Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive–compulsive disorder

Arnold, Paul Daniel; MacMaster, Frank P.; Richter, Margaret A.; Hanna, Gregory L.; Sicard, Tricia; Burroughs, Eliza; Mirza, Yousha; Easter, Phillip C.; Rose, Michelle; Kennedy, James L.; Rosenberg, David R.

doi:10.1016/j.pscychresns.2009.02.005

« Previous Next »Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 136-139, 15 May 2009

Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive–compulsive disorder

Paul Daniel Arnold
- Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
- Department of Psychiatry, 1st Floor Elm Wing, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
- Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
- Corresponding author. Department of Psychiatry, 1st Floor Elm Wing, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8. Tel.: +1 416 813 6936; fax: +1 416 813 5326.
Frank P. MacMaster
- Wayne State University, Detroit, MI, United States
- The Children's Hospital of Michigan, Detroit, MI, United States
Margaret A. Richter
- Anxiety Disorders Clinic, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
Gregory L. Hanna
- University of Michigan, Ann Arbor, MI, United States
Tricia Sicard
- Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
Eliza Burroughs
- Anxiety Disorders Clinic, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
Yousha Mirza
- Wayne State University, Detroit, MI, United States
- The Children's Hospital of Michigan, Detroit, MI, United States
Phillip C. Easter
- Wayne State University, Detroit, MI, United States
- The Children's Hospital of Michigan, Detroit, MI, United States
Michelle Rose
- Wayne State University, Detroit, MI, United States
- The Children's Hospital of Michigan, Detroit, MI, United States
James L. Kennedy
- Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
David R. Rosenberg
- Wayne State University, Detroit, MI, United States
- The Children's Hospital of Michigan, Detroit, MI, United States

Received 9 January 2009; received in revised form 12 February 2009; accepted 19 February 2009.

Abstract

In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.

Keywords: Glutamate transporter, Magnetic resonance spectroscopy, N-methyl-d-aspartate