Psychiatry Research: Neuroimaging
Volume 172, Issue 1 , Pages 49-54 , 30 April 2009

Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression

  • Talaignair N. Venkatraman

      Affiliations

    • The Departments of Radiology, Duke University Medical Center, Durham, NC, United States
    • The Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States
  • ,
  • Ranga R. Krishnan

      Affiliations

    • The Departments of Psychiatry, Duke University Medical Center, Durham, NC, United States
    • The Duke-NUS Graduate Medical School Singapore, Singapore
  • ,
  • David C. Steffens

      Affiliations

    • The Departments of Psychiatry, Duke University Medical Center, Durham, NC, United States
  • ,
  • Allen W. Song

      Affiliations

    • The Departments of Psychiatry, Duke University Medical Center, Durham, NC, United States
    • The Departments of Radiology, Duke University Medical Center, Durham, NC, United States
    • The Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States
  • ,
  • Warren D. Taylor

      Affiliations

    • The Departments of Psychiatry, Duke University Medical Center, Durham, NC, United States
    • Corresponding Author InformationCorresponding author. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, United States. Tel.: +1 919 668 7887; fax: +1 919 681 7668.

Received 18 December 2007 ,Revised 1 May 2008 ,Accepted 4 July 2008.

References 

  1. Auer DP, Putz B, Kraft E, Lipinski B, Schill J, Holsboer F. Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biological Psychiatry. 2000;47:305–313
  2. Auer DP, Schirmer T, Heidenreich JO, Herzog J, Pütz B, Dichgans M. Altered white and gray matter metabolism in CADASIL: a proton MR spectroscopy and 1H-MRSI study. Neurology. 2001;56:635–642
  3. Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biological Psychiatry. 2006;60:1356–1363
  4. Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H, Peterson J, et al. Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. American Journal of Psychiatry. 2004;161:99–108
  5. Bhakoo KK, Pearce D. In vivo expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy. Journal of Neurochemistry. 2000;74:254–262
  6. Binesh N, Kumar A, Hwang S, Mintz J, Thomas MA. Neurochemistry of late-life major depression: a pilot two-dimensional MR spectroscopic study. Journal of Magnetic Resonance Imaging. 2004;20:1039–1045
  7. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Annals of the New York Academy of Sciences. 1987;508:333–348
  8. Chakraborty G, Mekala P, Yahya D, Wu G, Ledeen RW. Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. Journal of Neurochemistry. 2001;78:736–745
  9. Charles HC, Lazeyras F, Krishnan KR, Boyko OB, Payne ME, Moore D. Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1994;18:1121–1127
  10. Chen CH, Suckling J, Ooi C, Fu CH, Williams SC, Walsh ND, et al. Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology. 2007;33:1909–1918
  11. Cotter D, Mackay D, Landau S, Kerwin R, Everall I. Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Archives of General Psychiatry. 2001;58:545–553
  12. Drevets WC. Prefrontal cortical-amygdalar metabolism in major depression. Annals of the New York Academy of Sciences. 1999;877:614–637
  13. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state” a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–198
  14. Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial application to human brain in vivo. Magnetic Resonance in Medicine. 1989;9:79–93
  15. Frodl T, Meisenzahl EM, Zetzsche T, Hohne T, Banac S, Schorr C, et al. Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up. Journal of Clinical Psychiatry. 2004;65:492–499
  16. Hamidi M, Drevets WC, Price JL. Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes. Biological Psychiatry. 2004;55:563–569
  17. Hasler G, Neumeister A, van der Veen JW, Tumonis T, Bain EE, Shen J, et al. Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biological Psychiatry. 2005;58:969–973
  18. Hasler G, van der Veen JW, Tumonis T, Meyers N, Shen J, Drevets WC. Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Archives of General Psychiatry. 2007;64:193–200
  19. Kumar A, Thomas A, Lavretsky H, Yue K, Huda A, Curran J, et al. Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. American Journal of Psychiatry. 2002;159:630–636
  20. Kusumakar V, MacMaster FP, Gates L, Sparkes SJ, Khan SC. Left medial temporal cytosolic choline in early onset depression. Canadian Journal of Psychiatry. 2001;46:959–964
  21. Li L, Chen S, Liu J, Zhang J, He Z, Lin X. Magnetic resonance imaging and magnetic resonance spectroscopy study of deficits in the hippocampal structure in fire victims with recent-onset posttraumatic stress disorder. Canadian Journal of Psychiatry. 2006;51:431–437
  22. McLean MA, Woermann FG, Barker GJ, Duncan JS. Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter. Magnetic Resonance in Medicine. 2000;44:401–411
  23. Mervaala E, Fohr J, Kononen M, Valkonen-Korhonen M, Vainio P, Partanen K, et al. Quantitative MRI of the hippocampus and amygdala in severe depression. Psychological Medicine. 2000;30:117–125
  24. Michael N, Erfurth A, Ohrmann P, Arolt V, Heindel W, Pfleiderer B. Metabolic changes in within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression. Psychological Medicine. 2003;33:1277–1284
  25. Michael N, Erfurth A, Ohrmann P, Arolt V, Heindel W, Pfleiderer B. Neurotrophic effects of electroconvulsive therapy: a proton magnetic resonance spectroscopy study of the left amygdalar region in patients with treatment-resistant depression. Neuropsychopharmacology. 2003;28:720–725
  26. Miguel-Hidalgo JJ, Baucom C, Dilley G, Overholser JC, Meltzer HY, Stockmeier CA, et al. Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder. Biological Psychiatry. 2000;48:861–873
  27. Moffett JR, Namboodiri MA, Cangro CB, Neale JH. Immunohistochemical localization of N-acetylaspartate in rat brain. Neuroreport. 1991;2:131–134
  28. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. British Journal of Psychiatry. 1979;134:382–389
  29. Murata T, Kimura H, Omori M, Kado H, Kosaka H, Iidaka T, et al. MRI white matter hyperintensities, 1H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early-and late-onset cases. International Journal of Geriatric Psychiatry. 2001;16:1129–1135
  30. Nagae-Poetscher LM, Bonekamp D, Barker PB, Brant LJ, Kaufmann WE, Horska A. Asymmetry and gender effects in functionally lateralized cortical regions: a proton MRS imaging study. Journal of Magnetic Resonance Imaging. 2004;19:27–33
  31. Ongur D, Drevets WC, Price JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:13290–13295
  32. Pauly J, Leroux P, Nishimura D, Macovski A. Parameter relations for the Shinnar-Le Roux selective excitation pulse design algorithm. IEEE Transactions on Medical Imaging. 1991;10:53–65
  33. Pfeiderer B, Michael N, Erfurth A, Ohrmann P, Hohmann U, Wolgast M, et al. Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Research. 2003;122:185–192
  34. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biological Psychiatry. 2003;54:504–514
  35. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry. 2003;54:515–528
  36. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine. 1993;30:672–679
  37. Provencher S. LCModel & LCMgui User's Guide. 2007;http://s-provencher.com/pub/LCModel/manual/manual.pdf.
  38. Rajkowska G, Miguel-Hidalgo JJ. Gliogenesis and glial pathology in depression. CNS & Neurological Disorders Drug Targets. 2007;6:219–233
  39. Rajkowska G, Miguel-Hidalgo JJ, Dubey P, Stockmeier CA, Krishnan KR. Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients. Biological Psychiatry. 2005;58:297–306
  40. Rajkowska G, Miguel-Hidalgo JJ, Wei J, Dilley G, Pittman SD, Meltzer HY, et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biological Psychiatry. 1999;45:1085–1098
  41. Renshaw PF, Lafer B, Babb SM, Fava M, Stoll AL, Christensen JD, et al. Basal ganglia choline levels in depression and response to fluoxetine treatment: an in vivo proton magnetic resonance spectroscopy study. Biological Psychiatry. 1997;15:837–843
  42. Robins LN, Helzer JE, Croughan J, Ratcliff KS. National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics, and validity. Archives of General Psychiatry. 1981;38:381–389
  43. Si X, Miguel-Hidalgo JJ, O'Dwyer G, Stockmeier CA, Rajkowska G. Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression. Neuropsychopharmacology. 2004;29:2088–2096
  44. Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience. 1991;45:37–45
  45. Steffens DC, McQuoid DR, Krishnan KRR. The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach. Psychopharmacology Bulletin. 2002;36:58–68
  46. Stockmeier CA, Mahajan GJ, Konick LC, Overholser JC, Jurjus GJ, Meltzer HY, et al. Cellular changes in the postmortem hippocampus in major depression. Biological Psychiatry. 2004;56:640–650
  47. Taylor WD, MacFall JR, Payne ME, McQuoid DR, Steffens DC, Provenzale JM, et al. Greater MRI lesion volumes in elderly depressed subjects than in control subjects. Psychiatry Research Neuroimaging. 2005;139:1–7
  48. Taylor WD, MacFall JR, Gerig G, Krishnan KR. Structural integrity of the uncinate fasciculus in geriatric depression: relationship with age of onset. Neuropsychiatric Disease and Treatment. 2007;3:669–674
  49. Taylor WD, MacFall JR, Payne ME, McQuoid DR, Steffens DC, Provenzale JM, et al. Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms. Psychological Medicine. 2007;37:1763–1773
  50. Tran TK, Vigneron DB, Sailasuta N, Tropp J, Le Roux P, Kurhanewicz J, et al. Very selective suppression pulses for clinical MRSI studies of brain and prostate cancer. Magnetic Resonance in Medicine. 2000;43:23–33
  51. Urenjak J, Williams SR, Gadian DG, Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. Journal of Neuroscience. 1993;13:981–989
  52. Vaishnavi S, Taylor WD. Neuroimaging in late-life depression. International Review of Psychiatry. 2006;18:443–451
  53. van Elst LT, Ludaescher P, Thiel T, Büchert M, Hesslinger B, Bohus M, et al. Evidence of disturbed amygdalar energy metabolism in patients with borderline personality disorder. Neuroscience Letters. 2007;417:36–41
  54. Vythilingam M, Charles HC, Tupler LA, Blitchington T, Kelly L, Krishnan KRR. Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study. Biological Psychiatry. 2003;54:744–750
  55. Yildiz-Yesiloglu A, Ankerst DP. Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis. Psychiatry Research Neuroimaging. 2006;147:1–25

PII: S0925-4927(08)00094-2

doi: 10.1016/j.pscychresns.2008.07.001

Psychiatry Research: Neuroimaging
Volume 172, Issue 1 , Pages 49-54 , 30 April 2009