Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 9-13 , 30 April 2010

Reduced hippocampal and parahippocampal volumes in murderers with schizophrenia

  • Yaling Yang

      Affiliations

    • Laboratory of NeuroImaging, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • Adrian Raine

      Affiliations

    • Department of Criminology, Psychiatry, and Psychology, University of Pennsylvania. Philadelphia, PA, USA
    • ,
  • Chen-Bo Han

      Affiliations

    • Department of Forensic Psychiatry, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
    • ,
  • Robert A. Schug

      Affiliations

    • Department of Psychology, University of Southern California. Los Angeles, CA, USA
    • ,
  • Arthur W. Toga

      Affiliations

    • Laboratory of NeuroImaging, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    • ,
  • Katherine L. Narr

      Affiliations

    • Laboratory of NeuroImaging, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

Received 13 June 2009 ,Revised 27 October 2009 ,Accepted 29 October 2009.

References 

  1. American Psychological Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: Author; 1994;
  2. Antonova E, Sharma T, Morris R, Kumari V. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophrenia Research. 2004;70:117–145
  3. Barkataki I, Kumari V, Das M, Taylor P, Sharma T. Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder. Behavioral Brain Research. 2006;169:239–247
  4. Chinese Society of Psychiatry. The Chinese Classification and Diagnostic Criteria of Mental Disorders, Version 3 (CCMD-3). Jinan: Chinese Society of Psychiatry; 2001;
  5. Davidson RJ, Putnam KM, Larson CL. Dysfunction in the neural circuitry of emotion regulation — a possible prelude to violence. Science. 2000;289:591–594
  6. Eichenbaum H, Lipton PA. Towards a functional organization of the medial temporal lobe memory system: role of parahippocampal and medial entorhinal cortical areas. Hippocampus. 2008;18:1314–1324
  7. Gong YX. Manual for the Wechsler Adults Intelligence Scale: revised in China. 2nd ed. Changsha, Hunan, China: Hunan Medical College; 1992;
  8. Gray JA, McNaughton N. The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System. 2nd ed. New York: Appleton-Century-Crofts; 2000;
  9. Harrison PJ. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychophamacology (Berlin). 2004;174:151–162
  10. Hodgins S. Violent behaviour among people with schizophrenia: a framework for investigations of causes, and effective treatment, and prevention. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 2008;363:2505–2518
  11. Kumari V, Barkataki I, Goswami S, Flora S, Das M, Taylor P. Dysfunctional, but not functional, impulsivity is associated with a history of seriously violent behavior and reduced orbitofrontal and hippocampal volumes in schizophrenia. Psychiatry Research: Neuroimaging. 2009;173:39–44
  12. Kuperberg GR, Broome MR, McGuire PK, David AS, Eddy M, Ozawa F, et al. Regionally localized thinning of the cerebral cortex in schizophrenia. Archives of General Psychiatry. 2003;60:878–888
  13. Machado CJ, Bachevalier J. The impact of selective amygdala, orbital frontal cortex, or hippocampal formation lesions on established social relationships in rhesus monkeys (Macaca mulatta). Behavioral Neuroscience. 2006;120:761–786
  14. Narayan VM, Narr KL, Kumari V, Woods RP, Thompson PM, Toga AW, et al. Regional cortical thinning in subjects with violent antisocial personality disorder or schizophrenia. American Journal of Psychiatry. 2007;164:1418–1427
  15. Narr KL, Toga AW, Szeszko P, Thompson PM, Woods RP, Robinson D, et al. Cortical thinning in cingulate and occipital cortices in first episode schizophrenia. Biological Psychiatry. 2005;58:32–40
  16. Narr KL, Bilder RM, Toga AW, Woods RP, Szeszko PR, Robinson D, et al. Mapping cortical thickness and gray matter concentration in first episode schizophrenia. Cerebral Cortex. 2005;15:708–719
  17. Naudts K, Hodgins S. Neurobiological correlates of violent behavior among persons with schizophrenia. Schizophrenia Bulletin. 2006;32:562–572
  18. Nesvåg R, Lawyer G, Vernäs K, Fjell AM, Walhovd KB, Frigessi A, et al. Regional thinning of the cerebral cortex in schizophrenia: effects of diagnosis, age, and antipsychotic medication. Schizophrenia Research. 2008;98:16–28
  19. Puri BK, Counsell SJ, Saeed N, Bustos MG, Treasaden IH, Bydder GM. Regional grey matter volumetric changes in forensic schizophrenia patients: an MRI study comparing the brains structure of patients who have seriously and violently offended with that of patients who have not. BMC Psychiatry. 2008;8(Suppl 1):S6
  20. Raine A, Lencz T, Bihrle S, LaCasse L, Colletti P. Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Archives of General Psychiatry. 2000;57:119–127
  21. Reiss AL, Abrams MT, Singer HS, Ross JL, Denckla MB. Brain development, gender and IQ in children. A volumetric imaging study. Brain. 1996;119:1763–1774
  22. Schug RA, Raine A. Comparative meta-analyses of neuropsychological functioning in antisocial schizophrenic persons. Clinical Psychology Review. 2009;29:230–242
  23. Taki Y, Kinomura S, Sato K, Goto R, Inoue K, Okada K, et al. Both global gray matter volume and regional gray matter volume negatively correlate with lifetime alcohol intake in non-alcohol-dependent Japanese men: a volumetric analysis and a voxel-based morphometry. Alcoholism, Clinical and Experimental Research. 2006;30:1045–1050
  24. Tu Z, Narr KL, Dollar P, Dinov I, Thompson PM, Toga AW. Brain anatomical structure segmentation by hybrid discriminative/generative models. IEEE Transactions on Medical Imaging. 2008;27:495–508
  25. Weinberger DR. Schizophrenia and the frontal lobe. Trends in Neuroscience. 1988;11:367–370
  26. Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry. 2000;157:16–25
  27. Yang Y, Raine A, Narr KL, Lencz T, LaCasse L, Colletti P, et al. Localisation of increased prefrontal white matter in pathological liars. British Journal of Psychiatry. 2007;190:174–175
  28. Yang Y, Raine A, Narr KL, Colletti P, Toga AW. Abnormal temporal and prefrontal cortical gray matter thinning in psychopaths. Molecular Psychiatry. 2009;14:561–562

PII: S0925-4927(09)00246-7

doi: 10.1016/j.pscychresns.2009.10.013

Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 9-13 , 30 April 2010

Article Tools

* Image Usage & Resolution