Psychiatry Research: Neuroimaging
Volume 173, Issue 1 , Pages 71-76 , 15 July 2009

Increased subgenual prefrontal cortex size in remitted patients with major depressive disorder

  • Kaan Yucel

      Affiliations

    • Mood Disorders Program, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, Ontario, Canada
    • Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Margaret McKinnon

      Affiliations

    • Mood Disorders Program, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, Ontario, Canada
    • Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Ramandeep Chahal

      Affiliations

    • Mood Disorders Program, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, Ontario, Canada
    • Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Valerie Taylor

      Affiliations

    • Mood Disorders Program, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, Ontario, Canada
    • Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Kathryn Macdonald

      Affiliations

    • Mood Disorders Program, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, Ontario, Canada
    • Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Russell Joffe

      Affiliations

    • UMDNJ-New Jersey Medical School, Newark, NJ, USA
    • ,
  • Glenda MacQueen

      Affiliations

    • Mood Disorders Program, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, Ontario, Canada
    • Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    • Corresponding Author InformationCorresponding author. Mood Disorders Program, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, Ontario, Canada. Tel.: +1 905 522 1155x35496; fax: +1 905 575 6029.

Received 13 December 2007 ,Revised 21 May 2008 ,Accepted 4 July 2008.

References 

  1. Allman JM, Hakeem A, Erwin JM, Nimchinsky E, Hof P. The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Annals of the New York Academy of Sciences. 2001;935:107–117
  2. Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H, Peterson J, et al. Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. American Journal of Psychiatry. 2004;161:99–108
  3. Botteron KN, Raichle ME, Drevets WC, Heath AC, Todd RD. Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biological Psychiatry. 2002;51:342–344
  4. Brambilla P, Nicoletti MA, Harenski K, Sassi RB, Mallinger AG, Frank E, et al. Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects. Neuropsychopharmacology. 2002;27:792–799
  5. Bremner JD, Vythilingam M, Vermetten E, Nazeer E, Adil J, Khan S, et al. Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry. 2002;51:273–279
  6. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Science. 2000;4:215–222
  7. Caetano SC, Kaur S, Brambilla P, Nicoletti M, Hatch JP, Sassi RB, et al. Smaller cingulate volumes in unipolar depressed patients. Biological Psychiatry. 2006;59:702–706
  8. Chen CH, Ridler K, Suckling J, Williams S, Fu CH, Merlo-Pich E, et al. Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment. Biological Psychiatry. 2007;62:407–414
  9. Coryell W, Nopoulos P, Drevets W, Wilson T, Andreasen NC. Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications. American Journal of Psychiatry. 2005;162:1706–1712
  10. Davidson RJ, Irwin W, Anderle MJ, Kalin NH. The neural substrates of affective processing in depressed patients treated with venlafaxine. American Journal of Psychiatry. 2003;160:64–75
  11. Drevets WC, Bogers W, Raichle ME. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. European Neuropsychopharmacology. 2002;12:527–544
  12. Drevets WC, Price JL, Simpson JR, Todd RD, Reich T, Vannier M, et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997;386:824–827
  13. First MB, Spritzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis 1 Disorders. In: Biometrics Research. New York: New York State Psychiatric Institute; 2001;
  14. Fornito A, Whittle S, Wood SJ, Velakoulis D, Pantelis C, Yucel M. The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortex. Neuroimage. 2006;33:843–854
  15. Fornito, A., Wood, S.J., Whittle, S., Fuller, J., Adamson, C., Saling, M.M., Velakoulis, D., Pantelis, C., Yücel, M., 2008. Variability of the paracingulate sulcus and morphometry of the medial frontal cortex: associations with cortical thickness, surface area, volume, and sulcal depth. Hum. Brain. Mapp. 29, 222–236.
  16. Gotlib IH, Sivers H, Gabrieli JD, Whitfield-Gabrieli S, Goldin P, Minor KL, et al. Subgenual anterior cingulate activation to valenced emotional stimuli in major depression. Neuroreport. 2005;16:1731–1734
  17. Greicius MD, Flores BH, Menon V, Glover GH, Solvason HB, Kenna H, et al. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biological Psychiatry. 2007;62:429–437
  18. Hastings RS, Parsey RV, Oquendo MA, Arango V, Mann JJ. Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression. Neuropsychopharmacology. 2004;29:952–959
  19. Hirayasu Y, Shenton ME, Salisbury DF, Kwon JS, Wible CG, Fischer IA, et al. Subgenual cingulate cortex volume in first-episode psychosis. Am. J. Psychiatry. 1999;156:1091–1093
  20. Holthoff VA, Beuthien-Baumann B, Zündorf G, Triemer A, Ludecke S, Winiecki P, et al. Changes in brain metabolism associated with remission in unipolar major depression. Acta Psychiatrica Scandinavica. 2004;110:184–194
  21. Kumari V, Mitterschiffthaler MT, Teasdale JD, Malhi GS, Brown RG, Giampietro V, et al. Neural abnormalities during cognitive generation of affect in treatment-resistant depression. Biological Psychiatry. 2003;54:777–791
  22. Lavretsky H, Ballmaier M, Pham D, Toga A, Kumar A. Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Am. J. Geriatr. Psychiatry. 2007;15:386–394
  23. Mai JK, Assheuer JK, Paxinos P. Atlas of the Human Brain. 1st ed.. San Diego: California: Academic Press Harcourt Brace & Company; 1997;
  24. Mayberg HS. Limbic-cortical dysregulation: a proposed model of depression. Journal of Neuropsychiatry and Clinical Neurosciences. 1997;9:471–481
  25. Mayberg HS, Brannan SK, Tekell JL, Silva JA, Mahurin RK, McGinnis S, et al. Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biological Psychiatry. 2000;48:830–843
  26. McCormick LM, Ziebell S, Nopoulos P, Cassell M, Andreasen NC, Brumm M. Anterior cingulate cortex: an MRI-based parcellation method. Neuroimage. 2006;32:1167–1175
  27. Pizzagalli DA, Oakes TR, Fox AS, Chung MK, Larson CL, Abercrombie HC, et al. Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. Molecular Psychiatry. 2004;9:393–405
  28. Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nature Neuroscience. 2007;10:1116–1124
  29. Siegle GJ, Carter CS, Thase ME. Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy. American Journal of Psychiatry. 2006;163:735–738
  30. Smith GS, Reynolds CF, Pollock B, Derbyshire S, Nofzinger E, Dew MA, et al. Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression. American Journal of Psychiatry. 1999;156:683–689
  31. Tang Y, Wang F, Xie G, Liu J, Li L, Su L, et al. Reduced ventral anterior cingulate and amygdala volumes in medication-naïve females with major depressive disorder: a voxel-based morphometric magnetic resonance imaging study. Psychiatry Research. 2007;156:83–86
  32. Vlassenko A, Sheline YI, Fischer K, Mintun MA. Cerebral perfusion response to successful treatment of depression with different serotoninergic agents. Journal of Neuropsychiatry and Clinical Neuroscience. 2004;16:360–363
  33. Yücel M, Wood SJ, Fornito A, Riffkin J, Velakoulis D, Pantelis C. Anterior cingulate dysfunction: implications for psychiatric disorders. Journal of Psychiatry and Neuroscience. 2003;28:350–354
  34. Yücel K, McKinnon MC, Chahal R, Taylor VH, Macdonald K, Joffe R, et al. Anterior cingulate volumes in never-treated patients with major depressive disorder. Neuropsychopharmacology. 2008;33:3157–3163

PII: S0925-4927(08)00103-0

doi: 10.1016/j.pscychresns.2008.07.013

Psychiatry Research: Neuroimaging
Volume 173, Issue 1 , Pages 71-76 , 15 July 2009

Article Tools

* Image Usage & Resolution