Psychiatry Research: Neuroimaging
Volume 181, Issue 1 , Pages 44-50 , 30 January 2010

White matter connectivity and psychosis in ultra-high-risk subjects: A diffusion tensor fiber tracking study

  • Bart D. Peters

      Affiliations

    • Department of Psychiatry, Adolescentclinic, Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 20 8913500; fax: +31 20 8913701.
    • ,
  • Peter M. Dingemans

      Affiliations

    • Department of Psychiatry, Adolescentclinic, Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands
    • ,
  • Nienke Dekker

      Affiliations

    • Department of Psychiatry, Adolescentclinic, Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands
    • ,
  • Jorik Blaas

      Affiliations

    • Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands
    • ,
  • Erik Akkerman

      Affiliations

    • Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands
    • ,
  • Therese A. van Amelsvoort

      Affiliations

    • Department of Psychiatry, Adolescentclinic, Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands
    • ,
  • Charles B. Majoie

      Affiliations

    • Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands
    • ,
  • Gerard J. den Heeten

      Affiliations

    • Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands
    • ,
  • Don H. Linszen

      Affiliations

    • Department of Psychiatry, Adolescentclinic, Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands
    • ,
  • Lieuwe de Haan

      Affiliations

    • Department of Psychiatry, Adolescentclinic, Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands

Received 15 November 2008 ,Revised 11 October 2009 ,Accepted 18 October 2009.

References 

  1. Bartzokis G. Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturation.. Neuropsychopharmacology. 2002;27:672–683
  2. Basser PJ, Pajevic S, Pierpaoli C, Duda J, Aldroubi A. In vivo fiber tractography using DT-MRI data. Magnetic Resonance in Medicine. 2000;44(4):625–632
  3. Beaulieu C. The basis of anisotropic water diffusion in the nervous system — a technical review. MR in Biomedicine. 2002;15:435–455
  4. Blaas J, Botha CP, Peters BD, Vos F, Post FH. Fast and reproducible fiber bundle selection in DTI visualization. In: Proceedings IEEE Visualization (October). 2005;p. 59–64
  5. Buchsbaum MS, Friedman J, Buchsbaum BR, Chu KW, Hazlett EA, Newmark R, et al. Diffusion tensor imaging in schizophrenia. Biological Psychiatry. 2006;60(11):1181–1187
  6. Bullmore ET, Frangou S, Murray RM. The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia.. Schizophrenia Research. 1997;28:143–156
  7. Burns J, Job D, Bastin ME, Whalley H, Macgillivray T, Johnstone EC, et al. Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study. British Journal of Psychiatry. 2003;182:439–443
  8. Cannon TD, Cadenhead K, Cornblatt B, Woods SW, Addington J, Walker E, et al. Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Archives of General Psychiatry. 2008;65(1):28–37
  9. Cheung V, Cheung C, McAlonan GM, Deng Y, Wong JG, Yip L, et al. A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychological Medicine. 2008;38(6):877–885
  10. Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, et al. Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. Archives of General Psychiatry. 1989;46(12):1145–1150
  11. Federspiel A, Begre S, Kiefer C, Schroth G, Strik WK, Dierks T. Alterations of white matter connectivity in first episode schizophrenia. Neurobiology of Disease. 2006;22(3):702–709
  12. Flynn SW, Lang DJ, Mackay AL, Goghari V, Vavasour IM, Whittall KP, et al. Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Molecular Psychiatry. 2003;8(9):811–820
  13. Foong J, Maier M, Clark CA, Barker GJ, Miller DH, Ron MA. Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study. Journal of Neurology, Neurosurgery and Psychiatry. 2000;68(2):242–244
  14. Fornito, A., Yung, A.R., Wood, S.J., Phillips, L.J., Nelson, B., Cotton, S., Velakoulis, D., McGorry, P.D., Pantelis, C., Yücel, M., 2008. Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals. Biological Psychiatry 64 (9), 758–765.
  15. Gasparotti R, Valsecchi P, Carletti F, Galluzzo A, Liserre R, Cesana B, et al. Reduced fractional anisotropy of corpus callosum in first-contact, antipsychotic drug-naive patients with schizophrenia. Schizophrenia Research. 2009;108(1–3):41–48
  16. Gulani V, Webb AG, Duncan ID, Lauterbur PC. Apparent diffusion tensor measurements in myelin-deficient rat spinal cords. Magnetic Resonance in Medicine. 2001;45:191–195
  17. Hao Y, Liu Z, Jiang T, Gong G, Liu H, Tan L, et al. White matter integrity of the whole brain is disrupted in first-episode schizophrenia. NeuroReport. 2006;17(1):23–26
  18. Hao Y, Yan Q, Liu H, Xu L, Xue Z, Song X, et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex. Schizophrenia Research. 2009;114(1–3):128–135
  19. Highley JR, Walker MA, Esiri MM, Crow TJ, Harrison PJ. Asymmetry of the uncinate fasciculus: a post-mortem study of normal subjects and patients with schizophrenia. Cerebral Cortex. 2002;12(11):1218–1224
  20. Highley JR, Esiri MM, McDonald B, Cortina-Borja M, Herron BM, Crow TJ. The size and fibre composition of the corpus callosum with respect to gender and schizophrenia: a post-mortem study. Brain. 1999;122:99–110
  21. Kanaan R, Barker G, Brammer M, Giampietro V, Shergill S, Woolley J, et al. White matter microstructure in schizophrenia: effects of disorder, duration and medication. British Journal of Psychiatry. 2009;194:236–242
  22. Karlsgodt KH, van Erp TG, Poldrack RA, Bearden CE, Nuechterlein KH, Cannon TD. Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia. Biological Psychiatry. 2008;63(5):512–518
  23. Keshavan MS, Diwadkar VA, Harenski K, Rosenberg DR, Sweeney JA, Pettegrew JW. Abnormalities of the corpus callosum in first episode, treatment naïve schizophrenia. Journal of Neurology, Neurosurgery and Psychiatry. 2002;72(6):757–760
  24. Keshavan MS, Berger G, Zipursky RB, Wood SJ, Pantelis C. Neurobiology of early psychosis. British Journal of Psychiatry. 2005;48:s8–s18
  25. Kim M, Ronen I, Ugurbil K, Kim DS. Spatial resolution dependence of DTI tractography in human occipito-callosal region. NeuroImage. 2006;32:1243–1249
  26. Klosterkötter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F. Diagnosing schizophrenia in the initial prodromal phase. Archives of General Psychiatry. 2001;58(2):158–164
  27. Klosterkötter J, Ruhrmann S, Schultze-Lutter F, Salokangas RK, Linszen D, Birchwood M, et al. The European Prediction of Psychosis Study (EPOS): integrating early recognition and intervention in Europe. World Psychiatry. 2005;4(3):161–167
  28. Kubicki M, Westin CF, Nestor PG, Wible CG, Frumin M, Maier SE, et al. Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biological Psychiatry. 2003;54:1171–1180
  29. Kubicki M, Westin CF, Maier SE, Frumin M, Nestor PG, Salisbury DF, et al. Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study. American Journal of Psychiatry. 2002;159(5):813–820
  30. Kumra S, Ashtari M, Cervellione K, Henderson I, Kester H, Roofeh D, et al. White matter abnormalities in early-onset schizophrenia: a voxelbased diffusion tensor imaging study. Journal of the American Academy of Child & Adolescent Psychiatry. 2005;44:937–941
  31. Mendelsohn A, Strous RD, Bleich M, Assaf Y, Hendler T. Regional axonal abnormalities in first episode schizophrenia: preliminary evidence based on high b-value diffusion-weighted imaging. Psychiatry Research: Neuroimaging. 2006;146(3):223–229
  32. Miller TJ, McGlashan TH, Rosen JL, Somjee L, Markovich PJ, Stein K, et al. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. American Journal of Psychiatry. 2002;159(5):863–865
  33. Minami T, Nobuhara K, Okugawa G, Takase K, Yoshida T, Sawada S, et al. Diffusion tensor magnetic resonance imaging of disruption of regional white matter in schizophrenia. Neuropsychobiology. 2003;47(3):141–145
  34. Mitelman SA, Newmark RE, Torosjan Y, Chu KW, Brickman AM, Haznedar MM, et al. White matter fractional anisotropy and outcome in schizophrenia. Schizophrenia Research. 2006;87(1–3):138–159
  35. Okugawa G, Nobuhara K, Minami T, Tamagaki C, Takase K, Sugimoto T, et al. Subtle disruption of the middle cerebellar peduncles in patients with schizophrenia. Neuropsychobiology. 2004;50:119–123
  36. Ono J, Harada K, Takahashi M, Maeda M, Ikenaka K, Sakurai K, et al. Differentiation between dysmyelination and demyelination using magnetic resonance diffusional anisotropy. Brain Research. 1995;671:141–148
  37. Pantelis C, Velakoulis D, McGorry PD, Wood SJ, Suckling J, Phillips LJ, et al. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet. 2003;361(9354):281–288
  38. Peters BD, de Haan L, Dekker N, Blaas J, Becker HE, Dingemans PM, et al. White matter fibertracking in first-episode schizophrenia, schizoaffective patients and subjects at ultra-high risk of psychosis. Neuropsychobiology. 2008;58(1):19–28
  39. Price G, Cercignani M, Parker GJ, Altmann DR, Barnes TR, Barker GJ, et al. White matter tracts in first-episode psychosis: a DTI tractography study of the uncinate fasciculus. Neuroimage. 2008;39(3):949–955
  40. Price G, Bagary MS, Cercignani M, Altmann DR, Ron MA. The corpus callosum in first episode schizophrenia: a diffusion tensor imaging study. Journal of Neurology, Neurosurgery and Psychiatry. 2005;76(4):585–587
  41. Price G, Cercignani M, Parker GJ, Altmann DR, Barnes TR, Barker GJ, et al. Abnormal brain connectivity in first-episode psychosis: a diffusion MRI tractography study of the corpus callosum. Neuroimage. 2007;35(2):458–466
  42. Rotarska-Jagiela A, Schonmeyer R, Oertel V, Haenschel C, Vogeley K, Linden DE. The corpus callosum in schizophrenia-volume and connectivity changes affect specific regions. Neuroimage. 2008;39:1522–1532
  43. Shergill SS, Kanaan RA, Chitnis XA, O'Daly O, Jones DK, Frangou S, et al. A diffusion tensor imaging study of fasciculi in schizophrenia. American Journal of Psychiatry. 2007;164(3):467–473
  44. Spitzer RL, Williams JB, Gibbon M, First MB. The structured clinical interview for DSM-III-R (SCID). I: History, rationale, and description. Archives of General Psychiatry. 1992;49(8):624–629
  45. Szeszko PR, Robinson DG, Ashtari M, Vogel J, Betensky J, Sevy S, et al. Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia. Neuropsychopharmacology. 2008;33(5):976–984
  46. Wang F, Sun Z, Cui L, Du X, Wang X, Zhang H, et al. Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging. American Journal of Psychiatry. 2004;161:573–575
  47. Walterfang M, McGuire PK, Yung AR, Phillips LJ, Velakoulis D, Wood SJ, et al. White matter volume changes in people who develop psychosis. British Journal of Psychiatry. 2008;193(3):210–215
  48. Walterfang M, Yung A, Wood AG, Reutens DC, Phillips L, Wood SJ, et al. Corpus callosum shape alterations in individuals prior to the onset of psychosis. Schizophrenia Research. 2008;103(1–3):1–10
  49. Wood SJ, Pantelis C, Velakoulis D, Yücel M, Fornito A, McGorry PD. Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophrenia Bulletin. 2008;34(2):322–329
  50. Yücel M, Wood SJ, Phillips LJ, Stuart GW, Smith DJ, Yung A, et al. Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness. British Journal of Psychiatry. 2003;182:518–524
  51. Yücel M, Wood SJ, Fornito A, Riffkin J, Velakoulis D, Pantelis CJ. Anterior cingulate dysfunction: implications for psychiatric disorders?. Psychiatry and Neuroscience. 2003;28(5):350–354

PII: S0925-4927(09)00241-8

doi: 10.1016/j.pscychresns.2009.10.008

Psychiatry Research: Neuroimaging
Volume 181, Issue 1 , Pages 44-50 , 30 January 2010

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