Psychiatry Research: Neuroimaging
Volume 172, Issue 3 , Pages 175-179 , 30 June 2009

Delusions and dorso-medial frontal cortex volume in first-episode schizophrenia: A voxel-based morphometry study

  • Thomas J. Whitford

      Affiliations

    • The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead, NSW, 2145, Australia
    • Corresponding Author InformationCorresponding author. The Brain Dynamics Centre, Acacia House, Westmead Hospital, Westmead, NSW, 2145, Australia. Tel.: +61 2 9845 8179; fax: +61 2 9845 8190.
    • ,
  • Tom F.D. Farrow

      Affiliations

    • The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead, NSW, 2145, Australia
    • SCANLab, Department of Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield, S5 7JT, UK
    • ,
  • Leanne M. Williams

      Affiliations

    • The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead, NSW, 2145, Australia
    • Discipline of Psychological Medicine, University of Sydney, Sydney, NSW, 2006, Australia
    • ,
  • Lavier Gomes

      Affiliations

    • Department of Radiology, Westmead Hospital, Westmead, NSW, 2145, Australia
    • ,
  • John Brennan

      Affiliations

    • Department of Child and Adolescent Psychiatry, Redbank House, Westmead Hospital, Westmead, NSW, 2145, Australia
    • ,
  • Anthony W.F. Harris

      Affiliations

    • The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead, NSW, 2145, Australia
    • Discipline of Psychological Medicine, University of Sydney, Sydney, NSW, 2006, Australia

Received 12 September 2007 ,Revised 9 June 2008 ,Accepted 4 July 2008.

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. revised 4th edition. Washington, D.C.: APA; 1994;
  2. Andreasen NC. A unitary model of schizophrenia: Bleuler's “fragmented phrene” as schizencephaly. Archives of General Psychiatry. 1999;56:781–787
  3. Ashburner J, Friston KJ. Voxel-based morphometry — the methods. NeuroImage. 2000;11:805–821
  4. Baare WFC, Hulshoff Pol HE, Hijman R, Mali WPT, Viergever MA, Kahn RS. Volumetric analysis of frontal lobe regions in schizophrenia: relation to cognitive function and symptomatology. Biological Psychiatry. 1999;45:1597–1605
  5. Baddeley A, Emslie H, Nimmo-Smith I. The Spot-the-Word test: a robust estimate of verbal intelligence based on lexical decision. British Journal of Clinical Psychology. 1993;32:55–65
  6. Barta PE, Pearlson GD, Powers RE, Richards SS, Tune LE. Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. American Journal of Psychiatry. 1990;147:1457–1462
  7. Bates AT, Kiehl KA, Laurens KR, Liddle PF. Error-related negativity and correct response negativity in schizophrenia. Clinical Neurophysiology. 2002;113:1454–1463
  8. Choi JS, Kang DH, Kim JJ, Ha TH, Roh KS, Youn T, et al. Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia. Psychiatry Research. Neuroimaging. 2005;139:239–247
  9. Chua SE, Wright IC, Poline J-B, Liddle PF, Murray RM, Frackowiak RSJ, et al. Grey matter correlates of syndromes in schizophrenia: a semi automated analysis of structural magnetic resonance images. British Journal of Psychiatry. 1997;170:406–410
  10. Flaum M, O'Leary DS, Swayze VW, Miller DD, Arndt S, Andresen NC. Symptom dimensions and brain morphology in schizophrenia and related psychotic disorders. Journal of Psychiatric Research. 1995;29:261–276
  11. Frith C. The neural basis of hallucinations and delusions. Comptes Rendus Biologies. 2005;328:169–175
  12. Frith CD, Done DJ. Experiences of alien control in schizophrenia reflect a disorder in the central monitoring of action. Psychological Medicine. 1989;19:359–363
  13. Garety P, Freeman D. Cognitive approaches to delusions: a critical review of theories and evidence. British Journal of Clinical Psychology. 1999;38:113–154
  14. Goel V, Gold B, Kanpur S, Houle S. The seats of reason? An imaging study of deductive and inductive reasoning. NeuroReport. 1997;8:1305–1310
  15. Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Bilker WB, et al. A follow-up magnetic resonance imaging study of schizophrenia: relationship of neuroanatomical changes to clinical and neurobehavioral measures. Archives of General Psychiatry. 1998;55:145–152
  16. Harris A, Brennan J, Anderson J, Taylor A, Sanbrook M, Fitzgerald D, et al. Clinical profiles, scope and general findings of the Western Sydney First Episode Psychosis Project. Australian & New Zealand Journal of Psychiatry. 2005;39:36–43
  17. Herrmann MJ, Rommler J, Ehlis AC, Heidrich A, Fallgatter AJ. Source localization (LORETA) of the error-related-negativity (ERN/Ne) and positivity (Pe). Cognitive Brain Research. 2004;294–299
  18. Hickie I, Hadzi-Pavlovic D, Scott E, Davenport T, Koschera A, Naismith S. SPHERE: a national depression project. Australasian Psychiatry. 1998;6:248–250
  19. Holroyd CB, Dien J, Coles MGH. Error-related scalp potentials elicited by hand and foot movements: evidence for an output-independent error-processing system in humans. Neuroscience Letters. 1998;242:65–68
  20. Hyman SE. Can neuroscience be integrated into the DSM-V?. Nature Neuroscience. 2007;8:725–732
  21. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  22. Kopp B, Rist F. An event-related brain potential substrate of disturbed response monitoring in paranoid schizophrenic patients. Journal of Abnormal Psychology. 1999;108:337–346
  23. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine. 2001;16:606–613
  24. Lahti AC, Weiler MA, Holcomb HH, Tamminga CA, Carpenter WT, McMahon R. Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia. Neuropsychopharmacology. 2006;31:221–230
  25. Lovibond PF, Lovibond SH. The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behaviour Research and Therapy. 1995;33:335–343
  26. Madsen AL, Karle A, Rubin P, Cortsen M, Andersen HS, Hemmingsen R. Progressive atrophy of the frontal lobes in first-episode schizophrenia: interaction with clinical course and neuroleptic treatment. Acta Psychiatrica Scandinavica. 1999;100:367–374
  27. Maher B. Delusional thinking and perceptual disorder. Journal of Individual Psychology. 1974;30:98–113
  28. Mathalon DH, Fedor M, Faustman WO, Gray M, Askari N, Ford JM. Response-monitoring dysfunction in schizophrenia: an event related brain potential study. Journal of Abnormal Psychology. 2002;111:22–41
  29. McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fisher IA, et al. MRI anatomy of schizophrenia. Biological Psychiatry. 1999;45:1099–1119
  30. Menon RR, Barta PE, Aylward EH, Richards SS, Vaughn DD, Tien AY, et al. Posterior superior temporal gyrus in schizophrenia: grey matter changes and clinical correlates. Schizophrenia Research. 1995;16:127–135
  31. Mlakar J, Jensterle J, Frith CD. Central monitoring deficiency and schizophrenic symptoms. Psychological Medicine. 1994;24:557–564
  32. Paillere-Martinot M-L, Caclin A, Artiges E, Poline J-B, Joliot M, Mallet L, et al. Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. Schizophrenia Research. 2001;50:19–26
  33. Parsons LM, Osherton D. New evidence for distinct right and left brain systems for deductive versus probabilistic reasoning. Cerebral Cortex. 2001;11:954–965
  34. Pearlson GD. Superior temporal gyrus and planum temporale in schizophrenia: a selective review. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 1997;21:1203–1229
  35. Rajarethinam RP, DeQuardo JR, Nalepa R, Tandon R. Superior temporal gyrus in schizophrenia: a volumetric magnetic resonance imaging study. Schizophrenia Research. 2000;41:303–312
  36. Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study. New England Journal of Medicine. 1992;327:604–612
  37. Sumich A, Chitnis XA, Fannon DG, O'Ceallaigh S, Doku VC, Faldrowicz A, et al. Unreality symptoms and volumetric measures of Heschl's gyrus and planum temporal in first-episode psychosis. Biological Psychiatry. 2005;57:947–950
  38. Talairach J, Tournoux P. Co Planar Steroetaxic Atlas of the Human Brain. New York: Thieme Medical Publishers; 1988;
  39. van Veen V, Carter CS. The timing of action-monitoring processes in the anterior cingulate cortex. Journal of Cognitive Neuroscience. 2002;14:593–602
  40. Whitford TJ, Farrow TF, Gomes L, Brennan J, Harris AW, Williams LM. Grey matter deficits and symptom profile in first episode schizophrenia. Psychiatry Research. Neuroimaging. 2005;139:229–238
  41. Wilkinson GS. The Wide Range Achievement Test — Administration Manual. Wilmingham: Wide Range Inc.; 1993;
  42. Williams LM, Das P, Liddell BJ, Olivieri G, Peduto AS, David AS, et al. Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes. Psychiatry Research. Neuroimaging. 2007;155:29–44
  43. Worsley KJ, Marrett S, Neelin P, Vandal AC, Friston KJ, Evans AC. A unified statistical approach for determining significant signals in images of cerebral activation. Human Brain Mapping. 1996;4:58–73

PII: S0925-4927(08)00098-X

doi: 10.1016/j.pscychresns.2008.07.011

Psychiatry Research: Neuroimaging
Volume 172, Issue 3 , Pages 175-179 , 30 June 2009

Article Tools

* Image Usage & Resolution