Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 109-116 , 15 May 2009

The neural basis of visuospatial perception in Alzheimer's disease and healthy elderly comparison subjects: An fMRI study

  • Subha N. Thiyagesh

      Affiliations

    • Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 114 226 1501; fax: +44 114 226 1522.
    • ,
  • Tom F.D. Farrow

      Affiliations

    • Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    • Co-principal author and alternate corresponding author with same address: Dr. Tom F.D. Farrow.
    • ,
  • Randolph W. Parks

      Affiliations

    • Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    • ,
  • Hector Accosta-Mesa

      Affiliations

    • Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    • ,
  • Claire Young

      Affiliations

    • Sheffield Care Trust, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    • ,
  • Iain D. Wilkinson

      Affiliations

    • Academic Unit of Radiology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    • ,
  • Michael D. Hunter

      Affiliations

    • Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    • ,
  • Peter W.R. Woodruff

      Affiliations

    • Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK

Received 5 September 2007 ,Revised 29 August 2008 ,Accepted 3 November 2008.

References 

  1. Ashburner J, Friston KJ. Voxel-based morphometry—the methods. NeuroImage. 2000;11:805
  2. Backus BT, Fleet DJ, Parker AJ, Heeger DJ. Human cortical activity correlates with stereoscopic depth perception. Journal of Neurophysiology. 2001;86:2054–2068
  3. Cheng K, Fujita H, Kanno I, Miura S, Tanaka K. Human cortical regions activated by wide-field visual motion: an H2(15)O PET study. Journal of Neurophysiology. 1995;74:413–427
  4. Chouinard PA, Paus T. The primary motor and premotor areas of the human cerebral cortex. Neuroscientist. 2006;12:143–152
  5. Claeys KG, Lindsey DT, De Schutter E, Orban GA. A higher order motion region in human inferior parietal lobule: evidence from fMRI. Neuron. 2003;40:631–642
  6. Corbetta M, Shulman GL. Control of goal-directed and stimuls-driven attention in the brain. Nature Reviews Neuroscience. 2002;201–215
  7. Crockett D, Tuokko H, Koch W, Parks R. The assessment of everyday functioning using the present funtioning questionnaire and the functional rating scale in elderly samples. Clinical Aerontologist. 1989;8:3–25
  8. Cronin-Golomb A. Vision in Alzheimer's disease. Gerontologist. 1995;35:370–376
  9. Farrow TFD, Thiyagesh SN, Wilkinson ID, Parks RW, Ingram L, Woodruff PWR. Fronto-temporal-lobe atrophy in early-stage Alzheimer's disease identified using an improved detection methodology. Psychiatry Research: Neuroimaging. 2007;155:11–19
  10. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–198
  11. Friston KJ, Price CJ. Degeneracy and redundancy in cognitive anatomy. Trends in Cognitive Sciences. 2003;7:151–152
  12. Fujimori M, Imamura T, Hirono N, Ishii K, Sasaki M, Mori E. Disturbances of spatial vision and object vision correlate differently with regional cerebral glucose metabolism in Alzheimer's disease. Neuropsychologia. 2000;38:1356–1361
  13. Garrido GEJ, Furuie SS, Buchpiguel CA, Bottino CMC, Almeida OP, Cid CG, et al. Relation between medial temporal atrophy and functional brain activity during memory processing in Alzheimer's disease: a combined MRI and SPECT study. Journal of Neurology, Neurosurgery, and Psychiatry. 2002;73:508–516
  14. Good CD, Johnsrude IS, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ. A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage. 2001;14:21–36
  15. Jackson GR, Owsley C. Visual dysfunction, neurodegenerative diseases, and aging. Neurologic Clinics of North America. 2003;21:709–728
  16. Justino L, Kergoat M, Bergman H, Chertkow H, Robillard A, Kergoat H. Neuroretinal function is normal in early dementia of the Alzheimer type. Neurobiology of Aging. 2001;22:691–695
  17. Karas GB, Scheltens P, Rombouts SARB, Visser PJ, van Schijndel RA, Fox NC, et al. Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. NeuroImage. 2004;23:708–716
  18. Kastner S, Ungerleider LG. The neural basis of biased competition in human visual cortex. Neuropsychologia. 2001;39:1263–1276
  19. Lamm C, Windischberger C, Leodolter U, Moser E, Bauer H. Evidence for premotor cortex activity during dynamic visuospatial imagery from single-trial functional magnetic resonance imaging and event-related slow cortical potentials. NeuroImage. 2001;14:268–283
  20. Lewis DA, Campbell MJ, Terry RD, Morrison JH. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. The Journal of Neuroscience. 1987;7:1799–1808
  21. Logan JM, Sanders AL, Snyder AZ, Morris JC, Buckner RL. Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging. Neuron. 2002;33:827–840
  22. Mendez MF, Mendez MA, Martin R, Smyth KA, Whitehouse PJ. Complex visual disturbances in Alzheimer's disease. Neurology. 1990;40:439–443
  23. Mendez MF, Cherrier MM, Meadows RS. Depth perception in Alzheimer's disease. Perceptual & Motor Skills. 1996;83:987–995
  24. Morrone MC, Tosetti M, Montanaro D, Fiorentini A, Cioni G, Burr DC. A cortical area that responds specifically to optic flow, revealed by fMRI. Nature Neuroscience. 2000;3:1322–1328
  25. Nishida Y, Hayashi O, Iwami T, Kimura M, Kani K, Ito R, et al. Stereopsis-processing regions in the human parieto-occipital cortex. Neuroreport. 2001;12:2259–2263
  26. Orban GA, Sunaert S, Todd JT, Van Hecke P, Marchal G. Human cortical regions involved in extracting depth from motion. Neuron. 1999;24:929–940
  27. Pariente J, Cole S, Henson R, Clare L, Kennedy A, Rossor M, et al. Alzheimer's patients engage an alternative network during a memory task. Annals of Neurology. 2005;58:870–879
  28. Pignatti R, Rabuffetti M, Imbornone E, Mantovani F, Alberoni M, Farina E, et al. Specific impairments of selective attention in mild Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology (Neuropsychology, Development). 2005;27:436–438
  29. Posner MI, Petersen SE. The attention system of the human brain. Annual Review of Neuroscience. 1990;13:25–42
  30. Prvulovic D, Hubl D, Sack AT, Melillo L, Maurer K, Frolich L, et al. Functional imaging of visuospatial processing in Alzheimer's disease. Neuroimage. 2002;17:1403–1414
  31. Ptito M, Kupers R, Faubert J, Gjedde A. Cortical representation of inward and outward radial motion in man. NeuroImage. 2001;14:1409–1415
  32. Remy F, Mirrashed F, Campbell B, Richter W. Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study. NeuroImage. 2005;25:253–266
  33. Rizzo M, Anderson SW, Dawson J, Myers R, Ball K. Visual attention impairments in Alzheimer's disease. Neurology. 2000;54:1954–1959
  34. Rizzo M, Anderson SW, Dawson J, Nawrot M. Vision and cognition in Alzheimer's disease. Neuropsychologia. 2000;38:1157–1169
  35. Rosen W, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. American Journal of Psychiatry. 1984;141(11):1356–1364
  36. Stern Y, Moeller JR, Anderson KE, Luber B, Zubin NR, DiMauro AA, et al. Different brain networks mediate task performance in normal aging and AD: defining compensation. Neurology. 2000;55:1291–1297
  37. Talaraich J, Tournoux P. A Co-planar Stereotactic Atlas of the Human Brain. Stuttgart: Thieme Medical Publishers; 1988;
  38. Taroyan NA, Thiyagesh S, Vigon L, Buckley D, Woodruff PW, Young C, et al. The effects of ageing on stereopsis. A VEP study. Documenta Ophthalmologica. 2004;108:185–196
  39. Thulborn KR, Martin C, Voyvodic JT. Functional MR imaging using a visually guided saccade paradigm for comparing activation patterns in patients with probable Alzheimer's disease and in cognitively able elderly volunteers. American Journal of Neuroradiology. 2000;21:524–531
  40. Tobimatsu S, Goto Y, Yamasaki T, Tsurusawa R, Taniwaki T. Non-invasive evaluation of face and motion perception in humans. Journal of Physiological Anthropology and Applied Human Sciences. 2004;23:273–276
  41. Trobe J. The Neurology of Vision. Contemporary Neurology Series. New York, NY: Oxford University Press; 2001;
  42. Tsao DY, Vanduffel W, Sasaki Y, Fize D, Knutsen TA, Mandeville JB, et al. Stereopsis activates V3A and caudal intraparietal areas in macaques and humans. Neuron. 2003;39:555–568
  43. Watson JD, Myers R, Frackowiak RS, Hajnal JV, Woods RP, Mazziotta JC, et al. Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. Cerebral Cortex. 1993;3:79–94
  44. Woodruff PW, Benson RR, Bandettini PA, Kwong KK, Howard RJ, Talavage T, et al. Modulation of auditory and visual cortex by selective attention is modality-dependent. Neuroreport. 1996;7:1909–1913
  45. Zec RF. Neuropsychological functioning in Alzheimer disease. In:  Parks RW,  Zec RF,  Wilson RS editor. Neuropsychology of Alzheimer's Disease and Other Dementias. New York: Oxford University Press; 1993;p. 3–80
  46. Zeki S, Watson JD, Lueck CJ, Friston KJ, Kennard C, Frackowiak RS. A direct demonstration of functional specialization in human visual cortex. The Journal of Neuroscience. 1991;11:641–649

PII: S0925-4927(08)00175-3

doi: 10.1016/j.pscychresns.2008.11.002

Psychiatry Research: Neuroimaging
Volume 172, Issue 2 , Pages 109-116 , 15 May 2009

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