Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 48-52 , 30 April 2010

Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: A study using 1H magnetic resonance spectroscopy

  • Yanyan Huang

      Affiliations

    • Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai 200040, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 21 52887281; fax: +86 21 52887315.
    • First author.
  • ,
  • Wenjie Chen

      Affiliations

    • Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai 200040, China
    • First author.
  • ,
  • Yuxin Li

      Affiliations

    • Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
    • First author.
  • ,
  • Xiaoyan Wu

      Affiliations

    • Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai 200040, China
  • ,
  • Xiaomei Shi

      Affiliations

    • Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai 200040, China
  • ,
  • Daoying Geng

      Affiliations

    • Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China

Received 10 October 2008 ,Revised 14 November 2009 ,Accepted 22 November 2009.

References 

  1. Batra N, Seres-Mailo J, Hanstock C, Seres P, Khudabux J, Bellavance F, et al. Proton magnetic resonance spectroscopy measurement of brain glutamate levels in premenstrual dysphoric disorder. Biological Psychiatry. 2008;63:1178–1184
  2. Block W, Träber F, von Widdern O, Metten M, Schild H, Maier W, et al. Proton MR spectroscopy of the hippocampus at 3T in patients with unipolar major depressive disorder: correlates and predictors of treatment response. International Journal of Neuropsychopharmacology. 2009;12:415–422
  3. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Annals of the New York Academy of Science. 1987;508:333–348
  4. Boulanger Y, Labelle M, Khiat A. Role of phospholipase A(2) on the variations of the coline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases. Brain Research. Brain Research Reviews. 2000;33:380–389
  5. Chemerinski E, Robinson RG, Arndt S, Kosier JT. The effect of remission of poststroke depression on activities of daily living in a double-blind randomized treatment study. Journal of Nervous and Mental Disease. 2001;189:421–425
  6. Castren E. Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection. Molecular Neurobiology. 2004;29:289–302
  7. Czeh T, Michaelis B, Watanabe T, Frahm J, de Biurrun G, van Kampen M, et al. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:12796–12801
  8. Davidson RJ, Irwin W, Anderle MJ, Kalin NH. The neural substrates of affective processing in depressed patients treated with venlafaxine. American Journal of Psychiatry. 2003;160:64–75
  9. Deicken RF, Pegues MP, Anzalone S, Feiwell R, Soher B. Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. American Journal of Psychiatry. 2003;160:873–882
  10. Demougeot C, Bertrand N, Prigent-Tessier A, Garnier P, Mossiat C, Giroud M, et al. Reversible loss of N-acetyl-aspartate in rats subjected to long-term focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism. 2003;23:482–489
  11. Ende G, Braus DF, Walter S, Weber-Fahr W, Henn FA. The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study. Archives of General Psychiatry. 2000;57:937–943
  12. Ende G, Demirakca T, Walter S, Wokrina T, Sartorius A, Wildqruber D, et al. Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression. European Archives of Psychiatry and Clinical Neuroscience. 2007;257:36–39
  13. Gabbay V, Hess DA, Liu S, Babb JS, Klein RG, Gonen O. Laterialized caudate metabolite abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study. American Journal of Psychiatry. 2007;164:1881–1889
  14. Gainotti G, Antonucci G, Marra C, Paulucci S. Relation between depression after stroke, antidepressant therapy and functional recovery. Journal of Neurology, Neurosurgery and Psychiatry. 2001;71:258–261
  15. Gaspar P, Cases O, Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nature reviews. Neuroscience. 2003;4:1002–1012
  16. Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neuroscience. 2002;5:1242–1247
  17. Glodzik-Sobanska L, Slowik A, McHugh P, Sobiecka B, Kozub J, Rich KE, et al. Single voxel proton magnetic resonance spectroscopy in post-stroke depression. Psychiatry Research: Neuroimaging. 2006;148:111–120
  18. Gonul AS, Kula M, Bilgin AG, Tutus A, Oguz A. The regional cerebral blood flow changes in major depressive disorder with and without psychotic features. Progress in Neuro-psychopharmacology and Biological Psychiatry. 2004;28:1015–1021
  19. Gonul AS, Kitis O, Ozan E, Akdeniz F, Eker C, Eker OD, et al. The effect of antidepressant treatment on N-acetyl aspartate levels of medial frontal cortex in drug-free depressed patients. Progress in Neuro-psychopharmacology and Biological Psychiatry. 2006;30:120–125
  20. Gruber S, Frey R, Mlynárik V, Stadlbauer A, Heiden A, Kasper S, et al. Quantification of metabolic differences in the frontal brain of depressive patients and controls obtained by 1H-MRS at 3 Tesla. Investigative Radiology. 2003;38:403–408
  21. Hammen T, Schwarz M, Doelken M, Kerling F, Engelhorn T, Stadlbauer A, et al. 1H-MR spectroscopy indicates severity markers in temporal lobe epilepsy: correlations between metabolic alterations, seizures, and epileptic discharges in EEG. Epilepsia. 2007;48:263–269
  22. Haase A, Frahm J, Hänicke W, Matthaei D. 1H NMR chemical shift selective (CHESS) imaging. Physics in Medicine and Biology. 1985;30:341–344
  23. Halasy K, Somogyi P. Subdivisions in the multiple GABAergic innervation of granule cells in the dentate gyrus of the rat hippocampus. European Journal of Neuroscience. 1993;5:411–429
  24. Jacobs BL, Praag H, Gage FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Molecular Psychiatry. 2000;5:262–269
  25. Kanner AM. Structural MRI changes of the brain in depression. Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS). 2004;35:46–52
  26. Kennedy SH, Evans KR, Kruger S, Mayberg HS, Meyer JH, McCann S, et al. Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. American Journal of Psychiatry. 2001;158:899–905
  27. Kronmüller KT, Pantel J, Köhler S, Victor D, Giesel F, Magnotta VA, et al. Hippocampal volume and 2-year outcome in depression. British Journal of Psychiatry. 2008;192:472–473
  28. LaBar KS, Cabeza R. Cognitive neuroscience of emotional memory. Nature Reviews. Neuroscience. 2006;7:54–64
  29. Li L, Chen S, Liu J, Zhang J, He Z, Lin X. Magnetic resonance imaging and magnetic resonance spectroscopy study of deficits in the hippocampal structure in fire victims with recent-onset posttraumatic stress disorder. Canadian Journal of Psychiatry. 2006;51:431–437
  30. Mattson MP, Maudsley S, Martin B. A neural signaling triumvirate that influences ageing and age-related disease: insuli/IGF-1, BDNF and serotonin. Ageing Research Reviews. 2004;3:445–464
  31. Michael N, Erfurth A, Ohrmann P, Arolt V, Heindel W, Pfleiderer B. Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression. Psychological Medicine. 2003;33:1277–1284
  32. Mirza Y, O'Neill J, Smith EA, Russell A, Smith JM, Banerjee SP, et al. Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive–compulsive disorder versus major depression and healthy controls. Journal of Child Neurology. 2006;21:106–111
  33. Moore GJ, Bebchuk JM, Hasanat K, Chen G, Seraji-Bozorqzad N, Wilds IB, et al. Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?. Biological Psychiatry. 2000;48:1–8
  34. Moore RY, Halaris AE. Hippocampal innervation by serotonin neurons of the midbrain raphe in the rat. Journal of Comparative Neurology. 1975;164:171–183
  35. Namboodiri AMA, Peethambaran A, Mathew R, Sambhu PA, Hershfield J, Moffett JR, et al. Canavan disease and the role of N-acetylaspartate in myelin synthesis. Molecular and Cellular Endocrinology. 2006;252:216–223
  36. Pears MR, Cooper JD, Mitchison RJ, Mortishire-Smith RJ, Pearce DA, Griffin JL. High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease. Journal of Biological Chemistry. 2005;280:42508–42514
  37. Pfleiderer B, Michael N, Erfurth A, Ohrmann P, Hohmann U, Wolgast M, et al. Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Research: Neuroimaging. 2003;122:185–192
  38. Renshaw PF, Yurgelun-Todd DA, Tohen M, Gruber S, Cohen BM. Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis. American Journal of Psychiatry. 1995;52:444–446
  39. Ross B, Michaelis T. Clinical applications of magnetic resonance spectroscopy. Magnetic Resonance Quarterly. 1994;10:191–247
  40. Sappey-Marinier D, Calabrese G, Hetherington HP, Fisher SN, Deicken R, van Dyke C, et al. Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities. Magnetic Resonance in Medicine. 1992;26:313–327
  41. Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience. 1991;45:37–45
  42. Szulc A, Galińska B, Tarasów E, Kubas B, Dzienis W, Konarzewska B, et al. N-acetylaspartate (NAA) levels in selected areas of the brain in patients with chronic schizophrenia treated with typical and atypical neuroleptics: a proton magnetic resonance spectroscopy (1H MRS) study. Medical Science Monitor. 2007;13(Suppl 1):17–22
  43. Venkatraman TN, Krishnan RR, Steffens DC, Song AW, Taylor WD. Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression. Psychiatry Research. Neuroimaging. 2009;172:49–54
  44. Urenjak J, Williams SR, Gadian DG, Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. Journal of Neuroscience. 1993;13:981–989
  45. van Elst LT, Ludaescher P, Thiel T, Büchert M, Hesslinger B, Bohus M, et al. Evidence of disturbed amygdalar energy metabolism in patients with borderline personality disorder. Neuroscience Letters. 2007;417:36–41
  46. Yildiz-Yesiloglu A, Ankerst DP. Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis. Psychiatry Research: Neuroimaging. 2006;147:1–25

PII: S0925-4927(09)00278-9

doi: 10.1016/j.pscychresns.2009.11.009

Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 48-52 , 30 April 2010