Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 67-72 , 30 April 2010

Volumetry of the human amygdala — An anatomical study

  • Jiri Brabec

      Affiliations

    • Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, Czech Republic
    • Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    • Corresponding Author InformationCorresponding author. Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, U Nemocnice 3, 128 00 Praha 2, Czech Republic.
    • ,
  • Aaron Rulseh

      Affiliations

    • Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, Czech Republic
    • ,
  • Brian Hoyt

      Affiliations

    • Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, Czech Republic
    • ,
  • Martin Vizek

      Affiliations

    • Institute of Pathological Physiology and Laboratory for Neuroimaging Research, 2nd Medical School, Charles University in Prague, Czech Republic
    • ,
  • Daniel Horinek

      Affiliations

    • Institute of Pathological Physiology and Laboratory for Neuroimaging Research, 2nd Medical School, Charles University in Prague, Czech Republic
    • ,
  • Jakub Hort

      Affiliations

    • Department of Neurology, University Hospital Motol, 2nd Medical School, Charles University in Prague, Czech Republic
    • ,
  • Pavel Petrovicky

      Affiliations

    • Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, Czech Republic

Received 16 February 2009 ,Revised 13 October 2009 ,Accepted 11 November 2009.

References 

  1. Allen JS, Bruss J, Brown CK, Damasio H. Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region. Neurobiology of Aging. 2005;26:1245–1260
  2. Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah NJ, et al. Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps. Anatomy and Embryology (Berlin). 2005;210:343–352
  3. Barger N, Stefanacci L, Semendeferi K. A comparative volumetric analysis of the amygdaloid complex and basolateral division in the human and ape brain. American Journal of Physical Anthropology. 2007;134:392–403
  4. Bonilha L, Kobayashi E, Cendes E, Li LM. The importance of accurate anatomic assessment for the volumetric analysis of the amygdala. Brazilian Journal of Medical and Biological Research. 2005;38:409–418
  5. Bogerts B, Meertz E, Schonfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Archives of General Psychiatry. 1985;42:784–791
  6. Bogerts B, Lieberman JA, Ashtari M, Bilder RM, Degreef G, Lerner G, et al. Hippocampus–amygdala volumes and psychopathology in chronic schizophrenia. Biological Psychiatry. 1993;33:236–246
  7. Brierley B, Shaw P, David AS. The human amygdala: a systematic review and meta-analysis of volumetric magnetic resonance imaging. Brain Research. Brain Research Reviews. 2002;39:84–105
  8. Brockhaus H. Zur Normalen und patologischen Anatomie des Mandelkerngebiets. Journal für Psychologie und Neurologie. 1938;49:1–136
  9. Convit A, McHugh P, Wolf OT, de Leon MJ, Bobinski M, De Santi S, et al. MRI volume of the amygdala: a reliable method allowing separation from the hippocampal formation. Psychiatry Research: Neuroimaging. 1999;90:113–123
  10. Crosby EC, Humphrey T. Studies of the vertebrate telencephalon. II. The nuclear pattern of the anterior olfactory nucleus, tuberculum olfactorium and the amygdaloid complex in adult man. Journal of Comparative Neurology. 1941;74:309–352
  11. Dolan RJ. Functional neuroimaging of the human amygdala during emotional processing and learning. In:  Aggleton JP editors. The Amygdala. A Functional Analysis. second edition. Oxford: Oxford University Press; 2000;p. 631–653
  12. Doty TJ, Payne ME, Steffens DC, Beyer JL, Krishnan KR, LaBar KS. Age-dependent reduction of amygdala volume in bipolar disorder. Psychiatry Research: Neuroimaging. 2008;163:84–94
  13. Doyle CA, Slater P. Localization of neuronal and endothelial nitric oxide synthase isoforms in human hippocampus. Neuroscience. 1997;76:387–395
  14. Fernandez-Carriba S, Loeches A, Morcillo A, Hopkins WD. Asymmetry of facial expression of emotions by chimpanzees. Neuropsychologia. 2002;40:1523–1533
  15. Fox NC, Scahill RI, Crum WR, Rossor MN. Correlation between rates of brain atrophy and cognitive decline in AD. Neurology. 1999;52:1687–1689
  16. Freeman HD, Cantalupo C, Hopkins WD. Asymmetries in the hippocampus and amygdala of chimpanzees (Pan troglodytes). Behavioral Neuroscience. 2004;118:1460–1465
  17. Gur RE, Turetsky BI, Cowell PE, Finkelman C, Maany V, Grossman RI, et al. Temporolimbic volume reductions in schizophrenia. Archives of General Psychiatry. 2000;57:769–775
  18. Haug H, Kühl S, Mecke E, Sass NL, Wasner K. The significance of morphometric procedures in the investigation of age changes in cytoarchitectonic structures of the human brain. Journal für Hirnforschung. 1984;25:354–374
  19. Hauser MC. Right hemisphere dominance in the production of facial expression in monkeys. Science. 1993;261:475–477
  20. Heckers S, Heinsen H, Heinsen YC, Beckmann H. Limbic structures and lateral ventricle in schizophrenia. A quantitative postmortem study. Archives of General Psychiatry. 1990;47:1016–1022
  21. Heimer L. Basal forebrain in the context of schizophrenia. Brain Research. Brain Research Reviews. 2000;31:205–235
  22. Heimer L, Harlan RE, Alheid GF, Garcia MM, de Olmos J. Substantia innominata: a notion which impedes clinical–anatomical correlations in neuropsychiatric disorders. Neuroscience. 1997;76:957–1006
  23. Horinek D, Varjassyova A, Hort J. Magnetic resonance analysis of amygdalar volume in Alzheimer's disease. Current Opinions in Psychiatry. 2007;20:273–277
  24. Chance SA, Esiri MM, Crow TJ. Amygdala volume in schizophrenia: post-mortem study and review of magnetic resonance imaging findings. British Journal of Psychiatry. 2002;180:331–338
  25. Jack CR, Twomey CK, Zinsmeister AR, Sharbrough FW, Petersen RC, Cascino GD. Anterior temporal lobes and hippocampal formations: normative volumetric measurements from MR images in young adults. Radiology. 1989;172:549–554
  26. Jernigan TL, Archibald SL, Fennema-Notestine C, Gamst AC, Stout JC, Bonner J, et al. Effects of age on tissues and regions of the cerebrum and cerebellum. Neurobiology of Aging. 2001;22:581–594
  27. Kalviainen R, Salmenpera T, Partanen K, Vainio P, Riekkinen P, Pitkanen A. MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy. Epilepsy Research. 1997;28:39–50
  28. Laakso MP, Partanen K, Lehtovirta M, Hallikainen M, Hanninen T, Vainio P, et al. MRI of amygdala fails to diagnose early Alzheimer's disease. Neuroreport. 1995;6:2414–2418
  29. Lange H, Thörner G, Hopf A, Schröder KF. Morphometric studies of the neuropathological changes in choreatic diseases. Journal of Neurological Sciences. 1976;28:401–425
  30. Larson CL, Schaefer HS, Siegle GJ, Jackson CA, Anderle MJ, Davidson RJ. Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuli. Biological Psychiatry. 2006;60:410–417
  31. LeDoux JE. The amygdala and emotion: a view through fear. In:  Aggleton JP editors. The amygdala. A functional analysis. second edition. Oxford: Oxford University Press; 2000;p. 289–310
  32. Mai J, Assheuer J, Paxinos G. Atlas of the Human Brain. London: Acad. Press; 1997;
  33. Mu QW, Xie JX, Wen ZY, Weng YQ, Shuyun Z. A quantitative MR study of the hippocampal formation, the amygdala, and the temporal horn of the lateral ventricle in healthy subjects 40 to 90years of age. American Journal of Neuroradiology. 1999;20:207–211
  34. Mori E, Yoneda Y, Yamashita H, Hirono N, Ikeda M, Yamadori A. Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study. Journal of Neurology, Neurosurgery, and Psychiatry. 1997;63:214–221
  35. Nieuwenhuys R, Voogd J, van Huijzen Chr. Das Zentralnervensystem des Menschens. Berlin: Springer-Verlag; 1991;
  36. Pruessner JC, Kohler S, Crane J, Pruessner M, Lord C, Byrne A, et al. Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus. Cerebral Cortex. 2002;12:1342–1353
  37. Rasband WS. ImageJ. Bethesda, Maryland, USA: U.S. National Institutes of Health; 1997–2005;http://rsb.info.nih.gov/ij/
  38. Rodrigue KM, Raz N. Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults. Journal of Neuroscience. 2004;24:956–963
  39. Schumann CM, Amaral DG. Stereological estimation of the number of neurons in the human amygdaloid complex. Journal of Comparative Neurology. 2005;491:320–329
  40. Scott SA, DeKosky ST, Scheff SW. Volumetric atrophy of the amygdala in Alzheimer's disease: quantitative serial reconstruction. Neurology. 1991;41:351–356
  41. Scherer-Singler U, Vincent SR, Kimura H, McGeer EG. Demonstration of unique population of neurons with NADPH-diaphorase histochemistry. Journal of Neuroscience Methods. 1983;9:229–234
  42. Sheline YI, Gado MH, Price JL. Amygdala core nuclei volumes are decreased in recurrent major depression. Neuroreport. 1998;9:2023–2028
  43. Sims KS, Williams RS. The human amygdaloid complex: a cytologic and histochemical atlas using Nissl, myelin, acetylcholinesterase and nicotinamide adenine dinucleotide phosphate diaphorase staining. Neuroscience. 1990;36:449–472
  44. Stephan H, Frahm HD, Baron G. Comparison of brain structure volumes in Insectivora and primates. VII. Amygdaloid components. Journal für Hirnforschung. 1987;28:571–584
  45. ten Donkelaar HJ, Lohman AH. Klinische Anatomie en Embryologie. Maarssen: Elsevier; 2001;
  46. Strakowski SM, DelBello MP, Sax KW, Zimmerman ME, Shear PK, Hawkins JM, et al. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry. 1999;56:254–260
  47. Szeszko PR, Robinson D, Alvir JM, Bilder RM, Lencz T, Ashtari M, et al. Orbital frontal and amygdala volume reductions in obsessive–compulsive disorder. Archives of General Psychiatry. 1999;56:913–919
  48. Vereecken, T., 1993. The amygdaloid complex in Alzheimer's disease. Thesis, Nijmegen. ISBN 90-9006139-8.
  49. Watson C, Andermann F, Gloor P, Jonesgotman M, Peters T, Evans A, et al. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic-resonance-imaging. Neurology. 1992;42:1743–1750
  50. Whitwell JL, Sampson EL, Watt HC, Harvey RJ, Rossor MN, Fox NC. A volumetric magnetic resonance imaging study of the amygdala in frontotemporal lobar degeneration and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 2005;20:238–244
  51. Wright CI, Wedig MM, Williams D, Rauch SL, Albert MS. Novel fearful faces activate the amygdala in healthy young and elderly adults. Neurobiology of Aging. 2006;27:361–374
  52. Zarow C, Vinters HV, Ellis WG, Weiner MW, Mungas D, White L, et al. Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia. Annals of Neurology. 2005;57:896–903
  53. OsiriX Imaging Software. http://www.osirix-viewer.com.

PII: S0925-4927(09)00271-6

doi: 10.1016/j.pscychresns.2009.11.005

Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 67-72 , 30 April 2010

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