Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 1-8 , 30 April 2010

Correlation between amygdala volume and age in bipolar disorder — A systematic review and meta-analysis of structural MRI studies

  • Juliana Usher

      Affiliations

    • Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, Germany
    • ,
  • Stefan Leucht

      Affiliations

    • Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar of the Technical University Munich, Germany
    • ,
  • Peter Falkai

      Affiliations

    • Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, Germany
    • ,
  • Harald Scherk

      Affiliations

    • Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, Germany
    • AMEOS Klinikum Osnabrueck, Germany
    • Corresponding Author InformationCorresponding author. AMEOS Klinikum Osnabrück, Knollstr. 31, 49088 Osnabrück, Germany. Tel.: +49 541 313100; fax: +49 541 313119.

Received 1 July 2008 ,Revised 17 August 2009 ,Accepted 18 September 2009.

References 

  1. Altshuler LL, Bartzokis G, Grieder T, Curran J, Mintz J. Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity. Archives of General Psychiatry. 1998;55:663–664
  2. Altshuler LL, Bartzokis G, Grieder T, Curran J, Jimenez T, Leight K, et al. An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry. 2000;48:147–162
  3. Biederman J, Mick E, Faraone SV, Spencer T, Wilens TE, Wozniak J. Pediatric mania: a developmental subtype of bipolar disorder?. Biological Psychiatry. 2000;48:458–466
  4. Bielau H, Trubner K, Krell D, Agelink MW, Bernstein HG, Stauch R, et al. Volume deficits of subcortical nuclei in mood disorders A postmortem study. European Archives of Psychiatry and Clinical Neuroscience. 2005;255:401–412
  5. Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, et al. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry. 2003;60:1201–1208
  6. Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, et al. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorder. 2005;7:570–576
  7. Borenstein, M., Hedges, L., Higgins, J., Rothstein, H., 2006. Comprehensive Meta-analysis Version 2.
  8. Brambilla P, Harenski K, Nicoletti M, Sassi RB, Mallinger AG, Frank E, et al. MRI investigation of temporal lobe structures in bipolar patients. Journal of Psychiatric Research. 2003;37:287–295
  9. Carlson GA, Bromet EJ, Sievers S. Phenomenology and outcome of subjects with early- and adult-onset psychotic mania. American Journal of Psychiatry. 2000;157:213–219
  10. Chang K, Karchemskiy A, Barnea-Goraly N, Garrett A, Simeonova DI, Reiss A. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2005;44:565–573
  11. Chen BK, Sassi R, Axelson D, Hatch JP, Sanches M, Nicoletti M, et al. Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biological Psychiatry. 2004;56:399–405
  12. DelBello MP, Zimmerman ME, Mills NP, Getz GE, Strakowski SM. Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disorder. 2004;6:43–52
  13. DelBello MP, Adler CM, Strakowski SM. The neurophysiology of childhood and adolescent bipolar disorder. CNS Spectrums. 2006;11:298–311
  14. DerSimonian R, Laird N. Meta-analysis in clinical trials. Current Controlled Trials. 1986;7:177–188
  15. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–634
  16. Faraone SV, Glatt SJ, Tsuang MT. The genetics of pediatric-onset bipolar disorder. Biological Psychiatry. 2003;53:970–977
  17. Findling RL, Gracious BL, McNamara NK, Youngstrom EA, Demeter CA, Branicky LA, et al. Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder. Bipolar Disorder. 2001;3:202–210
  18. Foland LC, Altshuler LL, Sugar CA, Lee AD, Leow AD, Townsend J, et al. Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium. NeuroReport. 2008;19:221–224
  19. Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, et al. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. American Journal of Psychiatry. 2005;162:1256–1265
  20. Getz GE, DelBello MP, Fleck DE, Zimmerman ME, Schwiers ML, Strakowski SM. Neuroanatomic characterization of schizoaffective disorder using MRI: a pilot study. Schizophrenia Research. 2002;55:55–59
  21. McDonald C, Zanelli J, Rabe-Hesketh S, Ellison-Wright I, Sham P, Kalidindi S, et al. Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder. Biological Psychiatry. 2004;56:411–417
  22. McElroy SL, Strakowski SM, West SA, Keck PE, McConville BJ. Phenomenology of adolescent and adult mania in hospitalized patients with bipolar disorder. American Journal of Psychiatry. 1997;154:44–49
  23. Moore GJ, Bebchuk JM, Wilds IB, Chen G, Manji HK. Lithium-induced increase in human brain grey matter. Lancet. 2000;356:1241–1242
  24. Niu L, Matsui M, Zhou SY, Hagino H, Takahashi T, Yoneyama E, et al. Volume reduction of the amygdala in patients with schizophrenia: a magnetic resonance imaging study. Psychiatry Research. 2004;132:41–51
  25. Pearlson GD, Barta PE, Powers RE, Menon RR, Richards SS, Aylward EH, et al. Ziskind-Somerfeld Research Award, Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry. 1996;41:1–14
  26. Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP, et al. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biological Psychiatry. 2004;55:875–881
  27. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biological Psychiatry. 2003;54:515–528
  28. Rajkowska G. Cell pathology in bipolar disorder. Bipolar Disorder. 2002;4:105–116
  29. Rosso IM, Killgore WD, Cintron CM, Gruber SA, Tohen M, Yurgelun-Todd DA. Reduced amygdala volumes in first-episode bipolar disorder and correlation with cerebral white matter. Biological Psychiatry. 2007;61:743–749
  30. Scherk H, Falkai P. Effects of antipsychotics on brain structure. Current Opinion in Psychiatry. 2006;19:145–150
  31. Scherk H, Menzel P, Schneider-Axmann T, Kemmer C, Wobrock T, Reith W, et al. Amygdala volume in patients with schizophrenia or bipolar disorder. Abstract, Schizophrenia Bulletin. 2007;2:354
  32. Soares JC, Mann JJ. The anatomy of mood disorders—review of structural neuroimaging studies. Biological Psychiatry. 1997;41:86–106
  33. Strakowski SM, DelBello MP, Sax KW, Zimmerman ME, Shear PK, Hawkins JM, et al. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry. 1999;56:254–260
  34. Strakowski SM, Delbello MP, Adler CM. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Molecular Psychiatry. 2005;10:105–116
  35. Strasser HC, Lilyestrom J, Ashby ER, Honeycutt NA, Schretlen DJ, Pulver AE, et al. Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study. Biological Psychiatry. 2005;57:633–639
  36. Strober M, Morrell W, Burroughs J, Lampert C, Danforth H, Freeman R. A family study of bipolar I disorder in adolescence. Early onset of symptoms linked to increased familial loading and lithium resistance. Journal of Affective Disorders. 1988;15:255–268
  37. Swayze VW, Andreasen NC, Alliger RJ, Yuh WT, Ehrhardt JC. Subcortical and temporal structures in affective disorder and schizophrenia: a magnetic resonance imaging study. Biological Psychiatry. 1992;31:221–240
  38. Vawter MP, Freed WJ, Kleinman JE. Neuropathology of bipolar disorder. Biological Psychiatry. 2000;48:486–504
  39. Velakoulis D, Wood SJ, Wong MT, McGorry PD, Yung A, Phillips L, et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Archives of General Psychiatry. 2006;63:139–149
  40. Weinberger DR, McClure RK. Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain?. Archives of General Psychiatry. 2002;59:553–558
  41. Wilens TE, Biederman J, Forkner P, Ditterline J, Morris M, Moore H, et al. Patterns of comorbidity and dysfunction in clinically referred preschool and school-age children with bipolar disorder. Journal of Child and Adolescent Psychopharmacology. 2003;13:495–505
  42. Yucel K, McKinnon MC, Taylor VH, Macdonald K, Alda M, Young LT, et al. Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study. Psychopharmacology (Berlin). 2007;195:357–367
  43. Yucel K, Taylor VH, McKinnon MC, Macdonald K, Alda M, Young LT, et al. Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment. Neuropsychopharmacology. 2008;33:361–367

PII: S0925-4927(09)00215-7

doi: 10.1016/j.pscychresns.2009.09.004

Psychiatry Research: Neuroimaging
Volume 182, Issue 1 , Pages 1-8 , 30 April 2010

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