Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 128-135, 15 May 2009

The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia

  • Tsutomu Takahashi

      Affiliations

    • Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    • ,
  • Michio Suzuki

      Affiliations

    • Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    • Corresponding Author InformationCorresponding author. Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Tel.: +81 76 434 2281; fax: +81 76 434 5030.
    • ,
  • Masahiko Tsunoda

      Affiliations

    • Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • ,
  • Nobuhisa Maeno

      Affiliations

    • Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
    • ,
  • Yasuhiro Kawasaki

      Affiliations

    • Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    • ,
  • Shi-Yu Zhou

      Affiliations

    • Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    • Department of Psychiatry and Medical Psychology, Dalian Medical University, Dalian, China
    • ,
  • Hirofumi Hagino

      Affiliations

    • Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • ,
  • Lisha Niu

      Affiliations

    • Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • ,
  • Hiroshi Tsuneki

      Affiliations

    • Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • ,
  • Soushi Kobayashi

      Affiliations

    • Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • ,
  • Toshiyasu Sasaoka

      Affiliations

    • Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • ,
  • Hikaru Seto

      Affiliations

    • Department of Radiology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • ,
  • Masayoshi Kurachi

      Affiliations

    • Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    • ,
  • Norio Ozaki

      Affiliations

    • Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan

Received 24 July 2008; received in revised form 26 November 2008; accepted 31 January 2009.

Abstract 

The Disrupted-in-Schizophrenia-1 (DISC1) polymorphism is a strong candidate for a schizophrenia-susceptibility gene as it is widely expressed in cortical and limbic regions, but the effect of its genotype variation on brain morphology in schizophrenia is not well known. This study examined the association between the DISC1 Ser704Cys polymorphism and volumetric measurements for a broad range of fronto–parietal, temporal, and limbic–paralimbic regions using magnetic resonance imaging in a Japanese sample of 33 schizophrenia patients and 29 healthy comparison subjects. The Cys carriers had significantly larger volumes of the medial superior frontal gyrus and short insular cortex than the Ser homozygotes only for healthy comparison subjects. The Cys carriers tended to have a smaller supramarginal gyrus than the Ser homozygotes in schizophrenia patients, but not in healthy comparison subjects. The right medial superior frontal gyrus volume was significantly correlated with daily dosage of antipsychotic medication in Ser homozygote schizophrenia patients. These different genotype effects of the DISC1 Ser704Cys polymorphism on the brain morphology in schizophrenia patients and healthy comparison subjects suggest that variation in the DISC1 gene might be, at least partly, involved in the neurobiology of schizophrenia. Our findings also suggest that the DISC1 genotype variation might have some relevance to the medication effect on brain morphology in schizophrenia.

Keywords: DISC1, Magnetic resonance imaging, Supramarginal gyrus, Insular cortex, Prefrontal cortex, Antipsychotic medication

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PII: S0925-4927(09)00023-7

doi:10.1016/j.pscychresns.2009.01.005

Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 128-135, 15 May 2009

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