Psychiatry Research: Neuroimaging
Volume 174, Issue 2 , Pages 81-88 , 30 November 2009

Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: A meta-analysis

  • Yaling Yang

      Affiliations

    • Laboratory of NeuroImaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 310 663 2088; fax: +1 310 372 4964.
  • ,
  • Adrian Raine

      Affiliations

    • Department of Criminology, Psychiatry, and Psychology, University of Pennsylvania, Philadelphia, PA, United States

Received 17 July 2008 ,Revised 18 March 2009 ,Accepted 22 March 2009.

References 

  1. Amen DG, Stubblefield M, Carmicheal B, Thisted R. Brain SPECT findings and aggressiveness. Annals of Clinical Psychiatry. 1996;8(3):129–137
  2. Anckarsater H. Central nervous changes in social dysfunction: autism, aggression, and psychopathy. Brain Research Bulletin. 2006;69(3):259–265
  3. Angrilli A, Palomba D, Cantagallo A, Maietti A, Stegagno L. Emotional impairment after right orbitofrontal lesion in a patient without cognitive deficits. Neuroreport,. 1999;10(8):1741–1746
  4. Antonucci AS, Gansler DA, Tan S, Bhadelia R, Patz S, Fulwiler C. Orbitofrontal correlates of aggression and impulsivity in psychiatric patients. Psychiatry Research: Neuroimaging. 2006;147(2–3):213–220
  5. Barkataki I, Kumari V, Das M, Taylor P, Sharma T. Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder. Behavioural Brain Research. 2006;169(2):239–247
  6. Bechara A. The role of emotion in decision making: evidence from neurological patients with orbitofrontal damage. Brain and Cognition. 2004;55(1):30–40
  7. Blair RJ. Neurocognitive models of aggression, the antisocial personality disorders, and psychopathy. Journal of Neurology, Neurosurgery, & Psychiatry. 2001;71(6):727–731
  8. Birbaumer N, Veit R, Lotze M, Erb M, Hermann C, Grodd W, et al. Deficient fear conditioning in psychopathy: a functional magnetic resonance imaging study. Archive General Psychiatry. 2005;62(7):799–805
  9. Borenstein AR, Wu Y, Mortimer JA, Schellenberg GD, McCormick WC, Bowen JD, et al. Developmental and vascular risk factors for Alzheimer's disease. Neurobiology of Aging. 2005;26(3):325–334
  10. Brower MC, Price BH. Neuropsychiatry of frontal lobe dysfunction in violent and criminal behavior: a critical review. Journal of Neurology, Neurosurgery, & Psychiatry. 2001;71(6):720–726
  11. Campbell TG. The best of a bas bunch: the ventromedial prefrontal cortex and dorsal anterior cingulate cortex in decision-making. Journal of Neuroscience. 2007;27(3):447–448
  12. Coccaro EF, McCloskey MS, Fitzgerald DA, Phan KL. Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression. Biological Psychiatry. 2007;62(2):168–178
  13. Cohen J. Statistical Power Analysis for the Behavioural Sciences. 2nd ed.. New York: Academic Press; 1988;
  14. Colvin MK, Dunbar K, Grafman J. The effects of frontal lobe lesions on goal achievement in the water jug task. Journal of Cognitive Neuroscience,. 2001;13(8):1129–1147
  15. Creasy JL, Partain CL, Price RP. Quality of clinical MR images and the use of contrast agents. Radiographics,. 1995;15(3):683–696
  16. Critchley HD, Simmons A, Daly EM, Russell A, van Amelsvoort T, Robertson DM, et al. Prefrontal and medial temporal correlates of repetitive violence to self and others. Biological Psychiatry. 2000;47(10):928–934
  17. Damasio, A.R., 1994. Descartes' Error: Emotion, Reason, and the Human Brain. Grosset/ Putnam, New York.
  18. Danckert J, Maruff P, Ymer C, Kinsella G, Yucel M, de Graaff S, et al. Goal-directed selective attention and response competition monitoring: evidence from unilateral parietal and anterior cingulate lesions. Neuropsychology. 2000;14(1):16–28
  19. Davidson RJ, Putnam KM, Larson CL. Dysfunction in the neural circuitry of emotion regulation — a possible prelude to violence. Science. 2000;289(5479):591–594
  20. Dolan MC, Deakin JF, Roberts N, Anderson IM. Quantitative frontal and temporal structural MRI studies in personality-disordered offenders and control subjects. Psychiatry Research: NeuroImaging. 2002;116(3):133–149
  21. Dum RP, Strick PL. The origin of corticospinal projections from the premotor areas in the frontal lobe. Journal of Neuroscience. 1991;11(6):667–689
  22. Duncan J, Owen AM. Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends in Neuroscience. 2000;23(10):475–483
  23. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–634
  24. Erlinger PJ, Damasio AR. Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology. 1985;35(12):1731–1741
  25. Frankle WG, Lombardo I, New AS, Goodman M, Talbot PS, Huang Y, et al. Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652. American Journal of Psychiatry. 2005;162(5):915–923
  26. George DT, Rawlings RR, Williams WA, Phillips MJ, Fong G, Kerich M, et al. A select group of perpetrators of domestic violence: evidence of decreased metabolism in the right hypothalamus and reduced relationships between cortical/subcortical brain structures in position emission tomography. Psychiatry Research: NeuroImaging. 2004;130(1):11–25
  27. Gordon HL, Baird AA, End A. Functional differences among those high and low on a trait measure of psychopathy. Biological Psychiatry. 2004;56(7):516–521
  28. Gorenstein EE, Newman JP. Disinhibitory psychopathology: a new perspective and a model for research. Psychological Review. 1980;87(2):301–315
  29. Goyer PF, Andreason PJ, Semple WE, Clayton AH. Positron-emission tomography and personality disorders. Neuropsychopharmacology. 1994;10(1):21–28
  30. Grattan LM, Eslinger PJ. Long-term psychological consequences of childhood frontal lobe lesion in patient DT. Brain and Cognition. 1992;20(1):185–195
  31. Hare RD. Manual for the Revised Psychopathy Checklist. 2nd ed.. Toronto, ON, Canada: Multi-Health Systems; 2003;
  32. Hedges LV, Olkin I. Statistical Methods for Meta-Analysis. San Diego: Academic Press; 1985;
  33. Henry B, Moffitt TE. Neuropsychological and neuroimaging studies of juvenile delinquency and adult criminal behavior. In: Handbook of Antisocial Behavior. 1997;p. 280–288
  34. Hirono N, Mega MS, Dinov ID, Mishkin F, Cummings JL. Left frontaltemporal hypoperfusion is associate with aggression in patients with dementia. Archives of Neurology. 2000;57(6):861–866
  35. Holmes SE, Slaughter JR, Kashani J. Risk factors in childhood that lead to the development of conduct disorder and antisocial personality disorder. Child Psychiatry and Human Development. 2001;31(3):183–193
  36. Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO. Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study. Biological Psychiatry. 2002;52(1):9–14
  37. Hoptman MJ, Volavka J, Weiss EM, Czobor P, Szeszko PR, Gerig G, et al. Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder. Psychiatry Research: NeuroImaging. 2005;140(2):133–145
  38. Hornak J, Bramham J, Rolls ET, Morris RG, O'Doherty J, Bullock PR, et al. Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulated cortices. Brain. 2003;126(7):1691–1712
  39. Hornak J, O'Doherty J, Bramham J, Rolls ET, Morris RG, Bullock PR, et al. Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. Journal of Cognitive Neuroscience. 2004;16(3):463–478
  40. Intrator J, Hare R, Stritzke P, Brichtswein K, Dorfman D, Harpur T, et al. A brain imaging (single photon emission computerized tomography) study of semantic and affective processing in psychopaths. Biological Psychiatry. 1997;42(2):96–103
  41. Johnson CA, Cioffi GA, Liemann JR, Sample PA, Zangwill LM, Weinreb RN. The relationship between structural and functional alternations in glaucoma: a review. Seminars in Ophthalmology. 2000;15(4):221–233
  42. Joyal CC, Putkonen A, Mancini-Marie A, Hodgins S, Kononen M, Boulay L, et al. Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study. Schizophrenia Research. 2007;91(1–3):97–102
  43. Juhasz C, Behen ME, Muzik O, Chugani DC, Chugani HT. Bilateral medial prefrontal and temporal neocortical hypometabolism in children with epilepsy and aggression. Epilepsia. 2001;42(8):991–1001
  44. Kiehl KA. A cognitive neuroscience perspective on psychopathy: evidence for paralimbic system dysfunction. Psychiatry Research. 2006;142(2–3):107–128
  45. Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, et al. Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biological Psychiatry. 2001;50(9):677–684
  46. Kiehl KA, Smith AM, Mendrek A, Forster BB, Hare RD, Liddle PF. Temporal lobe abnormalities in semantic processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Psychiatry Research. 2004;130(3):27–42
  47. Kosson DS. Psychopathy and dual-task performance under focusing conditions. Journal of Abnormal Psychology. 1998;105(3):391–400
  48. Kruesi MJ, Casanova MF, Mannheim G, Johnson-Bilder A. Reduced temporal lobe volume in early onset conduct disorder. Psychiatry Research. 2004;132(1):1–11
  49. Kuruoglu AC, Arikan Z, Vural G, Karatas M, Arac M, Isik E. Single photon emission computerized tomography in chronic alcoholism: antisocial personality disorder may be associated with decreased frontal perfusion. British Journal of Psychiatry. 1996;169(3):348–354
  50. Kumari V, Das M, Hodgins S, Zachariah E, Barkataki I, Howlett M, et al. Association between violent behavior and impaired prepulse inhibition of the startle response in antisocial personality disorder and schizophrenia. Behavioural Brain Research. 2005;158(1):159–166
  51. Laakso MP, Gunning-Dixon F, Vaurio O, Repo-Tiihonen E, Soininen H, Tiihonen J. Prefrontal volume in habitually violent subjects with antisocial personality disorder and type 2 alcoholism. Psychiatry Research. 2002;114(2):95–102
  52. Levin CS, Hoffman EJ. Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution. Physics in Medicine and Biology. 1999;44(3):781–799
  53. Li TQ, Mathews VP, Wang Y, Dunn D, Kronenberger W. Adolescents with disruptive behavior disorder investigated using an optimized MR diffusion tensor imaging protocol. Annals of the New York Academy of Sciences. 2005;1064:184–192
  54. Li CS, Kosten TR, Sinha R. Antisocial personality and stress-induced brain activation in cocaine-dependent patients. NeuroReport. 2006;17(3):243–247
  55. Lilienfeld SO, Andrews BP. Developmental and preliminary validation of a self-report measure of psychopathic personality traits in noncriminal populations. Journal of Personality Assessment. 1996;66(3):488–524
  56. Mathews VP, Kronenberger WG, Wang Y, Lurito JT, Lowe MJ, Dunn DW. Media violence exposure and frontal lobe activation measured by functional magnetic resonance imaging in aggressive and nonaggressive adolescents. Journal of Computer Assisted Tomography. 2005;29(3):287–292
  57. Mena JC, Cuellar H, Vargas D, Riascos R. PET and SPECT in drug and substance abuse. Topics in Magnetic Resonance Imaging. 2005;16(3):253–256
  58. Menon RS, Thomas CG, Gati JS. Investigation of BOLD contrast in fMRI using multi-shot EPI. NMR in Biomedicine. 1997;10(4–5):179–182
  59. McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA, et al. MRI anatomy of schizophrenia. Biological Psychiatry. 1999;45(9):1099–1119
  60. Müller JL, Sommer M, Wagner V, Lange K, Taschler H, Roder CH, et al. Abnormalities in emotion processing within cortical and subcortical regions in criminal psychopaths: evidence from a functional magnetic resonance imaging study using pictures with emotional content. Biological Psychiatry. 2003;54(2):152–162
  61. Nakano S, Asada T, Yamashita F, Kitamura N, Matsuda H, Hirai S, et al. Relationship between antisocial behavior and regional cerebral blood flow in frontotemporal dementia. Neuroimage. 2006;32(1):301–306
  62. Oder W, Goldenberg G, Spatt J, Podreka I, Binder H, Deecke L. Behavioural and psychosocial and regional cerebral blood flow: a SPECT study. Journal of Neurology, Neurosurgery, and Psychiatry. 1992;55(6):475–480
  63. Ongur D, Ferry AT, Price JL. Architectonic subdivision of the human orbital and medial prefrontal cortex. Journal of Comparative Neurology. 2003;460(3):425–449
  64. Orwin RG. A fail safe N for effect size in meta-analysis. Journal of Educational Statistics. 1983;8(2):157–159
  65. Parsey RV, Oquendo MA, Simpson NR, Ogden RT, Van Heertum R, Arango V, et al. Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100625. Brain Research. 2002;954(2):173–182
  66. Petrides M, Pandya DN. Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. European Journal of Neuroscience. 1999;11(3):1011–1036
  67. Petrides M, Pandya DN. Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey. European Journal of Neuroscience. 2001;16(2):291–310
  68. Raine A. The psychopathology of crime: Criminal behavior as a clinical disorder. San Diego: Academic Press; 1993;
  69. Raine A. Biosocial studies of antisocial and violent behavior in children and adults: a review. Journal of Abnormal Child Psychology. 2002;30(5):311–326
  70. Raine A, Buchsbaum MS. Violence, brain imaging, and neuropsychology. In: Aggression and violence: Genetic, neurobiological, and biosocial perspectives. 1996;p. 195–217
  71. Raine A, Yang Y. The neuroanatomical bases of psychopathy: a review of brain imaging findings. In:  Patrick CJ editors. Handbook of Psychopathy. New York: Guilford; 2004;
  72. Raine A, Yang Y. Neural foundations to moral reasoning and antisocial behavior. Soc Cognitive and Affective Neuroscience,. 2006;1:203–213
  73. Raine A, Buchsbaum M, LaCasse L. Brain abnormalities in murderers indicated by positron emission tomography. Biological Psychiatry. 1997;42(6):495–508
  74. Raine A, Lencz T, Bihrle S, LaCasse L, Colletti P. Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Archives of General Psychiatry. 2000;57(2):119–127
  75. Rilling JK, Glenn AL, Jairam MR, Pagnoni G, Goldsmith DR, Elfenbein HA, et al. Neural correlates of social cooperation and non-cooperation as a function of psychopathy. Biological Psychiatry. 2007;61(11):1260–1270
  76. Rosenthal R. Combining results of independent studies. Psychological Bulletin. 1978;85(1):185–193
  77. Rosenthal R. The “file drawer problem” and tolerance for null results. Psychological Bulletin. 1979;86(3):638–641
  78. Rosenthal R. Meta-analysis: a review. Psychosomatic Medicine. 1991;53(3):247–271
  79. Schneider F, Habel U, Kessler C, Posse S, Grodd W, Muller-Gartner H. Functional imaging of conditioned aversive emotional responses in antisocial personality disorder. Neuropsychobiology. 2000;42(4):192–201
  80. Soderstrom H, Tullberg M, Wikkelso C, Ekholm S, Forsman A. Reduced regional cerebral blood flow in non-psychotic violent offenders. Psychiatry Research: NeuroImaging. 2000;98(1):29–41
  81. Soderstrom H, Hultin L, Tullberg M, Wikkelso C, Ekholm S, Forsman A. Reduced frontotemporal perfusion in psychopathic personality. Psychiatry Research. 2002;114(2):81–94
  82. Spampinato MV, Castillo M, Rojas R, Palacios E, Frascheri L, Descartes F. Magnetic resonance imaging findings in substance abuse: alcohol and alcoholism and syndromes associated with alcohol abuse. Topics in Magnetic Resonance Imaging. 2005;16(3):223–230
  83. Stadler C, Sterzer P, Schmeck K, Krebs A, Kleinschmidt A, Poustka F. Reduced anterior cingulate activation in aggressive children and adolescents during affective stimulation: association with temperament traits. Journal of Psychiatric Research. 2007;41(5):410–417
  84. Sterzer P, Stadler C, Krebs A, Kleinschmidt A, Poustka F. Abnormal neural responses to emotional visual stimuli in adolescents with conduct disorder. Biological Psychiatry. 2005;57(1):7–15
  85. Stuss DT, Floden D, Alexander MP, Levine B, Katz D. Stroop performance in focal lesion patients: dissociation of processes and frontal lobe lesion location. Neuropsychologia. 2001;39(8):771–786
  86. Thomsen T, Specht K, Rimol LM, Hammer A, Nyttingnes J, Ersland L, et al. Brain localization of attentional control in different age groups by combining functional and structural MRI. Neuroimage. 2004;22(2):912–919
  87. Tranel D, Bechara A, Denburg NL. Asymmetric functional roles of right and left ventromedial prefrontal cortices in social conduct, decision-making, and emotional processing. Cortex. 2002;38(4):589–612
  88. Veit R, Flor H, Erb M, Hermann C, Lotze M, Grodd W, et al. Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neuroscience Letters. 2002;238:233–236
  89. Vermeiren R, Deboutte D, Ruchkin V, Schwab-Stone M. Antisocial behaviour and mental health. Findings from three communities. European Child & Adolescent Psychiatry. 2002;11(4):168–175
  90. Volkow ND, Tancredi LR, Grant C, Gillespie H, Valentine A, Mullani N, et al. Brain glucose metabolism in violent psychiatric patients: a preliminary study. Psychiatry Research: NeuroImaging. 1995;61(4):243–253
  91. Volz KG, Schubotz RI, von Cramon DY. Decision-making and the frontal lobes. Current Opinion in Neurology. 2006;19(4):401–406
  92. Woermann FG, Van Elst LT, Koepp MJ, Free SL, Thompson PJ, Trimble MR, et al. Reduction of frontal neocortical grey matter associated with affective aggression in patients with temporal lobe epilepsy: an objective voxel by voxel analysis of automatically segmented MRI. Journal of Neurology, Neurosurgery, and Psychiatry. 2000;68(2):162–169
  93. Yang Y, Raine A. Functional and structural brain imaging research on psychopathy. In:  Felthous AH,  Sass H editor. International Handbook on Psychopathic Disorders and the Law. New Jersey: Wiley; 2006;
  94. Yang Y, Raine A. Functional neuroanatomy of psychopathy. Psychiatry. 2008;7(3):133–136
  95. Yang Y, Glenn A, Raine A. Brain abnormalities in antisocial individuals: implications for the law. Behavioral Science and the Law. 2008;26(1):65–83

PII: S0925-4927(09)00088-2

doi: 10.1016/j.pscychresns.2009.03.012

Psychiatry Research: Neuroimaging
Volume 174, Issue 2 , Pages 81-88 , 30 November 2009