Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 121-129 , 28 February 2010

Multi-level comparison of empathy in schizophrenia: An fMRI study of a cartoon task

  • Seung Jae Lee

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
    • Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, South Korea
  • ,
  • Do Hyung Kang

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
  • ,
  • Chi-Won Kim

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
  • ,
  • Bon Mi Gu

      Affiliations

    • Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Seoul, South Korea
  • ,
  • Ji-Young Park

      Affiliations

    • Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Seoul, South Korea
  • ,
  • Chi-Hoon Choi

      Affiliations

    • Department of Radiology, National Medical Center, Seoul, South Korea
  • ,
  • Na Young Shin

      Affiliations

    • Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Seoul, South Korea
  • ,
  • Jong-Min Lee

      Affiliations

    • Department of Biomedical Engineering, Hanyang University, Seoul, South Korea
  • ,
  • Jun Soo Kwon

      Affiliations

    • Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
    • Brain & Cognitive Science-WCU program, College of Natural Science, SNU, Seoul, South Korea
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea. Tel.: +82 2 20722972; fax: +82 2 7479063.

Received 5 October 2008 ,Revised 9 August 2009 ,Accepted 11 August 2009.

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). 4th ed.. Washington, DC: APA; 1994;
  2. Amminger GP, Pape S, Rock D, Roberts SA, Ott SL, Squires-Wheeler E, et al. Relationship between childhood behavioral disturbance and later schizophrenia in the New York High-Risk Project. American Journal of Psychiatry. 1999;156:525–530
  3. Amodio DM, Frith CD. Meeting of minds: the medial frontal cortex and social cognition. Nature Reviews Neuroscience. 2006;7:268–277
  4. Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends of Cognitive Sciences. 2004;8:170–177
  5. Beauregard M, Levesque J, Bourgouin P. Neural correlates of conscious self-regulation of emotion. Journal of Neuroscience. 2001;21:RC165
  6. Bird CM, Castelli F, Malik O, Husain M. The impact of extensive medial frontal lobe damage on ‘Theory of Mind’ and cognition. Brain. 2004;127:914–928
  7. Blair RJ, Morris JS, Frith CD, Perrett DI, Dolan RJ. Dissociable neural responses to facial expressions of sadness and anger. Brain. 1999;122:883–893
  8. Blair RJ. Responding to the emotions of others: dissociating forms of empathy through the study of typical and psychiatric populations. Consciousness and Cognition. 2005;14:698–718
  9. Bookheimer S. Functional MRI of language: new approaches to understanding the cortical organization of semantic processing. Annual Review of Neuroscience. 2002;25:151–188
  10. Bora E, Gökçen S, Veznedaroglu B. Empathic abilities in people with schizophrenia. Psychiatry Research. 2008;160:23–29
  11. Bottini G, Corcoran R, Sterzi R, Paulesu E, Schenone P, Scarpa P, et al. The role of the right hemisphere in the interpretation of figurative aspects of language. A positron emission tomography activation study. Brain. 1994;117:1241–1253
  12. Brüne M. “Theory of mind” in schizophrenia: a review of the literature. Schizophrenia Bulletin. 2005;31:21–42
  13. Brunet-Gouet E, Decety J. Social brain dysfunctions in schizophrenia: a review of neuroimaging studies. Psychiatry Research. 2006;148:75–92
  14. Brunet E, Sarfati Y, Hardy-Bayle MC, Decety J. Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia. Neuropsychologia. 2003;41:1574–1582
  15. Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, Coppola R, et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex. 2000;10:1078–1092
  16. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. American Journal of Psychiatry. 2003;160:2209–2215
  17. Chakrabarti B, Baron-Cohen S. Empathizing: neurocognitive developmental mechanisms and individual differences. Progress in Brain Research. 2006;156:403–417
  18. Cirillo MA, Seidman LJ. Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms. Neuropsychology Review. 2003;13:43–77
  19. Corcoran R. Theory of Mind and Schizophrenia. Washington, DC: American Psychological Association; 2001;
  20. Crespo-Facorro B, Nopoulos PC, Chemerinski E, Kim JJ, Andreasen NC, Magnotta V. Temporal pole morphology and psychopathology in males with schizophrenia. Psychiatry Research: Neuroimaging. 2004;132:107–115
  21. Davis MH. Measuring individual differences in empathy: evidence for a multidimensional approach. Journal of Personality and Social Psychology. 1983;44:113–126
  22. Decety J, Jackson PL. The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Review. 2004;3:71–100
  23. Derntl B, Finkelmeyer A, Toygar TK, Hülsmann A, Schneider F, Falkenberg DI, et al. Generalized deficit in all core components of empathy in schizophrenia. Schizophrenia Research. 2009;108:197–206
  24. Farrant A, Morris RG, Russell T, Elwes R, Akanuma N, Alarcon G, et al. Social cognition in frontal lobe epilepsy. Epilepsy and Behavior. 2005;7:506–516
  25. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis I Disorder, Patient Edition (SCID-P), version 2. In: New York State Psychiatric Institute, Biometrics Research, New York. 1995;
  26. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis I Disorder — Non-patient Edition (SCID-I/NP), Version 2. In: New York State Psychiatric Institute, Biometrics Research, New York. 1995;
  27. Frith CD, Corcoran R. Exploring ‘theory of mind’ in people with schizophrenia. Psychological Medicine. 1996;26:521–530
  28. Friston KJ, Liddle PF, Frith CD, Hirsch SR, Frackowiak RS. The left medial temporal region and schizophrenia. A PET study. Brain. 1992;115:367–382
  29. Gilbert SJ, Spengler S, Simons JS, Steele JD, Lawrie SM, Frith CD, et al. Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis. Journal of Cognitive Neuroscience. 2006;18:932–948
  30. Grabowski TJ, Damasio H, Tranel D, Ponto LL, Hichwa RD, Damasio AR. A role for left temporal pole in the retrieval of words for unique entities. Human Brain Mapping. 2001;13:199–212
  31. Hodges SD, Wegner DM. Automatic and controlled empathy. In:  Ikes W editors. Empathic Accuracy. New York: Guilford, Press; 1997;p. 311–339
  32. Ickes, W. (Ed.), 1997. Empathic Accuracy. Guilford Press, New York.
  33. Ickes W. Everyday Mind Reading. New York: Prometheus; 2003;
  34. Kasai K, Shenton ME, Salisbury DF, Onitsuka T, Toner SK, Yurgelun-Todd D, et al. Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosis. Archives of General Psychiatry. 2003;60:1069–1077
  35. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  36. Langdon R, Coltheart M. Mentalising, schizotypy, and schizophrenia. Cognition. 1999;71:43–71
  37. Lee J, Park S. Working memory impairments in schizophrenia: a meta-analysis. Journal of Abnormal Psychology. 2005;114:599–611
  38. Lee KH, Brown WH, Egleston PN, Green RD, Farrow TF, Hunter MD, et al. A functional magnetic resonance imaging study of social cognition in schizophrenia during an acute episode and after recovery. American Journal of Psychiatry. 2006;163:1926–1933
  39. Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, Halpern E, et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biological Psychiatry. 2000;48:99–109
  40. Marjoram D, Job DE, Whalley HC, Gountouna VE, McIntosh AM, Simonotto E, et al. A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia. Neuroimage. 2006;31:1850–1858
  41. Mazza M, De Risio A, Tozzini C, Roncone R, Casacchia M. Machiavellianism and Theory of Mind in people affected by schizophrenia. Brain and Cognition. 2003;51:262–269
  42. Mitchell RL, Elliott R, Barry M, Cruttenden A, Woodruff PW. Neural response to emotional prosody in schizophrenia and in bipolar affective disorder. British Journal of Psychiatry. 2004;184:223–230
  43. Nichelli P, Grafman J, Pietrini P, Clark K, Lee KY, Miletich R. Where the brain appreciates the moral of a story. Neuroreport. 1995;6:2309–2313
  44. Niemi LT, Suvisaari JM, Tuulio-Henriksson A, Lonnqvist JK. Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies. Schizophrenia Research. 2003;60:239–258
  45. Noppeney U, Price CJ. A PET study of stimulus- and task-induced semantic processing. Neuroimage. 2002;15:927–935
  46. Norman RM, Scholten DJ, Malla AK, Ballageer T. Early signs in schizophrenia spectrum disorders. Journal of Nervous and Mental Disease. 2005;193:17–23
  47. Olson IR, Plotzker A, Ezzyat Y. The Enigmatic temporal pole: a review of findings on social and emotional processing. Brain. 2007;130:1718–1731
  48. Pinkham AE, Penn DL, Perkins DO, Lieberman J. Implications for the neural basis of social cognition for the study of schizophrenia. American Journal of Psychiatry. 2003;160:815–824
  49. Preston SD, de Waal FB. Empathy: its ultimate and proximate bases. Behavioral and Brain Sciences. 2002;25:1–20
  50. Premack D, Woodruff G. Does the chimpanzee have a theory of mind?. Behavioral and Brain Sciences. 1978;1:515–526
  51. Psychological Assessment Resources . Computerized Wisconsin Card Sort Task Version 4 (WCST). PAR, Inc., Lutz, FL; 2003;
  52. Roncone R, Falloon IR, Mazza M, De Risio A, Pollice R, Necozione S, et al. Is theory of mind in schizophrenia more strongly associated with clinical and social functioning than with neurocognitive deficits?. Psychopathology. 2002;35:280–288
  53. Russell TA, Rubia K, Bullmore ET, Soni W, Suckling J, Brammer MJ, et al. Exploring the social brain in schizophrenia: left prefrontal underactivation during mental state attribution. American Journal of Psychiatry. 2000;157:2040–2042
  54. Saxe R. Uniquely human social cognition. Current Opinion in Neurobiology. 2006;16:1–5
  55. Shamay-Tsoory SG, Shur S, Harari H, Levkovitz Y. Neurocognitive basis of impaired empathy in schizophrenia. Neuropsychology. 2007;21:431–438
  56. Shammi P, Stuss DT. Humour appreciation: a role of the right frontal lobe. Brain. 1999;122:657–666
  57. Shaw RJ, Dong M, Lim KO, Faustman WO, Pouget ER, Alpert M. The relationship between affect expression and affect recognition in schizophrenia. Schizophrenia Research. 1999;37:245–250
  58. Sugiura M, Kawashima R, Nakamura K, Sato N, Nakamura A, Kato T, et al. Activation reduction in anterior temporal cortices during repeated recognition of faces of personal acquaintances. Neuroimage. 2001;13:877–890
  59. Völlm BA, Taylor AN, Richardson P, Corcoran R, Stirling J, McKie S, et al. Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage. 2006;29:90–98
  60. Woodruff PW. Auditory hallucinations: Insights and questions from neuroimaging. Cognitive Neuropsychiatry. 2004;9:73–91
  61. Wright IC, Ellison ZR, Sharma T, Friston KJ, Murray RM, McGuire PK. Mapping of grey matter changes in schizophrenia. Schizophrenia Research. 1999;35:1–14
  62. Yeom TH, Park YS, Oh KJ, Kim JG, Lee YH. The Manual for Korean–Wechsler Adult Intelligence Scale. Seoul: Korean Guidance; 1992;

PII: S0925-4927(09)00193-0

doi: 10.1016/j.pscychresns.2009.08.003

Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 121-129 , 28 February 2010