Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 130-135 , 28 February 2010

Increased left striatal dopamine transmission in unaffected siblings of schizophrenia patients in response to acute metabolic stress

  • Jerome Brunelin

      Affiliations

    • Université de Lyon, Lyon, F-69003, France; Université Lyon 1, Lyon, EA4166; CH Le Vinatier, Bron, F-69677, France; Institut Fédératif des Neurosciences de Lyon (IFNL), Hôpital neurologique, Bron, F-69394, France
    • Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, PO BOX 616 (DRT 10), 6200 MD Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. EA 4166, Service du Pr d'Amato, CH le vinatier, 95 bd Pinel 69677 Bron Cedex, France. Tel.: +33 4 37 91 55 65.
    • ,
  • Thierry d'Amato

      Affiliations

    • Université de Lyon, Lyon, F-69003, France; Université Lyon 1, Lyon, EA4166; CH Le Vinatier, Bron, F-69677, France; Institut Fédératif des Neurosciences de Lyon (IFNL), Hôpital neurologique, Bron, F-69394, France
    • ,
  • Jim Van Os

      Affiliations

    • Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, PO BOX 616 (DRT 10), 6200 MD Maastricht, The Netherlands
    • Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    • ,
  • Nicolas Costes

      Affiliations

    • CERMEP—Imagerie du vivant, PET Department, 59 Boulevard Pinel, F-69667 Bron, France
    • ,
  • Marie-Françoise Suaud Chagny

      Affiliations

    • Université de Lyon, Lyon, F-69003, France; Université Lyon 1, Lyon, EA4166; CH Le Vinatier, Bron, F-69677, France; Institut Fédératif des Neurosciences de Lyon (IFNL), Hôpital neurologique, Bron, F-69394, France
    • ,
  • Mohamed Saoud

      Affiliations

    • Université de Lyon, Lyon, F-69003, France; Université Lyon 1, Lyon, EA4166; CH Le Vinatier, Bron, F-69677, France; Institut Fédératif des Neurosciences de Lyon (IFNL), Hôpital neurologique, Bron, F-69394, France

Received 26 January 2009 ,Revised 9 September 2009 ,Accepted 8 October 2009.

References 

  1. Abi-Dargham A, Kegeles LS, Zea-Ponce Y, Mawlawi O, Martinez D, Mitropoulou V, et al. Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide. Biological Psychiatry. 2004;55:1001–1006
  2. Adler CM, Elman I, Weisenfeld N, Kestler L, Pickar D, Breier A. Effects of acute metabolic stress on striatal dopamine release in healthy volunteers. Neuropsychopharmacology. 2000;22:545–550
  3. Boileau I, Dagher A, Leyton M, Gunn RN, Baker GB, Diksic M, et al. Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men. Archives of General Psychiatry. 2006;63:1386–1395
  4. Bracha HS, Livingston RL, Clothier J, Linington BB, Karson CN. Correlation of severity of psychiatric patients' delusions with right hemispatial inattention (left-turning behavior). American Journal of Psychiatry. 1993;150:330–332
  5. Breier A, Davis OR, Buchanan RW, Moricle LA, Munson RC. Effects of metabolic perturbation on plasma homovanillic acid in schizophrenia. Relationship to prefrontal cortex volume. Archives of General Psychiatry. 1993;50:541–550
  6. Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, et al. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proceedings of the National Academy of Sciences of the United States of America. 1997;94:2569–2574
  7. Brunelin J, d'Amato T, Van Os J, Cochet A, Suaud-Chagny MF, Saoud M. Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizophrenia, their unaffected siblings and controls. Schizophrenia Research. 2008;100:206–211
  8. Brunelin J, d'Amato T, van Os J, Dalery J, Suaud-Chagny MF, Saoud M. Serotonergic response to stress: a protective factor against abnormal dopaminergic reactivity in schizophrenia?. European Psychiatry. 2007;22:362–364
  9. Brunelin J, Poulet E, Bediou B, Kallel L, Dalery J, d'Amato T, et al. Low frequency Repetitive Transcranial Magnetic Stimulation improves source monitoring deficit in hallucinating patients with schizophrenia. Schizophrenia Research. 2006;81(1):41–45
  10. Collip D, Myin-Germeys I, Van Os J. Does the concept of “sensitization” provide a plausible mechanism for the putative link between the environment and schizophrenia?. Schizophrenia Bulletin. 2008;34:220–225
  11. Dumas P, Saoud M, Gutknecht C, Dalery J, d'Amato T. French translations and adaptations of questionnaires of magical thinking (MIS, Eckblad and Chapman, 1983) and perception disorders (PAS, Chapman et al., 1978). Encephale. 1999;25:422–428
  12. Early TS, Posner MI, Reiman EM, Raichle ME. Hyperactivity of the left striato-pallidal projection. Part I: Lower level theory. Psychiatric developments. 1989;7:85–108
  13. Early TS, Posner MI, Reiman EM, Raichle ME. Left striato-pallidal hyperactivity in schizophrenia. Part II: Phenomenology and thought disorder. Psychiatric developments. 1989;7:109–121
  14. Elman I, Sokoloff L, Adler CM, Weisenfeld N, Breier A. The effects of pharmacological doses of 2-deoxyglucose on cerebral blood flow in healthy volunteers. Brain Research. 1999;815:243–249
  15. Grace AA. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience. 1991;41:1–24
  16. Gruzelier JH. Functional neuropsychophysiological asymmetry in schizophrenia: a review and reorientation. Schizophrenia Bulletin. 1999;25:91–120
  17. Gur RE, Calkins ME, Gur RC, Horan WP, Nuechterlein KH, Seidman LJ, et al. The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes. Schizophrenia Bulletin. 2007;33:49–68
  18. Hietala J, Syvälahti E, Vuorio K, Räkköläinen V, Bergman J, Haaparanta M, et al Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients. Lancet. 1995;346:1130–1131
  19. Hirvonen J, van Erp TG, Huttunen J, Aalto S, Någren K, Huttunen M, et al. Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia. Archives of General Psychiatry. 2005;62:371–378
  20. Howes OD, McDonald C, Cannon M, Arseneault L, Boydell J, Murray RM. Pathways to schizophrenia: the impact of environmental factors. International Journal of Neuropsychopharmacoly. 2004;7(1):S7–S13
  21. Huttunen J, Heinimaa M, Svirskis T, Nyman M, Kajander J, Forsback S, et al. Striatal dopamine synthesis in first-degree relatives of patients with schizophrenia. Biological Psychiatry. 2008;63:114–117
  22. Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. Journal of Cerebral Blood Flow Metabolism. 2007;27(9):1533–1539
  23. Koepp MJ, Gunn RN, Lawrence AD, Cunningham VJ, Dagher A, Jones T, et al. Evidence for striatal dopamine release during a video game. Nature. 1998;6682:266–268
  24. Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, et al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:9235–9240
  25. Levine J, Martine T, Feraro R, Kimhi R, Bracha HS. Medicated chronic schizophrenic patients do not demonstrate left turning asymmetry. Neuropsychobiology. 1997;36:22–24
  26. Louilot A, Le Moal M. Lateralized interdependence between limbicotemporal and ventrostriatal dopaminergic transmission. Neuroscience. 1994;59:495–500
  27. Marcelis M, Cavalier E, Gielen J, Delespaul P, Van Os J. Abnormal response to metabolic stress in schizophrenia: marker of vulnerability or acquired sensitization?. Psychological Medicine. 2004;34:1103–1111
  28. McGowan S, Lawrence AD, Sales T, Quested D, Grasby P. Presynaptic dopaminergic dysfunction in schizophrenia: a positron emission tomographic [18f]fluorodopa study. Archives of General Psychiatry. 2004;61:134–142
  29. Meyer-Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, et al. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nature Neuroscience. 2002;5:267–271
  30. Mohr C, Bracha HS, Brugger P. Magical ideation modulates spatial behavior. Journal of Neuropsychiatry and Clinical Neuroscience. 2003;15:168–174
  31. Mohr C, Landis T, Bracha HS, Fathi M, Brugger P. Levodopa reverses gait asymmetries related to anhedonia and magical ideation. European Archives of Psychiatry and Clinical Neuroscience. 2005;255:33–39
  32. Myin-Germeys I, Marcelis M, Krabbendam L, Delespaul P, van Os J. Subtle fluctuations in psychotic phenomena as functional states of abnormal dopamine reactivity in individuals at risk. Biological Psychiatry. 2005;58:105–110
  33. Oswald LM, Wong DF, Zhou Y, Kumar A, Brasic J, Alexander M, et al. Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release. Neuroimage. 2007;36:153–166
  34. Phillips LJ, McGorry PD, Garner B, Thompson KN, Pantelis C, Wood SJ, et al. Stress, the hippocampus and the hypothalamic-pituitary-adrenal axis: implications for the development of psychotic disorders. The Australian and New Zealand Journal of Psychiatry. 2006;40(9):725–741
  35. Pruessner JC, Champagne F, Meaney MJ, Dagher A. Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride. Journal of Neurosciences. 2004;24:2825–2831
  36. Reynolds GP. Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature. 1983;305(5934):527–529
  37. Silbersweig DA, Stern E, Frith C, Cahill C, Holmes A, Grootoonk S, et al A functional neuroanatomy of hallucinations in schizophrenia. Nature. 1995;378:176–179
  38. Soliman A, O'Driscoll GA, Pruessner J, Holahan AL, Boileau I, Gagnon D, et al. Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study. Neuropsychopharmacology. 2008;33(8):2033–2041
  39. Vollenweider FX, Vontobel P, Hell D, Leenders KL. 5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man—a PET study with [11C]raclopride. Neuropsychopharmacology. 1999;20:424–433

PII: S0925-4927(09)00221-2

doi: 10.1016/j.pscychresns.2009.10.002

Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 130-135 , 28 February 2010

Article Tools

* Image Usage & Resolution