Psychiatry Research: Neuroimaging
Volume 173, Issue 3 , Pages 177-182 , 30 September 2009

Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophrenia

  • Jacqueline H. Sanz

      Affiliations

    • Department of Psychology, University of California Los Angeles, Los Angeles, CA, United States
    • Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, Maryland, United States
    • Corresponding Author InformationCorresponding author. Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095, United States. Tel.: +1 443 923 4478; fax: +1 443 923 4470.
  • ,
  • Katherine H. Karlsgodt

      Affiliations

    • Department of Psychology, University of California Los Angeles, Los Angeles, CA, United States
  • ,
  • Carrie E. Bearden

      Affiliations

    • Department of Psychology, University of California Los Angeles, Los Angeles, CA, United States
    • Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, United States
    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States
  • ,
  • Theo G.M. van Erp

      Affiliations

    • Department of Psychology, University of California Los Angeles, Los Angeles, CA, United States
  • ,
  • Rajesh R. Nandy

      Affiliations

    • Department of Psychology, University of California Los Angeles, Los Angeles, CA, United States
  • ,
  • Joseph Ventura

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States
  • ,
  • Keith Nuechterlein

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States
  • ,
  • Tyrone D. Cannon

      Affiliations

    • Department of Psychology, University of California Los Angeles, Los Angeles, CA, United States
    • Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, United States
    • Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States

Received 3 July 2008 ,Revised 9 January 2009 ,Accepted 21 February 2009.

References 

  1. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC.
  2. Andreasen NC. The Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa; 1983;
  3. Andreasen NC. The Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa; 1984;
  4. Andreasen NC, Arndt S, Alliger R, Miller D, Flaum M. Symptoms of schizophrenia. Methods, meanings, and mechanisms. Archives of General Psychiatry. 1995;52:341–351
  5. Auther A, Smith C, Cornblatt B. Global Functioning Scale: Social (GFS: Social). Glen Oaks, NY: Zucker Hillside Hospital; 2006;
  6. Barch DM, Sheline YI, Csernansky JG, Snyder AZ. Working memory and prefrontal cortical dysfunction: specificity to schizophrenia compared with major depression. Biological Psychiatry. 2003;53:376–384
  7. Behrens TE, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CAM, Boulby PA, et al. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nature Neuroscience. 2003;6:750–757
  8. Callicott JH, Bertolino A, Mattay VS, Langheim FJP, Duyn J, Coppola R, et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex. 2000;10:1078–1092
  9. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. American Journal of Psychiatry. 2003;160:2209–2215
  10. Cannon TD, Glahn DC, Kim J, van Erp TGM, Karlsgodt KH, Cohen MS, et al. Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Archives of General Psychiatry. 2005;62:1071–1080
  11. Cowan N. The magical number 4 in short-term memory: a reconsideration of mental storage capacity. Behavioral and Brain Sciences. 2001;24:87–114
  12. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnetic Resonance in Medicine. 1995;33:636–647
  13. Friston KJ, Worsley KJ, Frakowiak RSJ, Mazziotta JC, Evans AC. Assessing the significance of focal activations using their spatial extent. Human Brain Mapping. 1994;1:214–220
  14. Glahn DC, Ragland JD, Abramoff A, Barrett J, Laird AR, Bearden CE, et al. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Human Brain Mapping. 2005;25:60–69
  15. Goldman-Rakic PS, Selemon LD. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophrenia Bulletin. 1997;23:437–458
  16. Goldstein MJ. Further data concerning the relation between premorbid adjustment and paranoid symptomatology. Schizophrenia Bulletin. 1978;4:236–243
  17. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia?. American Journal of Psychiatry. 1996;153:321–330
  18. Green MF. Stimulating the development of drug treatments to improve cognition in schizophrenia. Annual Review of Clinical Psychology. 2007;3:159–180
  19. Green MF, Braff DL. Translating the basic and clinical cognitive neuroscience of schizophrenia to drug development and clinical trials of antipsychotic medications. Biological Psychiatry. 2001;49:374–384
  20. Jenkinson M. Estimation of smoothness from the residual field: FMRIB technical report TR00MJ3. 2001;http://www.fmrib.ox.ac.uk/analysis/techrep/tr00mj3/tr00mj3/.
  21. Jenkinson M, Smith S. A global optimisation method for robust affine registration of brain images. Medical Image Analysis. 2001;5:143–156
  22. Jenkinson M, Bannister P, Brady M, Smith S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 2002;17:825–841
  23. Karlsgodt KH, Glahn DC, van Erp TGM, Therman S, Huttunen M, Manninen M, et al. The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophrenia Research. 2007;89:191–197
  24. Karlsgodt KH, Sanz JH, van Erp TGM, Bearden CE, Nuechterlein KH, Cannon TD. Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia. Schizophrenia Research. 2009;108:143–150
  25. Manoach DS. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophrenia Research. 2003;60:285–298
  26. Manoach DS, Press DZ, Thangaraj V, Searl MM, Goff DC, Halpern E, et al. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task as measured by fMRI. Biological Psychiatry. 1999;45:1128–1137
  27. Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, Halpern E, et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biological Psychiatry. 2000;48:99–109
  28. McIntosh AR, Bookstein FL, Haxby JV, Grady CL. Spatial pattern analysis of functional brain images using partial least squares. Neuroimage. 1996;3:143–157
  29. Menon V, Anagnoson RT, Mathalon DH, Glover GH, Pfefferbaum A. Functional neuroanatomy of auditory working memory in schizophrenia: relation to positive and negative symptoms. Neuroimage. 2001;13:433–446
  30. Nestor PG, O'Donnell BF, McCarley RW, Niznikiewicz M, Barnard J, Jen Shen Z, et al. A new statistical method for testing hypotheses of neuropsychological/MRI relationships in schizophrenia: partial least squares analysis. Schizophrenia Research. 2002;53:57–66
  31. Niendam TA, Bearden CE, Johnson JK, Cannon TD. Global Functioning Scale: Role (GFS: Role). Los Angeles: University of California; 2006;
  32. Perlstein WM, Carter CS, Noll DC, Cohen JD. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. American Journal of Psychiatry. 2001;158:1105–1113
  33. Ragland JD, Gur RC, Glahn DC, Censits DM, Smith RJ, Lazarev MG, et al. Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia: a positron emission tomography study. Neuropsychology. 1998;12:399–413
  34. Selemon LD, Goldman-Rakic PS. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biological Psychiatry. 1999;45:17–25
  35. Selemon LD, Rajkowska G, Goldman-Rakic PS. Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17. Archives of General Psychiatry. 1995;52:805–818
  36. Selemon LD, Rajkowska G, Goldman-Rakic PS. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method. Journal of Comparative Neurology. 1998;392:402–412
  37. Sternberg S. High-speed scanning in human memory. Science. 1966;153(736):652–654
  38. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004;23:S208–219
  39. Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE. Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Archives of General Psychiatry. 1998;55:1097–1103
  40. Strauss JS, Carpenter WT. The prediction of outcome in schizophrenia. I. Characteristics of outcome. Archives of General Psychiatry. 1972;27:739–746
  41. Ventura J, Green M, Shaner A, Liberman RP. Training and quality assurance on the BPRS: “The Drift Busters.. International Journal of Methods in Psychiatric Research. 1993;3:221–244
  42. Ventura J, Liberman RP, Green MF, Shaner A, Mintz J. Training and quality assurance with the Structured Clinical Interview for DSM-IV I/P (SCID). Psychiatry Research. 1998;79:163–173
  43. Walter H, Wunderlich AP, Blakenhorn M, Schafer S, Tomczak R, Spitzer M, et al. No hypofrontality, but absence of prefrontal lateralization comparing verbal and spatial working memory in schizophrenia. Schizophreina Research. 2003;61:175–184
  44. Whalley HC, Gountouna VE, Hall J, McIntosh A, Whyte MC, Simonotto E, et al. Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia. BMC Psychiatry. 2007;7:61–71
  45. Wible CG, Lee K, Molina I, Hashimoto R, Preus AP, Roach BJ, et al. fMRI activity correlated with auditory hallucinations during performance of a working memory task: data from the FBIRN consortium study. Schizophrenia Bulletin. 2009;35:47–57
  46. Woods RP, Grafton ST, Holmes CJ, Cherry SR, Mazziotta JC. Automated image registration: I. General methods and intrasubject, intramodality validation. Journal of Computer Assisted Tomography. 1998;22:139–152
  47. Woolrich MW, Ripley BD, Brady M, Smith SM. Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage. 2001;14:1370–1386
  48. Worsley KJ, Evans AC, Marrett S, Neelin P. A three-dimensional statistical analysis for CBF activation studies in human brain. Journal of Cerebral Blood Flow and Metabolism. 1992;12:900–918
  49. Yoon JH, Minzenberg MJ, Ursu S, Walters R, Wendelken C, Ragland JD, et al. Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral disorganization, and global function. American Journal of Psychiatry. 2008;165:1006–1014

PII: S0925-4927(09)00058-4

doi: 10.1016/j.pscychresns.2009.02.008

Psychiatry Research: Neuroimaging
Volume 173, Issue 3 , Pages 177-182 , 30 September 2009