Psychiatry Research: Neuroimaging
Volume 172, Issue 1 , Pages 55-60 , 30 April 2009

Pituitary gland volume in currently depressed and remitted depressed patients

  • Valentina Lorenzetti

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, VIC. Australia
    • ORYGEN Research Centre, Melbourne, VIC. Australia
    • The University of Melbourne and Melbourne Health, VIC. Australia
    • Department of Psychology, University of Bologna, Viale Berti Pichat 5, 40126, Bologna, Italy
    • ,
  • Nicholas B. Allen

      Affiliations

    • ORYGEN Research Centre, Melbourne, VIC. Australia
    • The University of Melbourne and Melbourne Health, VIC. Australia
    • ,
  • Alex Fornito

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, VIC. Australia
    • ,
  • Christos Pantelis

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, VIC. Australia
    • ,
  • Giovanni De Plato

      Affiliations

    • Department of Psychology, University of Bologna, Viale Berti Pichat 5, 40126, Bologna, Italy
    • ,
  • Anthony Ang

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, VIC. Australia
    • ,
  • Murat Yücel

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, VIC. Australia
    • ORYGEN Research Centre, Melbourne, VIC. Australia
    • The University of Melbourne and Melbourne Health, VIC. Australia
    • Corresponding Author InformationCorresponding author. Melbourne Neuropsychiatry Centre, c/o AG Building, 161 Barry St, Carlton South, Victoria 3053, Australia. Tel.: +61 3 8344 1877; fax: +61 3 9348 0469.

Received 13 January 2008 ,Revised 11 April 2008 ,Accepted 12 June 2008.

References 

  1. Axelson DA, Doraiswamy PM, Boyko OB, Escalona PR, McDonald WM, Ritchie JC, et al. In vivo assessment of pituitary volume with magnetic resonance imaging and systematic stereology: relationship to dexamethasone suppression test results in patients. Psychiatry Research. 1992;44:63–70
  2. Babor TF, De La Fuente JR, Saunders J, Grant M. The Alcohol Use Disorders Identification Test: Guidelines for use in Primary Health Care. Geneva, Switzerland: World Health Organization; 1992;
  3. Barden N. Implication of the hypothalamic–pituitary–adrenal axis in the pathophysiology of depression. Journal of Psychiatry & Neuroscience. 2004;29:185–193
  4. Beck AT, Steer RT. Beck Depression Inventory Manual. San Antonio: Harcourt Brace Jovanovich; 1987;
  5. Cerqueira JJ, Catania C, Sotiropoulos I, Schubert M, Kalish R, Almeida OFX, et al. Corticosteroid status influences the volume of the rat cingulate cortex — a magnetic resonance imaging study. Journal of Psychiatric Research. 2005;39:451–460
  6. Chao HM, Choo PH, McEwen BS. Glucocorticoid and mineralocorticoid receptor mRNA expression in rat brain. Neuroendocrinology. 1989;50:365–371
  7. Christensen MV, Kessing LV. The hypothalamo-pituitary–adrenal axis in major affective disorder: a review. North Journal of Psychiatry. 2001;55:359–363
  8. Davidson RJ, Pizzagalli DA, Nitschke JB, Putnam K. Depression: perspectives from affective neuroscience. Annual Review of Psychology. 2002;53:545–574
  9. Diorio D, Viau V, Meaney MJ. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic–pituitary–adrenal responses to stress. Journal of Neuroscience. 1993;13:3839–3847
  10. Elster AD. Modern imaging of the pituitary. Radiology. 1993;187:1–14
  11. Eritaia J, Wood SJ, Stuart GW. An optimized method for estimating intracranial volume from magnetic resonance images. Magnetic Resonance in Medicine. 2000;44:973–977
  12. Fejò del Mello ADA, Fejò de Mello M, Carpenter LL, Price LH. Update on stress and depression: the role of the hypothalamic–pituitary–adrenal (HPA) axis. Revista Brasileira de Psiquiatria. 2003;25:231–238
  13. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for Axis 1 DSM-IV Disorders. New York: New York State Psychiatric Institute; 2001;
  14. Garner BA. PhD. An Investigation of the Two-Hit Neurodevelopmental Hypothesis of Schizophrenia: Animal and Clinical Studies. Melbourne: Department of Psychiatry, The University of Melbourne; 2004;236
  15. Garner BA, Pariante CM, Wood SJ, Velakoulis D, Phillips L, Soulsby B, et al. Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis. Biological Psychiatry. 2005;58:417–423
  16. Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neuroscience. 1999;2:861–863
  17. Gold P, Chrousis G, Kellner C, Post R, Roy A, Augerinos P, et al. Psychiatric implications of the basic and clinical studies with corticotropin-releasing factor. American Journal of Psychiatry. 1984;141:619–627
  18. Gotgay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America. 2004;101:8174–8179
  19. Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, et al. Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary–adrenocortical responsiveness. Frontiers in Neuroendocrinology. 2003;24:151–180
  20. Herman JP, Ostrander MM, Mueller NK, Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary–adrenocortical axis. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2005;29:1201–1213
  21. Holsboer F, Gerken A, Stalla G, Muller O. Blunted aldosterone and ACTH release after human CRH administration in depressed patients. American Journal of Psychiatry. 1987;144:229–231
  22. Jiang HK, Wang JY, Lin JC. The central mechanism of hypothalamic–pituitary–adrenocortical system hyperfunction in depressed patients. Psychiatry and Clinical Neurosciences. 2000;54:227–234
  23. Kato K, Saeki N, Yamaura A. Morphological changes on MR imaging of the normal pituitary gland related to age and sex. Main emphasis on pubescent females. Journal of Clinical Neuroscience. 2002;9:53–56
  24. Krishnan KRR, Doraiswamy PM, Lurie SN, Figiel GS, Husain MM, Boyko OB, et al. Pituitary size in depression. Journal of Clinical Endocrinology and Metabolism. 1991;72:256–259
  25. Lucassen PJ, Heine VM, Muller MB, Van Der Beek EM, Wiegant VM, De Kloet EM, et al. Stress, depression and hippocampal apoptosis. CNS & Neurological Disorders — Drug Targets. 2006;5:531–546
  26. Lurie SN, Doraiswamy PM, Husain MM, Boyko OB, Ellinwood EHJ, Figiel GS, et al. In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age. Journal of Clinical Endocrinology and Metabolism. 1990;71:505–508
  27. MacMaster FP, Kusumakar V. MRI study of the pituitary gland in adolescent depression. Journal of Psychiatric Research. 2004;38:231–236
  28. MacMaster FP, Russell A, Mirza Y, Keshavan MS, Taormina SP, R., B. , et al. Pituitary volume in treatment-naïve pediatric major depressive disorder. Biological Psychiatry. 2006;60:862–866
  29. MacMaster FP, Keshavan M, Mirza Y, Carrey N, Upadhyaya AR, El-Sheikh R, et al. Development and sexual dimorphism of the pituitary gland. Life Sciences. 2007;80:940–944
  30. Mason, B.L., and Pariante, C.M., 2006. The Effects of Antidepressants on the Hypothalamic–Pituitary–Adrenal Axis. Drug News and Perspectives 19, 603.
  31. Mitchell AJ. The role of corticotropin releasing factor in depressive illness: a critical review. Neuroscience and Biobehavioral Reviews. 1998;22:635–651
  32. Nemeroff CB, Krishnan KR, Reed D, Leder L, Beam C, Dunnik NR. Adrenal gland enlargement in major depression. A computer tomographic study. Archives of General Psychiatry. 1992;49:384–387
  33. Pariante CM. Depression, stress and the adrenal axis. Neuroendocrinology. 2003;15:811–812
  34. Pariante CM, Miller AH. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biological Psychiatry. 2001;49:391–404
  35. Pariante CM, Thomas SA, Lovestone S, Makoff A, Kerwin RW. Do antidepressants regulate how cortisol affects the brain?. Psychoneuroendocrinology. 2004;29:423–447
  36. Pariante CM, Vassilopoulou K, Velakoulis D, Phillips L, Soulsby B, Wood SJ, et al. Pituitary volume in psychosis. British Journal of Psychiatry. 2004;185:5–10
  37. Pariante CM, Dazzan P, Danese A, Morgan KD, Brudaglio F, Morgan C, et al. Increased pituitary in antipsychotic-free and antipsychotic-treated patients of the AEsop first-onset psychosis study. Neuropsychopharmacology. 2005;30:1923–1931
  38. Parker KJ, Schatzberg AF, Lyons DM. Neuroendocrine aspects of hypercortisolism in major depression. Hormones and Behavior. 2003;43:60–66
  39. Rubin RT, Phillips JJ, Sadow TF, McCracken JT. Adrenal gland volume in major depression: increase during the depressive episode and decrease with successful treatment. Archives of General Psychiatry. 1995;52:
  40. Sapolsky RM, Zola-Morgan S, Squire L. Inhibition of glucocorticoid secretion by the hippocampal formation in the primate. The Journal of Neuroscience. 1991;11:3695–3704
  41. Sassi R, Nicoletti M, Brambilla P, Harenski K, Mallinger AG, Frank E, et al. Decreased pituitary volumes in patients with bipolar disorder. Biological Psychiatry. 2001;50:271–280
  42. Schwartz PJ, Loe JA, Bash CN, Bove K, Turner EH, Frank JA, et al. Seasonality and pituitary volume. Psychiatry Research Neuroimaging Section. 1997;74:151–157
  43. Sheline YI. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbility. Biological Psychiatry. 2000;48:791–800
  44. Smith SM. Fast robust automated brain extraction. Human Brain Mapping. 2002;17:143–155
  45. Sowell ER, Thompson PM, Holmes CJ, Jernigan TL, Toga AW. In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nature Neuroscience. 1999;2:859–861
  46. Sowell ER, Thompson PM, Tessner KD, Toga AW. Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: inverse relationships during postadolescent brain maturation. The Journal of Neuroscience. 2001;21:8819–8829
  47. Sowell ER, Thompson PM, Toga AW. Mapping changes in the human cortex throughout the span of life. The Neuroscientist. 2004;10:372–392
  48. Swaab DF, Bao AM, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Research Reviews. 2005;4:141–194
  49. Szot P, Bale TL, Dorsa DM. Distribution of messenger RNA for the vasopressin V1a receptor in the CNS of male and female rats. Brain Research. 1994;24:1–10
  50. Takano K, Utsonomiya H, Ono H, Ohfu M, Okazaki M. Normal development of the pituitary gland: assessment with three-dimensional MR volumetry. American Journal of Neuroradiology. 1999;20:312–315
  51. Varghese FP, Brown ES. The hypothalamic–pituitary–adrenal axis in major depressive disorder: a brief primer for primary care physicians. Primary Care Companion to the Journal of Clinical Psychiatry. 2001;3:151–155
  52. Watson D, Clark L, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of Personality and Social Psychology. 1988;54:1063–1070
  53. Watson D, Clark L, Weber K, Assenheimer J, Strauss M, McCormick R. Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales. Journal of Abnormal Psychology. 1995;104:3–14
  54. Wechsler D. Manual for the Wechsler Abbreviated Scale of Intelligence. San Antonio, TX: The Psychological Corporation; 1999;
  55. Wechsler D. Manual for the Wechsler Test of Adult Reading (WTAR). San Antonio, TX: The Psychological Corporation; 2001;
  56. Young EA, Haskett RF, Murphy-Weinberg V, Watson SJ, Akil H. Loss of glucocorticoids fast feedback in depression. Archives of General Psychiatry. 1991;48:693–698
  57. Zhang Y, Brady M, Smith SM. Segmentation of brain MR images through a hidden Markov random field model and the expectation maximization algorithm. IEEE Transactions on Medical Imaging. 2001;20:45–57

PII: S0925-4927(08)00089-9

doi: 10.1016/j.pscychresns.2008.06.006

Psychiatry Research: Neuroimaging
Volume 172, Issue 1 , Pages 55-60 , 30 April 2009

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