Psychiatry Research: Neuroimaging
Volume 173, Issue 1 , Pages 31-38 , 15 July 2009

Changes in prefrontal and amygdala activity during olanzapine treatment in schizophrenia

  • Giuseppe Blasi

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Teresa Popolizio

      Affiliations

    • Department of Neuroradiology, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy
    • ,
  • Paolo Taurisano

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Grazia Caforio

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Raffaella Romano

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Annabella Di Giorgio

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Fabio Sambataro

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    • ,
  • Valeria Rubino

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Valeria Latorre

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Luciana Lo Bianco

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Leonardo Fazio

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Marcello Nardini

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Daniel R. Weinberger

      Affiliations

    • Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    • ,
  • Alessandro Bertolino

      Affiliations

    • Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • Department of Neuroradiology, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy
    • Corresponding Author InformationCorresponding author. Dipartimento di Scienze Neurologiche e Psichiatriche, Università degli Studi di Bari, Piazza Giulio Cesare, 9, 70124 Bari, Italy. Tel.: +39 080 5478572; fax: +39 080 5593204.

Received 29 February 2008 ,Revised 29 July 2008 ,Accepted 8 September 2008.

References 

  1. Adolphs R, Tranel D, Damasio AR. The human amygdala in social judgment. Nature. 1998;393:470–474
  2. Akil M, Pierri JN, Whitehead RE, Edgar CL, Mohila C, Sampson AR, et al. Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects. American Journal of Psychiatry. 1999;156:1580–1589
  3. Aleman A, Kahn RS. Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia?. Progress in Neurobiology. 2005;77:283–298
  4. Altshuler L, Bookheimer S, Proenza MA, Townsend J, Sabb F, Firestine A, et al. Increased amygdala activation during mania: a functional magnetic resonance imaging study. American Journal of Psychiatry. 2005;162:1211–1213
  5. Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends in Cognitive Sciences. 2004;8:170–177
  6. Bertolino A, Blasi G, Caforio G, Latorre V, De Candia M, Rubino V, et al. Functional lateralization of the sensorimotor cortex in patients with schizophrenia: effects of treatment with olanzapine. Biological Psychiatry. 2004;56:190–197
  7. Bertolino A, Caforio G, Blasi G, De Candia M, Latorre V, Petruzzella V, et al. Interaction of COMT Val108/158 Met genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. American Journal of Psychiatry. 2004;161:1798–1805
  8. Bertolino A, Arciero G, Rubino V, Latorre V, De Candia M, Mazzola V, et al. Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style. Biological Psychiatry. 2005;57:1517–1525
  9. Blasi G, Bertolino A. Imaging genomics and response to treatment with antipsychotics in schizophrenia. NeuroRx. 2006;3:117–130
  10. Brunet-Gouet E, Decety J. Social brain dysfunctions in schizophrenia: a review of neuroimaging studies. Psychiatry Research. Neuroimaging. 2006;148:75–92
  11. Das P, Kemp AH, Flynn G, Harris AW, Liddell BJ, Whitford TJ, et al. Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia. Schizophrenia Research. 2007;90:284–294
  12. Dwivedi Y, Rizavi HS, Pandey GN. Differential effects of haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 2002;301:197–209
  13. Edwards J, Jackson HJ, Pattison PE. Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clinical Psychology Review. 2002;22:789–832
  14. Fahim C, Stip E, Mancini-Marie A, Gendron A, Mensour B, Beauregard M. Differential hemodynamic brain activity in schizophrenia patients with blunted affect during quetiapine treatment. Journal of Clinical Psychopharmacology. 2005;25:367–371
  15. Fakra E, Salgado-Pineda P, Delaveau P, Hariri AR, Blin O. Neural bases of different cognitive strategies for facial affect processing in schizophrenia. Schizophrenia Research. 2008;100:191–205
  16. Freeman D, Garety PA, Kuipers E. Persecutory delusions: developing the understanding of belief maintenance and emotional distress. Psychological Medicine. 2001;31:1293–1306
  17. Fumagalli F, Bedogni F, Maragnoli ME, Gennarelli M, Perez J, Racagni G, et al. Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus. Journal of Neuroscience Research. 2003;74:74–80
  18. Fusar-Poli P, Broome MR, Matthiasson P, Williams SC, Brammer M, McGuire PK. Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study. European Neuropsychopharmacology. 2007;17:492–500
  19. Gessa GL, Devoto P, Diana M, Flore G, Melis M, Pistis M. Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex. Neuropsychopharmacology. 2000;22:642–649
  20. Glascher J, Adolphs R. Processing of the arousal of subliminal and supraliminal emotional stimuli by the human amygdala. Journal of Neuroscience. 2003;23:10274–10282
  21. Grace AA. Gating of information flow within the limbic system and the pathophysiology of schizophrenia. Brain Research. Brain Research Reviews. 2000;31:330–341
  22. Grace AA, Rosenkranz JA. Regulation of conditioned responses of basolateral amygdala neurons. Physiology & Behavior. 2002;77:489–493
  23. Gur RE, Loughead J, Kohler CG, Elliott MA, Lesko K, Ruparel K, et al. Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia. Archives of General Psychiatry. 2007;64:1356–1366
  24. Hariri AR, Bookheimer SY, Mazziotta JC. Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport. 2000;11:43–48
  25. Hariri AR, Mattay VS, Tessitore A, Fera F, Weinberger DR. Neocortical modulation of the amygdala response to fearful stimuli. Biological Psychiatry. 2003;53:494–501
  26. Hariri AR, Mattay VS, Tessitore A, Fera F, Smith WG, Weinberger DR. Dextroamphetamine modulates the response of the human amygdala. Neuropsychopharmacology. 2002;27:1036–1040
  27. Holt DJ, Kunkel L, Weiss AP, Goff DC, Wright CI, Shin LM, et al. Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophrenia Research. 2006;82:153–162
  28. Honey GD, Bullmore ET, Soni W, Varatheesan M, Williams SC, Sharma T. Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 1999;96:13432–13437
  29. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry. 2003;160:13–23
  30. Kosaka H, Omori M, Murata T, Iidaka T, Yamada H, Okada T, et al. Differential amygdala response during facial recognition in patients with schizophrenia: an fMRI study. Schizophrenia Research. 2002;57:87–95
  31. Kring AM, Neale JM. Do schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion?. Journal of Abnormal Psychology. 1996;105:249–257
  32. Kumakura Y, Cumming P, Vernaleken I, Buchholz HG, Siessmeier T, Heinz A, et al. Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography study. Journal of Neuroscience. 2007;27:8080–8087
  33. Laviolette SR. Dopamine modulation of emotional processing in cortical and subcortical neural circuits: evidence for a final common pathway in schizophrenia?. Schizophrenia Bulletin. 2007;33:971–981
  34. LeDoux J. Fear and the brain: where have we been, and where are we going?. Biological Psychiatry. 1998;44:1229–1238
  35. LeDoux JE, Iwata J, Cicchetti P, Reis DJ. Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. Journal of Neuroscience. 1988;8:2517–2529
  36. Liberzon I, Phan KL, Decker LR, Taylor SF. Extended amygdala and emotional salience: a PET activation study of positive and negative affect. Neuropsychopharmacology. 2003;28:726–733
  37. Meisenzahl EM, Scheuerecker J, Zipse M, Ufer S, Wiesmann M, Frodl T, et al. Effects of treatment with the atypical neuroleptic quetiapine on working memory function: a functional MRI follow-up investigation. European Archives of Psychiatry and Clinical Neuroscience. 2006;256:522–531
  38. Meyer-Lindenberg A, Mervis CB, Berman KF. Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour. Nature Reviews. Neuroscience. 2006;7:380–393
  39. Meyer-Lindenberg A, Buckholtz JW, Kolachana BARH, Pezawas L, Blasi G, Wabnitz A, et al. Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:6269–6274
  40. Morris JS, Ohman A, Dolan RJ. Conscious and unconscious emotional learning in the human amygdala. Nature. 1998;393:467–470
  41. Ochsner KN, Gross JJ. The cognitive control of emotion. Trends in Cognitive Sciences. 2005;9:242–249
  42. Ochsner KN, Ray RD, Cooper JC, Robertson ER, Chopra S, Gabrieli JD, et al. For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage. 2004;23:483–499
  43. Ohira H, Nomura M, Ichikawa N, Isowa T, Iidaka T, Sato A, et al. Association of neural and physiological responses during voluntary emotion suppression. Neuroimage. 2006;29:721–733
  44. Paradiso S, Andreasen NC, Crespo-Facorro B, O'Leary DS, Watkins GL, Boles Ponto LL, et al. Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomography. American Journal of Psychiatry. 2003;160:1775–1783
  45. Pezze MA, Feldon J. Mesolimbic dopaminergic pathways in fear conditioning. Progress in Neurobiology. 2004;74:301–320
  46. Pozzi L, Hakansson K, Usiello A, Borgkvist A, Lindskog M, Greengard P, et al. Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum. Journal of Neurochemistry. 2003;86:451–459
  47. Purdon SE, Jones BD, Stip E, Labelle A, Addington D, David SR, et al. Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol. The Canadian Collaborative Group for research in schizophrenia. Archives of General Psychiatry. 2000;57:249–258
  48. Rosenkranz JA, Grace AA. Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo. Journal of Neuroscience. 1999;19:11027–11039
  49. Rosenkranz JA, Grace AA. Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats. Journal of Neuroscience. 2001;21:4090–4103
  50. Rubino V, Blasi G, Latorre V, Fazio L, d'Errico I, Mazzola V, et al. Activity in medial prefrontal cortex during cognitive evaluation of threatening stimuli as a function of personality style. Brain Research Bulletin. 2007;74:250–257
  51. Russell TA, Reynaud E, Kucharska-Pietura K, Ecker C, Benson PJ, Zelaya F, et al. Neural responses to dynamic expressions of fear in schizophrenia. Neuropsychologia. 2007;45:107–123
  52. Sanjuan J, Lull JJ, Aguilar EJ, Marti-Bonmati L, Moratal D, Gonzalez JC, et al. Emotional words induce enhanced brain activity in schizophrenic patients with auditory hallucinations. Psychiatry Research. Neuroimaging. 2007;154:21–29
  53. Seamans JK, Yang CR. The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Progress in Neurobiology. 2004;74:1–58
  54. Stephan KE, Magnotta VA, White T, Arndt S, Flaum M, O'Leary DS, et al. Effects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor task. Psychological Medicine. 2001;31:1065–1078
  55. Stip E, Fahim C, Mancini-Marie A, Bentaleb LA, Mensour B, Mendrek A, et al. Restoration of frontal activation during a treatment with quetiapine: an fMRI study of blunted affect in schizophrenia. Progress in Neuropsychopharmacology and Biological Psychiatry. 2005;29:21–26
  56. Streit M, Ioannides A, Sinnemann T, Wolwer W, Dammers J, Zilles K, et al. Disturbed facial affect recognition in patients with schizophrenia associated with hypoactivity in distributed brain regions: a magnetoencephalographic study. American Journal of Psychiatry. 2001;158:1429–1436
  57. Surguladze S, Russell T, Kucharska-Pietura K, Travis MJ, Giampietro V, David AS, et al. A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia. Biological Psychiatry. 2006;60:423–431
  58. Takahashi H, Koeda M, Oda K, Matsuda T, Matsushima E, Matsuura M, et al. An fMRI study of differential neural response to affective pictures in schizophrenia. Neuroimage. 2004;22:1247–1254
  59. Tessitore A, Hariri AR, Fera F, Smith WG, Das S, Weinberger DR, et al. Functional changes in the activity of brain regions underlying emotion processing in the elderly. Psychiatry Research. Neuroimaging. 2005;139:9–18
  60. Tessitore A, Hariri AR, Fera F, Smith WG, Chase TN, Hyde TM, et al. Dopamine modulates the response of the human amygdala: a study in Parkinson's disease. Journal of Neuroscience. 2002;22:9099–9103
  61. Wang AT, Dapretto M, Hariri AR, Sigman M, Bookheimer SY. Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2004;43:481–490
  62. Williams LM, Das P, Liddell BJ, Kemp AH, Rennie CJ, Gordon E. Mode of functional connectivity in amygdala pathways dissociates level of awareness for signals of fear. Journal of Neuroscience. 2006;26:9264–9271
  63. Williams LM, Das P, Harris AW, Liddell BB, Brammer MJ, Olivieri G, et al. Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. American Journal of Psychiatry. 2004;161:480–489
  64. Williams LM, Das P, Liddell BJ, Olivieri G, Peduto AS, David AS, et al. Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes. Psychiatry Research. Neuroimaging. 2007;155:29–44
  65. Wolf RC, Vasic N, Hose A, Spitzer M, Walter H. Changes over time in frontotemporal activation during a working memory task in patients with schizophrenia. Schizophrenia Research. 2007;91:141–150
  66. Wright CI, Wedig MM, Williams D, Rauch SL, Albert MS. Novel fearful faces activate the amygdala in healthy young and elderly adults. Neurobiology of Aging. 2006;27:361–374

PII: S0925-4927(08)00143-1

doi: 10.1016/j.pscychresns.2008.09.001

Psychiatry Research: Neuroimaging
Volume 173, Issue 1 , Pages 31-38 , 15 July 2009

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