Psychiatry Research: Neuroimaging
Volume 174, Issue 3 , Pages 163-170 , 30 December 2009

Effect of the TaqIA polymorphism on ethanol response in the brain

  • Edythe D. London

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    • Department of Molecular and Medical Pharmacology of the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    • Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, United States
    • Corresponding Author InformationCorresponding author. Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90024-1759, United States. Tel.: +1 310 525 0606; fax: +1 310 825 0812.
  • ,
  • Steven M. Berman

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    • Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, United States
  • ,
  • Parvenah Mohammadian

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
  • ,
  • Terrie Ritchie

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
  • ,
  • Mark A. Mandelkern

      Affiliations

    • Department of Physics, University of California Irvine, Irvine, CA 92697, United States
  • ,
  • Mary K.W. Susselman

      Affiliations

    • Ahmanson-Lovelace Brain Mapping Center, University of California Los Angeles, Los Angeles, CA 90095, United States
  • ,
  • Florian Schlagenhauf

      Affiliations

    • Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Charité Mitte, Berlin, Germany
  • ,
  • Ernest P. Noble

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    • Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, United States

Received 20 March 2009 ,Revised 17 July 2009 ,Accepted 17 July 2009.

References 

  1. Barr CL, Kidd KK. Population frequencies of the A1 allele at the dopamine D2 receptor locus. Biological Psychiatry. 1993;34:204–209
  2. Beck AT, Ward CH, Mednelson M, Mock J, Erbaugh J. An inventory for measuring depression. Archives of General Psychiatry. 1961;4:561–571
  3. Berggren U, Fahlke C, Aronsson E, Karanti A, Eriksson M, Blennow K, et al. The taqI DRD2 A1 allele is associated with alcohol-dependence although its effect size is small. Alcohol and Alcoholism. 2006;41:479–485
  4. Berman SM, Noble EP. The D 2 dopamine receptor (DRD2) gene and family stress; interactive effects on cognitive functions in children. Behavior Genetics. 1997;27:33–43
  5. Berman S, Ozkaragoz T, Young RM, Noble EP. D2 dopamine receptor gene polymorphism discriminates two kinds of novelty seeking. Personality and Individual Differences. 2002;33:867–882
  6. Berman SM, Ozkaragoz T, Noble EP, Antolin T, Sheen C, Siddarth P, et al. Differential associations of sex and D2 dopamine receptor (DRD2) genotype with negative affect and other substance abuse risk markers in children of alcoholics. Alcohol. 2003;30:201–210
  7. Biller A, Bartsch AJ, Homola G, Solymosi L, Bendszus M. The effect of ethanol on human brain metabolites longitudinally characterized by proton MR spectroscopy. Journal of Cerebral Blood Flow and Metabolism. 2009;29:891–902
  8. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, et al. Allelic association of human dopamine D 2 receptor gene in alcoholism. Journal of the American Medical Association. 1990;263:2055–2260
  9. Blum K, Braverman ER, Holder JM, Lubar JF, Monastra VJ, Miller D, et al. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. Journal of Psychoactive Drugs. 2000;32(Suppl, i–iv):1–112
  10. Cohen MX, Young J, Baek JM, Kessler C, Ranganath C. Individual differences in extraversion and dopamine genetics predict neural reward responses. Cognitve Brain Research. 2005;25:851–861
  11. Conner BT, Noble EP, Berman SM, Ozkaragoz T, Ritchie T, Antolin T, et al. DRD2 genotypes and substance use in adolescent children of alcoholics. Drug and Alcohol Dependence. 2005;79:379–387
  12. Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nature Reviews Neuroscience. 2002;3:655–666
  13. Croissant B, Rist F, Demmel R, Olbrich R. Alcohol-induced heart rate response dampening during aversive and rewarding stress paradigms in subjects at risk for alcoholism. International Journal of Psychophysiology. 2006;61:253–261
  14. Croissant B, Demmel R, Rist F, Olbrich R. Exploring the link between gender, sensation seeking, and family history of alcoholism in cortisol stress-response dampening. Biological Psychology. 2008;79:268–274
  15. Dalley JW, Fryer TD, Brichard L, Robinson ES, Theobald DE, Laane K, et al. Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science. 2007;315:1267–1270
  16. de Wit H, Metz J, Wagner N, Cooper M. Behavioral and subjective effects of ethanol: relationship to cerebral metabolism using PET. Alcoholism Clinical and Experimental Research. 1990;14:482–489
  17. First MB, Spitzer RL, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-IP, Version 2.0). New York, NY: Biometrics Research Department, New York State Psychiatric Institute; 1996;
  18. Friston KJ, Holmes AP, Worsley KJ, Poline JP, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping. 1995;2:189–210
  19. Grandy DK, Zhang Y, Civelli O. PCR detection of the TaqA RFLP at the DRD2 locus. Human Molecular Genetics. 1993;2:2197
  20. Heidelberg University Hospital . From The Glass To The Brain In Six Minutes. 2009;Science Daily, June 15, http://www.sciencedaily.com/releases/2009/06/090615144339.htm
  21. Heinz A, Siessmeier T, Wrase J, Buchholz HG, Grunder G, Kumakura Y, et al. Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients. American Journal of Psychiatry. 2005;162:1515–1520
  22. Ingvar M, Ghatan PH, Wirsen-Meurling A, Risberg J, Von Heijne G, Stone-Elander S, et al. Alcohol activates the cerebral reward system in man. Journal of Studies on Alcohol. 1998;59:258–269
  23. Jia F, Pignataro L, Harrison NL. GABAA receptors in the thalamus: alpha4 subunit expression and alcohol sensitivity. Alcohol. 2007;41:177–185
  24. Jonsson EG, Nothen MM, Grunhage F, Farde L, Nakashima Y, Propping P, et al. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Molecular Psychiatry. 1999;4:290–296
  25. Kirsch P, Reuter M, Mier D, Lonsdorf T, Stark R, Gallhofer B, et al. Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward. Neuroscience Letters. 2006;405:196–201
  26. Koob GF, Le Moal M. Addiction and the brain antireward system. Annual Review of Psychology. 2008;59:29–53
  27. Kulikova M, Timofeeva M, Maluchenko N, Tonevitsky A. Effect of polymorphisms in the dopaminergic system genes on the mental fatigue. In: Presented at Conference, “1st International ISBS Summer School on Behavioral Genetics and Neuroscience of Stress.” St. Petersburg, Russia. 2008;
  28. Kulikova MA, Trushkin EV, Timofeeva MA, Shlepzova VA, Schegolkova JV, Maluchenko NV, et al. Genetic markers of predisposition to increased anxiety. Bulletin of Experimental Biology and Medicine. 2008;146:774–778
  29. Lawford BR, Young R, Noble EP, Kann B, Ritchie T. The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. European Psychiatry. 2006;21:180–185
  30. Li MD, Ma JZ, Beuten J. Progress in searching for susceptibility loci and genes for smoking-related behaviour. Clinical Genetics. 2004;66:382–392
  31. Li TK, Hewitt BG, Grant BF. Alcohol use disorders and mood disorders: a National Institute on Alcohol Abuse and Alcoholism perspective. Biological Psychiatry. 2004;56:718–720
  32. Madrid GA, MacMurray J, Lee JW, Anderson BA, Comings DE. Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholism. Alcohol. 2001;23:117–122
  33. McNair D, Lorr M, Droppleman L. Profile of Mood States (Manual). San Diego: Educational and Industrial Testing Service; 1971;
  34. Morris EP, Stewart SH, Ham LS. The relationship between social anxiety disorder and alcohol use disorders: a critical review. Clinical Psychology Review. 2005;25:734–760
  35. Neville MJ, Johnstone EC, Walton RT. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Human Mutation. 2004;23:540–545
  36. Nixon SJ, Parsons OA. Application of the Tridimensional Personality Questionnaire to a population of alcoholics and other substance abusers. Alcoholism, Clinical and Experimental Research. 1990;14:513–517
  37. Noble EP. Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review. European Psychiatry. 2000;15:79–89
  38. Noble EP. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2003;116B:103–125
  39. Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ. Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Archives of General Psychiatry. 1991;48:648–654
  40. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9:97–113
  41. Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE. Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Annals of Neurology. 1979;6:371–388
  42. Pohjalainen T, Rinne JO, Nagren K, Lehikoinen P, Anttila K, Syvalahti EK, et al. The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Molecular Psychiatry. 1998;3:256–260
  43. Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido T, et al. The [18 F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circulation Research. 1979;44:127–137
  44. Sammi MK, Pan JW, Telang FW, Schuhlein D, Molina PE, Volkow ND, et al. Measurements of human brain ethanol T(2) by spectroscopic imaging at 4 T. Magnetic Resonance in Medicine. 2000;44:35–40
  45. Savoie TM, Emory EK, Moody-Thomas S. Acute alcohol intoxication in socially drinking female and male offspring of alcoholic fathers. Journal of Studies on Alcohol. 1988;49:430–435
  46. Sher KJ, Levenson RW. Risk for alcoholism and individual differences in the stress-response—dampening effect of alcohol. Journal of Abnormal Psychology. 1982;91:350–367
  47. Silberman Y, Shi L, Brunso-Bechtold JK, Weiner JL. Distinct mechanisms of ethanol potentiation of local and paracapsular GABAergic synapses in the rat basolateral amygdala. Journal of Pharmacology and Experimental Therapeutics. 2008;324:251–260
  48. Sinha R, Li CS. Imaging stress- and cue-induced drug and alcohol craving: association with relapse and clinical implications. Drug and Alcohol Review. 2007;26:25–31
  49. Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. New York, NY: Theme Medical Publishers Inc.; 1988;
  50. Taylor SE, Burklund LJ, Eisenberger NI, Lehman BJ, Hilmert CJ, Lieberman MD. Neural bases of moderation of cortisol stress responses by psychosocial resources. Journal of Personality and Social Psychology. 2008;95:197–211
  51. Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK, et al. D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics. 1997;7:479–484
  52. Volkow ND, Fowler JS, Wang GJ, Swanson JM. Dopamine in drug abuse and addiction: results from imaging studies and treatment implications. Molecular Psychiatry. 2004;9:557–569
  53. Volkow ND, Wang GJ, Begleiter H, Porjesz B, Fowler JS, Telang F, et al. High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors. Archives of General Psychiatry. 2006;63:999–1008
  54. Volkow ND, Wang GJ, Franceschi D, Fowler JS, Thanos PP, Maynard L, et al. Low doses of alcohol substantially decrease glucose metabolism in the human brain. NeuroImage. 2006;29:295–301
  55. Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Childress AR, et al. Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. Journal of Neuroscience. 2006;26:6583–6588
  56. Volkow ND, Fowler JS, Wang GJ, Swanson JM, Telang F. Dopamine in drug abuse and addiction: results of imaging studies and treatment implications. Archives of Neurology. 2007;64:1575–1579
  57. Volkow ND, Ma Y, Zhu W, Fowler JS, Li J, Rao M, et al. Moderate doses of alcohol disrupt the functional organization of the human brain. Psychiatry Research: Neuroimaging. 2008;162:205–213
  58. Ward MF, Wender PH, Reimherr FW. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. American Journal of Psychiatry. 1993;150:885–890
  59. White MJ, Morris CP, Lawford BR, Young RM. Behavioral phenotypes of impulsivity related to the ANKK1 gene are independent of an acute stressor. Behavior and Brain Function. 2008;4:54
  60. Wong DF, Kuwabara H, Schretlen DJ, Bonson KR, Zhou Y, Nandi A, et al. Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. Neuropsychopharmacology. 2006;31:2716–2727
  61. Yoder KK, Morris ED, Constantinescu CC, Cheng TE, Normandin MD, O'Connor SJ, et al. When what you see isn't what you get: alcohol cues, alcohol administration, prediction error, and human striatal dopamine. Alcoholism, Clinical and Experimental Research. 2009;33:139–149
  62. Young RM, Lawford BR, Nutting A, Noble EP. Advances in molecular genetics and the prevention and treatment of substance misuse: implications of association studies of the A1 allele of the D2 dopamine receptor gene. Addictive Behaviors. 2004;29:1275–1294

PII: S0925-4927(09)00173-5

doi: 10.1016/j.pscychresns.2009.07.008

Psychiatry Research: Neuroimaging
Volume 174, Issue 3 , Pages 163-170 , 30 December 2009