Psychiatry Research: Neuroimaging
Volume 174, Issue 2 , Pages 97-104 , 30 November 2009

Efficiency of working memory encoding in twins discordant for schizophrenia

  • Peter Bachman

      Affiliations

    • Department of Psychology, University of California, Los Angeles (UCLA), 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 310 206 7174; fax: +1 310 206 5895.
    • ,
  • Junghoon Kim

      Affiliations

    • Moss Rehabilitation Research Institute, 1200 W. Tabor Rd., Philadelphia, PA 19141, United States
    • ,
  • Cindy M. Yee

      Affiliations

    • Department of Psychology, University of California, Los Angeles (UCLA), 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, United States
    • Department of Psychiatry and Biobehavioral Sciences, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, United States
    • ,
  • Sebastian Therman

      Affiliations

    • Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
    • ,
  • Marko Manninen

      Affiliations

    • Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
    • ,
  • Jouko Lönnqvist

      Affiliations

    • Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
    • ,
  • Jaakko Kaprio

      Affiliations

    • Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
    • Department of Public Health, Faculty of Medicine, P.O. Box 41, Mannerheimintie 172, FIN-00014 Helsinki, University of Helsinki, Finland
    • ,
  • Matti O. Huttunen

      Affiliations

    • Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
    • ,
  • Risto Näätänen

      Affiliations

    • Cognitive Brain Research Unit, Department of Psychology, P.O. Box 9, Siltavuorenpenger 20 C, FIN-00014 Helsinki, University of Helsinki, Finland
    • Helsinki Brain Research Centre, P.O. Box 9, Siltavuorenpenger 20 C, FIN-00014 Helsinki, University of Helsinki, Helsinki, Finland
    • ,
  • Tyrone D. Cannon

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, United States

Received 27 May 2008 ,Revised 24 April 2009 ,Accepted 24 April 2009.

References 

  1. Andreasen NC. The Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, IA: The University of Iowa; 1984;
  2. Andreasen NC. The Scale for the Assessment of Negative Symptoms (SANS). Iowa City, IA: The University of Iowa; 1984;
  3. Barch DM. The cognitive neuroscience of schizophrenia. Annual Review of Clinical Psychology. 2005;1:321–353
  4. Bertolino A, Caforio G, Blasi G, De Candia M, Latorre V, Petruzzella V. Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. American Journal of Psychiatry. 2004;161:1798–1805
  5. Birbaumer N, Elbert T, Canavan AG, Rockstroh B. Slow potentials of the cerebral cortex and behavior. Physiological Reviews. 1990;70:1–41
  6. Bramon E, McDonald C, Croft RJ, Landau S, Filbey F, Gruzelier JH, et al. Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study. Neuroimage. 2005;27:960–968
  7. Butler PD, Martinez A, Foxe JJ, Kim D, Zemon V, Silipo G, et al. Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments. Brain. 2007;130:417–430
  8. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. American Journal of Psychiatry. 2003;160:2209–2215
  9. Cameron AM, Geffen GM, Kavanagh DJ, Wright MJ, McGrath JJ, Geffen LB. Event-related potential correlates of impaired visuospatial working memory in schizophrenia. Psychophysiology. 2003;40:702–715
  10. Cannon TD, Kaprio J, Lönnqvist J, Huttunen M, Koskenvuo M. The genetic epidemiology of schizophrenia in a Finnish twin cohort: a population-based modeling study. Archives of General Psychiatry. 1998;55:67–74
  11. Chiu P, Ambady N, Deldin P. Contingent negative variation to emotional in- and out-group stimuli differentiates high- and low-prejudiced individuals. Journal of Cognitive Neuroscience. 2004;16:1830–1839
  12. Davenport ND, Sponheim SR, Stanwyck JJ. Neural anomalies during visual search in schizophrenia patients and unaffected siblings of schizophrenia patients. Schizophrenia Research. 2006;82:15–26
  13. Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of Neuroscience Methods. 2004;134:9–21
  14. Donchin E, Coles MGH. Is the P300 component a manifestation of context updating?. Behavioral and Brain Sciences. 1988;11:357–374
  15. Doniger GM, Foxe JJ, Murray MM, Higgins BA, Javitt DC. Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia. Archives of General Psychiatry. 2002;59:1011–1020
  16. Fuller RL, Luck SJ, McMahon RP, Gold JM. Working memory consolidation is abnormally slow in schizophrenia. Journal of Abnormal Psychology. 2005;114:279–290
  17. Gasperoni TL, Ekelund J, Huttunen M, Palmer CG, Tuulio-Henriksson A, Lönnqvist J, et al. Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. American Journal of Medical Genetics. 2003;116B:8–16
  18. Glahn DC, Therman S, Manninen M, Huttunen M, Kaprio J, Lönnqvist J, et al. Spatial working memory as an endophenotype for schizophrenia. Biological Psychiatry. 2003;53:624–626
  19. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry. 2003;160:636–645
  20. Granholm E, Morris SK, Sarkin AJ, Asarnow RF, Jeste DV. Pupillary responses index overload of working memory resources in schizophrenia. Journal of Abnormal Psychology. 1997;106:458–467
  21. Groom MJ, Bates AT, Jackson GM, Calton TG, Liddle PF, Hollis C. Event-related potentials in adolescents with schizophrenia and their siblings: a comparison with attention-deficit/hyperactivity disorder. Biological Psychiatry. 2008;63:784–792
  22. Haenschel C, Bittner RA, Haertling F, Rotarska-Jagiela A, Maurer K, Singer W, et al. Contribution of impaired early-stage visual processing to working memory dysfunction in adolescents with schizophrenia. Archives of General Psychiatry. 2007;64:1229–1240
  23. Handy TC, Mangun GR. Attention and spatial selection: electrophysiological evidence for modulation by perceptual load. Perception and Psychophysics. 2000;62:175–186
  24. Hockey GR. Compensatory control in the regulation of human performance under stress and high workload: a cognitive-energetical framework. Biological Psychology. 1997;45:73–93
  25. Jasper HH. Report of the Committee on Methods of Clinical Examination in Electroencephalography. Electroencephalography and Clinical Neurophysiology. 1958;10:370–371
  26. Jeon YW, Polich J. Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. Psychophysiology. 2003;40:684–701
  27. Jung TP, Makeig S, Westerfield M, Townsend J, Courchesne E, Sejnowski TJ. Removal of eye activity artifacts from visual event-related potentials in normal and clinical subjects. Clinical Neurophysiology. 2000;111:1745–1758
  28. Kahneman D. Attention and Effort. New Jersey: Prentice Hall; 1973;
  29. Kaprio J, Koskenvuo M. Genetic and environmental factors in complex diseases: the older Finnish twin cohort. Twin Research. 2002;5:358–365
  30. Karlsgodt KH, Glahn DC, van Erp TG, Therman S, Huttunen M, Manninen M. The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophrenia Research. 2007;89:191–197
  31. Klein C, Rockstroh B, Cohen R, Berg P. Contingent negative variation (CNV) and determinants of the post-imperative negative variation (PINV) in schizophrenic patients and healthy controls. Schizophrenia Research. 1996;21:97–110
  32. Lee J, Park S. Working memory impairments in schizophrenia: a meta-analysis. Journal of Abnormal Psychology. 2005;114:599–611
  33. Loranger, A.W., Sussman, V.L., Oldham, J.M., Russakoff, L.M., 1985. Personality Disorder Examination: A Structured Interview for Making Diagnosis of DSM-III-R Personality Disorders. Cornell Medical College, White Plains, N.Y.
  34. Low A, Rockstroh B, Harsch S, Berg P, Cohen R. Event-related potentials in a working-memory task in schizophrenics and controls. Schizophrenia Research. 2000;46:175–186
  35. Mangia S, Giove F, Tkáč I, Logothetis NK, Henry P-G, Olman CA, et al. Metabolic and hemodynamic events after changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings. Journal of Cerebral Blood Flow and Metabolism. 2008;1–23
  36. Manoach DS. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophrenia Research. 2003;60:285–298
  37. McEvoy LK, Smith ME, Gevins A. Dynamic cortical networks of verbal and spatial working memory: effects of memory load and task practice. Cerebral Cortex. 1998;8:563–574
  38. Muller NG, Knight RT. Age-related changes in fronto-parietal networks during spatial memory: an ERP study. Brain Research: Cognitive Brain Research. 2002;13:221–234
  39. Nunez P, Srinivasan R. Electric Fields of the Brain. The Neurophysics of EEG. 2nd ed.. New York: Oxford University Press; 2006;
  40. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Archives of General Psychiatry. 1992;49:975–982
  41. Park S, Holzman PS, Goldman-Rakic PS. Spatial working memory deficits in the relatives of schizophrenic patients. Archives of General Psychiatry. 1995;52:821–828
  42. Piskulic D, Olver JS, Norman TR, Maruff P. Behavioral studies of spatial working memory dysfunction in schizophrenia: a quantitative literature review. Psychiatry Research. 2007;150:111–121
  43. Potkin SG, Turner JA, Brown GG, McCarthy G, Greve DN, Glover GH, et al. Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study. Schizophrenia Bulletin. 2009;35:19–31
  44. Roth WT, Kopell BS, Tinklenberg JR, Darley CF, Sikora R, Vesecky TB. The contingent negative variation during a memory retrieval task. Electroencephalography and Clinical Neurophysiology. 1975;38:171–174
  45. Rypma B, Berger JS, Prabhakaran V, Bly BM, Kimberg DY, Biswal B, et al. Neural correlates of cognitive efficiency. NeuroImage. 2006;33:969–979
  46. Saperstein AM, Fuller RL, Avila MT, Adami H, McMahon RP, Thaker GK, et al. Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunction. Schizophrenia Bulletin. 2006;32:498–506
  47. Schlösser RGM, Koch K, Wagner G, Nenadic I, Roebel M, Schachtzabel C. Inefficient executive cognitive control in schizophrenia preceded by altered functional activation during information encoding: an fMRI study. Neuropsychologia. 2008;46:336–347
  48. Sirevaag EJ, Kramer AF, Coles MG, Donchin E. Resource reciprocity: an event-related brain potentials analysis. Acta Psycholica (Amsterdam). 1989;70:77–97
  49. Smulders FTY, Kok A, Kenemans JL, Bashore TR. The temporal selectivity of additive factor effects on the reaction process revealed in ERP component latencies. Acta Psychologica. 1995;90:97–109
  50. Spitzer RL, Endicott J, Williams JB. Research diagnostic criteria. Archives of General Psychiatry. 1979;36:1381–1383
  51. Sumich A, Kumari V, Dodd P, Ettinger U, Hughes C, Zachariah E, et al. N100 and P300 amplitude to Go and No-Go variants of the auditory oddball in siblings discordant for schizophrenia. Schizophrenia Research. 2008;98:265–277
  52. Tan HY, Choo WC, Fones CS, Chee MW. The effect of working memory performance on functional MRI in schizophrenia. Schizophrenia Research. 2005;74:179–194
  53. Thermenos HW, Seidman LJ, Breiter H, Goldstein JM, Goodman JM, Poldrack R. Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study. Biological Psychiatry. 2004;55:490–500
  54. Van Snellenberg JX, Torres IJ, Thornton AE. Functional neuroimaging of working memory in schizophrenia: task performance as a moderating variable. Neuropsychology. 2006;20:497–510
  55. Virtanen J, Rinne T, Ilmoniemi RJ, Näätänen R. MEG-compatible multichannel EEG electrode array. Electroencephalography and Clinical Neurophysiology. 1996;99:568–580
  56. Vogel EK, Luck SJ. Delayed working memory consolidation during the attentional blink. Psychonomic Bulletin and Review. 2002;9:739–743
  57. Waldo MC, Adler LE, Freedman R. Defects in auditory sensory gating and their apparent compensation in relatives of schizophrenics. Schizophrenia Research. 1988;1:19–24
  58. Walter WG, Cooper R, Aldridge VJ, McCallum WC, Winter AL. Contingent negative variation: an electric sign of sensorimotor association and expectancy in the human brain. Nature. 1964;203:380–384
  59. Winterer G, Weinberger DR. Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends in Neurosciences. 2004;27:683–690

☆ Previous presentation: Portions of this work were presented at the meeting of the Society for Psychophysiology Research in Vancouver, BC, October 25–29, 2006.

PII: S0925-4927(09)00111-5

doi: 10.1016/j.pscychresns.2009.04.010

Psychiatry Research: Neuroimaging
Volume 174, Issue 2 , Pages 97-104 , 30 November 2009

Article Tools

* Image Usage & Resolution