Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 90-96 , 28 February 2010

Influences of lobar gray matter and white matter lesion load on cognition and mood

  • Susanne G. Mueller

      Affiliations

    • Center for Imaging of Neurodegenerative Diseases, VAMC/University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA
    • Corresponding Author InformationCorresponding author. Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs (DVA) Medical Center, 4150 Clement Street, San Francisco, CA, 94121, USA. Tel.: +1 415 221 4810x2538; fax: +1 415 668 2864.
  • ,
  • Wendy J. Mack

      Affiliations

    • Department of Preventive Medicine, University of Southern California, Los Angeles, CA, 90089, USA
  • ,
  • Dan Mungas

      Affiliations

    • Department of Neurology, School of Medicine, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
  • ,
  • Joel H. Kramer

      Affiliations

    • Department of Neurology, San Francisco Medical Center, University of California, 905 Parnassus Avenue, San Francisco, CA. 94143, USA
  • ,
  • Valerie Cardenas-Nicolson

      Affiliations

    • Center for Imaging of Neurodegenerative Diseases, VAMC/University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA
  • ,
  • Helen Lavretsky

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plaza, 37-372A, Los Angeles, CA, 90095, USA
  • ,
  • Maxwell Greene

      Affiliations

    • Center for Imaging of Neurodegenerative Diseases, VAMC/University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA
  • ,
  • Norbert Schuff

      Affiliations

    • Center for Imaging of Neurodegenerative Diseases, VAMC/University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA
  • ,
  • Helena C. Chui

      Affiliations

    • Department of Neurology, University of Southern California, 1510 San Pablo Street, Suite 618, Los Angeles, CA 90033, USA
  • ,
  • Michael W. Weiner

      Affiliations

    • Center for Imaging of Neurodegenerative Diseases, VAMC/University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA

Received 7 October 2008 ,Revised 30 March 2009 ,Accepted 4 August 2009.

References 

  1. Andreescu C, Butters MA, Begley A, Rajji T, Wu M, Meltzer CC, et al. Gray matter changes in late life depression — a structural MRI analysis. Neuropsychopharmacology. 2008;33:2566–2572
  2. Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H. Anterior cingulate, gyrus rectus and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. American Journal of Psychiatry. 2004;161:99–108
  3. Brown WR, Moody DM, Challa VR, Thore CR, Anstrom JA. Venous collagenosis and arteriolar tortuosity in leukaraiosis. Journal of the Neurological Sciences. 2002;203–204:159–163
  4. Burton EJ, McKeith IG, Burn DJ, Firbank MJ, O'Brien JT. Progression of white matter hyperintensities in Alzheimer's Disease, dementia with Lewy bodies, and Parkinson Disease dementia: a comparison with normal aging. American Journal of Geriatric Psychiatry. 2006;14:842–849
  5. Enzinger C, Fazekas F, Ropele S, Schmidt R. Progression of cerebral white matter lesions — clinical and radiological considerations. Journal of the Neurological Sciences. 2007;257:5–10
  6. Heiden A, Kettenbach J, Fischer P, Schein B, Ba-Ssalamah A, Frey R, et al. White matter hyperintensity and chronicity of depression. Journal of Psychiatric Research. 2005;39:285–293
  7. Jellinger KA. Understanding the pathology of vascular cognitive impairment. Journal of the Neurological Sciences. 2005;229–230:57–63
  8. Koevari E, Gold G, Hermann FR, Canuto A, Hof PR, Bouras C, et al. Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke. 2004;35:410–414
  9. Lavretsky H, Ballmaier M, Pham D, Toga A, Kumar A. Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. American Journal of Geriatric Psychiatry. 2007;15:386–394
  10. Lavretsky H, Zheng L, Weiner MW, Mungas D, Reed B, Kramer JH, et al. The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia. International Journal of Geriatric Psychiatry. 2008;23:1040–1050
  11. Lee DY, Choo IH, Kim KW, Jhoo JH, Youn JC, Lee UY, et al. White matter changes associated with psychotic symptoms in Alzheimer's disease patients. Journal of Neuropsychiatry and Clinical Neuroscience. 2006;18:191–198
  12. Lind K, Jonsson M, Karlson I, Sjoegren M, Wallin A, Edman A. Depressive symptoms and white matter changes in patients with dementia. International Journal of Geriatric Psychiatry. 2006;21:119–125
  13. Liotti M, Mayberg HS, Brannan SK, McGinnis S, Jerabek P, Fox PT. Differential limbic–cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders. Biological Psychiatry. 2000;48:30–42
  14. Lopez OL, Becker JT, Reynolds CF, Jungreis CA, Weinman S, DeKosky ST. Psychiatric correlates of MR deep white matter lesions in probable Alzheimer's Disease. J of Neuropsychiatry and Clinical Neurosciences. 1997;9:246–250
  15. Maes F, Collignon A, Vandermeulen D, Marchal G, Suetens P. Multimodality image registration by maximization of mutual information. IEEE Transactions on Medical Imaging. 1997;16:187–198
  16. Minett TSC, Dean JL, Firbank M, English P, O'Brien JT. Subjective memory complaints, white matter lesions, depressive symptoms, and cognition in elderly patients. American Journal of Geriatric Psychiatry. 2005;13:665–671
  17. Mondrego PJ, Ferrandez J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type. A prospective study. Archives of Neurology. 2004;61:1290–1293
  18. Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner MW, Schuff N, et al. MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology. 2001;57:2229–2235
  19. Mungas D, Reed BR, Jagust WJ, DeCarli C, Mack WJ, Kramer JH, et al. Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease. Neurology. 2002;59:867–873
  20. Mungas D, Reed BR, Kramer JH. Psychometrically matched measures of global cognition, memory and executive function for assessment of cognitive decline in older persons. Neuropsychology. 2003;17:380–392
  21. Mungas D, Harvey D, Reed B, Jagust W, DeCarli C, Beckett L, et al. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology. 2005;65:565–571
  22. O'Sullivan M, Jones DK, Summer PE, Morris RG, Williams SCR, Markus HS. Evidence for cortical disconnection as a mechanism of age-related cognitive decline. Neurology. 2001;57:632–638
  23. Payne JL, Lyketsos CG, Steele C, Baker L, Galik E, Kopunek S, et al. Relationship of cognitive and functional impairment to depressive features in Alzheimer's disease and other dementias. Journal of Neuropsychiatry and Clinical Neuroscience. 1998;10:440–447
  24. Rainer MK, Mucke HAM, Zehetmayer S, Krampla W, Kuselbauer T, Weissgram S, et al. Data from the VIA study does not support the concept of vascular depression. American Journal of Geriatric Psychiatry. 2006;14:531–537
  25. Reed BR, Mungas DM, Kramer JH, Ellis W, Vinters HV, Zarow C, et al. Profiles of neuropsychological impairment in autopsy defined Alzheimer's disease and cerebrovascular disease. Brain. 2007;130:731–739
  26. Scheltens P, Barkhof F, Leys D, Wolters EC, Ravid R, Kamphorst W. Histopathological correlates of white matter changes on MRI in Alzheimer's disease and normal aging. Neurology. 1995;45:883–888
  27. Schneider J, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology. 2007;86:2197–2204
  28. Simpson S, Allen H, Tomenson B, Burns A. Neurological correlates of depressive symptoms in Alzheimer's disease and vascular dementia. Journal of Affective Disorders. 1999;53:129–136
  29. Studholme C, Cardenas V, Maudsley A, Weiner MW. An intensity consistent filtering approach to the analysis of deformation tensor derived maps of brain shape. Neuroimage. 2003;4:1638–1649
  30. Studholme C, Cardenas V, Song E, Ezekiel F, Maudsley A, Weiner MW. Accurate template based correction of brain intensity distortion with application to dementia and aging. IEEE Transactions of Medical Imaging. 2004;23:99–110
  31. Taylor WD, Steffens DC, Krishnan KR. Psychiatric disease in the twenty-first century: the case of subcortical ischemic depression. Biological Psychiatry. 2006;60:1299–1303
  32. Taylor WD, MacFall JR, Payne ME, McQuoid DR, Steffens DC, Provenzale JM, et al. Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms. Psychosocial Medicine. 2007;37:1763–1773
  33. Tekin S, Cummings JL. Frontal–subcortical neuronal circuits and clinical neuropsychiatry. An update. Journal of Psychosomatic Research. 2002;53:647–654
  34. Teodorczuk A, O'Brien JT, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, et al. White matter changes and late-life depressive symptoms. British Journal of Psychiatry. 2007;191:212–217
  35. Thomas AJ, O'Brien JT. Depression and cognition in older adults. Current Opinion in Psychiatry. 2008;21:8–13
  36. Thomas AJ, O'Brien JT, Davis S, Ballard C, Barber R, Kalaria RN, et al. Ischemic basis for deep white matter hyperintensities in major depression. Archives of General Psychiatry. 2002;59:785–792
  37. Van der Flier WM, van Straaten ECW, Barkhof F, Verdelho A, Madureira S, Pantoni L, et al. Small vessel disease and general cognitive function on nondisabled elderly: the LADIS study. Stroke. 2005;36:2116–2120
  38. Van Leemput K, Maes F, Vandermeulen D, Suetens P. Automated model-based tissue classification of MR images of the brain. IEEE Transactions of Medical Imaging. 1999;18:897–908
  39. Van Leemput K, Maes F, Vandermeulen D, Colchester A, Suetens P. Automated segmentation of multiple sclerosis lesions by model outlier detection. IEEE Transactions of Medical Imaging. 2001;20:677–688
  40. Wakayama A, Graf R, Rosner G, Heiss WD. Deafferentation versus cortical ischemia in a rabbit model of middle cerebral artery occlusion. Stroke. 1989;20:1071–1078

PII: S0925-4927(09)00178-4

doi: 10.1016/j.pscychresns.2009.08.002

Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 90-96 , 28 February 2010