Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 117-120 , 15 May 2009

Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging

  • Adam M. Brickman

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    • Corresponding Author InformationCorresponding author. Taub Institute for Research on Alzheimer's, Disease and the Aging Brain, Box 16, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, United States. Tel.: +1 212 342 1348; fax: +1 212 342 1838.
    • ,
  • Amir Zahra

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    • ,
  • Jordan Muraskin

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    • ,
  • Jason Steffener

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    • ,
  • Christopher M. Holland

      Affiliations

    • Center for Neurological Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
    • Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United States
    • ,
  • Christian Habeck

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    • ,
  • Ajna Borogovac

      Affiliations

    • Department of Biomedical Engineering, Columbia University, New York, NY, United States
    • ,
  • Marco A. Ramos

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    • ,
  • Truman R. Brown

      Affiliations

    • Department of Biomedical Engineering, Columbia University, New York, NY, United States
    • Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    • ,
  • Iris Asllani

      Affiliations

    • Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    • ,
  • Yaakov Stern

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States

Received 1 July 2008 ,Revised 10 October 2008 ,Accepted 13 November 2008.

References 

  1. Alsop DC, Detre JA. Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism. 1996;16:1236–1249
  2. Andrews-Hanna JR, Snyder AZ, Vincent JL, Lustig C, Head D, Raichle ME, et al. Disruption of large-scale brain systems in advanced aging. Neuron. 2007;56:924–935
  3. Asllani I, Habeck C, Scarmeas N, Borogovac A, Brown TR, Stern Y. Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism. 2008;28(4):725–736
  4. Brickman AM, Honig LS, Scarmeas N, Tatarina O, Sanders L, Albert MS, et al. Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease. Archives of Neurology. 2008;65:1202–1208
  5. Brickman AM, Schupf N, Manly JJ, Luchsinger JA, Andrews H, Tang MX, et al. Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan. Archives of Neurology. 2008;65:1053–1061
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  9. Holland CM, Smith EE, Csapo I, Gurol ME, Brylka DA, Killiany RJ, et al. Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging. Stroke. 2008;39(4):1127–1133
  10. Jefferson AL, Tate DF, Poppas A, Brickman AM, Paul RH, Gunstad J, et al. Lower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease. Journal of the American Geriatrics Society. 2007;55:1044–1048
  11. Kraut MA, Beason-Held LL, Elkins WD, Resnick SM. The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism. 2008;28:190–197
  12. Marstrand JR, Garde E, Rostrup E, Ring P, Rosenbaum S, Mortensen EL, et al. Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities. Stroke. 2002;33:972–976
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  14. O'Sullivan M, Lythgoe DJ, Pereira AC, Summers PE, Jarosz JM, Williams SC, et al. Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology. 2002;59:321–326
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  16. Sachdev P, Wen W, Shnier R, Brodaty H. Cerebral blood volume in T2-weighted white matter hyperintensities using exogenous contrast based perfusion MRI. Journal of Neuropsychiatry and Clinical Neurosciences. 2004;16:83–92
  17. ten Dam VH, van den Heuvel DM, de Craen AJ, Bollen EL, Murray HM, Westendorp RG, et al. Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities. Radiology. 2007;243:198–203

PII: S0925-4927(08)00189-3

doi: 10.1016/j.pscychresns.2008.11.006

Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 117-120 , 15 May 2009

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