Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 93-98 , 15 May 2009

The neural basis of unconditional love

  • Mario Beauregard

      Affiliations

    • Centre de Recherche en Neuropsychologie et Cognition (CERNEC), Département de Psychologie, Université de Montréal, C.P. 6128, succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7
    • Département de Radiologie, Université de Montréal, Canada
    • Centre de Recherche en Sciences Neurologiques (CRSN), Université de Montréal, Canada
    • Centre de Recherche, Institut Universitaire de Gériatrie de Montréal (CRIUGM), Canada
    • Corresponding Author InformationCorresponding author. Centre de Recherche en Neuropsychologie et Cognition (CERNEC), Département de Psychologie, Université de Montréal, C.P. 6128, succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7. Tel.: +1 514 343 7651; fax +1 514 343 5787.
  • ,
  • Jérôme Courtemanche

      Affiliations

    • Centre de Recherche en Neuropsychologie et Cognition (CERNEC), Département de Psychologie, Université de Montréal, C.P. 6128, succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7
    • Centre de Recherche, Institut Universitaire de Gériatrie de Montréal (CRIUGM), Canada
  • ,
  • Vincent Paquette

      Affiliations

    • Centre de Recherche en Neuropsychologie et Cognition (CERNEC), Département de Psychologie, Université de Montréal, C.P. 6128, succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7
    • Centre de Recherche, Institut Universitaire de Gériatrie de Montréal (CRIUGM), Canada
  • ,
  • Évelyne Landry St-Pierre

      Affiliations

    • Centre de Recherche en Neuropsychologie et Cognition (CERNEC), Département de Psychologie, Université de Montréal, C.P. 6128, succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7

Received 17 March 2008 ,Revised 22 September 2008 ,Accepted 12 November 2008.

References 

  1. Aron A, Fisher H, Mashek DJ, Strong G, Li H, Brown LL. Reward, motivation, and emotion systems associated with early-stage intense romantic love. Journal of Neurophysiology. 2005;94:327–337
  2. Augustine JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Research Reviews. 1996;22:229–244
  3. Bartels A, Zeki S. The neural basis of romantic love. NeuroReport. 2000;11:3829–3834
  4. Bartels A, Zeki S. The neural correlates of maternal and romantic love. Neuroimage. 2004;21:1155–1166
  5. Breiter HC, Rosen BR. Functional magnetic resonance imaging of brain reward circuitry in the human. Annals of the New York Academy of Sciences. 1999;877:523–547
  6. Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, et al. Acute effects of cocaine on human brain activity and emotion. Neuron. 1997;19:591–611
  7. Breiter HC, Aharon I, Kahneman D, Dale A, Shizgal P. Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron. 2001;30:619–639
  8. Corbetta M, Miezin FM, Shulman GL, Petersen SE. A PET study of visuospatial attention. Journal of Neuroscience. 1993;13:1202–1226
  9. Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ. Neural systems supporting interoceptive awareness. Nature Neuroscience. 2004;7:189–195
  10. Damasio AR. The Feeling of What Happens: Body and Emotion in the Making of Consciousness. New York: Harcourt Brace; 1999;
  11. Decety J, Jackson PL. The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Reviews. 2004;3:71–100
  12. Delgado MR, Nystrom LE, Fissell C, Noll DC, Fiez JA. Tracking the hemodynamic responses to reward and punishment in the striatum. Journal of Neurophysiology. 2000;84:3072–3077
  13. Delgado MR, Locke HM, Stenger VA, Fiez JA. Dorsal striatum responses to reward and punishment: effects of valence and magnitude manipulations. Cognitive, Affective, & Behavioral Neuroscience. 2003;3:27–38
  14. Eisenberg N. Emotion, regulation, and moral development. Annual Review of Psychology. 2000;51:665–697
  15. Elliott R, Friston KJ, Dolan RJ. Dissociable neural responses in human reward systems. Journal of Neuroscience. 2000;20:6159–6165
  16. Elliott R, Newman JL, Longe OA, Deakin JF. Differential response patterns in the striatum and orbitofrontal cortex to financial reward in humans: a parametric functional magnetic resonance imaging study. Journal of Neuroscience. 2003;23:303–307
  17. Elliott R, Newman JL, Longe OA, Deakin JF. Instrumental responding for rewards is associated with enhanced neuronal response in subcortical reward systems. Neuroimage. 2004;21:984–990
  18. Filbey FM, Claus E, Audette AR, Niculescu M, Banich MT, Tanabe J, et al. Exposure to the taste of alcohol elicits activation of the mesocorticolimbic neurocircuitry. Neuropsychopharmacology. 2008;33:1391–1401
  19. Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study?. NeuroImage. 1999;10:1–5
  20. Hernandez G, Hamdani S, Rajabi H, Conover K, Stewart J, Arvanitogiannis A, et al. Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences. Behavioral Neuroscience. 2006;120:888–904
  21. Holstege G, Georgiadis JR, Paans AM, Meiners LC, van der Graaf FH, Reinders AA. Brain activation during human male ejaculation. Journal of Neuroscience. 2003;23:9185–9193
  22. Jenkins JS, Ang VT, Hawthorn J, Rossor MN, Iversen LL. Vasopressin, oxytocin and neurophysins in the human brain and spinal cord. Brain Research. 1984;291:111–117
  23. Karama S, Lecours AR, Leroux J-M, Bourgouin P, Beaudoin G, Joubert S, et al. Areas of brain activation in males and females during viewing of erotic film excerpts. Human Brain Mapping. 2002;16:1–13
  24. Kawagoe R, Takikawa Y, Hikosaka O. Expectation of reward modulates cognitive signals in the basal ganglia. Nature Neuroscience. 1998;1:411–416
  25. Knutson B, Adams CM, Fong GW, Hommer D. Anticipation of increasing monetary reward selectively recruits nucleus accumbens. Journal of Neuroscience. 2001;21:RC159
  26. Kosel M, Sturm V, Frick C, Lenartz D, Zeidler G, Brodesser D, et al. Mood improvement after deep brain stimulation of the internal globus pallidus for tardive dyskinesia in a patient suffering from major depression. Journal of Psychiatric Research. 2007;41:801–803
  27. Lane RD, Fink GR, Chau PM-L, Dolan RJ. Neural activation during selective attention to subjective emotional responses. NeuroReport. 1997;8:3969–3972
  28. Lane RD, Reiman EM, Axelrod B, Yun LS, Holmes A, Schwartz GE. Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex. Journal of Cognitive Neuroscience. 1998;10:525–535
  29. Lauwereyns J, Takikawa Y, Kawagoe R, Kobayashi S, Koizumi M, Coe B, et al. Feature-based anticipation of cues that predict reward in monkey caudate nucleus. Neuron. 2002;33:463–473
  30. Lutz A, Brefczynski-Lewis J, Johnstone T, Davidson RJ. Regulation of the neural circuitry of emotion by compassion meditation: effects of meditative expertise. PLoS ONE. 2008;26:e1897
  31. Martin-Soelch C, Leenders KL, Chevalley AF, Missimer J, Kunig G, Magyar S, et al. Reward mechanisms in the brain and their role in dependence: evidence from neurophysiological and neuroimaging studies. Brain Research Reviews. 2001;36:139–149
  32. Menon V, Levitin DJ. The rewards of music listening: response and physiological connectivity of the mesolimbic system. Neuroimage. 2005;15:175–184
  33. Mesulam M-M, Mufson EJ. Insula of the old world monkey. III: efferent cortical output and comments on function. Journal of Comparative Neurology. 1982;212:38–52
  34. Noriuchi M, Kikuchi Y, Senoo A. The functional neuroanatomy of maternal love: mother's response to infant's attachment behaviors. Biological Psychiatry. 2008;63:415–423
  35. O 'Doherty JP, Deichmann R, Critchley HD, Dolan RJ. Neural responses during anticipation of a primary taste reward. Neuron. 2002;33:815–826
  36. Olazábal DE, Young LJ. Species and individual differences in juvenile female alloparental care are associated with oxytocin receptor density in the striatum and the lateral septum. Hormones and Behavior. 2006;49:681–687
  37. Ortigue S, Bianchi-Demicheli F, Hamilton AF, Grafton ST. The neural basis of love as a subliminal prime: an event-related functional magnetic resonance imaging study. Journal of Cognitive Neuroscience. 2007;19:1218–1230
  38. Phan KL, Wager T, Taylor SF, Liberzon I. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage. 2002;16:331–348
  39. Phillips ML, Young AW, Senior C, Brammer M, Andrew C, Calder AJ, et al. A specific neural substrate for perceiving facial expressions of disgust. Nature. 1997;389:495–498
  40. Phillips PE, Stuber GD, Heien ML, Wightman RM, Carelli RM. Subsecond dopamine release promotes cocaine seeking. Nature. 2003;422:614–618
  41. Post SG. Unlimited Love. West Conshohocken, PA: Templeton Foundation Press; 2003;
  42. Rauch SL, Shin LM, Dougherty DD, Alpert NM, Orr SP, Lasko M, et al. Neural activation during sexual and competitive arousal in healthy men. Psychiatry Research. 1999;91:1–10
  43. Ruby P, Decety J. How would you feel versus how do you think she would feel? A neuroimaging study of perspective-taking with social emotions. Journal of Cognitive Neuroscience. 2004;16:988–999
  44. Salinas JA, White NM. Contributions of the hippocampus, amygdala, and dorsal striatum to the response elicited by reward reduction. Behavioral Neuroscience. 1998;112:812–826
  45. Schultz W. Multiple reward signals in the brain. Nature Reviews. Neuroscience. 2000;1:199–207
  46. Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD. Empathy for pain involves the affective but not sensory components of pain. Science. 2004;303:1157–1162
  47. Singer T, Seymour B, O'Doherty JP, Stephan KE, Dolan RJ, Frith CD. Empathic neural responses are modulated by the perceived fairness of others. Nature. 2006;439:466–469
  48. Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M. Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain. 2001;124:1720–1733
  49. Sorokin PA. Altruistic Love: A Study of American Good Neighbors and Christian Saints. Boston: Beacon Press; 1950;
  50. Steffen PR, Masters KS. Does compassion mediate the intrinsic religion-health relationship?. Annals of Behavioral Medicine. 2005;30:217–224
  51. Stoleru S, Gregoire MC, Gerard D, Decety J, Lafarge E, Cinotti L, et al. Neuroanatomical correlates of visually evoked sexual arousal in human males. Archives of Sexual Behavior. 1999;28:1–21
  52. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. Stuttgart: Thieme Medical; 1988;
  53. Vandenberghe R, Gitelman DR, Parrish TB, Mesulam MM. Functional specificity of superior parietal mediation of spatial shifting. Neuroimage. 2001;14:661–673
  54. White NM, Hiroi N. Preferential localization of self-stimulation sites in striosomes/patches in the rat striatum. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:6486–6491
  55. Wise RA. Neurobiology of addiction. Current Opinion in Neurobioliogy. 1996;6:243–251
  56. Zeki S. The neurobiology of love. FEBS Letters. 2007;581:2575–2579

PII: S0925-4927(08)00188-1

doi: 10.1016/j.pscychresns.2008.11.003

Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 93-98 , 15 May 2009