Psychiatry Research: Neuroimaging
Volume 173, Issue 3 , Pages 238-242 , 30 September 2009

Spectroscopic correlates of antidepressant response to sleep deprivation and light therapy: A 3.0 Tesla study of bipolar depression

  • Francesco Benedetti

      Affiliations

    • Department of Neuropsychiatric Sciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy
    • Corresponding Author InformationCorresponding author. Istituto Scientifico Ospedale San Raffaele, Department of Clinical Neurosciences, San Raffaele Turro, Via Stamira d'Ancona 20, Milano, Italy. Tel.: +39 02 26433156; fax: +39 02 26433265.
  • ,
  • Giovanna Calabrese

      Affiliations

    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy
    • Unità Operativa Radiologia, Azienda Ospedaliera G. Salvini, Garbagnate Milanese, Milan, Italy
  • ,
  • Alessandro Bernasconi

      Affiliations

    • Department of Neuropsychiatric Sciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy
  • ,
  • Marcello Cadioli

      Affiliations

    • Department of Neuroradiology, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • Philips Medical Systems, Milan, Italy
  • ,
  • Cristina Colombo

      Affiliations

    • Department of Neuropsychiatric Sciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy
  • ,
  • Sara Dallaspezia

      Affiliations

    • Department of Neuropsychiatric Sciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy
  • ,
  • Andrea Falini

      Affiliations

    • Department of Neuroradiology, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy
  • ,
  • Daniele Radaelli

      Affiliations

    • Department of Neuropsychiatric Sciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy
    • Dottorato in Neuroscienze e Disturbi del Comportamento, Dipartimento di Scienze Farmacologiche, Università degli Studi di Palermo, Italy
  • ,
  • Giuseppe Scotti

      Affiliations

    • Department of Neuroradiology, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy
  • ,
  • Enrico Smeraldi

      Affiliations

    • Department of Neuropsychiatric Sciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
    • C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy

Received 22 March 2007 ,Revised 30 July 2008 ,Accepted 12 August 2008.

References 

  1. Andin J, Stenfors C, Ross SB, Marcusson J. Modulation of neuronal Glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline. Brain Research. Molecular Brain Research. 2004;126:74–77
  2. Auer DP, Putz B, Kraft E, Lipinski B, Schill J, Holsboer F. Reduced Glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biological Psychiatry. 2000;47:305–313
  3. Benedetti F, Campori E, Barbini B, Cigala Fulgosi M, Colombo C. Dopaminergic augmentation of sleep deprivation effects in bipolar depression. Psychiatry Research. 2001;104:239–246
  4. Benedetti F, Barbini B, Colombo C, Smeraldi E. Chronotherapeutics in a psychiatric ward. Sleep Medicine Reviews. 2007;11:509–522
  5. Benedetti F, Bernasconi A, Blasi V, Cadioli M, Colombo C, Falini A, et al. Neural and genetic correlates of antidepressant response to sleep deprivation: a fMRI study of moral valence decision in bipolar depression. Archives of Gneral. Psychiatry. 2007;64:179–187
  6. Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, et al. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry. 2000;47:351–354
  7. Bruhn H, Stoppe G, Staedt J, Merboldt , Hanicke W, Frahm J. Quantitative proton MRS in vivo shows cerebral myo-inositol and cholines to be unchanged in manic-depressive patients treated with lithium. Proceedings of the Society of Magnetic Resonance in Medicine. 1993;1543:
  8. Castillo M, Kwock L, Courvoisie H, Hooper SR. Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations. American Journal of Neuroradiology. 2000;21:832–838
  9. Cecil KM, DelBello MP, Morey R, Strakowski SM. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disorder. 2002;4:357–365
  10. Chaki S, Yoshikawa R, Hirota S, Shimazaki T, Maeda M, Kawashima N. MGS0039: a potent and selective group II metabotropic Glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 2004;46:457–467
  11. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd edition. Hillsdale, NJ: Erlbaum; 1988;
  12. Cooper J, Bloom F, Roth R. Aminoacid transmitters. The biochemical basis of neuropharmacology. 8th ed.. New York: Oxford University Press; 2003;
  13. Crane GE. The psychotropic effect of cycloserine: a new use of an antibiotic. Comprehensive Psychiatry. 1961;2:51–59
  14. Dager SR, Friedman SD, Parow A, Demopulos C, Stoll AL, Lyoo IK, et al. Brain metabolic alterations in medication-free patients with bipolar disorder. Archives of General Psychiatry. 2004;61:450–458
  15. Ebert D, Feistel H, Kaschka W, Barocka A, Pirner A. Single photon emission computerized tomography assessment of cerebral dopamine D2 receptor blockade in depression before and after sleep deprivation. Preliminary results. Biological Psychiatry. 1994;35:880–885
  16. Faul F, Erdfelder E, Lang A-G, Buchner A. G⁎Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods. 2007;39:175–191
  17. Friedman SD, Dager SR, Parow A, Hirashima F, Demopulos C, Stoll AL, et al. Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder. Biological Psychiatry. 2004;56:340–348
  18. Gerner RH, Paot RM, Gillin JC, Bunney WE. Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals. Psychiatry Research. 1979;15:21–40
  19. Golembiowska K, Dziubina A. Effect of acute and chronic administration of citalopram on Glutamate and aspartate release in the rat prefrontal cortex. Polish Journal of Pharmacology. 2000;52:441–448
  20. Golembiowska K, Dziubina A. Involvement of adenosine in the effect of antidepressants on Glutamate and aspartate release in the rat prefrontal cortex. Naunyn-Schmiedeberg's Archives of Pharmacology. 2001;363:663–670
  21. Gruetter R, Adriany G, Choi IY, Henry TG, Lei H, Oz G. Localized in vivo C NMR spectroscopy of the brain. NMR in Biomedicine. 2003;16:313–338
  22. Hurd R, Sailasuta N, Srinivasan R, Vigneron DB, Pelletier D, Nelson SJ. Measurement of brain glutamate using TE-averaged PRESS at 3T. Magnetic Resonance in Medicine. 2004;51:435–440
  23. Javitt DC. Glutamate as a therapeutic target in psychiatric disorders. Molecular Psychiatry. 2004;9:984–997
  24. Kos T, Popik P. A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice. Behavioural Pharmacology. 2005;16:155–161
  25. Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, et al. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Molecular Psychiatry. 2002;7(Suppl. 1):S71–S80
  26. Kugaya A, Sanacora G. Beyond monoamines: glutamatergic function in mood disorders. CNS Spectrums. 2005;10:808–819
  27. Michael N, Erfurth A, Ohrmann P, Arolt V, Heindel W, Pfleiderer B. Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression. Psychological Medicine. 2003;33:1277–1284
  28. Michael N, Erfurth A, Ohrmann P, Gossling M, Arolt V, Heindel W. Acute mania is accompanied by elevated Glutamate/Glutamine levels within the left dorsolateral prefrontal cortex. Psychopharmacology. 2003;168:344–346
  29. Michael-Titus AT, Bains S, Geetle J, Whelpton R. Imipramine and phenelzine decrease Glutamate overflow in the prefrontal cortex. A possible mechanism of neuroprotection in major depression?. Neuroscience. 2000;100:681–684
  30. Mirza Y, Tang J, Russell A, Banerjee SP, Bhandari R, Ivey J, et al. Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression. Journal of the American Academy of Child and Adolescent Psychiatry. 2004;43:341–348
  31. Muramatsu M, Lapiz MD, Tanaka E, Grenhoff J. Serotonin inhibits synaptic Glutamate currents in rat nucleus accumbens neurons via presynaptic 5-HT1B receptors. European Journal of Neuroscience. 1998;10:2371–2379
  32. Nudmamud-Thanoi S, Reynolds GP. The NR1 subunit of the Glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders. Neuroscience Letters. 2004;372:173–177
  33. Nowak G, Ordway GA, Paul IA. Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Research. 1995;675:157–164
  34. Palucha A, Branski P, Szewczyk B, Wieronska JM, Klak K, Pilc A. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacology Biochemistry and Behavior. 2005;81:901–906
  35. Paul IA, Nowak G, Layer RT, Popik P, Skolnick P. Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. Journal of Pharmacology and Experimental Therapeutics. 1994;269:95–102
  36. Pfleiderer B, Michael N, Erfurth A, Ohrmann P, Hohmann U, Wolgast M, et al. Effective electroconvulsive therapy reverses Glutamate/Glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Research. 2003;122:185–192
  37. Rogoz Z, Skuza G, Kusmider M, Wojcikowski J, Kot M, Daniel WA. Synergistic effect of imipramine and amantadine in the forced swimming test in rats. Behavioral and pharmacokinetic studies. Polish Journal of Pharmacology. 2004;56:179–185
  38. Rosenberg DR, Mirza Y, Russell A, Tang J, Smith JM, Banerjee SP, et al. Reduced anterior cingulate Glutamatergic concentrations in childhood OCD and major depression versus healthy controls. Journal of the American Academy of Child and Adolescent Psychiatry. 2004;43:1146–1153
  39. Rosenberg DR, Macmaster FP, Mirza Y, Smith JM, Easter PC, Banerjee SPB, et al. Reduced anterior cingulate Glutamate in pediatric major depression: a magnetic resonance spectroscopy study. Biological Psychiatry. 2005;58:700–704
  40. Sanacora G, Kendell SF, Feniton L, Coric V, Krystal JH. Riluzole augmentation for treatment resistant depression. American Journal of Psychiatry. 2004;161:2132
  41. Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of General Psychiatry. 2004;61:705–713
  42. Scarr E, Pavey G, Sundram S, MacKinnon A, Dean B. Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder. Bipolar Disorder. 2003;5:257–264
  43. Shibuya-Tayoshi S, Tayoshi S, Sumitani S, Ueno SI, Harada M, Ohmori T. Lithium effects on brain glutamatergic and GABAergic systems of healthy volunteers as measured by proton magnetic resonance spectroscopy. Progress in Neuropsychopharmacology and Biological Psychiatry. 2008;32:249–256
  44. Singh J, Zarate CA, Krystal AD. Case report: successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine. Psychopharmacology (Berl.). 2004;173:227–228
  45. Smeraldi E, Benedetti F, Barbini B, Campori C, Colombo C. Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression: a placebo-controlled trial. Neuropsychopharmacology. 1999;20:380–385
  46. Tordera RM, Pei Q, Sharp T. Evidence for increased expression of the vesicular Glutamate transporter, VGLUT1, by a course of antidepressant treatment. Journal of Neurochemistry. 2005;94:875–883
  47. Vale S, Espejel MA, Dominguez JC. Amantadine in depression. Lancet. 1971;2:437
  48. Wirz-Justice A, Van den Hoofdakker RH. Sleep deprivation in depression: what do we know, where do we go?. Biological Psychiatry. 1999;46:445–453
  49. Wirz-Justice A, Terman M, Oren DA, Goodwin FK, Kripke DF, Whybrow PC, et al. Brightening depression. Science. 2004;303:467–469
  50. Wirz-Justice A, Benedetti F, Berger M, Lam RW, Martiny K, Terman M, et al. Chronotherapeutics (light and wake therapy) in affective disorders. Psychological Medicine. 2005;35:939–944
  51. Wu J, Buchsbaum M, Bunney WE. Clinical neurochemical implications of sleep deprivation's effects on the anterior cingulate of depressed responders. Neuropsychopharmacology. 2001;25:S74–S78
  52. Yildiz-Yesiloglu A, Ankerst DP. Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings. Progress in Neuropsychopharmacology and Biological Psychiatry. 2006;30:969–995
  53. Zarate CA, Payne JL, Quiroz J, Sporn J, Denicoff KK, Luckenbaugh D, et al. An open-label trial of riluzole in patients with treatment-resistant major depression. American Journal of Psychiatry. 2004;161:171–174
  54. Zarate CA, Quiroz JA, Singh JB, Denicoff KD, De Jesus G, Luckenbaugh DA, et al. An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression. Biological Psychiatry. 2005;57:430–432

PII: S0925-4927(08)00124-8

doi: 10.1016/j.pscychresns.2008.08.004

Psychiatry Research: Neuroimaging
Volume 173, Issue 3 , Pages 238-242 , 30 September 2009