Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 108-113 , 28 February 2010

Increased incidence and size of cavum septum pellucidum in children with chromosome 22q11.2 deletion syndrome

  • Elliott A. Beaton

      Affiliations

    • Department of Psychiatry, University of California, Davis, CA, USA
    • UC Davis M.I.N.D. Institute, University of California, Davis, Sacramento, CA, USA
  • ,
  • Yufeng Qin

      Affiliations

    • UC Davis M.I.N.D. Institute, University of California, Davis, Sacramento, CA, USA
    • Department of Child Development, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
  • ,
  • Vy Nguyen

      Affiliations

    • Department of Psychiatry, University of California, Davis, CA, USA
    • UC Davis M.I.N.D. Institute, University of California, Davis, Sacramento, CA, USA
  • ,
  • Joel Johnson

      Affiliations

    • Department of Psychiatry, University of California, Davis, CA, USA
    • UC Davis M.I.N.D. Institute, University of California, Davis, Sacramento, CA, USA
  • ,
  • Joseph D. Pinter

      Affiliations

    • Department of Pediatrics, Division of Neurology, Oregon Health and Science University, Portland, OR, USA
  • ,
  • Tony J. Simon

      Affiliations

    • Department of Psychiatry, University of California, Davis, CA, USA
    • UC Davis M.I.N.D. Institute, University of California, Davis, Sacramento, CA, USA
    • Corresponding Author InformationCorresponding author. UC Davis M.I.N.D. Institute, 2825 50th St., Sacramento, CA 95817, USA. Tel.: +1 916 703 0407; fax: +1 916 734 3384.

Received 3 April 2009 ,Revised 12 August 2009 ,Accepted 17 October 2009.

References 

  1. Antshel KM, Kates WR, Roizen N, Fremont W, Shprintzen RJ. 22q11.2 deletion syndrome: genetics, neuroanatomy and cognitive/behavioral features. Neuropsychology, Development, and Cognition. Section C, Child Neuropsychology. 2005;11:5–19
  2. Bearden CE, Woodin MF, Wang PP, Moss E, McDonald-McGinn D, Zackai E, et al. The neurocognitive phenotype of the 22q11.2 deletion syndrome: selective deficit in visual–spatial memory. Journal of Clinical and Experimental Neuropsychology. 2001;23:447–464
  3. Bish JP, Nguyen V, Ding L, Ferrante S, Simon TJ. Thalamic reductions in children with chromosome 22q11.2 deletion syndrome. Neuroreport. 2004;15:1413–1415
  4. Bish JP, Ferrante S, McDonald-McGinn D, Zackai E, Simon TJ. Maladaptive conflict monitoring as evidence for executive dysfunction in children with chromosome 22q11.2 deletion syndrome. Developmental Science. 2005;8:36–43
  5. Bodensteiner JB, Schaefer GB. Wide cavum septum pellucidum: a marker of disturbed brain development. Pediatric Neurology. 1990;6:391–394
  6. Bodensteiner JB, Schaefer GB. Dementia pugilistica and cavum septi pellucidi: born to box?. Sports Medicine. 1997;24:361–365
  7. Born CM, Meisenzahl EM, Frodl T, Pfluger T, Reiser M, Möller HJ, et al. The septum pellucidum and its variants. European Archives of Psychiatry and Clinical Neuroscience. 2004;254:295–302
  8. Brisch R, Bernstein H-G, Krell D, Stauch R, Trübner K, Dobrowolny H, et al. Volumetric analysis of septal region in schizophrenia and affective disorder. European Archives of Psychiatry and Clinical Neuroscience. 2007;257:140–148
  9. Campbell LE, Daly E, Toal F, Stevens A, Azuma R, Catani M, et al. Brain and behaviour in children with 22q11.2 deletion syndrome: a volumetric and voxel-based morphometry MRI study. Brain. 2006;129:1218–1228
  10. Crippa JAdS, Zuardi AW, Busatto GF, Sanches RF, Santos AC, Araújo D, et al. Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study. European Psychiatry. 2006;21:291–299
  11. DeBoer T, Wu Z, Lee A, Simon T. Hippocampal volume reduction in children with chromosome 22q11.2 deletion syndrome is associated with cognitive impairment. Behavioral and Brain Functions. 2007;3:54
  12. Dickey CC, McCarley RW, Xu ML, Seidman LJ, Voglmaier MM, Niznikiewicz MA, et al. MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder. Schizophrenia Research. 2007;89:49–58
  13. DiGeorge A. A new concept of the cellular basis of immunity. Journal of Pediatrics. 1965;67:907
  14. Driscoll DA, Budarf ML, Emanuel BS. A genetic etiology for DiGeorge syndrome: consistent deletions and microdeletions of 22q11. American Journal of Human Genetics. 1992;50:924–933
  15. Eliez S, Schmitt JE, White CD, Reiss AL. Children and adolescents with Velocardiofacial Syndrome: a volumetric study. American Journal of Psychiatry. 2000;157:409–415
  16. Eliez S, Blasey CM, Schmitt EJ, White CD, Hu D, Reiss AL. Velocardiofacial syndrome: are structural changes in the temporal and mesial temporal regions related to schizophrenia. American Journal of Psychiatry. 2001;158:447–453
  17. Filipović B, Prostran M, Ilanković N, Filipović B. Predictive potential of cavum septi pellucidi (CSP) in schizophrenics, alcoholics and persons with past head trauma. European Archives of Psychiatry and Clinical Neuroscience. 2004;254:228–230
  18. Flashman LA, Roth RM, Pixley HS, Cleavinger HB, McAllister TW, Vidaver R, et al. Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates. Psychiatry Research. Neuroimaging. 2007;154:147–155
  19. Galarza M, Merlo AB, Ingratta A, Albanese EF, Albanese AM. Cavum septum pellucidum and its increased prevalence in schizophrenia: a neuroembryological classification. Journal of Neuropsychiatry and Clinical Neurosciences. 2004;16:41–46
  20. Kates WR, Burnette CP, Jabs EW, Rutberg J, Murphy AM, Grados M, et al. Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis. Biological Psychiatry. 2001;49:677–684
  21. Kwon JS, Shenton ME, Hirayasu Y, Salisbury DF, Fischer IA, Dickey CC, et al. MRI study of cavum septi pellucidi in schizophrenia, affective disorder, and schizotypal personality disorder. American Journal of Psychiatry. 1998;155:509–515
  22. McDonald-McGinn DM, Kirschner R, Goldmuntz E, Sullivan K, Eicher P, Gerdes M, et al. The Philadelphia Story: the 22q11.2 deletion: report on 250 patients. Genetic Counseling. 1999;10:11–24
  23. Moss EM, Batshaw ML, Solot CB, Gerdes M, McDonald-McGinn DM, Driscoll DA, et al. Psychoeducational profile of the 22q11.2 microdeletion: a complex pattern. Journal of Pediatrics. 1999;134:193–198
  24. Murphy KC, Jones LA, Owen MJ. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Archives of General Psychiatry. 1999;56:940–945
  25. Needelman H, Schroeder B, Sweney M, Schmidt J, Bodensteiner JB, Schaefer B. Ontogeny and physiology of the cavum septum pellucidum in premature infants. Journal of Child Neurology. 2006;21:298–301
  26. Nopoulos P, Krie A, Andreasen NC. Enlarged cavum septi pellucidi in patients with schizophrenia: clinical and cognitive correlates. Journal of Neuropsychiatry and Clinical Neurosciences. 2000;12:344–349
  27. Oskarsdottir S, Vujic M, Fasth A. Incidence and prevalence of the 22q11 deletion syndrome: a population-based study in Western Sweden. Archives of Disease in Childhood. 2004;89:148–151
  28. Sarwar M. The septum pellucidum: normal and abnormal. American Journal of Neuroradiology. 1989;10:989–1005
  29. Shashi V, Muddasani S, Santos CC, Berry MN, Kwapil TR, Lewandowski E, et al. Abnormalities of the corpus callosum in nonpsychotic children with chromosome 22q11 deletion syndrome. Neuroimage. 2004;21:1399–1406
  30. Shprintzen RJ. Velo-cardio-facial syndrome: 30years of study. Developmental Disabilities Research Reviews. 2008;14:3–10
  31. Shprintzen RJ, Goldberg RB, Lewin ML, Sidoti EJ, Berkman MD, Argamaso RV, et al. A new syndrome involving cleft palate, cardiac anomalies, typical facies, and learning disabilities: velo-cardio-facial syndrome. Cleft Palate Journal. 1978;15:56–62
  32. Simon TJ. A new account of the neurocognitive foundations of impairments in space, time and number processing in children with chromosome 22q11.2 deletion syndrome. Developmental Disabilities Research Reviews. 2008;14:52–58
  33. Simon TJ, Bearden CE, McDonald-McGinn DM, Zackai E. Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome. Cortex. 2005;41:145–155
  34. Simon TJ, Ding L, Bish JP, McDonald-McGinn DM, Zackai EH, Gee J. Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study. NeuroImage. 2005;25:169–180
  35. Sobin C, Kiley-Brabeck K, Daniels S, Blundell M, Anyane-Yeboa K, Karayiorgou M. Networks of attention in children with the 22q11 deletion syndrome. Developmental Neuropsychology. 2004;26:611–626
  36. Swillen A, Vandeputte L, Cracco J, Maes B, Ghesquiere P, Devriendt K, et al. Neuropsychological, learning and psychosocial profile of primary school aged children with the velo-cardio-facial syndrome (22q11 deletion): evidence for a nonverbal learning disability?. Child Neuropsychology. 1999;5:230–241
  37. Takahashi T, Suzuki M, Hagino H, Niu L, Zhou S-Y, Nakamura K, et al. Prevalence of large cavum septi pellucidi and its relation to the medial temporal lobe structures in schizophrenia spectrum. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2007;31:1235–1241
  38. van Amelsvoort T, Daly E, Robertson D, Suckling J, Ng V, Critchley H, et al. Structural brain abnormalities associated with the deletion at chromosome 22q11. British Journal of Psychiatry. 2001;178:412–419
  39. van Amelsvoort T, Daly E, Henry J, Robertson D, Ng V, Owen M, et al. Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia: preliminary results of a structural magnetic resonance imaging study. Archives of General Psychiatry. 2004;61:1085–1096
  40. Wechsler D. Wechsler Intelligence Scale for Children III. San Antonio, TX: Psychological Corporation; 1991;
  41. Wechsler D. WISC-IV Technical and Interpretive Manual. San Antonio: The Psychological Corporation; 2003;
  42. Woodin MF, Wang PP, Aleman D, McDonald-McGinn DM, Zackai EH, Moss EM. Neuropsychological profile of children and adolescents with the 22q11.2 microdeletion. Genetics in Medicine. 2001;3:34–39

PII: S0925-4927(09)00242-X

doi: 10.1016/j.pscychresns.2009.10.009

Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 108-113 , 28 February 2010