Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 97-100, 28 February 2010

Orbital frontal cortex in treatment-naïve pediatric obsessive–compulsive disorder

Department of Psychiatry & Behavioral Neurosciences, Wayne State University, Children's Hospital of Michigan, Detroit, MI 48201, USA

Received 5 May 2009; received in revised form 13 July 2009; accepted 28 August 2009.

Abstract 

The orbital frontal cortex (OFC) has been implicated in obsessive–compulsive disorder (OCD). Participants comprised 28 treatment-naïve pediatric OCD patients and 21 controls, who were examined using magnetic resonance imaging. OCD patients had larger right but not left OFC white matter volume than controls. This is fresh evidence implicating white matter in OCD.

Keywords: Magnetic resonance imaging, Obsessive–compulsive disorder, Orbital prefrontal cortex

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PII: S0925-4927(09)00197-8

doi:10.1016/j.pscychresns.2009.08.005

Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 97-100, 28 February 2010

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