Psychiatry Research: Neuroimaging
Volume 174, Issue 1 , Pages 1-8 , 30 October 2009

Higher diffusion in striatum and lower fractional anisotropy in white matter of methamphetamine users

  • Daniel Alicata

      Affiliations

    • Department of Psychiatry, John A. Burns School of Medicine, Honolulu, HI 96813, United States
    • Corresponding Author InformationCorresponding author. Mail Code 1356 Lusitana Street, 7th Floor, Honolulu HI 96813, United States. Tel.: +1 808 586 7456; fax: +1 808 586 7486.
    • ,
  • Linda Chang

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, Honolulu, HI 96813, United States
    • ,
  • Christine Cloak

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, Honolulu, HI 96813, United States
    • ,
  • Kylie Abe

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, Honolulu, HI 96813, United States
    • ,
  • Thomas Ernst

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, Honolulu, HI 96813, United States

Received 22 January 2008 ,Revised 20 March 2009 ,Accepted 20 March 2009.

References 

  1. Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007;4:316–329
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Press; 2000;
  3. Bae SC, Lyoo IK, Sung YH, Yoo J, Chung A, Yoon SJ, et al. Increased white matter hyperintensities in male methamphetamine abusers. Drug and Alcohol Dependence. 2006;81:83–88
  4. Berman S, O'Neill J, Fears S, Bartzokis G, London ED. Abuse of amphetamines and structural abnormalities in the brain. Annals of the New York Academy of Sciences. 2008;1141:195–220
  5. Bhagat YA, Beaulieu C. Diffusion anisotropy in subcortical white matter and cortical gray matter: changes with aging and the role of CSF-suppression. Journal of Magnetic Resonance Imaging. 2004;20:216–227
  6. Brody AL, Mandelkern MA, Jarvik ME, Lee GS, Smith EC, Huang JC, et al. Differences between smokers and nonsmokers in regional gray matter volumes and densities. Biological Psychiatry. 2004;55:77–84
  7. Chang L, Cloak C, Patterson K, Grob C, Miller EN, Ernst T. Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response. Biological Psychiatry. 2005;57:967–974
  8. Chang L, Ernst T, Speck O, Grob CS. Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities. American Journal of Psychiatry. 2005;162:361–369
  9. Chang L, Alicata D, Ernst T, Volkow N. Structural and metabolic brain changes in the striatum associated with methamphetamine abuse. Addiction 102 Suppl. 2007;1:16–32
  10. Chung A, Lyoo IK, Kim SJ, Hwang J, Bae SC, Sung YH, et al. Decreased frontal white-matter integrity in abstinent methamphetamine abusers. International Journal of Neuropsychopharmacology. 2007;10:765–775
  11. Elkashef AM, Rawson RA, Anderson AL, Li SH, Holmes T, Smith EV, et al. Bupropion for the treatment of methamphetamine dependence. Neuropsychopharmacology. 2007;33:1162–1170
  12. Ernst T, Chang L, Leonido-Yee M, Speck O. Evidence for long-term neurotoxicity associated with methamphetamine abuse: a 1H MRS study. Neurology. 2000;54:1344–1349
  13. Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR. New insights into the mechanism of action of amphetamines. Annual Review of Pharmacology and Toxicology. 2007;47:681–698
  14. Gallinat J, Meisenzahl E, Jacobsen LK, Kalus P, Bierbrauer J, Kienast T, et al. Smoking and structural brain deficits: a volumetric MR investigation. European Journal of Neuroscience. 2006;24:1744–1750
  15. Harvey DC, Lacan G, Tanious SP, Melega WP. Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. Brain Research. 2000;871:259–270
  16. Iritani BJ, Hallfors DD, Bauer DJ. Crystal methamphetamine use among young adults in the USA. Addiction. 2007;102:1102–1113
  17. Irwan R, Sijens PE, Potze JH, Oudkerk M. Correlation of proton MR spectroscopy and diffusion tensor imaging. Magnetic Resonance Imaging. 2005;23:851–858
  18. Jacobsen LK, Picciotto MR, Heath CJ, Frost SJ, Tsou KA, Dwan RA, et al. Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure. Journal of Neuroscience. 2007;27:13491–13498
  19. Jernigan TL, Gamst AC, Archibald SL, Fennema-Notestine C, Mindt MR, Marcotte TD, et al. Effects of methamphetamine dependence and HIV infection on cerebral morphology. American Journal of Psychiatry. 2005;162:1461–1472
  20. Jiang H, van Zijl PC, Kim J, Pearlson GD, Mori S. DtiStudio: resource program for diffusion tensor computation and fiber bundle tracking. Computer Methods and Programs in Biomedicine. 2006;81:106–116
  21. Kim SJ, Lyoo IK, Hwang J, Sung YH, Lee HY, Lee DS, et al. Frontal glucose hypometabolism in abstinent methamphetamine users. Neuropsychopharmacology. 2005;30:1383–1391
  22. Kim SJ, Lyoo IK, Hwang J, Chung A, Hoon Sung Y, Kim J, et al. Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers. International Journal of Neuropsychopharmacology. 2006;9:221–228
  23. Kim IS, Kim YT, Song HJ, Lee JJ, Kwon DH, Lee HJ, et al. Reduced corpus callosum white matter microstructural integrity revealed by diffusion tensor eigenvalues in abstinent methamphetamine addicts. Neurotoxicology. 2009;30:209–213
  24. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, et al. Diffusion tensor imaging: concepts and applications. Journal of Magnetic Resonance Imaging. 2001;13:534–546
  25. Lim KO, Choi SJ, Pomara N, Wolkin A, Rotrosen JP. Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. Biological Psychiatry. 2002;51:890–895
  26. Lim KO, Wozniak JR, Mueller BA, Franc DT, Specker SM, Rodriguez CP, et al. Brain macrostructural and microstructural abnormalities in cocaine dependence. Drug and Alcohol Dependence. 2008;92:164–172
  27. Moeller FG, Hasan KM, Steinberg JL, Kramer LA, Dougherty DM, Santos RM, et al. Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imaging. Neuropsychopharmacology. 2005;30:610–617
  28. Moeller FG, Hasan KM, Steinberg JL, Kramer LA, Valdes I, Lai LY, et al. Diffusion tensor imaging eigenvalues: preliminary evidence for altered myelin in cocaine dependence. Psychiatry Research: Neuroimaging. 2007;154:253–258
  29. Moeller FG, Steinberg JL, Lane SD, Buzby M, Swann AC, Hasan KM, et al. Diffusion tensor imaging in MDMA users and controls: association with decision making. American Journal of Drug and Alcohol Abuse. 2007;33:777–789
  30. Moszczynska A, Fitzmaurice P, Ang L, Kalasinsky KS, Schmunk GA, Peretti FJ, et al. Why is parkinsonism not a feature of human methamphetamine users?. Brain. 2004;127:363–370
  31. Nordahl TE, Salo R, Possin K, Gibson DR, Flynn N, Leamon M, et al. Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects: a preliminary proton MRS study. Psychiatry Research: Neuroimaging. 2002;116:43–52
  32. Pfefferbaum A, Adalsteinsson E, Rohlfing T, Sullivan EV. Diffusion tensor imaging of deep gray matter brain structures: effects of age and iron concentration. Neurobiology of Aging. 2008;
  33. Rose JE, Behm FM, Westman EC, Mathew RJ, London ED, Hawk TC, et al. PET studies of the influences of nicotine on neural systems in cigarette smokers. American Journal of Psychiatry. 2003;160:323–333
  34. Salo R, Nordahl TE, Natsuaki Y, Leamon MH, Galloway GP, Waters C, et al. Attentional control and brain metabolite levels in methamphetamine abusers. Biological Psychiatry. 2007;61:1272–1280
  35. Salo R, Nordahl TE, Buonocore MH, Natsuaki Y, Waters C, Moore CD, et al. Cognitive control and white matter callosal microstructure in methamphetamine-dependent subjects: a diffusion tensor imaging study. Biological Psychiatry. 2009;65:122–128
  36. Sekine Y, Iyo M, Ouchi Y, Matsunaga T, Tsukada H, Okada H, et al. Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET. American Journal of Psychiatry. 2001;158:1206–1214
  37. Sekine Y, Minabe Y, Kawai M, Suzuki K, Iyo M, Isoda H, et al. Metabolite alterations in basal ganglia associated with methamphetamine-related psychiatric symptoms. A proton MRS study. Neuropsychopharmacology. 2002;27:453–461
  38. Sekine Y, Ouchi Y, Takei N, Yoshikawa E, Nakamura K, Futatsubashi M, et al. Brain serotonin transporter density and aggression in abstinent methamphetamine abusers. Archives of General Psychiatry. 2006;63:90–100
  39. Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K, et al. Methamphetamine causes microglial activation in the brains of human abusers. Journal of Neuroscience. 2008;28:5756–5761
  40. Substance Abuse and Mental Health Services Administration (2007). Results from the 2006 national survey on drug use and health: national findings. DHHS Publication No. SMA 07-4293, NSDUH Series H-32, Rockville, MD. Office of Applied Studies, Substance Abuse and Mental Health Services Administration.
  41. Sung YH, Cho SC, Hwang J, Kim SJ, Kim H, Bae S, et al. Relationship between N-acetyl-aspartate in gray and white matter of abstinent methamphetamine abusers and their history of drug abuse: a proton magnetic resonance spectroscopy study. Drug and Alcohol Dependence. 2007;88:28–35
  42. Tang CY, Friedman J, Shungu D, Chang L, Ernst T, Stewart D, et al. Correlations between diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (1H MRS) in schizophrenic patients and normal controls. BioMed Central Psychiatry. 2007;7:25
  43. Thomas DM, Kuhn DM. Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine. Journal of Neurochemistry. 2005;92:790–797
  44. Thomas DM, Walker PD, Benjamins JA, Geddes TJ, Kuhn DM. Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. Journal of Pharmacology And Experimental Therapeutics. 2004;311:1–7
  45. Thomas DM, Francescutti-Verbeem DM, Kuhn DM. The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity. Journal of Neurochemistry. 2007;105:605–616
  46. Thompson PM, Hayashi KM, Simon SL, Geaga JA, Hong MS, Sui Y, et al. Structural abnormalities in the brains of human subjects who use methamphetamine. Journal of Neuroscience. 2004;24:6028–6036
  47. Volkow ND, Chang L, Wang GJ, Fowler JS, Franceschi D, Sedler M, et al. Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. Journal of Neuroscience. 2001;21:9414–9418
  48. Volkow ND, Chang L, Wang GJ, Fowler JS, Franceschi D, Sedler MJ, et al. Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. American Journal of Psychiatry. 2001;158:383–389
  49. Volkow ND, Chang L, Wang GJ, Fowler JS, Leonido-Yee M, Franceschi D, et al. Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. American Journal of Psychiatry. 2001;158:377–382
  50. Wilson JM, Kalasinsky KS, Levey AI, Bergeron C, Reiber G, Anthony RM, et al. Striatal dopamine nerve terminal markers in human, chronic methamphetamine users. Nature Medicine. 1996;2:699–703
  51. Yamamoto BK, Bankson MG. Amphetamine neurotoxicity: cause and consequence of oxidative stress. Critical Reviews in Neurobiology. 2005;17:87–117

PII: S0925-4927(09)00087-0

doi: 10.1016/j.pscychresns.2009.03.011

Psychiatry Research: Neuroimaging
Volume 174, Issue 1 , Pages 1-8 , 30 October 2009

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