Psychiatry Research: Neuroimaging
Volume 181, Issue 3 , Pages 183-192 , 30 March 2010

Brain activation during the perception of distorted body images in eating disorders

  • Yoshie Miyake

      Affiliations

    • Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
  • ,
  • Yasumasa Okamoto

      Affiliations

    • Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
  • ,
  • Keiichi Onoda

      Affiliations

    • Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
  • ,
  • Mitsuhaya Kurosaki

      Affiliations

    • Hiroshima University Health Service Center, Hiroshima, Japan
  • ,
  • Naoko Shirao

      Affiliations

    • Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
  • ,
  • Yuri Okamoto

      Affiliations

    • Hiroshima University Health Service Center, Hiroshima, Japan
  • ,
  • Shigeto Yamawaki

      Affiliations

    • Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    • Corresponding Author InformationCorresponding author. 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. Tel.: +81 82 257 5205; fax: +81 82 257 5209.

Received 14 October 2008 ,Revised 5 August 2009 ,Accepted 1 September 2009.

References 

  1. Adolphs R. Social cognition and the human brain. Trends in Cognitive Sciences. 1999;3:469–479
  2. Adolphs R, Tranel D, Damasio H, Damasio AR. Fear and the human amygdala. Journal of Neuroscience. 1995;15:5879–5891
  3. Akirav I, Maroun M. The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear. Neural Plasticity. 2007;30873:1–11
  4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: American Psychiatric Press; 1994;
  5. Bailer UF, Price JC, Meltzer CC, Mathis CA, Frank GK, Weissfeld L, et al. Altered 5-HT2A receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness. Neuropsychopharmacology. 2004;29:1143–1155
  6. Buchel C, Dolan RJ. Classical fear conditioning in functional neuroimaging. Current Opinion in Neurobiology. 2000;10:219–223
  7. Cash TF, Deagle EA. The nature and extent of body-image disturbances in anorexia nervosa and bulimia nervosa: a meta-analysis. International Journal of Eating Disorders. 1997;22:107–125
  8. Couturier J, Lock J. What is recovery in adolescent anorexia nervosa?. International Journal of Eating Disorders. 2006;39:550–555
  9. Downing PE, Jiang Y, Shuman M, Kanwisher N. A cortical area selective for visual processing of the human body. Science. 2001;293:2470–2473
  10. Drevets WC, Raichle ME. Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive process: implications for interaction between cognition and emotion. Cognition and Emotion. 1998;12:353–385
  11. Ellison Z, Foong J, Howard R, Bullmore E, Williams S, Treasure J. Functional anatomy of calorie fear in anorexia. Lancet. 1998;352:1192
  12. Fairburn CG, Cooper Z. The eating disorders examination. In:  Fairburn CG,  Wilson GT editor. Binge Eating: Nature, Assessment & Treatment. 12th ed. New York: Guilford Press; 1993;
  13. Fairburn CG, Harrison PJ. Eating disorders. Lancet. 2003;361:407–416
  14. First MB, Gibbon M, Spitzer RL, Williams JB, Benjamin LS. Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). Washington, DC: American Psychiatric Press; 1997;
  15. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis I Disorders—Clinician Version (SCID-I: CV). Washington, DC: American Psychiatric Press; 1997;
  16. Fossati P, Hevenor SJ, Graham SJ, Grady C, Keightley ML, Craik F. In search of the emotional self: an FMRI study using positive and negative emotional words. American Journal of Psychiatry. 2003;160:1938–1945
  17. Friederich HC, Uher R, Brooks S, Giampietro V, Brammer M, Williams SC, et al. I'm not as slim as that girl: neural bases of body shape self-comparison to media images. Neuroimage. 2007;37:674–681
  18. Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study?. Neuroimage. 1999;10:1–5
  19. Garner DM. Eating Disorder Inventory-2 (EDI-2). Psychological Assessment Resources: Odessa, FL; 1991;
  20. Grunwald M, Ettrich C, Assmann B, Dahne A, Krause W, Busse F, et al. Deficits in haptic perception and right parietal theta power changes in patients with anorexia nervosa before and after weight gain. International Journal of Eating Disorders. 2001;29:417–428
  21. Gusnard DA, Akbudak E, Shulman GL, Raichle ME. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:4259–4264
  22. Halgren E, Walter RD, Cherlow DG, Crandall PH. Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. Brain. 1978;101:83–117
  23. Isenberg N, Silbersweig D, Engelien A, Emmerich S, Malavade K, Beattie B, et al. Linguistic threat activates the human amygdala. Proceedings of the National Academy of Sciences of the United States of America. 1999;96:10456–10459
  24. Johnson SC, Baxter LC, Wilder LS, Pipe JG, Heiserman JE, Prigatano GP. Neural correlates of self-reflection. Brain. 2002;125:1808–1814
  25. Kaye WH, Frank GK, Meltzer CC, Price JC, McConaha CW, Crossan PJ, et al. Altered serotonin 2A receptor activity in women who have recovered from bulimia nervosa. American Journal of Psychiatry. 2001;158:1152–1155
  26. Kelley WM, Macrae CN, Wyland CL, Caglar S, Inati S, Heatherton TF. Finding the self? An event-related fMRI study. Journal of Cognitive Neuroscience. 2002;14:785–794
  27. Kurosaki N, Shirao N, Yamashita H, Okamoto Y, Yamawaki S. Distorted images of one's own body activates the prefrontal cortex and limbic/paralimbic system in young women: a functional magnetic resonance imaging study. Biological Psychiatry. 2006;59:380–386
  28. LaBar KS, Gatenby JC, Gore JC, LeDoux JE, Phelps EA. Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron. 1998;20:937–945
  29. LeDoux JE. Emotion circuits in the brain. Annual Review of Neuroscience. 2000;23:155–184
  30. Morris JS, Ohman A, Dolan RJ. Conscious and unconscious emotional learning in the human amygdala. Nature. 1998;393:467–470
  31. Oldfield RC. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia. 1971;9:97–113
  32. Reiman EM, Lane RD, Ahern GL, Schwartz GE, Davidson RJ, Friston KJ, et al. Neuroanatomical correlates of externally and internally generated human emotion. American Journal of Psychiatry. 1997;154:918–925
  33. Rodin J, Silberstein LR, Striegel-Moore RH. Women and weight: a normative discontent. In:  Sonderegger TB editors. Psychology and Gender. Lincoln: University of Nebraska Press; 1993;p. 267–307
  34. Saxe R, Jamal N, Powell L. My body or yours? The effect of visual perspective on cortical body representations. Cerebral Cortex. 2006;16:178–182
  35. Schwoebel J, Coslett HB. Evidence for multiple, distinct representations of the human body. Journal of Cognitive Neuroscience. 2005;17:543–553
  36. Scott SK, Young AW, Calder AJ, Hellawell DJ, Aggleton JP, Johnson M. Impaired auditory recognition of fear and anger following bilateral amygdala lesions. Nature. 1997;385:254–257
  37. Seeger G, Braus DF, Ruf M, Goldberger U, Schmidt MH. Body image distortion reveals amygdala activation in patients with anorexia nervosa—a functional magnetic resonance imaging study. Neuroscience Letters. 2002;326:25–28
  38. Smeets MA, Kosslyn SM. Hemispheric differences in body image in anorexia nervosa. International Journal of Eating Disorders. 2001;29:409–416
  39. Thompson JK, Heinberg LJ, Altabe M, Tantleff-Dunn S. Exacting beauty. Washington, DC: American Psychological Association; 1999;
  40. Tiggemann M, Wilson-Barrett E. Children's figure ratings: relationship to self-esteem and negative stereotyping. International Journal of Eating Disorders. 1998;23:83–88
  41. Uher R, Murphy T, Friederich HC, Dalgleish T, Brammer MJ, Giampietro V, et al. Functional neuroanatomy of body shape perception in healthy and eating-disordered women. Biological Psychiatry. 2005;58:990–997
  42. Ungerleider LG, Courtney SM, Haxby JV. A neural system for human visual working memory. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:883–890
  43. Vitousek KM, Stumpf RE. Difficulties in the assessment of personality traits and disorders in eating-disordered individuals. Eating Disorders. 2005;13:37–60
  44. Wagner A, Ruf M, Braus DF, Schmidt MH. Neuronal activity changes and body image distortion in anorexia nervosa. Brain Imaging. 2003;14:2193–2195
  45. Wagner A, Barbarich N, Frank G, Bailer UF, Weissfeld L, Henrt S, et al. Personality traits after recovery from eating disorders: do subtypes differ?. International Journal of Eating Disorders. 2006;39:276–284
  46. Williams LM, Kemp AH, Felmingham K, Barton M, Olivieri G, Peduto A, et al. Trauma modulates amygdala and medial prefrontal responses to consciously attended fear. Neuroimage. 2006;29:347–357
  47. Zysset S, Huber O, Ferstl E, von, Cramon DY. The anterior frontomedian cortex and evaluative judgment: an fMRI study. Neuroimage. 2002;15:983–991

PII: S0925-4927(09)00198-X

doi: 10.1016/j.pscychresns.2009.09.001

Psychiatry Research: Neuroimaging
Volume 181, Issue 3 , Pages 183-192 , 30 March 2010