Longitudinal 4.0 Tesla 31P magnetic resonance spectroscopy changes in the anterior cingulate and left thalamus in first episode schizophrenia

Miller, Jodi; Williamson, Peter; Jensen, J. Eric; Manchanda, Rahul; Menon, Ravi; Neufeld, Richard; Rajakumar, Nagalingam; Pavlosky, William; Densmore, Maria; Schaefer, Betsy; Drost, Dick J.

doi:10.1016/j.pscychresns.2008.10.001

« Previous Next »Psychiatry Research: Neuroimaging
Volume 173, Issue 2 , Pages 155-157, 30 August 2009

Longitudinal 4.0 Tesla ³¹P magnetic resonance spectroscopy changes in the anterior cingulate and left thalamus in first episode schizophrenia

Jodi Miller
- Lawson Health Research Institute, London, Ontario, Canada
- Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
Peter Williamson
- Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
- Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
- Corresponding author. University Hospital- LHSC, 339 Windermere Rd., London, Ontario, Canada N6A 5A5. Tel./fax: +1 519 663 3935.
J. Eric Jensen
- Brain Imaging Center, McLean Hospital., Belmont, MA 02478, USA
Rahul Manchanda
- Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Ravi Menon
- Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
- Laboratory for Functional Magnetic Resonance Research, John P. Robarts Research Institute, London, Ontario, Canada
Richard Neufeld
- Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
- Department of Psychology, University of Western Ontario, London, Ontario, Canada
Nagalingam Rajakumar
- Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
William Pavlosky
- Department of Radiology and Nuclear Medicine, University of Western Ontario, London, Ontario, Canada
Maria Densmore
- Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Betsy Schaefer
- Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Dick J. Drost
- Lawson Health Research Institute, London, Ontario, Canada
- Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
- Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
- Department of Radiology and Nuclear Medicine, University of Western Ontario, London, Ontario, Canada

Received 18 January 2008; received in revised form 25 September 2008; accepted 2 October 2008.

Abstract

Progressive volumetric losses in schizophrenia may be preceded by abnormal cell membrane metabolism. Longitudinal changes in membrane metabolites were quantified with ³¹P MRS in the anterior cingulate and left thalamus of 13 first episode schizophrenic patients and 13 healthy volunteers at baseline and 30 months. Glycerophosphocholine was higher in patients at baseline in the anterior cingulate and glycerophosphoethanolamine was lower in the left thalamus at 30 months compared with patients at baseline and volunteers at 30 months. These observations suggest longitudinal changes in membrane metabolites consistent with a neurodegenerative process in certain cases of schizophrenia.

Keywords: Membrane metabolites, Chemical shift imaging, Neurodegeneration