al. Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 2006;17:1085–1089
  50. Rubinsztein JS, Michael A, Underwood BR, Tempest M, Sahakian BJ. Impaired cognition and decision-making in bipolar depression but no ‘affective bias’ evident. Psychological Medicine. 2006;36:629–639
  51. Semendeferi K, Armstrong E, Schleicher A, Zilles K, Van Hoesen GW. Prefrontal cortex in humans and apes: a comparative study of area 10. American Journal of Physical Anthropology. 2001;114:224–241
  52. Senturk V, Goker C, Bilgic A, Olmez S, Tugcu H, Oncu B, et al. Impaired verbal memory and otherwise spared cognition in remitted bipolar patients on monotherapy with lithium or valproate. Bipolar Disorders. 2007;9(Suppl 1):136–144
  53. Siegle GJ, Thompson W, Carter CS, Steinhauer SR, Thase ME. Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biological Psychiatry. 2007;61:198–209
  54. Silverstone PH, Bell EC, Willson MC, Dave S, Wilman AH. Lithium alters brain activation in bipolar disorder in a task- and state-dependent manner: an fMRI study. Annals of General Psychiatry. 2005;4:14
  55. Smith SM. Fast robust automated brain extraction. Human Brain Mapping. 2002;17:143–155
  56. Smith EE, Jonides J. Neuroimaging analyses of human working memory. Proceedings of the National Academy of Sciences, U S A. 1998;95:12061–12068
  57. Strakowski SM, Adler CM, Holland SK, Mills N, DelBello MP. A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology. 2004;29:1734–1740
  58. Tam WC, Sewell KW, Deng HC. Information processing in schizophrenia and bipolar disorder: a discriminant analysis. Journal of Nervous and Mental Disease. 1998;186:597–603
  59. Thompson JM, Gray JM, Hughes JH, Watson S, Young AH, Ferrier IN. Impaired working memory monitoring in euthymic bipolar patients. Bipolar Disorders. 2007;9:478–489
  60. Trivedi JK, Goel D, Sharma S, Singh AP, Sinha PK, Tandon R. Cognitive functions in stable schizophrenia & euthymic state of bipolar disorder. Indian Journal of Medical Research. 2007;126:433–439
  61. Trivedi JK, Dhyani M, Sharma S, Sinha PK, Singh AP, Tandon R. Cognitive functions in euthymic state of bipolar disorder: an Indian study. Cognitive Neuropsychiatry. 2008;13:135–147
  62. van Gorp WG, Altshuler L, Theberge DC, Wilkins J, Dixon W. Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study. Archives of General Psychiatry. 1998;55:41–46
  63. Wager TD, Smith EE. Neuroimaging studies of working memory: a meta-analysis. Cognitive, Affective & Behavioral Neuroscience. 2003;3:255–274
  64. Wagner AD, Desmond JE, Glover GH, Gabrieli JD. Prefrontal cortex and recognition memory. Functional-MRI evidence for context-dependent retrieval processes. Brain. 1998;121(Pt 10):1985–2002
  65. Woolrich MW, Ripley BD, Brady M, Smith SM. Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage. 2001;14:1370–1386
  66. Woolrich MW, Behrens TE, Smith SM. Constrained linear basis sets for HRF modelling using Variational Bayes. Neuroimage. 2004;21:1748–1761
  67. Worsley KJ, Poline JB, Friston KJ, Evans AC. Characterizing the response of PET and fMRI data using multivariate linear models. Neuroimage. 1997;6:305–319
  68. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. British Journal of Psychiatry. 1978;133:429–435
  69. Yurgelun-Todd DA, Gruber SA, Kanayama G, Killgore WD, Baird AA, Young AD. fMRI during affect discrimination in bipolar affective disorder. Bipolar Disorders. 2000;2:237–248
  70. Zhang JX, Leung HC, Johnson MK. Frontal activations associated with accessing and evaluating information in working memory: an fMRI study. Neuroimage. 2003;20:1531–1539

PII: S0925-4927(09)00279-0

doi: 10.1016/j.pscychresns.2009.11.010

Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 22-29 , 30 April 2010