Psychiatry Research: Neuroimaging
Volume 164, Issue 2 , Pages 154-159 , 30 November 2008

Single voxel magnetic resonance spectroscopy at 3 Tesla in a memory disorders clinic: Early right hippocampal NAA/Cr loss in mildly impaired subjects

  • Maria T. Caserta

      Affiliations

    • Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, University of South Florida, 3515 E. Fletcher Ave., MDC 14, Tampa, FL 33613, USA. Tel.: +813 974 3519; fax: +813 974 2478.
    • ,
  • Ann Ragin

      Affiliations

    • Department of Radiology, Northwestern University, Chicago, IL, USA
    • ,
  • Adriana P. Hermida

      Affiliations

    • Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
    • ,
  • R. John Ahrens

      Affiliations

    • Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
    • ,
  • Leon Wise

      Affiliations

    • Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA

Received 13 April 2007 ,Revised 27 February 2008 ,Accepted 11 April 2008.

References 

  1. Ackl N, Ising M, Schreiber YA, Atiya M, Sonntag A, Auer DP. Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. Neuroscience Letters. 2005;384:23–28
  2. Block W, Jessen F, Traber F, Flacke S, Manka C, Lamerichs R, et al. Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease. Archives of Neurology. 2002;59:828–834
  3. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathologica. 1991;82:239–259
  4. Chantal S, Labelle M, Bouchard RW, Braun CM, Boulanger Y. Correlation of regional proton magnetic resonance spectroscopic metabolic changes with cognitive deficits in mild Alzheimer disease. Archives of Neurology. 2002;59:955–962
  5. Chao LL, Schuff N, Kramer JH, Du AT, Capizzano AA, O'Neill J, et al. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients. Neurology. 2005;64:282–289
  6. deToledo-Morrell L, Stoub TR, Bulgakova M, Wilson RS, Bennett DA, Leurgans S, et al. MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiology of Aging. 2004;25:1197–1203
  7. Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain. 2002;125:2332–2341
  8. Firbank MJ, Harrison RM, O'Brien JT. A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease. Dementia and Geriatric Cognitive Disorders. 2002;14:64–76
  9. Huang W, Alexander GE, Chang L, Shetty HU, Krasuski JS, Rapoport SI, et al. Brain metabolite concentration and dementia severity in Alzheimer's disease: 1H MRS study. Neurology. 2001;57:626–632
  10. Lehtovirta M, Laakso MP, Frisoni GB, Soininen H. How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies. Neurobiology of Aging. 2000;21:293–300
  11. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  12. Mega MS, Small GW, Xu ML, Felix J, Manese M, Tran NP, et al. Hippocampal atrophy in persons with age-associated memory impairment: volumetry within a common space. Psychosomatic Medicine. 2002;64:487–492
  13. Miller SL, Celone K, Depeau K, Diamond E, Dickerson BC, Rentz D, et al. Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proceedings of the National Academy of Sciences of the United States of America. 2008;105:2181–2186
  14. Modrego PJ, Fayed N, Pina MA. Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy. The American Journal of Psychiatry. 2005;162:667–675
  15. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:1133–1142
  16. Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, et al. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD. Neurology. 2002;58:928–935
  17. Soininen H, Partanen K, Pitkanen A, Hallikainen M, Hanninen T, Helisalmi S, et al. Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele. Neurology. 1995;45:391–392
  18. Soininen HS, Partanen K, Pitkanen A, Vainio P, Hanninen T, Hallikainen M, et al. Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: correlation to visual and verbal memory. Neurology. 1994;44:1660–1668
  19. Tapiola T, Pennanen C, Tapiola M, Tervo S, Kivipelto M, Hanninen T, et al. MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study. Neurobiology of Aging. 2008;29:31–38
  20. Valenzuela MJ, Sachdev P. Magnetic resonance spectroscopy in AD. Neurology. 2001;56:592–598

PII: S0925-4927(08)00067-X

doi: 10.1016/j.pscychresns.2008.04.002

Psychiatry Research: Neuroimaging
Volume 164, Issue 2 , Pages 154-159 , 30 November 2008

Article Tools

* Image Usage & Resolution