Psychiatry Research: Neuroimaging
Volume 173, Issue 2 , Pages 135-142 , 30 August 2009

Neural response to lidocaine in healthy subjects

  • Bryon Adinoff

      Affiliations

    • Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States
    • VA North Texas Health Care System, Dallas, TX, United States
    • Corresponding Author InformationCorresponding author. 5323 Harry Hines Blvd., Dallas, TX 75390-8564, United States. Tel.: +1 214 645 6975; fax: +1 214 645 6976.
    • ,
  • Michael D. Devous Sr.

      Affiliations

    • Nuclear Medicine Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States
    • ,
  • Donald C. Cooper

      Affiliations

    • Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States
    • ,
  • Susan E. Best

      Affiliations

    • Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States
    • VA North Texas Health Care System, Dallas, TX, United States
    • ,
  • Thomas S. Harris

      Affiliations

    • Nuclear Medicine Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States
    • ,
  • Mark J. Williams

      Affiliations

    • Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States

Received 19 May 2008 ,Revised 24 February 2009 ,Accepted 4 March 2009.

References 

  1. Adinoff B, Brady K, Sonne S, Mirabella RF, Kellner CH. Cocaine-like effects of intravenous procaine in cocaine addicts. Addiction Biology. 1998;3:189–196
  2. Adinoff B, Devous MD, Best SM, George MS, Alexander D, Payne K. Limbic responsiveness to procaine in cocaine-addicted subjects. American Journal of Psychiatry. 2001;158:390–398
  3. Adinoff B, Devous MD, Best SE, Alexander D, Kelly Payne J, Williams M. Dose–response measures of rCBF and subjective changes following procaine in healthy female volunteers. Psychiatry Research: Neuroimaging. 2002;114:123–135
  4. Adinoff B, Devous MD, Best SE, Chandler P, Alexander D, Payne K, et al. Gender differences in limbic responsiveness, by SPECT, following a pharmacologic challenge in healthy subjects. Neuroimage. 2003;18:697–706
  5. Adinoff B, Devous MD, Best SE, Harris TS, Chandler P, Frock SD, et al. Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation. Drug and Alcohol Dependence. 2003;71:255–268
  6. Adinoff B. Neurobiologic processes in drug reward and addiction. Harvard Review of Psychiatry. 2004;12:305–320
  7. Agin D, Hersh L, Holtzman D. The action of anesthetics on excitable membranes: a quantum-chemical analysis. Proceedings of the National Academy of Sciences of the United States of America. 1965;53:952–958
  8. Attal N, Gaude V, Brasseur L, Dupuy M, Guirimand F, Parker F, et al. Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study. Neurology. 2000;54:564–574
  9. Barann M, Gothert M, Fink K, Bonisch H. Inhibition by anaesthetics of 14C-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells. Naunyn-Schmiedeberg's Arch Pharmacol. 1993;347:125–132
  10. Butterworth JF, Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology. 1990;72:711–734
  11. Colpaert FC, Niemegeers CJ, Janssen PA. Discriminative stimulus properties of cocaine: neuropharmacological characteristics as derived from stimulus generalization experiments. Pharmacology, Biochemistry and Behavior. 1979;10:535–546
  12. Cooper DC, Klipec WD, Fowler MA, Ozkan ED. A role for the subiculum in the brain motivation/reward circuitry. Behavioural Brain Research. 2006;174:225–231
  13. Derogatis LR, Melisaratos N. The Brief Symptom Inventory: an introductory report. Psychol. Med. 1983;13:595–605
  14. Detsch O, Erkens U, Jacofsky U, Thiel A, Kochs E, Hempelmann G. Topographical analysis of the EEG effects of a subconvulsive dose of lidocaine in healthy volunteers. Acta Anaesthesiologica Scandinavica. 1997;41:1039–1046
  15. Dormehl IC, Lipp MD, Hugo N, Daublaender M, Picard JA. Influence of intravenously administered lidocaine on cerebral blood flow in a baboon model standardized under controlled general anaesthesia using single-photon emission tomography and technetium-99m hexamethylpropylene amine oxime. European Journal of Nuclear Medicine. 1993;20:1095–1098
  16. Fischman MW, Schuster CR, Hatano Y. A comparison of the subjective and cardiovascular effects of cocaine and lidocaine in humans. Pharmacology, Biochemistry and Behavior. 1983;18:123–127
  17. Fischman MW, Schuster CR, Rajfer S. A comparison of the subjective and cardiovascular effects of cocaine and procaine in humans. Pharmacology, Biochemistry and Behavior. 1983;18:711–716
  18. Flynn DD, Vaishnav AA, Mash DC. Interactions of cocaine with primary and secondary recognition sites on muscarinic receptors. Molecular Pharmacology. 1992;41:736–742
  19. Foldes FF, Molloy R, Mc NP, Koukal LR. Comparison of toxicity of intravenously given local anesthetic agents in man. JAMA. 1960;172:1493–1498
  20. Galer BS, Miller KV, Rowbotham MC. Response to intravenous lidocaine infusion differs based on clinical diagnosis and site of nervous system injury. Neurology. 1993;43:1233–1235
  21. Garza RD, Johanson CE. The discriminative stimulus properties of cocaine in the rhesus monkey. Pharmacology, Biochemistry and Behavior. 1983;19:145–148
  22. Jarbe TU. Discriminative stimulus properties of cocaine. Effects of apomorphine, haloperidol, procaine and other drugs. Neuropharmacology. 1984;23:899–907
  23. Karpen JW, Hess GP. Cocaine, phencyclidine, and procaine inhibition of the acetylcholine receptor: characterization of the binding site by stopped-flow measurements of receptor-controlled ion flux in membrane vesicles. Biochemistry. 1986;25:1777–1785
  24. Kellner CH, Post RM, Putnam F, Cowdry R, Gardner D, Kling MA, et al. Intravenous procaine as a probe of limbic system activity in psychiatric patients and normal controls. Biological Psychiatry. 1987;22:1107–1126
  25. Ketter TA, Andreason PJ, George MS, Lee C, Gill DS, Parekh PI, et al. Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Archives of General Psychiatry. 1996;53:59–69
  26. Lile JA. Pharmacological determinants of the reinforcing effects of psychostimulants: relation to agonist substitution treatment. Experimental and Clinical Psychopharmacology. 2006;14:20–33
  27. Middaugh LD, McGroarty KK, Groseclose CH, Adinoff B. Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice. Psychopharmacology. 1998;136:44–49
  28. Niu L, Abood LG, Hess GP. Cocaine: mechanism of inhibition of a muscle acetylcholine receptor studied by a laser-pulse photolysis technique. Proceedings of the National Academy of Sciences of the United States of America. 1995;92:12008–12012
  29. Plewnia C, Bischof F, Reimold M. Suppression of verbal hallucinations and changes in regional cerebral blood flow after intravenous lidocaine: a case report. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2007;31:301–303
  30. Ritz MC, George FR. Cocaine-induced seizures and lethality appear to be associated with distinct central nervous system binding sites. Journal of Pharmacology and Experimental Therapeutics. 1993;264:1333–1343
  31. Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science. 1987;237:1219–1223
  32. Roden DM. Antiarrhythmic drugs. In:  Harmand JG,  Limbird LE,  Gilman AG editor. The Pharmacological Basis of Therapeutics. Tenth Edition. New York: McGraw-Hill; 2001;p. 933–970
  33. Servan-Schreiber D, Perlstein WM, Cohen JD, Mintun M. Selective pharmacological activation of limbic structures in human volunteers: a positron emission tomography study. Journal of Neuropsychiatry and Clinical Neurosciences. 1998;10:148–159
  34. Sharkey J, Ritz MC, Schenden JA, Hanson RC, Kuhar MJ. Cocaine inhibits muscarinic cholinergic receptors in heart and brain. Journal of Pharmacology and Experimental Therapeutics. 1988;246:1048–1052
  35. Silverman PB, Schultz KA. Comparison of cocaine and procaine disciminative stimuli. Drug Development Research. 1989;16:427–433
  36. Stark-Adamec C, Adamec RE, Graham JM, Bruun-Meyer SE, Perrin RG, Pollock D, et al. Analysis of facial displays and verbal report to assess subjective state in the non-invasive detection of limbic system activation by procaine hydrochloride. Behavioural Brain Research. 1982;4:77–94
  37. Sun W, Rebec GV. Lidocaine inactivation of ventral subiculum attenuates cocaine-seeking behavior in rats. Journal of Neuroscience. 2003;23:10258–10264
  38. Swanson KL, Albuquerque EX. Nicotinic acetylcholine receptor ion channel blockade by cocaine: the mechanism of synaptic action. Journal of Pharmacology and Experimental Therapeutics. 1987;243:1202–1210
  39. Taepavarapruk P, Phillips AG. Neurochemical correlates of relapse to d-amphetamine self-administration by rats induced by stimulation of the ventral subiculum. Psychopharmacology. 2003;168:99–108
  40. Talairach J, Tournoux P. Co-planar Stereotactic Atlas of the Human Brain. New York: Thieme Medical Publishers, Inc.; 1988;
  41. Tella SR, Goldberg SR. Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2001;25:639–656
  42. Usubiaga JE, Wikinski J, Ferrero R, Usubiaga LE, Wikinski R. Local anesthetic-induced convulsions in man—an electroencephalographic study. Anesthesia and Analgesia. 1966;45:611–620
  43. Usubiaga JE, Moya F, Wikinski JA, Wikinski R, Usubiaga LE. Relationship between the passage of local anaesthetics across the blood-brain barrier and their effects on the central nervous system. British Journal of Anaesthesia. 1967;39:943–947
  44. Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science. 2001;292:1175–1178
  45. Wilcox KM, Rowlett JK, Paul IA, Ordway GA, Woolverton WL. On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns. Psychopharmacology. 2000;153:139–147
  46. Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. Synapse. 2005;58:220–228
  47. Woodward JJ, Compton DM, Balster RL, Martin BR. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. European Journal of Pharmacology. 1995;277:7–13
  48. Woolverton WL, Balster RL. Reinforcing properties of some local anesthetics in rhesus monkeys. Pharmacology, Biochemistry and Behavior. 1979;11:669–672
  49. Woolverton WL, Balster RL. Behavioral pharmacology of local anesthetics: reinforcing and discriminative stimulus effects. Pharmacology, Biochemistry and Behavior. 1982;16:491–500

PII: S0925-4927(09)00060-2

doi: 10.1016/j.pscychresns.2009.03.001

Psychiatry Research: Neuroimaging
Volume 173, Issue 2 , Pages 135-142 , 30 August 2009

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