Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 85-89 , 28 February 2010

Metabolic alterations associated with impaired clock drawing in Lewy body dementia

  • Robert Perneczky

      Affiliations

    • Department of Psychiatry and Psychotherapy, Technische Ismaninger Str. 22, 81675 München, Germany
    • Corresponding Author InformationCorresponding author. Psychiatrische Klinik der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany. Tel.: +49 89 4140 6055; fax: +49 89 4140 4888.
  • ,
  • Alexander Drzezga

      Affiliations

    • Department of Nuclear Medicine, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany
  • ,
  • Henning Boecker

      Affiliations

    • Department of Nuclear Medicine, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany
    • Department of Radiology, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
  • ,
  • Andres O. Ceballos-Baumann

      Affiliations

    • Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany
  • ,
  • Michael Valet

      Affiliations

    • Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany
  • ,
  • Regina Feurer

      Affiliations

    • Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany
  • ,
  • Hans Förstl

      Affiliations

    • Department of Psychiatry and Psychotherapy, Technische Ismaninger Str. 22, 81675 München, Germany
  • ,
  • Alexander Kurz

      Affiliations

    • Department of Psychiatry and Psychotherapy, Technische Ismaninger Str. 22, 81675 München, Germany
  • ,
  • Peter Häussermann

      Affiliations

    • Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 München, Germany
    • Centre for Integrative Psychiatry, Niemannsweg 147, 24105 Kiel, Germany

Received 17 October 2007 ,Revised 3 August 2009 ,Accepted 3 August 2009.

References 

  1. Boecker H, Ceballos-Baumann AO, Volk D, Conrad B, Forstl H, Haussermann P. Metabolic alterations in patients with Parkinson disease and visual hallucinations. Archives of Neurology. 2007;64(7):984–988
  2. Bokde AL, Teipel SJ, Drzezga A, Thissen J, Bartenstein P, Dong W, et al. Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 2005;20(6):352–357
  3. Cahn-Weiner DA, Sullivan EV, Shear PK, Fama R, Lim KO, Yesavage JA, et al. Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease. Journal of the International Neuropsychological Society. 1999;5(6):502–509
  4. Cahn-Weiner DA, Williams K, Grace J, Tremont G, Westervelt H, Stern RA. Discrimination of dementia with Lewy bodies from Alzheimer disease and Parkinson disease using the clock drawing test. Cognitive and Behavioral Neurology. 2003;16(2):85–92
  5. Cavanna A, Trimble M. The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006;129:564–583
  6. Chumbley JR, Friston KJ. False discovery rate revisited: FDR and topological inference using Gaussian random fields. Neuroimage. 2009;44(1):62–70
  7. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308–2314
  8. Eickhoff SB, Stephan KE, Mohlberg H, Grefkes C, Fink GR, Amunts K, et al. A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. Neuroimage. 2005;25(4):1325–1335
  9. Fahn S, Elton R. Members of the UPDRS development commitee: Unified Parkinson's rating scale. In:  Fahn S,  Marsden C,  Calne D,  Goldstein M editor. Recent developments in Parkinson's disease. Florhan Park: MacMillan Healthcare Information; 1987;p. 153–304
  10. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state” A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12(3):189–198
  11. Formisano E, Linden DE, Di Salle F, Trojano L, Esposito F, Sack AT, et al. Tracking the mind's image in the brain I: time-resolved fMRI during visuospatial mental imagery. Neuron. 2002;35(1):185–194
  12. Frackowiak RS, Friston KJ, Frith CD, Dolan RJ, Mazziotta JC. Human Brain Function. USA: Academic Press; 1997;
  13. Gnanalingham KK, Byrne EJ, Thornton A. Clock-face drawing to differentiate Lewy body and Alzheimer type dementia syndromes. Lancet. 1996;347(9002):696–697
  14. Hamilton JM, Salmon DP, Galasko D, Raman R, Emond J, Hansen LA, et al. Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies. Neuropsychology. 2008;22(6):729–737
  15. Ino T, Asada T, Ito J, Kimura T, Fukuyama H. Parieto-frontal networks for clock drawing revealed with fMRI. Neuroscience Research. 2003;45(1):71–77
  16. Lee DY, Seo EH, Choo IH, Kim SG, Lee JS, Lee DS, et al. Neural correlates of the clock drawing test performance in Alzheimer's disease: a FDG-PET study. Dementia and Geriatric Cognitive Disorders. 2008;26(4):306–313
  17. Lehmann C, Vannini P, Wahlund LO, Almkvist O, Dierks T. Increased sensitivity in mapping task demand in visuospatial processing using reaction-time-dependent hemodynamic response predictors in rapid event-related fMRI. Neuroimage. 2006;31(2):505–512
  18. Lundstrom B, Petersson K, Andersson J, Johansson M, Fransson P, Ingvar M. Isolating the retrieval of imagined pictures during episode memory: activation of the left precuneus and left prefrontal cortex. Neuroimage. 2003;20:1934–1943
  19. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65(12):1863–1872
  20. Mendez MF, Ala T, Underwood KL. Development of scoring criteria for the clock drawing task in Alzheimer's disease. Journal of the American Geriatrics Society. 1992;40(11):1095–1099
  21. Minoshima S, Foster NL, Sima AA, Frey KA, Albin RL, Kuhl DE. Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Annals of Neurology. 2001;50(3):358–365
  22. Morris JC, Mohs RC, Rogers H, Fillenbaum G, Heyman A. Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. Psychopharmacology Bulletin. 1988;24(4):641–652
  23. Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. Journal of Nuclear Medicine. 2008;49(3):390–398
  24. Nagahama Y, Okina T, Suzuki N, Nabatame H, Matsuda M. Neural correlates of impaired performance on the clock drawing test in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 2005;19(5–6):390–396
  25. Newberg A, Cotter A, Udeshi M, Brinkman F, Glosser G, Alavi A, et al. Brain metabolism in the cerebellum and visual cortex correlates with neuropsychological testing in patients with Alzheimer's disease. Nuclear Medicine Communications. 2003;24(7):785–790
  26. Perneczky R, Drzezga A, Boecker H, Forstl H, Kurz A, Haussermann P. Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations. Dementia and Geriatric Cognitive Disorders. 2008;25(6):531–538
  27. Perneczky R, Drzezga A, Boecker H, Granert O, Förstl H, Kurz A, et al. FDG PET correlates of impaired activities of daily living in dementia with Lewy bodies: implications for cognitive reserve. American Journal of Geriatric Psychiatry. 2009;17:188–195
  28. Perneczky R, Hartmann J, Grimmer T, Drzezga A, Kurz A. Cerebral metabolic correlates of the clinical dementia rating scale in mild cognitive impairment. Journal of Geriatric Psychiatry and Neurology. 2007;20(2):84–88
  29. Perneczky R, Haussermann P, Diehl-Schmid J, Boecker H, Forstl H, Drzezga A, et al. Metabolic correlates of brain reserve in dementia with lewy bodies: an FDG PET study. Dementia and Geriatric Cognitive Disorders. 2007;23(6):316–322
  30. Perneczky R, Wagenpfeil S, Komossa K, Grimmer T, Diehl J, Kurz A. Mapping scores onto stages: mini-mental state examination and clinical dementia rating. American Journal of Geriatric Psychiatry. 2006;14:139–144
  31. Prvulovic D, Hubl D, Sack AT, Melillo L, Maurer K, Frolich L, et al. Functional imaging of visuospatial processing in Alzheimer's disease. Neuroimage. 2002;17(3):1403–1414
  32. Rouleau I, Salmon DP, Butters N. Longitudinal analysis of clock drawing in Alzheimer's disease patients. Brain and Cognition. 1996;31(1):17–34
  33. Sack AT, Sperling JM, Prvulovic D, Formisano E, Goebel R, Di Salle F, et al. Tracking the mind's image in the brain II: transcranial magnetic stimulation reveals parietal asymmetry in visuospatial imagery. Neuron. 2002;35(1):195–204
  34. Seigerschmidt E, Mosch E, Siemen M, Forstl H, Bickel H. The clock drawing test and questionable dementia: reliability and validity. International Journal of Geriatric Psychiatry. 2002;17(11):1048–1054
  35. Selemon L, Goldman-Rakic P. Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey; evidence for a distributed neural network subserving spatially guided behavior. Journal of Neurscience. 1988;8:4049–4068
  36. Shulman KI. Clock-drawing: is it the ideal cognitive screening test?. International Journal of Geriatric Psychiatry. 2000;15(6):548–561
  37. Sunderland T, Hill JL, Mellow AM, Lawlor BA, Gundersheimer J, Newhouse PA, et al. Clock drawing in Alzheimer's disease. A novel measure of dementia severity. Journal of the American Geriatrics Society. 1989;37(8):725–729
  38. Takahashi M, Sato A, Nakajima K, Inoue A, Oishi S, Ishii T, et al. Poor performance in clock-drawing test associated with visual memory deficit and reduced bilateral hippocampal and left temporoparietal regional blood flows in Alzheimer's disease patients. Psychiatry and Clinical Neurosciences. 2008;62(2):167–173
  39. Thomann PA, Toro P, Dos Santos V, Essig M, Schroder J. Clock drawing performance and brain morphology in mild cognitive impairment and Alzheimer's disease. Brain and Cognition. 2008;67(1):88–93
  40. Thomas AJ, Burn DJ, Rowan EN, Littlewood E, Newby J, Cousins D, et al. A comparison of the efficacy of donepezil in Parkinson's disease with dementia and dementia with Lewy bodies. International Journal of Geriatric Psychiatry. 2005;20(10):938–944
  41. Trojano L, Grossi D, Linden DE, Formisano E, Goebel R, Cirillo S, et al. Coordinate and categorical judgements in spatial imagery. An fMRI study. Neuropsychologia. 2002;40(10):1666–1674
  42. Ueda H, Kitabayashi Y, Narumoto J, Nakamura K, Kita H, Kishikawa Y, et al. Relationship between clock drawing test performance and regional cerebral blood flow in Alzheimer's disease: a single photon emission computed tomography study. Psychiatry and Clinical Neurosciences. 2002;56(1):25–29
  43. Vannini P, Almkvist O, Dierks T, Lehmann C, Wahlund LO. Reduced neuronal efficacy in progressive mild cognitive impairment: a prospective fMRI study on visuospatial processing. Psychiatry Research: Neuroimaging. 2007;156(1):43–57
  44. Vannini P, Almkvist O, Franck A, Jonsson T, Volpe U, Kristoffersen Wiberg M, et al. Task demand modulations of visuospatial processing measured with functional magnetic resonance imaging. Neuroimage. 2004;21(1):58–68
  45. Vannini P, Lehmann C, Dierks T, Jann K, Viitanen M, Wahlund LO, et al. Failure to modulate neural response to increased task demand in mild Alzheimer's disease: fMRI study of visuospatial processing. Neurobiology of Disease. 2008;31(3):287–297
  46. Watson YI, Arfken CL, Birge SJ. Clock completion: an objective screening test for dementia. Journal of the American Geriatrics Society. 1993;41(11):1235–1240
  47. Wimo A, Winblad B, Aguero-Torres H, E vS. The magnitude of dementia occurrence in the world. Alzheimer Disease and Associated Disorders. 2003;17:63–67
  48. Wise SP, Boussaoud D, Johnson PB, Caminiti R. Premotor and parietal cortex: corticocortical connectivity and combinatorial computations. Annual Review of Neuroscience. 1997;20:25–42
  49. Wolf-Klein GP, Silverstone FA, Levy AP, Brod MS. Screening for Alzheimer's disease by clock drawing. Journal of the American Geriatrics Society. 1989;37(8):730–734

PII: S0925-4927(09)00177-2

doi: 10.1016/j.pscychresns.2009.08.001

Psychiatry Research: Neuroimaging
Volume 181, Issue 2 , Pages 85-89 , 28 February 2010