Psychiatry Research: Neuroimaging
Volume 173, Issue 2 , Pages 128-134 , 30 August 2009

Sexually dimorphic gray matter volume reduction in patients with panic disorder

  • Takeshi Asami

      Affiliations

    • Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • ,
  • Hidenori Yamasue

      Affiliations

    • Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Fumi Hayano

      Affiliations

    • Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • ,
  • Motoaki Nakamura

      Affiliations

    • Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • ,
  • Kumi Uehara

      Affiliations

    • Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • ,
  • Tatsui Otsuka

      Affiliations

    • Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • ,
  • Tomohide Roppongi

      Affiliations

    • Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • ,
  • Namiko Nihashi

      Affiliations

    • Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • ,
  • Tomio Inoue

      Affiliations

    • Department of Radiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • ,
  • Yoshio Hirayasu

      Affiliations

    • Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
    • Corresponding Author InformationCorresponding author.

Received 7 January 2008 ,Revised 3 September 2008 ,Accepted 2 October 2008.

References 

  1. Ashburner J, Friston KJ. Voxel-based morphometry—the methods. Neuroimage. 2000;11:805–821
  2. Biggs JT, Wylie LT, Ziegler VE. Validity of the Zung Self-rating Depression Scale. British Journal of Psychiatry. 1978;132:381–385
  3. Bisaga A, Katz JL, Antonini A, Wright CE, Margouleff C, Gorman JM, et al. Cerebral glucose metabolism in women with panic disorder. American Journal of Psychiatry. 1998;155:1178–1183
  4. Butler T, Pan H, Epstein J, Protopopescu X, Tuescher O, Goldstein M, et al. Fear-related activity in subgenual anterior cingulate differs between men and women. Neuroreport. 2005;16:1233–1236
  5. Coplan JD, Lydiard RB. Brain circuits in panic disorder. Biological Psychiatry. 1998;44:1264–1276
  6. Craig AD. Interoception: the sense of the physiological condition of the body. Current Opinion in Neurobiology. 2003;13:500–505
  7. Critchley HD, Corfield DR, Chandler MP, Mathias CJ, Dolan RJ. Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans. Journal of Physiology. 2000;523(Pt 1):259–270
  8. Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ. Neural systems supporting interoceptive awareness. Nature Neuroscience. 2004;7:189–195
  9. De Bellis MD, Kuchibhatla M. Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder. Biological Psychiatry. 2006;60:697–703
  10. Eaton WW, Kessler RC, Wittchen HU, Magee WJ. Panic and panic disorder in the United States. American Journal of Psychiatry. 1994;151:413–420
  11. First M, Spitzer R, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I —Clinician Version, 4th ed. Washington DC: American Psychiatric Press; 1997;
  12. Fischer H, Andersson JL, Furmark T, Fredrikson M. Brain correlates of an unexpected panic attack: a human positron emission tomographic study. Neuroscience Letters. 1998;251:137–140
  13. Fontaine R, Breton G, Dery R, Fontaine S, Elie R. Temporal lobe abnormalities in panic disorder: an MRI study. Biological Psychiatry. 1990;27:304–310
  14. Friston K, Holmes A, Worsley K, Poline J, Frith C, Frackowiak R. Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping. 1995;2:189–210
  15. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage. 2002;15:870–878
  16. Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, et al. Reductions in occipital cortex GABA levels in panic disorder detected with 1 h-magnetic resonance spectroscopy. Archives of General Psychiatry. 2001;58:556–561
  17. Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage. 2001;14:685–700
  18. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage. 2001;14:21–36
  19. Gorman JM, Kent JM, Sullivan GM, Coplan JD. Neuroanatomical hypothesis of panic disorder, revised. American Journal of Psychiatry. 2000;157:493–505
  20. Hamann S. Sex differences in the responses of the human amygdala. Neuroscientist. 2005;11:288–293
  21. Hollingshead A. Two-Factor Index of Social Position. New Haven, C.T.: Yale University Press; 1965;
  22. Im K, Lee J, Lee J, Shin Y, Kim I, Kwon J, et al. Gender difference analysis of cortical thickness in healthy young adults with surface-based methods. Neuroimage. Neuroimage. 2006;31:31–38
  23. Lee YS, Hwang J, Kim SJ, Sung YH, Kim J, Sim ME, et al. Decreased blood flow of temporal regions of the brain in subjects with panic disorder. Journal of Psychiatric Research. 2006;40:528–534
  24. Massana G, Serra-Grabulosa JM, Salgado-Pineda P, Gasto C, Junque C, Massana J, et al. Parahippocampal gray matter density in panic disorder: a voxel-based morphometric study. American Journal of Psychiatry. 2003;160:566–568
  25. Massana G, Serra-Grabulosa JM, Salgado-Pineda P, Gasto C, Junque C, Massana J, et al. Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging. Neuroimage. 2003;19:80–90
  26. Meyer JH, Swinson R, Kennedy SH, Houle S, Brown GM. Increased left posterior parietal–temporal cortex activation after d-fenfluramine in women with panic disorder. Psychiatry Research. 2000;98:133–143
  27. Nieuwenhuys R, Voogd J, Huijzen C. The human central nervous system. A Synopsis and Atlas. 3rd-R ed.. New York; 1988;
  28. Pillay SS, Gruber SA, Rogowska J, Simpson N, Yurgelun-Todd DA. fMRI of fearful facial affect recognition in panic disorder: the cingulate gyrus–amygdala connection. Journal of Affective Disorder. 2006;94:173–181
  29. Protopopescu X, Pan H, Tuescher O, Cloitre M, Goldstein M, Engelien A, et al. Increased brainstem volume in panic disorder: a voxel-based morphometric study. Neuroreport. 2006;17:361–363
  30. Sakai Y, Kumano H, Nishikawa M, Sakano Y, Kaiya H, Imabayashi E, et al. Changes in cerebral glucose utilization in patients with panic disorder treated with cognitive–behavioral therapy. Neuroimage. 2006;33:218–226
  31. Schoenbaum G, Chiba AA, Gallagher M. Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning. Nature Neuroscience. 1998;1:155–159
  32. Schunck T, Erb G, Mathis A, Gilles C, Namer IJ, Hode Y, et al. Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety. Neuroimage. 2006;31:1197–1208
  33. Shear MK, Maser JD. Standardized assessment for panic disorder research. A conference report. Archives of General Psychiatry. 1994;51:346–354
  34. Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E., Hergueta, T., Baker, R., Dunbar, G.C., 1998. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the Development and Validation of a Structured Diagnostic Psychiatric Interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59 Suppl 20, 22–33;quiz 34–57.
  35. Spielberger C, Gorsuch R, Lushene R. Stait-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press, Inc.; 1983;
  36. Uchida RR, Del-Ben CM, Santos AC, Araujo D, Crippa JA, Guimaraes FS, et al. Decreased left temporal lobe volume of panic patients measured by magnetic resonance imaging. Brazilian Journal of Medical and Biological Research. 2003;36:925–929
  37. Von Korff MR, Eaton WW, Keyl PM. The epidemiology of panic attacks and panic disorder. Results of three community surveys. American Journal of Epidemiology. 1985;122:970–981
  38. Vythilingam M, Anderson ER, Goddard A, Woods SW, Staib LH, Charney DS, et al. Temporal lobe volume in panic disorder—a quantitative magnetic resonance imaging study. Psychiatry Research. 2000;99:75–82
  39. Yamasue H, Abe O, Suga M, Yamada H, Inoue H, Tochigi M, et al. Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits. Cerebral Cortex. 2007;
  40. Yoo HK, Kim MJ, Kim SJ, Sung YH, Sim ME, Lee YS, et al. Putaminal gray matter volume decrease in panic disorder: an optimized voxel-based morphometry study. European Journal of Neuroscience. 2005;22:2089–2094

PII: S0925-4927(08)00156-X

doi: 10.1016/j.pscychresns.2008.10.004

Psychiatry Research: Neuroimaging
Volume 173, Issue 2 , Pages 128-134 , 30 August 2009

Article Tools

* Image Usage & Resolution