Psychiatry Research: Neuroimaging
Volume 174, Issue 2 , Pages 110-115 , 30 November 2009

White matter ‘potholes’ in early-onset schizophrenia: A new approach to evaluate white matter microstructure using diffusion tensor imaging

  • Tonya White

      Affiliations

    • Division of Child and Adolescent Psychiatry, F256/2B, University of Minnesota, Fairview University Medical Center, 2450 Riverside Avenue, Minneapolis, MN 55454, United States
    • Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, MN 55455, United States
    • Center for Neurobehavioral Development, School of Social Work, University of Minnesota, 105 Peters Hall, 1404 Gortner Avenue, Saint Paul, MN 55108, United States
    • Corresponding Author InformationCorresponding author. Division of Child and Adolescent Psychiatry, F256/2B, University of Minnesota, Fairview University Medical Center, 2450 Riverside Avenue, Minneapolis, MN 55454, United States. Tel.: +1 612 273 9762; fax: +1 612 273 9779.
    • Current address: Department of Child and Adolescent Psychiatry Erasmus MC-Sophia kamer WK219 Dr. Molewaterplein 60, Postbus 2060 3000 CB Rotterdam. Tel.: +31 (0) 10 703 7072; fax: +31 (0) 10 463 2111.
    • ,
  • Marcus Schmidt

      Affiliations

    • Division of Child and Adolescent Psychiatry, F256/2B, University of Minnesota, Fairview University Medical Center, 2450 Riverside Avenue, Minneapolis, MN 55454, United States
    • ,
  • Canan Karatekin

      Affiliations

    • Center for Neurobehavioral Development, School of Social Work, University of Minnesota, 105 Peters Hall, 1404 Gortner Avenue, Saint Paul, MN 55108, United States
    • Institute of Child Development, University of Minnesota, 51 East River Parkway, Minneapolis, MN 55455, United States

Received 16 November 2008 ,Revised 6 March 2009 ,Accepted 27 April 2009.

References 

  1. Agartz I, Andersson JL, Skare S. Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study. Neuroreport. 2001;12(10):2251–2254
  2. Andersson J, Jenkinson M, Smith S. Non-linear optimisation. In: FMRIB technical report TR07JA1 from www.fmrib.ox.ac.uk/analysis/techrep. 2007;
  3. Andersson J, Jenkinson M, Smith S. Non-linear registration, aka Spatial normalisation. In: FMRIB technical report TR07JA2 from www.fmrib.ox.ac.uk/analysis/techrep. 2007;
  4. Andreasen NC. The Scale for the Assessment of Negative Symptoms (SANS), Vol. The University of Iowa; 1983;
  5. Andreasen NC. The Scale for the Assessment of Positive Symptoms (SAPS), Vol. The University of Iowa; 1984;
  6. Asarnow RF, Nuechterlein KH, Fogelson D, Subotnik KL, Payne DA, Russell AT, et al. Schizophrenia and schizophrenia-spectrum personality disorders in the first-degree relatives of children with schizophrenia: the UCLA family study. Archives of General Psychiatry. 2001;58(6):581–588
  7. Dale AM, Fischl B, Sereno MI. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage. 1999;9(2):179–194
  8. Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, et al. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Archives of General Psychiatry. 2003;60(5):443–456
  9. Flynn SW, Lang DJ, Mackay AL, Goghari V, Vavasour IM, Whittall KP, et al. Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Molecular Psychiatry. 2003;8(9):811–820
  10. Frazier JA, McClellan J, Findling RL, Vitiello B, Anderson R, Zablotsky B, et al. Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics. Journal of the American Academy of Child and Adolescent Psychiatry. 2007;46(8):979–988
  11. Friedman JI, Tang C, Carpenter D, Buchsbaum M, Schmeidler J, Flanagan L, et al. Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients. American Journal of Psychiatry. 2008;165(8):1024–1032
  12. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome?. Clinical Neuroscience. 1995;3(2):89–97
  13. Gilmore CP, Donaldson I, Bo L, Owens T, Lowe JS, Evangelou N. Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord. Journal of Neurology, Neurosurgery and Psychiatry. 2009;80(2):182–187
  14. Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, et al. Genome-wide expression analysis reveals dysregulation of myelination- related genes in chronic schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 2001;98(8):4746–4751
  15. Heckers S, Heinsen H, Geiger B, Beckmann H. Hippocampal neuron number in schizophrenia. A stereological study. Archives of General Psychiatry. 1991;48(11):1002–1008
  16. Inoue Y, Nakajima S, Fukuda T, Nemoto Y, Shakudo M, Murata R, et al. Magnetic resonance images of tuberous sclerosis. Further observations and clinical correlations. Neuroradiology. 1988;30(5):379–384
  17. Jones DK, Symms MR, Cercignani M, Howard RJ. The effect of filter size on VBM analyses of DT-MRI data. Neuroimage. 2005;26(2):546–554
  18. Kanaan RA, Kim JS, Kaufmann WE, Pearlson GD, Barker GJ, McGuire PK. Diffusion tensor imaging in schizophrenia. Biological Psychiatry. 2005;58(12):921–929
  19. Kanaan RA, Shergill SS, Barker GJ, Catani M, Ng VW, Howard R, et al. Tract-specific anisotropy measurements in diffusion tensor imaging. Psychiatry Research: Neuroimaging. 2006;146(1):73–82
  20. Karoutzou G, Emrich HM, Dietrich DE. The myelin-pathogenesis puzzle in schizophrenia: a literature review. Molecular Psychiatry. 2008;13(3):245–260
  21. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36(7):980–988
  22. Kubicki M, McCarley R, Westin CF, Park HJ, Maier S, Kikinis R, et al. A review of diffusion tensor imaging studies in schizophrenia. Journal of Psychiatric Research. 2007;41(1–2):15–30
  23. Kyriakopoulos M, Bargiotas T, Barker GJ, Frangou S. Diffusion tensor imaging in schizophrenia. European Psychiatry. 2008;23(4):255–273
  24. Lachar D, Randle SL, Harper RA, Scott-Gurnell KC, Lewis KR, Santos CW, et al. The brief psychiatric rating scale for children (BPRS-C): validity and reliability of an anchored version. Journal of the American Academy of Child and Adolescent Psychiatry. 2001;40(3):333–340
  25. Makki MI, Chugani DC, Janisse J, Chugani HT. Characteristics of abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MR imaging in tuberous sclerosis complex. AJNR, American Journal of Neuroradiology. 2007;28(9):1662–1667
  26. Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, et al. Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage. 2008;40(2):570–582
  27. Oishi K, Zilles K, Amunts K, Faria A, Jiang H, Li X, et al. Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter. Neuroimage. 2008;43(3):447–457
  28. Rabe-Jablonska JK, Gmitrowticz A. Clinical picture and duration of prodromal period of schizophrenia in adolescents. Archives of Psychiatry and Psychotherapy. 2000;2(4):31–38
  29. Rapoport JL, Inoff-Germain G. Update on childhood-onset schizophrenia. Current Psychiatry Reports. 2000;2(5):410–415
  30. Rapoport JL, Giedd JN, Blumenthal J, Hamburger S, Jeffries N, Fernandez T, et al. Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. Archives of General Psychiatry. 1999;56(7):649–654
  31. Rueckert D, Sonoda LI, Hayes C, Hill DL, Leach MO, Hawkes DJ. Nonrigid registration using free-form deformations: application to breast MR images. IEEE Transactions on Medical Imaging. 1999;18(8):712–721
  32. Smith SM. Fast robust automated brain extraction. Human Brain Mapping. 2002;17(3):143–155
  33. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004;23(Suppl 1):S208–S219
  34. Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, et al. Tract-based spatial statistics: voxelwise analysis of multi–subject diffusion data. Neuroimage. 2006;31(4):1487–1505
  35. Stark AK, Uylings HB, Sanz-Arigita E, Pakkenberg B. Glial cell loss in the anterior cingulate cortex, a subregion of the prefrontal cortex, in subjects with schizophrenia. American Journal of Psychiatry. 2004;161(5):882–888
  36. Uranova NA, Vostrikov VM, Orlovskaya DD, Rachmanova VI. Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium. Schizophrenia Research. 2004;67(2–3):269–275
  37. Uranova NA, Vostrikov VM, Vikhreva OV, Zimina IS, Kolomeets NS, Orlovskaya DD. The role of oligodendrocyte pathology in schizophrenia. International Journal of Neuropsychopharmacology. 2007;10(4):537–545
  38. Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S. Fiber tract-based atlas of human white matter anatomy. Radiology. 2004;230(1):77–87
  39. White T, O'Leary D, Magnotta V, Arndt S, Flaum M, Andreasen NC. Anatomic and functional variability: the effects of filter size in group fMRI data analysis. Neuroimage. 2001;13(4):577–588
  40. White T, Nelson M, Lim KO. Diffusion tensor imaging in psychiatric disorders. Topics in Magnetic Resonance Imaging. 2008;19(2):97–109

PII: S0925-4927(09)00114-0

doi: 10.1016/j.pscychresns.2009.04.014

Psychiatry Research: Neuroimaging
Volume 174, Issue 2 , Pages 110-115 , 30 November 2009

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