Psychiatry Research: Neuroimaging
Volume 173, Issue 1 , Pages 1-7 , 15 July 2009

Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy

  • Ulrich Pilatus

      Affiliations

    • Institute of Neuroadiology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
  • ,
  • Christoph Lais

      Affiliations

    • Department of Psychiatry and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
  • ,
  • Anna du Mesnil de Rochmont

      Affiliations

    • Institute of Neuroadiology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
  • ,
  • Tillmann Kratzsch

      Affiliations

    • Department of Psychiatry and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
  • ,
  • Lutz Frölich

      Affiliations

    • Division of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Germany
  • ,
  • Konrad Maurer

      Affiliations

    • Department of Psychiatry and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
  • ,
  • Friedhelm E. Zanella

      Affiliations

    • Institute of Neuroadiology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
  • ,
  • Heinrich Lanfermann

      Affiliations

    • Institute of Neuroadiology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
  • ,
  • Johannes Pantel

      Affiliations

    • Department of Psychiatry and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Hospital of the Johann Wolfgang Goethe University Frankfurt/Main, Heinrich-Hoffmann-Str. 10, D-60528 Frankfurt/Main, Germany. Tel.: +49 69 63017094; fax: +49 69 63015189.

Received 26 March 2007 ,Revised 3 July 2008 ,Accepted 8 July 2008.

References 

  1. Ackl N, Ising M, Schreiber YA, Atiya M, Sonntag A, Auer DP. Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. Neuroscience Letters. 2005;384:23–28
  2. Adalsteinsson E, Sullivan EV, Kleinhans N, Spielman DM, Pfefferbaum A. Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease. Lancet. 2000;355:1696–1697
  3. Catani M, Cherubini A, Howard R, Tarducci R, Pelliccioli GP, Piccirilli M, et al. (1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging. Neuroreport. 2001;12:2315–2317
  4. Chantal S, Braun CM, Bouchard RW, Labelle M, Boulanger Y. Similar 1H magnetic resonance spectroscopic metabolic pattern in the medial temporal lobes of patients with mild cognitive impairment and Alzheimer disease. Brain Research. 2004;1003:26–35
  5. Chao LL, Schuff N, Kramer JH, Du AT, Capizzano AA, O'Neill J, et al. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients. Neurology. 2005;64:282–289
  6. Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain. 2002;125:2332–2341
  7. Dolan RJ, Paulesu E, Fletcher KJ. Human memory systems. 1997;367–404
  8. Falini A, Bozzali M, Magnani G, Pero G, Gambini A, Benedetti B, et al. A whole brain MR spectroscopy study from patients with Alzheimer's disease and mild cognitive impairment. Neuroimage. 2005;26:1159–1163
  9. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. . Journal of Psychiatric Research. 1975;12:189–198
  10. Frederick B, Satlin A, Wald LL, Hennen J, Bodick N, Renshaw PF. Brain proton magnetic resonance spectroscopy in Alzheimer disease: changes after treatment with xanomeline. American Journal of Geriatric Psychiatry. 2002;10:81–88
  11. Henriksen O. In vivo quantitation of metabolite concentrations in the brain by means of proton MRS. NMR in Biomedicine. 1995;8:139–148
  12. Jessen F, Block W, Traber F, Keller E, Flacke S, Lamerichs R, et al. Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients. Neurology. 2001;57:930–932
  13. Jessen F, Traeber F, Freymann K, Maier W, Schild HH, Block W. Treatment monitoring and response prediction with proton MR spectroscopy in AD. Neurology. 2006;67:528–530
  14. Kantarci K, Jack CR, Xu YC, Campeau NG, O'Brien PC, Smith GE, et al. Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: a 1H MRS study. Neurology. 2000;55:210–217
  15. Kantarci K, Smith GE, Ivnik RJ, Petersen RC, Boeve BF, Knopman DS, et al. 1H magnetic resonance spectroscopy, cognitive function, and apolipoprotein E genotype in normal aging, mild cognitive impairment and Alzheimer's disease. Journal of the International Neuropsychological Society. 2002;8:934–942
  16. Kantarci K, Reynolds G, Petersen RC, Boeve BF, Knopman DS, Edland SD, et al. Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. American Journal of Neuroradiology. 2003;24:843–849
  17. Kantarci K, Weigand SD, Petersen RC, Boeve BF, Knopman DS, Gunter J, et al. Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 2007;28:1330–1339
  18. Kemppainen NM, Aalto S, Wilson IA, Nagren K, Helin S, Bruck A, et al. Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease. Neurology. 2006;67:1575–1580
  19. Kreis R, Ernst T, Ross BD. Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magnetic Resonance in Medicine. 1993;30:424–437
  20. Metastasio A, Rinaldi P, Tarducci R, Mariani E, Feliziani FT, Cherubini A, et al. Conversion of MCI to dementia: role of proton magnetic resonance spectroscopy. Neurobiology of Aging. 2006;27:926–932
  21. Michaelis T, Merboldt K, Bruhn H, Hänicke W, Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology. 1993;187:219–227
  22. Modrego PJ, Fayed N, Pina MA. Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy. The American Journal of Psychiatry. 2005;162:667–675
  23. Pantel J, Schröder J, Schad LR, Friedlinger M, Knopp MV, Schmitt R, et al. Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type. Psychological Medicine. 1997;27:221–229
  24. Pantel J, Kratz B, Essig M, Schröder J. Parahippocampal volume deficits in subjects with aging-associated cognitive decline. The American Journal of Psychiatry. 2003;160:379–382
  25. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine. 1993;30:672–679
  26. Schönknecht P, Pantel J, Kruse A, Schröder J. Prevalence and natural course of aging-associated cognitive decline in a population-based sample of young-old subjects. The American Journal of Psychiatry. 2005;162:2071–2077
  27. Valenzuela MJ, Sachdev P. Magnetic resonance spectroscopy in AD. Neurology. 2001;56:592–598
  28. Welsh KA, Butters N, Mohs RC, Beekly D, Edland S, Fillenbaum G, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology. 1994;44:609–614
  29. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. Mild cognitive impairment—beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine. 2004;256:240–246
  30. Zhang Y, Schuff N, Jahng GH, Bayne W, Mori S, Schad L, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology. 2007;68:13–19

PII: S0925-4927(08)00106-6

doi: 10.1016/j.pscychresns.2008.07.015

Psychiatry Research: Neuroimaging
Volume 173, Issue 1 , Pages 1-7 , 15 July 2009