Psychiatry Research: Neuroimaging
Volume 172, Issue 3 , Pages 192-199 , 30 June 2009

Neural correlates of emotion processing in borderline personality disorder

  • Harold W. Koenigsberg

      Affiliations

    • Mount Sinai School of Medicine, New York, NY, United States
    • James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States
    • Corresponding Author InformationCorresponding author. Mount Sinai School of Medicine, James J Peters VA Medical Center, 116A, 130 West Kingsbridge Road, Bronx, NY 10468, United States. Tel.: +718 584 9000x5757; fax: +718 364 3576.
  • ,
  • Larry J. Siever

      Affiliations

    • Mount Sinai School of Medicine, New York, NY, United States
    • James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States
  • ,
  • Hedok Lee

      Affiliations

    • James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States
  • ,
  • Scott Pizzarello

      Affiliations

    • Department of Psychology, Florida State University, Tallahassee, FL, United States
  • ,
  • Antonia S. New

      Affiliations

    • Mount Sinai School of Medicine, New York, NY, United States
    • James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States
  • ,
  • Marianne Goodman

      Affiliations

    • Mount Sinai School of Medicine, New York, NY, United States
    • James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States
  • ,
  • Hu Cheng

      Affiliations

    • Indiana University, United States
  • ,
  • Janine Flory

      Affiliations

    • Department of Psychology, Queens College, Flushing, NY, United States
  • ,
  • Isak Prohovnik

      Affiliations

    • Mount Sinai School of Medicine, New York, NY, United States
    • James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States

Received 20 August 2007 ,Revised 19 May 2008 ,Accepted 4 July 2008.

References 

  1. Adolphs R, Spezio M. Role of the amygdala in processing visual social stimuli. Progress in Brain Research. 2006;156:363–378
  2. Allison T, Puce A, McCarthy G. Social perception from visual cues: role of the STS region. Trends in Cognitive Sciences. 2000;4:267–278
  3. Aron A, Fisher H, Mashek DJ, Strong G, Li H, Brown LL. Reward, motivation, and emotion systems associated with early-stage intense romantic love. Journal of Neurophysiology. 2005;94:327–337
  4. Bokde AL, Lopez-Bayo P, Meindl T, Pechler S, Born C, Faltraco F, et al. Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment. Brain. 2006;129:1113–1124
  5. Bradley MM, Lang PJ. Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. Journal of Behavior Therapy and Experimental Psychiatry. 1994;25:49–59
  6. Britton JC, Ho SH, Taylor SF, Liberzon I. Neuroticism associated with neural activation patterns to positive stimuli. Psychiatry Research: Neuroimaging. 2007;156:263–267
  7. Britton JC, Phan KL, Taylor SF, Welsh RC, Berridge KC, Liberzon I. Neural correlates of social and nonsocial emotions: an fMRI study. Neuroimage. 2006;31:397–409
  8. Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006;129:564–583
  9. Craig AD. Human feelings: why are some more aware than others?. Trends in Cognitive Sciences. 2004;8:239–241
  10. De La Fuente JM, Goldman S, Stanus E, Vizuete C, Morlan I, Bobes J, et al. Brain glucose metabolism in borderline personality disorder. Journal of Psychiatric Research. 1997;31:531–541
  11. Dickstein DP, Leibenluft E. Emotion regulation in children and adolescents: boundaries between normalcy and bipolar disorder. Development and Psychopathology. 2006;18:1105–1131
  12. Donegan NH, Sanislow CA, Blumberg HP, Fulbright RK, Lacadie C, Skudlarski P, et al. Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biological Psychiatry. 2003;54:1284–1293
  13. Driessen M, Herrmann J, Stahl K, Zwaan M, Meier S, Hill A, et al. Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Archives of General Psychiatry. 2000;57:1115–1122
  14. Duncan S, Barrett LF. The role of the amygdala in visual awareness. Trends in Cognitive Sciences. 2007;11:190–192
  15. Goossens L, Schruers K, Peeters R, Griez E, Sunaert S. Visual presentation of phobic stimuli: amygdala activation via an extrageniculostriate pathway?. Psychiatry Research: Neuroimaging. 2007;155:113–120
  16. Grimm S, Schmidt CF, Bermpohl F, Heinzel A, Dahlem Y, Wyss M, et al. Segregated neural representation of distinct emotion dimensions in the prefrontal cortex-an fMRI study. Neuroimage. 2006;30:325–340
  17. Harvey PD, Greenberg BR, Serper MR. The affective lability scales: development, reliability, and validity. Journal of Clinical Psychology. 1989;45:786–793
  18. Hazlett EA, New AS, Newmark R, Haznedar MM, Lo JN, Speiser LJ, et al. Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biological Psychiatry. 2005;58:614–623
  19. Herpertz SC, Dietrich TM, Wenning B, Krings T, Erberich SG, Willmes K, et al. Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study. Biological Psychiatry. 2001;50:292–298
  20. Juengling FD, Schmahl C, Hesslinger B, Ebert D, Bremner JD, Gostomzyk J, et al. Positron emission tomography in female patients with borderline personality disorder. Journal of Psychiatric Research. 2003;37:109–115
  21. Koenigsberg HW, Harvey PD, Mitropoulou V, New AS, Goodman M, Silverman J, et al. Are the interpersonal and identity disturbances in the borderline personality disorder criteria linked to the traits of affective instability and impulsivity?. Journal of Personality Disorders. 2001;15:358–370
  22. Koenigsberg HW, Harvey PD, Mitropoulou V, Schmeidler J, New AS, Goodman M, et al. Characterizing affective instability in borderline personality disorder. The American Journal of Psychiatry. 2002;159:784–788
  23. Lane RD, Reiman EM, Ahern GL, Schwartz GE, Davidson RJ. Neuroanatomical correlates of happiness, sadness, and disgust. The American Journal of Psychiatry. 1997;154:926–933
  24. Lane RD, Reiman EM, Bradley MM, Lang PJ, Ahern GL, Davidson RJ, et al. Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia. 1997;35:1437–1444
  25. Lang, P.J., B.M., Cuthbert, B.N., 2001. International Affective Pictures System (IAPS): Technical Manual and Affective Ratings. NIMH Center for the Study of Emotion and Attention, University of Florida, Gainesville, FL.
  26. Leyton M, Okazawa H, Diksic M, Paris J, Rosa P, Mzengeza S, et al. Brain regional alpha-[11C]methyl-l-tryptophan trapping in impulsive subjects with borderline personality disorder. The American Journal of Psychiatry. 2001;158:775–782
  27. Linehan M. Cognitive-Behavioral Treatment of Borderline Personality Disorder. New York: Guilford Press; 1993;
  28. Lynch TR, Rosenthal MZ, Kosson DS, Cheavens JS, Lejuez CW, Blair RJ. Heightened sensitivity to facial expressions of emotion in borderline personality disorder. Emotion. 2006;6:647–655
  29. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 2003;19:1233–1239
  30. Meyer B, Pilkonis PA, Beevers CG. What's in a (neutral) face? Personality disorders, attachment styles, and the appraisal of ambiguous social cues. Journal of Personality Disorders. 2004;18:320–336
  31. Morris JDR. Functional neuroanatomy of human emotion. In: F. K. ,  Frackowiak SJ,  Frith CD editor. Human Brain Function. London: Elsevier; 2004;p. 383–384
  32. New AS, Hazlett EA, Buchsbaum MS, Goodman M, Reynolds D, Mitropoulou V, et al. Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression. Archives of General Psychiatry. 2002;59:621–629
  33. Northoff G, Richter A, Gessner M, Schlagenhauf F, Fell J, Baumgart F, et al. Functional dissociation between medial and lateral prefrontal cortical spatiotemporal activation in negative and positive emotions: a combined fMRI/MEG study. Cerebral Cortex. 2000;10:93–107
  34. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9:97–113
  35. Paradiso S, Johnson DL, Andreasen NC, O'Leary DS, Watkins GL, Ponto LL, et al. Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant, and neutral visual stimuli in a PET study of normal subjects. The American Journal of Psychiatry. 1999;156:1618–1629
  36. Parvizi J, Anderson SW, Martin CO, Damasio H, Damasio AR. Pathological laughter and crying: a link to the cerebellum. Brain. 2001;124:1708–1719
  37. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biological Psychiatry. 2003;54:504–514
  38. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biological Psychiatry. 2003;54:515–528
  39. Satpute AB, Lieberman MD. Integrating automatic and controlled processes into neurocognitive models of social cognition. Brain Research. 2006;1079:86–97
  40. Schmahl CG, Vermetten E, Elzinga BM, Douglas Bremner J. Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder. Psychiatry Research: Neuroimaging. 2003;122:193–198
  41. Schnell K, Dietrich T, Schnitker R, Daumann J, Herpertz SC. Processing of autobiographical memory retrieval cues in borderline personality disorder. Journal of Affective Disorders. 2007;97:253–259
  42. Siever LJ, Buchsbaum MS, New AS, Spiegel-Cohen J, Wei T, Hazlett EA, et al. d,l-fenfluramine response in impulsive personality disorder assessed with [18F]fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology. 1999;20:413–423
  43. Soloff PH, Meltzer CC, Greer PJ, Constantine D, Kelly TM. A fenfluramine-activated FDG-PET study of borderline personality disorder. Biological Psychiatry. 2000;47:540–547
  44. Stiglmayr CE, Grathwol T, Linehan MM, Ihorst G, Fahrenberg J, Bohus M. Aversive tension in patients with borderline personality disorder: a computer-based controlled field study. Acta Psychiatrica Scandinavica. 2005;111:372–379
  45. Stone M. Toward a psychobiological theory of personality disorder. Dissociation. 1988;1:2–15
  46. Strange BA, Dolan RJ. Beta-adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses. Proc. Natl. Acad Sci. U.S.A. 2004;101:11454–11458
  47. Takahashi H, Koeda M, Oda K, Matsuda T, Matsushima E, Matsuura M, et al. An fMRI study of differential neural response to affective pictures in schizophrenia. Neuroimage. 2004;22:1247–1254
  48. Taylor JG, Fragopanagos NF. The interaction of attention and emotion. Neural Networks. 2005;18:353–369
  49. Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K, Lemieux L, et al. Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biological Psychiatry. 2003;54:163–171
  50. Thase ME, Ninan PT. New goals in the treatment of depression: moving toward recovery. Psychopharmacology Bulletin 36 Suppl. 2002;2:24–35
  51. Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nature Reviews. Neuroscience. 2005;6:533–544
  52. Vuilleumier P, Richardson MP, Armony JL, Driver J, Dolan RJ. Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nature Neuroscience. 2004;7:1271–1278
  53. Wagner AW, Linehan MM. Facial expression recognition ability among women with borderline personality disorder: implications for emotion regulation?. Journal of Personality Disorders. 1999;13:329–344
  54. Winston JS, Strange BA, O'Doherty J, Dolan RJ. Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nat. Neurosci. 2002;5:277–283

 Presented in part at the Annual Meeting of the Society for Biological Psychiatry, San Diego, CA, May 2007.

PII: S0925-4927(08)00096-6

doi: 10.1016/j.pscychresns.2008.07.010

Psychiatry Research: Neuroimaging
Volume 172, Issue 3 , Pages 192-199 , 30 June 2009