Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 97-100 , 28 February 2010

Orbital frontal cortex in treatment-naïve pediatric obsessive–compulsive disorder

Received 5 May 2009 ,Revised 13 July 2009 ,Accepted 28 August 2009.

References 

  1. Abbruzzese M, Bellodi L, Ferri S, Scarone S. Frontal lobe dysfunction in schizophrenia and obsessive–compulsive disorder: a neuropsychological study. Brain and Cognition. 1995;27:202–212
  2. Arnold PD, MacMaster FP, Hanna GL, Richter MA, Sicard T, Burroughs E, et al. Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive–compulsive disorder. Brain Imaging and Behavior. 2009;3:64–76
  3. Atmaca M, Yildirim H, Ozdemir H, Tezcan E, Poyraz AK. Volumetric MRI study of key brain regions implicated in obsessive–compulsive disorder. Progress In Neuro-Psychopharmacology & Biological Psychiatry. 2007;31:46–52
  4. Baxter LR, Schwartz JM, Guze BH, Bergman K, Szuba MP. PET imaging in obsessive compulsive disorder with and without depression. Journal of Clinical Psychiatry 51, Suppl: 61–69; discussion. 1990;70
  5. Gilbert AR, Moore GJ, Keshavan MS, Paulson LA, Narula V, MacMaster FP, et al. Decrease in thalamic volumes of pediatric patients with obsessive–compulsive disorder who are taking paroxetine. Archives of General Psychiatry. 2000;57:449–456
  6. Hamilton M. The assessment of anxiety states by rating. British Journal of Medical Psychology. 1959;32:50–55
  7. Hamilton M. Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology. 1967;6:278–296
  8. Hanna GL. Demographic and clinical features of obsessive–compulsive disorder in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry. 1995;34:19–27
  9. Joel D, Doljansky J, Roz N, Rehavi M. Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder. Neuroscience. 2005;130:25–36
  10. Joel D, Doljansky J, Schiller D. ‘Compulsive’ lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial prefrontal cortex. European Journal of Neuroscience. 2005;21:2252–2262
  11. Joel D, Klavir O. The effects of temporary inactivation of the orbital cortex in the signal attenuation rat model of obsessive compulsive disorder. Behavioral Neuroscience. 2006;120:976–983
  12. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36:980–988
  13. Kringelbach ML. The human orbitofrontal cortex: linking reward to hedonic experience. Nature Reviews. Neuroscience. 2005;6:691–702
  14. MacMaster FP, Keshavan MS, Dick EL, Rosenberg DR. Corpus callosal signal intensity in treatment-naive pediatric obsessive compulsive disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 1999;23:601–612
  15. MacMaster FP, O'Neill J, Rosenberg DR. Brain imaging in pediatric obsessive–compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2008;47:1262–1272
  16. Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, et al. White matter abnormalities in patients with obsessive–compulsive disorder and their first-degree relatives. American Journal of Psychiatry. 2008;165:1308–1315
  17. Mirza Y, O'Neill J, Smith EA, Russell A, Smith JM, Banerjee SP, et al. Increased medial thalamic creatine–phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive–compulsive disorder versus major depression and healthy controls. Journal of Child Neurology. 2006;21:106–111
  18. Nordahl TE, Benkelfat C, Semple WE, Gross M, King AC, Cohen RM. Cerebral glucose metabolic rates in obsessive compulsive disorder. Neuropsychopharmacology. 1989;2:23–28
  19. Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Savage CR, et al. Regional cerebral blood flow measured during symptom provocation in obsessive–compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Archives of General Psychiatry. 1994;51:62–70
  20. Rosenberg DR, Averbach DH, O'Hearn KM, Seymour AB, Birmaher B, Sweeney JA. Oculomotor response inhibition abnormalities in pediatric obsessive–compulsive disorder. Archives of General Psychiatry. 1997;54:831–838
  21. Rosenberg DR, Keshavan MS, Dick EL, Bagwell WW, MacMaster FP, Birmaher B. Corpus callosal morphology in treatment-naive pediatric obsessive compulsive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 1997;21:1269–1283
  22. Schmithorst VJ, Holland SK, Dardzinski BJ. Developmental differences in white matter architecture between boys and girls. Human Brain Mapping. 2008;29:696–710
  23. Smith EA, Russell A, Lorch E, Banerjee SP, Rose M, Ivey J, et al. Increased medial thalamic choline found in pediatric patients with obsessive–compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study. Biological Psychiatry. 2003;54:1399–1405
  24. Stewart SE, Platko J, Fagerness J, Birns J, Jenike E, Smoller JW, et al. A genetic family-based association study of OLIG2 in obsessive–compulsive disorder. Archives of General Psychiatry. 2007;64:209–214
  25. Szeszko PR, Robinson D, Alvir JM, Bilder RM, Lencz T, Ashtari M, et al. Orbital frontal and amygdala volume reductions in obsessive–compulsive disorder. Archives of General Psychiatry. 1999;56:913–919
  26. Szeszko PR, MacMillan S, McMeniman M, Chen S, Baribault K, Lim KO, et al. Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive–compulsive disorder. American Journal of Psychiatry. 2004;161:1049–1056
  27. Szeszko PR, MacMillan S, McMeniman M, Lorch E, Madden R, Ivey J, et al. Amygdala volume reductions in pediatric patients with obsessive–compulsive disorder treated with paroxetine: preliminary findings. Neuropsychopharmacology. 2004;29:826–832
  28. Whiteside SP, Port JD, Abramowitz JS. A meta-analysis of functional neuroimaging in obsessive–compulsive disorder. Psychiatry Research: Neuroimaging. 2004;132:69–79
  29. Whiteside SP, Port JD, Deacon BJ, Abramowitz JS. A magnetic resonance spectroscopy investigation of obsessive–compulsive disorder and anxiety. Psychiatry Research: Neuroimaging. 2006;146:137–147
  30. Zald DH, Kim SW. Anatomy and function of the orbital frontal cortex, I: anatomy, neurocircuitry; and obsessive–compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences. 1996;8:125–138
  31. Zald DH, Kim SW. Anatomy and function of the orbital frontal cortex, II: Function and relevance to obsessive–compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences. 1996;8:249–261

PII: S0925-4927(09)00197-8

doi: 10.1016/j.pscychresns.2009.08.005

Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 97-100 , 28 February 2010